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Aliases for UBXN7 Gene

Aliases for UBXN7 Gene

  • UBX Domain Protein 7 2 3 5
  • UBX Domain Containing 7 2 3
  • UBXD7 3 4
  • UBX Domain-Containing Protein 7 3
  • KIAA0794 4

External Ids for UBXN7 Gene

Previous HGNC Symbols for UBXN7 Gene

  • UBXD7

Previous GeneCards Identifiers for UBXN7 Gene

  • GC03M197564
  • GC03M196074
  • GC03M193377

Summaries for UBXN7 Gene

GeneCards Summary for UBXN7 Gene

UBXN7 (UBX Domain Protein 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transcription factor binding and ubiquitin binding.

UniProtKB/Swiss-Prot for UBXN7 Gene

  • Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.

Additional gene information for UBXN7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN7 Gene

Genomics for UBXN7 Gene

GeneHancer (GH) Regulatory Elements for UBXN7 Gene

Promoters and enhancers for UBXN7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I196430 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.3 +22.2 22206 3.1 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B ZNF143 DEK GC03P196432 UBXN7-AS1 UBXN7 TM4SF19 PCYT1A SLC51A ENSG00000273013 GC03P196445
GH03I196455 Enhancer 0.4 ENCODE 550.8 -0.8 -807 0.2 ZNF687 MNT UBXN7 PIR31870
GH03I196316 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 48.1 +136.2 136237 2.8 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B POLR2B E2F8 ZNF143 ZNF207 TCTEX1D2 ENSG00000272741 TM4SF19-AS1 SDHAP1 SDHAP2 UBXN7 LINC00969 RNU6ATAC24P RNF168 ENSG00000271662
GH03I196078 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 40.3 +373.3 373336 4.4 MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 MEF2D GLIS1 RCOR2 TFRC SDHAP1 SDHAP2 LINC00969 UBXN7 ACAP2 ENSG00000230732 RNU6ATAC24P MUC4 SENP5
GH03I196337 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 35.2 +114.9 114918 4.4 HDGF PKNOX1 ARNT SIN3A YY1 POLR2B ZNF766 E2F8 FOS SMARCB1 TM4SF19 TM4SF19-TCTEX1D2 SDHAP1 LINC00969 UBXN7 SDHAP2 ENSG00000230732 ACAP2 ENSG00000260261 ENSG00000231443
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBXN7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBXN7 gene promoter:

Genomic Locations for UBXN7 Gene

Genomic Locations for UBXN7 Gene
106,657 bases
Minus strand

Genomic View for UBXN7 Gene

Genes around UBXN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN7 Gene

Proteins for UBXN7 Gene

  • Protein details for UBXN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UBX domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • D3DXB3
    • Q6ZP77
    • Q86X20
    • Q8N327

    Protein attributes for UBXN7 Gene

    489 amino acids
    Molecular mass:
    54862 Da
    Quaternary structure:
    • Interacts with neddylated CUL2, ubiquitinated HIF1A, and VCP/p97.
    • Sequence=BAA34514.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85247.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBXN7 Gene

neXtProt entry for UBXN7 Gene

Post-translational modifications for UBXN7 Gene

  • Ubiquitination at posLast=8484, posLast=9999, isoforms=134, posLast=151151, isoforms=194, posLast=221221, and posLast=440440

Other Protein References for UBXN7 Gene

No data available for DME Specific Peptides for UBXN7 Gene

Domains & Families for UBXN7 Gene

Gene Families for UBXN7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBXN7 Gene

Suggested Antigen Peptide Sequences for UBXN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The UIM (ubiquitin-interacting motif) is required to engage the NEDD8 modification on cullins.
  • The UIM (ubiquitin-interacting motif) is required to engage the NEDD8 modification on cullins.
  • The UBX domain mediates interaction with VCP/p97.
  • The UBA domain is required for binding ubiquitinated-protein substrates.
genes like me logo Genes that share domains with UBXN7: view

Function for UBXN7 Gene

Molecular function for UBXN7 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.

