Aliases for UCN Gene
External Ids for UCN Gene
Previous GeneCards Identifiers for UCN Gene
This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]
GeneCards Summary for UCN Gene
UCN (Urocortin) is a Protein Coding gene. Diseases associated with UCN include Ulcerative Colitis and Systolic Heart Failure. Among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is CRH.
UniProtKB/Swiss-Prot Summary for UCN Gene
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).