This gene produces a long non-coding RNA that was found to be upregulated in bladder cancer and plays a regulatory role in cell proliferation. This transcript regulates several genes, including CREB (cAMP responsive element binding protein). Expression of this transcript is regulated by CCAAT/enhancer-binding protein-alpha. [provided by RefSeq, Dec 2017] See more...

Aliases for UCA1 Gene

RNA type for UCA1 Gene

lncRNA

Aliases for UCA1 Gene

External Ids for UCA1 Gene

Previous GeneCards Identifiers for UCA1 Gene

  • GC19U900573
  • GC19P015939
  • GC19P015511

Summaries for UCA1 Gene

Entrez Gene Summary for UCA1 Gene

  • This gene produces a long non-coding RNA that was found to be upregulated in bladder cancer and plays a regulatory role in cell proliferation. This transcript regulates several genes, including CREB (cAMP responsive element binding protein). Expression of this transcript is regulated by CCAAT/enhancer-binding protein-alpha. [provided by RefSeq, Dec 2017]

GeneCards Summary for UCA1 Gene

UCA1 (Urothelial Cancer Associated 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with UCA1 include Glandular Cystitis and Bladder Adenocarcinoma. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.

Rfam classification for UCA1 Gene

  • Urothelial cancer associated 1 conserved region

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for UCA1 Gene

Genomics for UCA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UCA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015826 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 266.2 +4.6 4560 12.9 BCLAF1 SP1 NCOR1 MYC IKZF1 ZNF592 POLR2A NFIC ZBTB10 YY1 UCA1 ENSG00000273782 LINC01764 ENSG00000269578 SIN3B AKAP8 CYP4F24P OR10H4 AKAP8L MED26
GH19J015841 Enhancer 1.2 Ensembl ENCODE dbSUPER 8.3 +15.9 15896 4.6 MYC NCOR1 IKZF1 CEBPA NFIC REST CEBPB HES1 MBD2 CTCF AKAP8L CYP4F24P CYP4F11 CLEC4OP CHERP ENSG00000269578 ENSG00000268189 UCA1 piR-30876-048 HSALNG0124399
GH19J015824 Enhancer 0.6 dbSUPER 10.5 -3.2 -3249 1.7 ZNF592 NFE2 RELA IRF9 ETV1 TAF7 HDAC8 PYGO2 ZNF507 ZNF354B ZNF861P C19orf44 CHERP AKAP8 CYP4F24P ENSG00000267904 ENSG00000269578 OR10H5 ENSG00000268087 OR10H4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UCA1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for UCA1 Gene

Latest Assembly
chr19:15,828,205-15,837,766
(GRCh38/hg38)
Size:
9,562 bases
Orientation:
Plus strand

Previous Assembly
chr19:15,939,757-15,947,131
(GRCh37/hg19 by Entrez Gene)
Size:
7,375 bases
Orientation:
Plus strand

chr19:15,939,771-15,947,130
(GRCh37/hg19 by Ensembl)
Size:
7,360 bases
Orientation:
Plus strand

Genomic View for UCA1 Gene

Genes around UCA1 on UCSC Golden Path with GeneCards custom track
UCA1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
UCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCA1 Gene

Proteins for UCA1 Gene

  • Protein details for UCA1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q2VCE5-Q2VCE5_HUMAN
    Recommended name:
    UCA1 protein
    Protein Accession:
    Q2VCE5

    Protein attributes for UCA1 Gene

    Size:
    60 amino acids
    Molecular mass:
    6544 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UCA1 Gene

Post-translational modifications for UCA1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for UCA1 Gene

Domains & Families for UCA1 Gene

Gene Families for UCA1 Gene

Suggested Antigen Peptide Sequences for UCA1 Gene

GenScript: Design optimal peptide antigens:
  • UCA1 protein (Q2VCE5_HUMAN)
genes like me logo Genes that share domains with UCA1: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UCA1 Gene

Function for UCA1 Gene

CRISPR products for research

miRNA for UCA1 Gene

miRTarBase miRNAs that target UCA1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UCA1 Gene

Localization for UCA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UCA1 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UCA1 Gene

