UCN3 Gene (Protein Coding)

Urocortin 3

GC10P005396
GIFtS:
38
This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in res... See more...

Aliases for UCN3 Gene

Aliases for UCN3 Gene

  • Urocortin 3 2 3 5
  • Stresscopin 2 3 4
  • SPC 2 3 4
  • Prepro-Urocortin 3 2 3
  • Urocortin III 3 4
  • Urocortin-3 3 4
  • Ucn III 3 4
  • UCNIII 2 3
  • UCN3 5
  • SCP 3

External Ids for UCN3 Gene

Previous GeneCards Identifiers for UCN3 Gene

  • GC10P005369

Summaries for UCN3 Gene

Entrez Gene Summary for UCN3 Gene

  • This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]

GeneCards Summary for UCN3 Gene

UCN3 (Urocortin 3) is a Protein Coding gene. Diseases associated with UCN3 include Body Mass Index Quantitative Trait Locus 11 and Disease Of Mental Health. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include hormone activity and corticotropin-releasing hormone receptor 2 binding. An important paralog of this gene is UCN2.

UniProtKB/Swiss-Prot Summary for UCN3 Gene

  • Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Gene Wiki entry for UCN3 Gene

Additional gene information for UCN3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UCN3 Gene

Genomics for UCN3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for UCN3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J005365 Promoter 0.3 EPDnew 250.7 +0.1 120 0.1 UCN3 piR-31321-001 TUBAL3
GH10J005364 Promoter 0.3 EPDnew 250.7 -0.1 -74 0.1 UCN3 ENSG00000280450 AKR1C4
GH10J005444 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 +83.0 82967 7 TBP MXD4 CEBPA MNT IKZF1 SMAD5 IRF2 ZFP64 MBD2 POLR2A NET1 ENSG00000232807 FBH1 TASOR2 NRBF2P5 TUBAL3 CALML5 ENSG00000256462 CALML3 CALML3-AS1
GH10J005594 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 +231.0 230977 4.2 FEZF1 NBN ZEB2 RXRA FOSL1 PRDM10 JUND INSM2 PKNOX1 NRF1 LASTR CALML3 CALML3-AS1 ENSG00000256462 CALML5 UCN3 GDI2 NET1 ASB13 HSALNG0075876
GH10J005411 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.6 +48.1 48135 2.6 TBP SP1 MXD4 IKZF1 SMAD5 MBD2 ZIC2 ZNF610 ARNT SIN3A NONHSAG005096.2 NET1 TUBAL3 UCN3 CALML5 piR-30287
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UCN3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UCN3

Top Transcription factor binding sites by QIAGEN in the UCN3 gene promoter:
  • Cdc5
  • Evi-1
  • FOXF2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Nkx3-1
  • POU3F2

Genomic Locations for UCN3 Gene

Latest Assembly
chr10:5,364,966-5,374,692
(GRCh38/hg38)
Size:
9,727 bases
Orientation:
Plus strand

Previous Assembly
chr10:5,406,929-5,416,655
(GRCh37/hg19 by Entrez Gene)
Size:
9,727 bases
Orientation:
Plus strand

chr10:5,406,972-5,416,169
(GRCh37/hg19 by Ensembl)
Size:
9,198 bases
Orientation:
Plus strand

Genomic View for UCN3 Gene

Genes around UCN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCN3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UCN3 Gene

Proteins for UCN3 Gene

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  1. Antibodies for research
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  3. Assay products for research

  • Protein details for UCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969E3-UCN3_HUMAN
    Recommended name:
    Urocortin-3
    Protein Accession:
    Q969E3
    Secondary Accessions:
    • Q496H2
    • Q5SR91

    Protein attributes for UCN3 Gene

    Size:
    161 amino acids
    Molecular mass:
    17961 Da
    Quaternary structure:
    • Binds with high affinity to CRF receptors 2-alpha and 2-beta.

    Three dimensional structures from OCA and Proteopedia for UCN3 Gene

neXtProt entry for UCN3 Gene

Protein Expression for UCN3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for UCN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UCN3 Gene

Domains & Families for UCN3 Gene

Gene Families for UCN3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for UCN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UCN3 Gene

GenScript: Design optimal peptide antigens:
  • Urocortin III (UCN3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969E3

UniProtKB/Swiss-Prot:

UCN3_HUMAN :
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Family:
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
genes like me logo Genes that share domains with UCN3: view

Function for UCN3 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for UCN3 Gene

UniProtKB/Swiss-Prot Function:
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Phenotypes From GWAS Catalog for UCN3 Gene

Gene Ontology (GO) - Molecular Function for UCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0051429 corticotropin-releasing hormone receptor binding IBA,IPI 11329063
GO:0051431 corticotropin-releasing hormone receptor 2 binding IEA --
genes like me logo Genes that share ontologies with UCN3: view
genes like me logo Genes that share phenotypes with UCN3: view

Animal Models for UCN3 Gene

MGI Knock Outs for UCN3:
  • Ucn3 Ucn3<tm1.1Jde>
  • Ucn3 Ucn3<tm1.1(KOMP)Vlcg>
  • Ucn3 Ucn3<tm1Pbl>

Animal Models for research

  • Taconic Biosciences Mouse Models for UCN3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UCN3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UCN3 Gene

Localization for UCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCN3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UCN3 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0030424 axon IEA --
GO:0043005 neuron projection IEA --
GO:0043196 varicosity IEA --
genes like me logo Genes that share ontologies with UCN3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UCN3 Gene

