Aliases for UCN3 Gene
External Ids for UCN3 Gene
Previous GeneCards Identifiers for UCN3 Gene
This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
GeneCards Summary for UCN3 Gene
UCN3 (Urocortin 3) is a Protein Coding gene. Diseases associated with UCN3 include Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hormone activity and corticotropin-releasing hormone receptor 2 binding. An important paralog of this gene is UCN2.
UniProtKB/Swiss-Prot Summary for UCN3 Gene
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.