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Aliases for UCN3 Gene

Aliases for UCN3 Gene

  • Urocortin 3 2 3 5
  • Stresscopin 2 3 4
  • Prepro-Urocortin 3 2 3
  • Urocortin III 3 4
  • Ucn III 3 4
  • SPC 3 4
  • Urocortin-3 3
  • UCNIII 3
  • SCP 3

External Ids for UCN3 Gene

Previous GeneCards Identifiers for UCN3 Gene

  • GC10P005369

Summaries for UCN3 Gene

Entrez Gene Summary for UCN3 Gene

  • This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]

GeneCards Summary for UCN3 Gene

UCN3 (Urocortin 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include hormone activity and corticotropin-releasing hormone receptor 2 binding.

UniProtKB/Swiss-Prot for UCN3 Gene

  • Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Gene Wiki entry for UCN3 Gene

Additional gene information for UCN3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCN3 Gene

Genomics for UCN3 Gene

GeneHancer (GH) Regulatory Elements for UCN3 Gene

Promoters and enhancers for UCN3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I005364 Promoter 0.5 EPDnew 550.8 -0.1 -117 0.1 UCN3 ENSG00000280450
GH10I005444 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10 +82.9 82924 7 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 NET1 LOC105376384 NRBF2P5 TUBAL3 GDI2 FBXO18 FAM208B CALML5 CALML3 CALML3-AS1
GH10I005411 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.6 +48.0 48021 2.2 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF48 YY1 POLR2B GLIS2 FOS NET1 FAM208B FBXO18 TUBAL3 LOC105376384 AKR1E2 ENSG00000226647 UCN3 CALML5
GH10I004825 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.3 -538.4 -538436 2 PKNOX1 ATF1 NEUROD1 SIN3A ZNF766 ZNF143 FOS CAVIN1 NCOA1 REST AKR1E2 UCN3 TUBAL3 AKR1C2 GC10P004844
GH10I005289 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -71.2 -71163 8.8 PKNOX1 ATF1 SIN3A ZNF48 TCF12 ZNF143 FOS REST ZNF592 SREBF1 LINC02561 TUBAL3 UCN3 ENSG00000239142 AKR1C3 AKR1E2 AKR1C7P GC10M005304
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UCN3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UCN3 gene promoter:

Genomic Locations for UCN3 Gene

Genomic Locations for UCN3 Gene
9,684 bases
Plus strand

Genomic View for UCN3 Gene

Genes around UCN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCN3 Gene

Proteins for UCN3 Gene

  • Protein details for UCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q496H2
    • Q5SR91

    Protein attributes for UCN3 Gene

    161 amino acids
    Molecular mass:
    17961 Da
    Quaternary structure:
    • Binds with high affinity to CRF receptors 2-alpha and 2-beta.

    Three dimensional structures from OCA and Proteopedia for UCN3 Gene

neXtProt entry for UCN3 Gene

Post-translational modifications for UCN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UCN3 Gene

Domains & Families for UCN3 Gene

Gene Families for UCN3 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for UCN3 Gene


Suggested Antigen Peptide Sequences for UCN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
genes like me logo Genes that share domains with UCN3: view

Function for UCN3 Gene

Molecular function for UCN3 Gene

UniProtKB/Swiss-Prot Function:
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Phenotypes From GWAS Catalog for UCN3 Gene

Gene Ontology (GO) - Molecular Function for UCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005179 hormone activity IEA --
GO:0051429 corticotropin-releasing hormone receptor binding IPI 11329063
GO:0051431 corticotropin-releasing hormone receptor 2 binding IEA --
genes like me logo Genes that share ontologies with UCN3: view
genes like me logo Genes that share phenotypes with UCN3: view

Animal Models for UCN3 Gene

MGI Knock Outs for UCN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for UCN3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UCN3 Gene

Localization for UCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCN3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UCN3 gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for UCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005622 intracellular IDA,IEA 11329063
GO:0030424 axon IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with UCN3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UCN3 Gene

Pathways & Interactions for UCN3 Gene

genes like me logo Genes that share pathways with UCN3: view

Pathways by source for UCN3 Gene

1 Qiagen pathway for UCN3 Gene

Gene Ontology (GO) - Biological Process for UCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress IEA --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA,IDA 11329063
GO:0007586 digestion IEA --
GO:0009749 response to glucose IEA --
GO:0009755 hormone-mediated signaling pathway IDA 11329063
genes like me logo Genes that share ontologies with UCN3: view