Pathways & Interactions for UCA1 Gene

genes like me logo Genes that share pathways with UCA1: view

Pathways by source for UCA1 Gene

1 BioSystems pathway for UCA1 Gene

Gene Ontology (GO) - Biological Process for UCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with UCA1: view

No data available for Interacting Proteins and SIGNOR curated interactions for UCA1 Gene

Drugs & Compounds for UCA1 Gene

No Compound Related Data Available

Transcripts for UCA1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for UCA1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000D5FB78_9606 lncRNA 2370 2

Ensembl: ENST00000645805 (view in UCSC) ,

LNCipedia: UCA1:13,

URS0000D62B06_9606 lncRNA 1733 2

Ensembl: ENST00000645156 (view in UCSC) ,

LNCipedia: UCA1:46,

URS0000D600F2_9606 lncRNA 1659 2

Ensembl: ENST00000645764 (view in UCSC) ,

LNCipedia: UCA1:16,

URS0000D62C87_9606 lncRNA 1577 2

Ensembl: ENST00000644400 (view in UCSC) ,

LNCipedia: UCA1:36,

URS0000D6250A_9606 lncRNA 1337 2

Ensembl: ENST00000644103 (view in UCSC) ,

LNCipedia: UCA1:40,

UCA1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for UCA1 Gene

19 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for UCA1 Gene

No ASD Table

Relevant External Links for UCA1 Gene

GeneLoc Exon Structure for
UCA1

Expression for UCA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UCA1 Gene

mRNA differential expression in normal tissues according to GTEx for UCA1 Gene

This gene is overexpressed in Bladder (x23.4) and Cervix - Endocervix (x8.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UCA1

SOURCE GeneReport for Unigene cluster for UCA1 Gene:

Hs.644234
genes like me logo Genes that share expression patterns with UCA1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UCA1 Gene

Orthologs for UCA1 Gene

Evolution for UCA1 Gene

ENSEMBL:
Gene Tree for UCA1 (if available)
TreeFam:
Gene Tree for UCA1 (if available)
Alliance of Genome Resources:
Additional Orthologs for UCA1

No data available for Orthologs for UCA1 Gene

Paralogs for UCA1 Gene

No data available for Paralogs for UCA1 Gene

Variants for UCA1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UCA1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UCA1 Gene

Variant ID Type Subtype PubMed ID
esv2671181 CNV deletion 23128226
esv2718244 CNV deletion 23290073
esv3334671 CNV duplication 20981092
nsv1064684 CNV gain 25217958
nsv1133007 OTHER inversion 24896259
nsv833766 CNV loss 17160897
nsv960799 CNV duplication 23825009

Additional Variant Information for UCA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UCA1
Leiden Open Variation Database (LOVD)
UCA1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for UCA1 Gene

Disorders for UCA1 Gene

MalaCards: The human disease database

(37) MalaCards diseases for UCA1 Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
glandular cystitis
  • cystitis glandularis
bladder adenocarcinoma
  • adenocarcinoma of bladder
prostatic adenoma
  • adenoma - prostate
temporal lobe epilepsy
  • epilepsy, temporal lobe
tongue squamous cell carcinoma
  • squamous cell carcinoma of tongue
- elite association - COSMIC cancer census association via MalaCards
Search UCA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UCA1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UCA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCA1 Gene

Publications for UCA1 Gene

  1. lncRNA UCA1 Contributes to Imatinib Resistance by Acting as a ceRNA Against miR-16 in Chronic Myeloid Leukemia Cells. (PMID: 27854515) Xiao Y … Zhang Z (DNA and cell biology 2017) 2 3 72
  2. UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. (PMID: 18501714) Wang F … Chen W (FEBS letters 2008) 2 3 72
  3. Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. (PMID: 17416635) Tsang WP … Kwok TT (RNA (New York, N.Y.) 2007) 2 3 72
  4. UCA1 promotes cell proliferation and invasion of gastric cancer by targeting CREB1 sponging to miR-590-3p. (PMID: 29516678) Gu L … Liu ZC (Cancer medicine 2018) 3 72
  5. Long non-coding RNA UCA1 upregulation promotes the migration of hypoxia-resistant gastric cancer cells through the miR-7-5p/EGFR axis. (PMID: 29723509) Yang Z … Liu Y (Experimental cell research 2018) 3 72

Products for UCA1 Gene

Sources for UCA1 Gene