This gene produces a long non-coding RNA that was found to be upregulated in bladder cancer and plays a regulatory role in cell proliferation. This transcript regulates several genes, including CREB (cAMP responsive element binding protein). Expression of this transcript is regulated by CCAAT/enhancer-binding protein-alpha. [provided by RefSeq, Dec 2017] See more...

Aliases for UCA1 Gene

Subcategory (RNA class) for UCA1 Gene

lncRNA

Quality Score for this RNA gene is

15

Aliases for UCA1 Gene

  • Urothelial Cancer Associated 1 2 3 5
  • Urothelial Cancer Associated 1 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 178 2 3
  • Cancer Up-Regulated Drug Resistant 2 3
  • UCA1 2 170
  • Onco-LncRNA-36 3
  • HSALNG0124349 169
  • NONHSAG025011 94
  • HSALNG0124398 169
  • UCA1 Protein 13
  • NCRNA00178 3
  • LINC00178 3
  • UCAT1 3
  • CUDR 3

External Ids for UCA1 Gene

Previous GeneCards Identifiers for UCA1 Gene

  • GC19U900573
  • GC19P015939
  • GC19P015511

Summaries for UCA1 Gene

Entrez Gene Summary for UCA1 Gene

  • This gene produces a long non-coding RNA that was found to be upregulated in bladder cancer and plays a regulatory role in cell proliferation. This transcript regulates several genes, including CREB (cAMP responsive element binding protein). Expression of this transcript is regulated by CCAAT/enhancer-binding protein-alpha. [provided by RefSeq, Dec 2017]

GeneCards Summary for UCA1 Gene

UCA1 (Urothelial Cancer Associated 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with UCA1 include Glandular Cystitis and Bladder Adenocarcinoma. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.

Rfam classification for UCA1 Gene

  • Urothelial cancer associated 1 conserved region

Additional gene information for UCA1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for UCA1 Gene

Genomics for UCA1 Gene

GeneHancer (GH) Regulatory Elements for UCA1 Gene

Promoters and enhancers for UCA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015826 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.2 +4.6 4559 12.9 ZBTB40 SP1 SMARCE1 POLR2A ATF1 FOS CREB1 HCFC1 CC2D1A NFYC ENSG00000273782 CHERP ENSG00000269578 AKAP8 C19orf44 MED26 SIN3B SYDE1 ENSG00000268087 TPM4
GH19J015841 Enhancer 1.2 Ensembl ENCODE dbSUPER 8.3 +16.0 15994 4.8 ZBTB40 CTCF SMARCE1 ELF1 HLF TEAD4 CBFA2T2 CEBPG SMARCA4 ZNF639 CYP4F24P CYP4F11 CLEC4O UCA1 piR-30876-048 LOC105369202 lnc-OR7C2-1
GH19J015824 Enhancer 0.6 dbSUPER 10.5 -3.3 -3250 1.7 ZKSCAN8 BACH1 ZNF639 ZNF740 NFE2 ZBTB11 ZNF766 E2F5 MEF2D ZNF644 ZNF861P lnc-OR10H1-2 C19orf44 CHERP AKAP8 CYP4F24P ENSG00000267904 ENSG00000269578 OR10H5 ENSG00000268087
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UCA1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for UCA1 Gene

Genomic Locations for UCA1 Gene
chr19:15,828,206-15,837,766
(GRCh38/hg38)
Size:
9,561 bases
Orientation:
Plus strand
chr19:15,939,757-15,947,130
(GRCh37/hg19)
Size:
7,374 bases
Orientation:
Plus strand

Genomic View for UCA1 Gene

Genes around UCA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCA1 Gene

Proteins for UCA1 Gene

  • Protein details for UCA1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q2VCE5-Q2VCE5_HUMAN
    Recommended name:
    UCA1 protein
    Protein Accession:
    Q2VCE5

    Protein attributes for UCA1 Gene

    Size:
    60 amino acids
    Molecular mass:
    6544 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UCA1 Gene

Post-translational modifications for UCA1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for UCA1 Gene

Domains & Families for UCA1 Gene

Gene Families for UCA1 Gene

Protein Domains for UCA1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for UCA1 Gene

GenScript: Design optimal peptide antigens:
  • UCA1 protein (Q2VCE5_HUMAN)
genes like me logo Genes that share domains with UCA1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UCA1 Gene

