Aliases for UBXN8 Gene
External Ids for UBXN8 Gene
Previous HGNC Symbols for UBXN8 Gene
Previous GeneCards Identifiers for UBXN8 Gene
p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]
GeneCards Summary for UBXN8 Gene
UBXN8 (UBX Domain Protein 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA-DNA hybrid ribonuclease activity. An important paralog of this gene is FAF1.
UniProtKB/Swiss-Prot Summary for UBXN8 Gene
Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction.