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Aliases for UCKL1 Gene

Aliases for UCKL1 Gene

  • Uridine-Cytidine Kinase 1 Like 1 2 3 5
  • EC 4 56
  • URKL1 3 4
  • Uridine-Cytidine Kinase 1-Like 1 2
  • Uridine-Cytidine Kinase-Like 1 3
  • Uridine Kinase-Like 1 2
  • UCK1-LIKE 3
  • UCK1L 3

External Ids for UCKL1 Gene

Previous HGNC Symbols for UCKL1 Gene

  • URKL1

Previous GeneCards Identifiers for UCKL1 Gene

  • GC20M062041
  • GC20M062571
  • GC20M059304

Summaries for UCKL1 Gene

Entrez Gene Summary for UCKL1 Gene

  • The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for UCKL1 Gene

UCKL1 (Uridine-Cytidine Kinase 1 Like 1) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include kinase activity and uridine kinase activity. An important paralog of this gene is UCK2.

UniProtKB/Swiss-Prot for UCKL1 Gene

  • May contribute to UTP accumulation needed for blast transformation and proliferation.

Gene Wiki entry for UCKL1 Gene

Additional gene information for UCKL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCKL1 Gene

Genomics for UCKL1 Gene

GeneHancer (GH) Regulatory Elements for UCKL1 Gene

Promoters and enhancers for UCKL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I063953 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563.3 +2.9 2928 5.5 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC GLIS1 UCKL1 PIR62018 ARFRP1 TNFRSF6B STMN3 TCEA2 HAR1A RTEL1 ZBTB46 ZNF512B
GH20I063947 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 572.5 +9.4 9357 5.9 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A FEZF1 UCKL1 MIR647 ENSG00000237371 GMEB2 CICP4 PRPF6 C20orf204 UCKL1-AS1 PIR37009
GH20I063657 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 35.8 +301.0 301000 2.7 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC RTEL1 STMN3 RTEL1-TNFRSF6B DIDO1 MIR647 GMEB2 UCKL1 CICP4 TCEA2 MRGBP
GH20I063845 Enhancer 1.5 Ensembl ENCODE dbSUPER 47.8 +112.1 112109 3.3 HDGF PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A YBX1 FEZF1 DMAP1 C20orf181 MIR647 DIDO1 UCKL1 PCMTD2 TNFRSF6B ZNF512B RTEL1 YTHDF1 ENSG00000237371
GH20I063971 Enhancer 1.5 Ensembl ENCODE dbSUPER 33.3 -14.2 -14168 3.8 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 MIR647 UCKL1 PRPF6 C20orf204 RTEL1 TNFRSF6B ARFRP1 YTHDF1 ENSG00000237371 PCMTD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UCKL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UCKL1 gene promoter:

Genomic Locations for UCKL1 Gene

Genomic Locations for UCKL1 Gene
19,607 bases
Minus strand

Genomic View for UCKL1 Gene

Genes around UCKL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCKL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCKL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCKL1 Gene

Proteins for UCKL1 Gene

  • Protein details for UCKL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uridine-cytidine kinase-like 1
    Protein Accession:
    Secondary Accessions:
    • B7Z8N2
    • Q5JWV0
    • Q70AQ5
    • Q8N524
    • Q9H3Z2

    Protein attributes for UCKL1 Gene

    548 amino acids
    Molecular mass:
    61141 Da
    Quaternary structure:
    • Interacts with RNF19B and EBV EBNA3.

    Alternative splice isoforms for UCKL1 Gene


neXtProt entry for UCKL1 Gene

Selected DME Specific Peptides for UCKL1 Gene


Post-translational modifications for UCKL1 Gene

  • Ubiquitinated by RNF19B; which induces proteasomal degradation.
  • Ubiquitination at isoforms=2, 3, 4111, isoforms=4387, and posLast=392392
  • Modification sites at PhosphoSitePlus

Domains & Families for UCKL1 Gene

Gene Families for UCKL1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the uridine kinase family.
  • Belongs to the uridine kinase family.
genes like me logo Genes that share domains with UCKL1: view

Function for UCKL1 Gene

Molecular function for UCKL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + uridine = ADP + UMP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + cytidine = ADP + CMP.
UniProtKB/Swiss-Prot Function:
May contribute to UTP accumulation needed for blast transformation and proliferation.

Enzyme Numbers (IUBMB) for UCKL1 Gene

Phenotypes From GWAS Catalog for UCKL1 Gene

Gene Ontology (GO) - Molecular Function for UCKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004849 uridine kinase activity TAS --
GO:0005515 protein binding IPI 12199906
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UCKL1: view
genes like me logo Genes that share phenotypes with UCKL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UCKL1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UCKL1 Gene

Localization for UCKL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCKL1 Gene

Cytoplasm. Nucleus. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UCKL1 gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 3
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UCKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA,TAS --
genes like me logo Genes that share ontologies with UCKL1: view

Pathways & Interactions for UCKL1 Gene

genes like me logo Genes that share pathways with UCKL1: view

Pathways by source for UCKL1 Gene

UniProtKB/Swiss-Prot Q9NWZ5-UCKL1_HUMAN

  • Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.
  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.