Function for UCA1 Gene

Animal Model Products

CRISPR Products

miRNA for UCA1 Gene

miRTarBase miRNAs that target UCA1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UCA1 Gene

Localization for UCA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UCA1 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UCA1 Gene

Pathways & Interactions for UCA1 Gene

genes like me logo Genes that share pathways with UCA1: view

Pathways by source for UCA1 Gene

1 BioSystems pathway for UCA1 Gene

Gene Ontology (GO) - Biological Process for UCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with UCA1: view

No data available for SIGNOR curated interactions for UCA1 Gene

Drugs & Compounds for UCA1 Gene

No Compound Related Data Available

Transcripts for UCA1 Gene

mRNA/cDNA for UCA1 Gene

(1) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(45) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(5) NONCODE transcripts :
(50) RNACentral transcripts :
(13) LncBook transcripts :
(48) LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCA1 Gene

No ASD Table

Relevant External Links for UCA1 Gene

GeneLoc Exon Structure for
UCA1
ECgene alternative splicing isoforms for
UCA1

Expression for UCA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UCA1 Gene

mRNA differential expression in normal tissues according to GTEx for UCA1 Gene

This gene is overexpressed in Bladder (x23.4) and Cervix - Endocervix (x8.6).

NURSA nuclear receptor signaling pathways regulating expression of UCA1 Gene:

UCA1

SOURCE GeneReport for Unigene cluster for UCA1 Gene:

Hs.644234
genes like me logo Genes that share expression patterns with UCA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UCA1 Gene

Orthologs for UCA1 Gene

Evolution for UCA1 Gene

ENSEMBL:
Gene Tree for UCA1 (if available)
TreeFam:
Gene Tree for UCA1 (if available)

No data available for Orthologs for UCA1 Gene

Paralogs for UCA1 Gene

No data available for Paralogs for UCA1 Gene

Variants for UCA1 Gene

Sequence variations from dbSNP and Humsavar for UCA1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000154015 -- 15,832,624(+) C/T intron_variant
rs1000178231 -- 15,834,944(+) A/G non_coding_transcript_variant
rs1000267710 -- 15,827,226(+) T/G upstream_transcript_variant
rs1000476101 -- 15,836,794(+) G/A downstream_transcript_variant
rs1000488880 -- 15,834,055(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UCA1 Gene

Variant ID Type Subtype PubMed ID
esv2671181 CNV deletion 23128226
esv2718244 CNV deletion 23290073
esv3334671 CNV duplication 20981092
nsv1064684 CNV gain 25217958
nsv1133007 OTHER inversion 24896259
nsv833766 CNV loss 17160897
nsv960799 CNV duplication 23825009

Additional Variant Information for UCA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UCA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for UCA1 Gene

Disorders for UCA1 Gene

MalaCards: The human disease database

(32) MalaCards diseases for UCA1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
glandular cystitis
  • cystitis glandularis
bladder adenocarcinoma
  • adenocarcinoma of bladder
prostatic hyperplasia, benign
  • bph
temporal lobe epilepsy
  • epilepsy, temporal lobe
acute myocardial infarction
- elite association - COSMIC cancer census association via MalaCards
Search UCA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UCA1

genes like me logo Genes that share disorders with UCA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCA1 Gene

Publications for UCA1 Gene

  1. lncRNA UCA1 Contributes to Imatinib Resistance by Acting as a ceRNA Against miR-16 in Chronic Myeloid Leukemia Cells. (PMID: 27854515) Xiao Y … Zhang Z (DNA and cell biology 2017) 2 3 56
  2. Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao WJ … Zhang ZY (World journal of gastroenterology 2013) 2 3 56
  3. UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. (PMID: 18501714) Wang F … Chen W (FEBS letters 2008) 2 3 56
  4. Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. (PMID: 17416635) Tsang WP … Kwok TT (RNA (New York, N.Y.) 2007) 2 3 56
  5. Long non-coding RNA UCA1 promoted the growth of adrenocortical cancer cells via modulating the miR-298-CDK6 axis. (PMID: 30935924) Guo N … Zhang Y (Gene 2019) 3 56

Products for UCA1 Gene

Sources for UCA1 Gene