This gene produces a long non-coding RNA that was found to be upregulated in bladder cancer and plays a regulatory role in cell proliferation. This transcript regulates several genes, including CREB (cAMP responsive element binding protein). Expression of this transcript is regulated by CCAAT/enhancer-binding protein-alpha. [provided by RefSeq, Dec 2017] See more...

Aliases for UCA1 Gene

Subcategory (RNA class) for UCA1 Gene

lncRNA

Number of RNA Genes sources:

4 / 17

Aliases for UCA1 Gene

  • Urothelial Cancer Associated 1 2 3 5
  • UCA1 2 5 165
  • Urothelial Cancer Associated 1 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 178 2 3
  • Cancer Up-Regulated Drug Resistant 2 3
  • Onco-LncRNA-36 2 3
  • LINC00178 2 3
  • UCAT1 2 3
  • CUDR 2 3
  • NONHSAG025011.2 91
  • HSALNG0124349 164
  • HSALNG0124398 164
  • UCA1 Protein 13
  • NCRNA00178 3

External Ids for UCA1 Gene

Previous GeneCards Identifiers for UCA1 Gene

  • GC19U900573
  • GC19P015939
  • GC19P015511

Summaries for UCA1 Gene

Entrez Gene Summary for UCA1 Gene

  • This gene produces a long non-coding RNA that was found to be upregulated in bladder cancer and plays a regulatory role in cell proliferation. This transcript regulates several genes, including CREB (cAMP responsive element binding protein). Expression of this transcript is regulated by CCAAT/enhancer-binding protein-alpha. [provided by RefSeq, Dec 2017]

GeneCards Summary for UCA1 Gene

UCA1 (Urothelial Cancer Associated 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with UCA1 include Glandular Cystitis and Bladder Adenocarcinoma. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.

Rfam classification for UCA1 Gene

  • Urothelial cancer associated 1 conserved region

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for UCA1 Gene

Genomics for UCA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UCA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015826 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 616.2 +4.6 4559 12.9 SP1 CREB1 PRDM10 REST TFE3 ZNF512 RFX1 LEF1 IKZF1 POLR2A UCA1 ENSG00000273782 LINC01764 ENSG00000269578 SIN3B AKAP8 CYP4F24P OR10H4 AKAP8L MED26
GH19J015841 Enhancer 1.2 Ensembl ENCODE dbSUPER 8.3 +16.0 15994 4.8 ZNF512 LEF1 IKZF1 JUND ZNF776 PKNOX1 MTA1 REST CTCF DPF2 AKAP8L CYP4F24P CYP4F11 CLEC4O CHERP ENSG00000269578 ENSG00000268189 UCA1 piR-30876-048 LOC105369202
GH19J015824 Enhancer 0.7 dbSUPER 10.5 -3.3 -3250 1.7 ZNF740 ZNF766 NFE2 E2F5 ZBTB11 MEF2D RELA ZNF644 TFDP1 HDAC8 ZNF861P lnc-OR10H1-2 C19orf44 CHERP AKAP8 CYP4F24P ENSG00000267904 ENSG00000269578 OR10H5 ENSG00000268087
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UCA1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for UCA1 Gene

Genomic Locations for UCA1 Gene
chr19:15,828,206-15,837,766
(GRCh38/hg38)
Size:
9,561 bases
Orientation:
Plus strand
chr19:15,939,757-15,947,130
(GRCh37/hg19)
Size:
7,374 bases
Orientation:
Plus strand

Genomic View for UCA1 Gene

Genes around UCA1 on UCSC Golden Path with GeneCards custom track
UCA1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
UCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCA1 Gene

Proteins for UCA1 Gene

  • Protein details for UCA1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q2VCE5-Q2VCE5_HUMAN
    Recommended name:
    UCA1 protein
    Protein Accession:
    Q2VCE5

    Protein attributes for UCA1 Gene

    Size:
    60 amino acids
    Molecular mass:
    6544 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UCA1 Gene

Post-translational modifications for UCA1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for UCA1 Gene

Domains & Families for UCA1 Gene

Gene Families for UCA1 Gene

Protein Domains for UCA1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for UCA1 Gene

GenScript: Design optimal peptide antigens:
  • UCA1 protein (Q2VCE5_HUMAN)
genes like me logo Genes that share domains with UCA1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UCA1 Gene