No data available for SIGNOR curated interactions for UCN3 Gene

Drugs & Compounds for UCN3 Gene

(6) Drugs for UCN3 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urocortin (rat) Pharma Endogenous CRF agonist 0

(1) Additional Compounds for UCN3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for UCN3 Gene

Compound Action Cas Number
Urocortin (rat) 171543-83-2
genes like me logo Genes that share compounds with UCN3: view

Drug Products

Transcripts for UCN3 Gene

mRNA/cDNA for UCN3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCN3 Gene

Urocortin 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCN3 Gene

No ASD Table

Relevant External Links for UCN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UCN3 Gene

mRNA differential expression in normal tissues according to GTEx for UCN3 Gene

This gene is overexpressed in Pancreas (x12.7), Pituitary (x11.9), Colon - Transverse (x8.4), and Small Intestine - Terminal Ileum (x5.7).

Protein differential expression in normal tissues from HIPED for UCN3 Gene

This gene is overexpressed in Pancreas (35.1) and Islet of Langerhans (33.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UCN3 Gene

Protein tissue co-expression partners for UCN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of UCN3 Gene:


SOURCE GeneReport for Unigene cluster for UCN3 Gene:


Evidence on tissue expression from TISSUES for UCN3 Gene

  • Nervous system(2.6)
  • Adrenal gland(2.4)
  • Heart(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with UCN3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UCN3 Gene

Orthologs for UCN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UCN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UCN3 33 34
  • 99.17 (n)
(Canis familiaris)
Mammalia UCN3 33 34
  • 77.43 (n)
(Rattus norvegicus)
Mammalia Ucn3 33
  • 76.6 (n)
(Bos Taurus)
Mammalia UCN3 33 34
  • 75.98 (n)
(Mus musculus)
Mammalia Ucn3 33 16 34
  • 74.33 (n)
(Monodelphis domestica)
Mammalia UCN3 34
  • 60 (a)
(Gallus gallus)
Aves UCN3 33
  • 70.8 (n)
(Anolis carolinensis)
Reptilia UCN3 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488336 33
  • 62.69 (n)
(Danio rerio)
Actinopterygii ucn3l 33 34
  • 59.4 (n)
Species where no ortholog for UCN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCN3 Gene

Gene Tree for UCN3 (if available)
Gene Tree for UCN3 (if available)

Paralogs for UCN3 Gene

No data available for Paralogs for UCN3 Gene

Variants for UCN3 Gene

Sequence variations from dbSNP and Humsavar for UCN3 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000170377 -- 5,374,393(+) C/T downstream_transcript_variant
rs1000558689 -- 5,363,819(+) T/C upstream_transcript_variant
rs1000583272 -- 5,363,569(+) T/A upstream_transcript_variant
rs1000880185 -- 5,369,025(+) T/C intron_variant
rs1001775347 -- 5,373,443(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UCN3 Gene

Variant ID Type Subtype PubMed ID
dgv351n106 CNV duplication 24896259
dgv356e59 CNV duplication 20981092
esv2660343 CNV deletion 23128226
esv2669711 CNV deletion 23128226
esv3891744 CNV gain 25118596
nsv1069011 CNV deletion 25765185
nsv1127081 CNV deletion 24896259
nsv1132837 CNV insertion 24896259
nsv549886 CNV loss 21841781

Variation tolerance for UCN3 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UCN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCN3 Gene

Disorders for UCN3 Gene

Additional Disease Information for UCN3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UCN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UCN3 Gene

Publications for UCN3 Gene

  1. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. (PMID: 11416224) Lewis K … Vale WW (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 22 58
  2. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. (PMID: 11329063) Hsu SY … Hsueh AJ (Nature medicine 2001) 3 4 22 58
  3. Suppression of progesterone production by stresscopin/urocortin 3 in cultured human granulosa-lutein cells. (PMID: 19351656) Yata A … Maruo T (Human reproduction (Oxford, England) 2009) 3 22 58
  4. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. (PMID: 18504423) Wong ML … Licinio J (Molecular psychiatry 2008) 3 44 58
  5. Common and divergent structural features of a series of corticotropin releasing factor-related peptides. (PMID: 18052377) Grace CR … Riek R (Journal of the American Chemical Society 2007) 4 22 58

Products for UCN3 Gene

Sources for UCN3 Gene

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