Aliases for UCK2 Gene
External Ids for UCK2 Gene
Previous HGNC Symbols for UCK2 Gene
Previous GeneCards Identifiers for UCK2 Gene
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 220.127.116.11) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
GeneCards Summary for UCK2 Gene
UCK2 (Uridine-Cytidine Kinase 2) is a Protein Coding gene. Diseases associated with UCK2 include Testicular Germ Cell Tumor and Human Monocytic Ehrlichiosis. Among its related pathways are Metabolism of nucleotides and Fluoropyrimidine Activity. Gene Ontology (GO) annotations related to this gene include kinase activity and dephospho-CoA kinase activity. An important paralog of this gene is UCK1.
UniProtKB/Swiss-Prot Summary for UCK2 Gene
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.