Aliases for UCK1 Gene
External Ids for UCK1 Gene
Previous GeneCards Identifiers for UCK1 Gene
This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]
GeneCards Summary for UCK1 Gene
UCK1 (Uridine-Cytidine Kinase 1) is a Protein Coding gene. Diseases associated with UCK1 include Muscular Dystrophy-Dystroglycanopathy. Among its related pathways are Metabolism of nucleotides and Metabolism. Gene Ontology (GO) annotations related to this gene include kinase activity and dephospho-CoA kinase activity. An important paralog of this gene is UCK2.
UniProtKB/Swiss-Prot Summary for UCK1 Gene
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.