Aliases for UCK2 Gene
External Ids for UCK2 Gene
Previous HGNC Symbols for UCK2 Gene
Previous GeneCards Identifiers for UCK2 Gene
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 18.104.22.168) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
GeneCards Summary for UCK2 Gene
UCK2 (Uridine-Cytidine Kinase 2) is a Protein Coding gene. Diseases associated with UCK2 include Testicular Germ Cell Tumor. Among its related pathways are Pyrimidine metabolism (KEGG) and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include kinase activity and dephospho-CoA kinase activity. An important paralog of this gene is UCK1.
UniProtKB/Swiss-Prot for UCK2 Gene
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.