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This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
UCN3 (Urocortin 3) is a Protein Coding gene. Diseases associated with UCN3 include Body Mass Index Quantitative Trait Locus 11 and Disease Of Mental Health. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include hormone activity and corticotropin-releasing hormone receptor 2 binding. An important paralog of this gene is UCN2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005179 | hormone activity | IEA | -- |
GO:0051429 | corticotropin-releasing hormone receptor binding | IBA,IPI | 11329063 |
GO:0051431 | corticotropin-releasing hormone receptor 2 binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0030424 | axon | IEA | -- |
GO:0043005 | neuron projection | IEA | -- |
GO:0043196 | varicosity | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | Glucocorticoid Pathway (HPA Axis), Pharmacodynamics | ||
4 | G-Beta Gamma Signaling |
CRHR Pathway
.44
|
|
5 | Presynaptic function of Kainate receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IEA,IDA | 11329063 |
GO:0007586 | digestion | IEA | -- |
GO:0009749 | response to glucose | IEA | -- |
GO:0009755 | hormone-mediated signaling pathway | IDA | 11329063 |
GO:0031669 | cellular response to nutrient levels | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Urocortin (rat) | Pharma | Endogenous CRF agonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Urocortin (rat) | 171543-83-2 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | UCN3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | UCN3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ucn3 30 |
|
||
Cow (Bos Taurus) |
Mammalia | UCN3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ucn3 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | UCN3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | UCN3 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | UCN3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100488336 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ucn3l 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs146162534 | Benign: not provided | 5,374,053(+) |
G/A NM_053049.4(UCN3):c.333G>A (p.Thr111=) |
SYNONYMOUS | |
rs199589151 | Likely Benign: not provided | 5,374,092(+) |
C/G NM_053049.4(UCN3):c.372C>G (p.Leu124=) |
SYNONYMOUS | |
rs782110045 | Likely Benign: not provided | 5,374,095(+) |
C/T NM_053049.4(UCN3):c.375C>T (p.Asp125=) |
SYNONYMOUS | |
rs10904481 | - |
p.Arg91Gly |
|||
rs12768730 | - |
p.Glu77Lys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv351n106 | CNV | duplication | 24896259 |
dgv356e59 | CNV | duplication | 20981092 |
esv2660343 | CNV | deletion | 23128226 |
esv2669711 | CNV | deletion | 23128226 |
esv3891744 | CNV | gain | 25118596 |
nsv1069011 | CNV | deletion | 25765185 |
nsv1127081 | CNV | deletion | 24896259 |
nsv1132837 | CNV | insertion | 24896259 |
nsv549886 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
body mass index quantitative trait locus 11 |
|
|
disease of mental health |
|
|