Phenotypes From GWAS Catalog for UBXN7 Gene

Gene Ontology (GO) - Molecular Function for UBXN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18775313
GO:0008134 transcription factor binding IPI 18775313
GO:0031625 ubiquitin protein ligase binding IDA 18775313
GO:0043130 ubiquitin binding IDA 18775313
genes like me logo Genes that share ontologies with UBXN7: view

Phenotypes for UBXN7 Gene

genes like me logo Genes that share phenotypes with UBXN7: view

Animal Model Products

CRISPR Products

miRNA for UBXN7 Gene

miRTarBase miRNAs that target UBXN7

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN7 Gene

Localization for UBXN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBXN7 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBXN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016604 nuclear body IDA --
GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex IDA 18775313
genes like me logo Genes that share ontologies with UBXN7: view

Pathways & Interactions for UBXN7 Gene

SuperPathways for UBXN7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with UBXN7: view

No data available for Pathways by source and SIGNOR curated interactions for UBXN7 Gene

Drugs & Compounds for UBXN7 Gene

No Compound Related Data Available

Transcripts for UBXN7 Gene

Unigene Clusters for UBXN7 Gene

UBX domain protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN7 Gene

No ASD Table

Relevant External Links for UBXN7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBXN7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBXN7 Gene

Protein differential expression in normal tissues from HIPED for UBXN7 Gene

This gene is overexpressed in Blymphocyte (7.6) and CD8 Tcells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBXN7 Gene

Protein tissue co-expression partners for UBXN7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBXN7 Gene:


SOURCE GeneReport for Unigene cluster for UBXN7 Gene:


Evidence on tissue expression from TISSUES for UBXN7 Gene

  • Nervous system(4.4)
  • Heart(4.3)
genes like me logo Genes that share expression patterns with UBXN7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBXN7 Gene

Orthologs for UBXN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBXN7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBXN7 33
  • 96.32 (n)
(Canis familiaris)
Mammalia UBXN7 33 34
  • 95.09 (n)
(Bos Taurus)
Mammalia UBXN7 33 34
  • 94.75 (n)
(Monodelphis domestica)
Mammalia UBXN7 34
  • 94 (a)
(Mus musculus)
Mammalia Ubxn7 33 16 34
  • 91.62 (n)
(Ornithorhynchus anatinus)
Mammalia UBXN7 34
  • 84 (a)
(Gallus gallus)
Aves UBXN7 33 34
  • 80.78 (n)
(Anolis carolinensis)
Reptilia UBXN7 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn7 33
  • 71.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14530 33
(Danio rerio)
Actinopterygii ubxn7 33 34
  • 70.16 (n)
Dr.14781 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7180 33
fruit fly
(Drosophila melanogaster)
Insecta CG8892 34
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBX5 34 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
Species where no ortholog for UBXN7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBXN7 Gene

Gene Tree for UBXN7 (if available)
Gene Tree for UBXN7 (if available)

Paralogs for UBXN7 Gene

No data available for Paralogs for UBXN7 Gene

Variants for UBXN7 Gene

Sequence variations from dbSNP and Humsavar for UBXN7 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000043919 -- 196,443,315(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000057824 -- 196,381,977(-) A/G intron_variant
rs1000087217 -- 196,394,631(-) A/C intron_variant
rs1000118607 -- 196,421,942(-) T/C intron_variant
rs1000142422 -- 196,450,835(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN7 Gene

Variant ID Type Subtype PubMed ID
nsv997797 CNV gain 25217958
nsv469831 CNV gain 16826518
nsv1131756 CNV deletion 24896259
nsv1009811 CNV gain 25217958
nsv1003066 CNV gain 25217958
esv3599283 CNV loss 21293372
esv32642 CNV loss 17666407
esv2672614 CNV deletion 23128226
esv2660436 CNV deletion 23128226

Variation tolerance for UBXN7 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBXN7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN7 Gene

Disorders for UBXN7 Gene

Additional Disease Information for UBXN7

No disorders were found for UBXN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN7 Gene

Publications for UBXN7 Gene

  1. UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation. (PMID: 22537386) Bandau S … Alexandru G (BMC biology 2012) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for UBXN7 Gene

Sources for UBXN7 Gene

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