Pathways & Interactions for UCN3 Gene

genes like me logo Genes that share pathways with UCN3: view

Pathways by source for UCN3 Gene

1 PharmGKB pathway for UCN3 Gene
1 KEGG pathway for UCN3 Gene
1 Qiagen pathway for UCN3 Gene
  • CRHR Pathway

Gene Ontology (GO) - Biological Process for UCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA,IDA 11329063
GO:0007586 digestion IEA --
GO:0009749 response to glucose IEA --
GO:0009755 hormone-mediated signaling pathway IDA 11329063
GO:0031669 cellular response to nutrient levels IBA 21873635
genes like me logo Genes that share ontologies with UCN3: view

No data available for SIGNOR curated interactions for UCN3 Gene

Drugs & Compounds for UCN3 Gene

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(5) Drugs for UCN3 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urocortin (rat) Pharma Endogenous CRF agonist 0

(2) Additional Compounds for UCN3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for UCN3 Gene

Compound Action Cas Number
Urocortin (rat) 171543-83-2
genes like me logo Genes that share compounds with UCN3: view

Drug products for research

Transcripts for UCN3 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for UCN3 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UCN3

Alternative Splicing Database (ASD) splice patterns (SP) for UCN3 Gene

No ASD Table

Relevant External Links for UCN3 Gene

GeneLoc Exon Structure for
UCN3

Expression for UCN3 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UCN3 Gene

mRNA expression in normal human tissues for UCN3 Gene
mRNA expression by GTEx for UCN3 GenemRNA expression by BioGPS for UCN3 Gene

mRNA differential expression in normal tissues according to GTEx for UCN3 Gene

This gene is overexpressed in Pancreas (x12.7), Pituitary (x11.9), Colon - Transverse (x8.4), and Small Intestine - Terminal Ileum (x5.7).

Protein differential expression in normal tissues from HIPED for UCN3 Gene

This gene is overexpressed in Pancreas (35.1) and Islet of Langerhans (33.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UCN3 Gene



Protein tissue co-expression partners for UCN3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UCN3

SOURCE GeneReport for Unigene cluster for UCN3 Gene:

Hs.511775

Evidence on tissue expression from TISSUES for UCN3 Gene

  • Nervous system(2.7)
  • Pancreas(2.6)
  • Adrenal gland(2.6)
  • Muscle(2.3)
  • Heart(2.3)
  • Intestine(2.2)
  • Skin(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with UCN3: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UCN3 Gene

Orthologs for UCN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UCN3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia UCN3 30 31
  • 99.17 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia UCN3 30 31
  • 77.43 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ucn3 30
  • 76.6 (n)
Cow
(Bos Taurus)
 Mammalia UCN3 30 31
  • 75.98 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ucn3 30 17 31
  • 74.33 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia UCN3 31
  • 60 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves UCN3 30
  • 70.8 (n)
Lizard
(Anolis carolinensis)
 Reptilia UCN3 31
  • 55 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100488336 30
  • 62.69 (n)
Zebrafish
(Danio rerio)
 Actinopterygii ucn3l 30 31
  • 59.4 (n)
 OneToOne
Species where no ortholog for UCN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for UCN3 Gene

ENSEMBL:
Gene Tree for UCN3 (if available)
TreeFam:
Gene Tree for UCN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UCN3: view image

Paralogs for UCN3 Gene

Paralogs for UCN3 Gene

genes like me logo Genes that share paralogs with UCN3: view

Variants for UCN3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UCN3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs146162534 Benign: not provided 5,374,053(+) G/A
NM_053049.4(UCN3):c.333G>A (p.Thr111=) 		SYNONYMOUS
rs199589151 Likely Benign: not provided 5,374,092(+) C/G
NM_053049.4(UCN3):c.372C>G (p.Leu124=) 		SYNONYMOUS
rs782110045 Likely Benign: not provided 5,374,095(+) C/T
NM_053049.4(UCN3):c.375C>T (p.Asp125=) 		SYNONYMOUS
rs10904481 - p.Arg91Gly
rs12768730 - p.Glu77Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UCN3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UCN3 Gene

Variant ID Type Subtype PubMed ID
dgv351n106 CNV duplication 24896259
dgv356e59 CNV duplication 20981092
esv2660343 CNV deletion 23128226
esv2669711 CNV deletion 23128226
esv3891744 CNV gain 25118596
nsv1069011 CNV deletion 25765185
nsv1127081 CNV deletion 24896259
nsv1132837 CNV insertion 24896259
nsv549886 CNV loss 21841781

Variation tolerance for UCN3 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UCN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UCN3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCN3 Gene

Disorders for UCN3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for UCN3 Gene - From: COP

Disorder Aliases PubMed IDs
body mass index quantitative trait locus 11
  • bmiq11
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards
Search UCN3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UCN3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UCN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCN3 Gene

Publications for UCN3 Gene

  1. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. (PMID: 11416224) Lewis K … Vale WW (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 23
  2. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. (PMID: 11329063) Hsu SY … Hsueh AJ (Nature medicine 2001) 3 4 23
  3. Suppression of progesterone production by stresscopin/urocortin 3 in cultured human granulosa-lutein cells. (PMID: 19351656) Yata A … Maruo T (Human reproduction (Oxford, England) 2009) 3 23
  4. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. (PMID: 18504423) Wong ML … Licinio J (Molecular psychiatry 2008) 3 41
  5. Common and divergent structural features of a series of corticotropin releasing factor-related peptides. (PMID: 18052377) Grace CR … Riek R (Journal of the American Chemical Society 2007) 4 23

ExternalLinks

View latest publications for UCN3 gene in Mastermind

Products for UCN3 Gene

Sources for UCN3 Gene