Gene Ontology (GO) - Biological Process for UCKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process IBA --
GO:0006222 UMP biosynthetic process IEA --
GO:0008152 metabolic process IEA --
GO:0009116 nucleoside metabolic process IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with UCKL1: view

No data available for SIGNOR curated interactions for UCKL1 Gene

Drugs & Compounds for UCKL1 Gene

(17) Drugs for UCKL1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Phosphoribosylpyrophosphoric Acid Approved, Experimental, Investigational Pharma Target 0
Guanosine triphosphate Experimental Pharma Target 0
Uracil Experimental, Investigational Pharma Target 0
Uridine monophosphate Experimental Pharma Target 0
5-Fluorouridine Experimental Pharma 0

(11) Additional Compounds for UCKL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Fluorouridine monophosphate
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
genes like me logo Genes that share compounds with UCKL1: view

Transcripts for UCKL1 Gene

Unigene Clusters for UCKL1 Gene

Uridine-cytidine kinase 1-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCKL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ·
SP1: - - - - - - - -
SP2: - -
SP3: - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: -
SP8: - - - -
SP9: - -
SP10: - - -
SP14: - -
SP15: - -
SP16: -
SP17: -

ExUns: 11c · 11d · 11e ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2: - -
SP12: -

Relevant External Links for UCKL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCKL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UCKL1 Gene

Protein differential expression in normal tissues from HIPED for UCKL1 Gene

This gene is overexpressed in Plasma (31.0), Monocytes (13.2), and Salivary gland (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UCKL1 Gene

Protein tissue co-expression partners for UCKL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UCKL1 Gene:


SOURCE GeneReport for Unigene cluster for UCKL1 Gene:


mRNA Expression by UniProt/SwissProt for UCKL1 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for UCKL1 Gene

  • Kidney(4.3)
  • Spleen(4.3)
  • Heart(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with UCKL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UCKL1 Gene

Orthologs for UCKL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCKL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 94 (a)
-- 34
  • 88 (a)
(Monodelphis domestica)
Mammalia UCKL1 34
  • 93 (a)
(Pan troglodytes)
Mammalia UCKL1 33 34
  • 91.99 (n)
(Canis familiaris)
Mammalia UCKL1 33 34
  • 88.49 (n)
(Rattus norvegicus)
Mammalia Uckl1 33
  • 87.06 (n)
(Bos Taurus)
Mammalia UCKL1 33 34
  • 86.88 (n)
(Mus musculus)
Mammalia Uckl1 33 16 34
  • 86.19 (n)
(Gallus gallus)
Aves ZNF512B 33 34
  • 82.97 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5693 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16539 33
(Danio rerio)
Actinopterygii uckl1b 33 34
  • 77.11 (n)
uckl1a 34
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1186 33
fruit fly
(Drosophila melanogaster)
Insecta l(2)k01209 34
  • 52 (a)
(Caenorhabditis elegans)
Secernentea F19B6.1 34
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URK1 34 36
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UKL5 33
  • 51.89 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
Species where no ortholog for UCKL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UCKL1 Gene

Gene Tree for UCKL1 (if available)
Gene Tree for UCKL1 (if available)

Paralogs for UCKL1 Gene

Paralogs for UCKL1 Gene

(4) SIMAP similar genes for UCKL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UCKL1: view

Variants for UCKL1 Gene

Sequence variations from dbSNP and Humsavar for UCKL1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000047260 -- 63,945,156(-) C/T 5_prime_UTR_variant, intron_variant
rs1000112354 -- 63,954,094(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000147204 -- 63,947,333(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000147518 -- 63,943,090(-) T/C 3_prime_UTR_variant, intron_variant
rs1000157374 -- 63,943,255(-) G/C 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UCKL1 Gene

Variant ID Type Subtype PubMed ID
esv29498 CNV gain 19812545
esv3361353 CNV duplication 20981092
esv996794 CNV insertion 20482838
nsv1160691 CNV deletion 26073780
nsv428381 CNV gain+loss 18775914
nsv469773 CNV gain 16826518
nsv509784 CNV insertion 20534489
nsv586695 CNV loss 21841781
nsv953309 CNV deletion 24416366

Variation tolerance for UCKL1 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UCKL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCKL1 Gene

Disorders for UCKL1 Gene

Additional Disease Information for UCKL1

No disorders were found for UCKL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UCKL1 Gene

Publications for UCKL1 Gene

  1. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PMID: 16709802) Fortier JM … Kornbluth J (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4 22 58
  2. Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells. (PMID: 19653100) Ambrose EC … Kornbluth J (Apoptosis : an international journal on programmed cell death 2009) 3 22 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for UCKL1 Gene

Sources for UCKL1 Gene

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