Function for UCA1 Gene

Animal Model Products

CRISPR Products

miRNA for UCA1 Gene

miRTarBase miRNAs that target UCA1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UCA1 Gene

Localization for UCA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UCA1 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UCA1 Gene

Pathways & Interactions for UCA1 Gene

genes like me logo Genes that share pathways with UCA1: view

Pathways by source for UCA1 Gene

1 BioSystems pathway for UCA1 Gene

Gene Ontology (GO) - Biological Process for UCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with UCA1: view

No data available for Interacting Proteins and SIGNOR curated interactions for UCA1 Gene

Drugs & Compounds for UCA1 Gene

No Compound Related Data Available

Transcripts for UCA1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for UCA1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000D5FB78_9606 lncRNA 2365 2

Ensembl: ENST00000645805 (view in UCSC) ,

LNCipedia: UCA1:13,

URS000075D6E2_9606 lncRNA 2314 2

HGNC: 37126,

RefSeq: NR_015379,

URS0000D62B06_9606 lncRNA 1731 2

Ensembl: ENST00000645156 (view in UCSC) ,

LNCipedia: UCA1:46,

URS0000D600F2_9606 lncRNA 1659 2

Ensembl: ENST00000645764 (view in UCSC) ,

LNCipedia: UCA1:16,

URS0000D62C87_9606 lncRNA 1572 2

Ensembl: ENST00000644400 (view in UCSC) ,

LNCipedia: UCA1:36,

UCA1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for UCA1 Gene

19 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCA1 Gene

No ASD Table

Relevant External Links for UCA1 Gene

GeneLoc Exon Structure for
UCA1

Expression for UCA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UCA1 Gene

mRNA differential expression in normal tissues according to GTEx for UCA1 Gene

This gene is overexpressed in Bladder (x23.4) and Cervix - Endocervix (x8.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UCA1

SOURCE GeneReport for Unigene cluster for UCA1 Gene:

Hs.644234

Evidence on tissue expression from TISSUES for UCA1 Gene

  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with UCA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UCA1 Gene

Orthologs for UCA1 Gene

Evolution for UCA1 Gene

ENSEMBL:
Gene Tree for UCA1 (if available)
TreeFam:
Gene Tree for UCA1 (if available)

No data available for Orthologs for UCA1 Gene

Paralogs for UCA1 Gene

No data available for Paralogs for UCA1 Gene

Variants for UCA1 Gene

Additional dbSNP identifiers (rs#s) for UCA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for UCA1 Gene

Variant ID Type Subtype PubMed ID
esv2671181 CNV deletion 23128226
esv2718244 CNV deletion 23290073
esv3334671 CNV duplication 20981092
nsv1064684 CNV gain 25217958
nsv1133007 OTHER inversion 24896259
nsv833766 CNV loss 17160897
nsv960799 CNV duplication 23825009

Additional Variant Information for UCA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UCA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for UCA1 Gene

Disorders for UCA1 Gene

MalaCards: The human disease database

(38) MalaCards diseases for UCA1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
glandular cystitis
  • cystitis glandularis
bladder adenocarcinoma
  • adenocarcinoma of bladder
prostatic hyperplasia, benign
  • bph
acute myocardial infarction
temporal lobe epilepsy
  • epilepsy, temporal lobe
- elite association - COSMIC cancer census association via MalaCards
Search UCA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UCA1

genes like me logo Genes that share disorders with UCA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCA1 Gene

Publications for UCA1 Gene

  1. lncRNA UCA1 Contributes to Imatinib Resistance by Acting as a ceRNA Against miR-16 in Chronic Myeloid Leukemia Cells. (PMID: 27854515) Xiao Y … Zhang Z (DNA and cell biology 2017) 2 3
  2. Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao WJ … Zhang ZY (World journal of gastroenterology 2013) 2 3
  3. UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. (PMID: 18501714) Wang F … Chen W (FEBS letters 2008) 2 3
  4. Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. (PMID: 17416635) Tsang WP … Kwok TT (RNA (New York, N.Y.) 2007) 2 3
  5. lncRNA UCA1 Increases Proliferation and Multidrug Resistance of Retinoblastoma Cells Through Downregulating miR-513a-5p. (PMID: 31702387) Yang L … Wang Y (DNA and cell biology 2020) 3

Products for UCA1 Gene

Sources for UCA1 Gene