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Aliases for UBXN2B Gene

Aliases for UBXN2B Gene

  • UBX Domain Protein 2B 2 3 5
  • NSFL1 Cofactor P37 3 4
  • P97 Cofactor P37 3 4
  • UBX Domain-Containing Protein 2B 3
  • P37 3

External Ids for UBXN2B Gene

Previous GeneCards Identifiers for UBXN2B Gene

  • GC08P059487
  • GC08P059323
  • GC08P054812

Summaries for UBXN2B Gene

GeneCards Summary for UBXN2B Gene

UBXN2B (UBX Domain Protein 2B) is a Protein Coding gene. Diseases associated with UBXN2B include Narcolepsy. Gene Ontology (GO) annotations related to this gene include ubiquitin binding. An important paralog of this gene is NSFL1C.

UniProtKB/Swiss-Prot for UBXN2B Gene

  • Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.

Additional gene information for UBXN2B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN2B Gene

Genomics for UBXN2B Gene

GeneHancer (GH) Regulatory Elements for UBXN2B Gene

Promoters and enhancers for UBXN2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I058410 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 571.6 +0.3 343 1.7 SMAD1 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B ZNF766 E2F8 UBXN2B LOC100421822
GH08I058395 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -14.4 -14442 3.2 ATF1 ZNF48 RAD21 RFX5 ZNF213 ZNF143 ZNF362 ZNF654 CEBPB REST SDCBP UBXN2B GC08P058299
GH08I058392 Enhancer 0.7 FANTOM5 dbSUPER 14.2 -18.4 -18360 0.3 CTCF POLR2A MAX UBXN2B SDCBP GC08P058299
GH08I058377 Enhancer 1.1 Ensembl ENCODE dbSUPER 8 -32.7 -32735 1.3 FOXA2 MAX CEBPG RAD21 YY1 ZNF316 RUNX3 MAFK RXRA CEBPB FAM110B UBXN2B GC08P058299
GH08I058254 Enhancer 1.2 VISTA Ensembl ENCODE 7 -154.6 -154642 3.4 ZNF687 CBFB BATF ZNF217 IKZF1 NBN ZNF24 MLLT1 RUNX3 IKZF2 UBXN2B FAM110B LOC101929528 GC08M057799
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBXN2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBXN2B gene promoter:

Genomic Locations for UBXN2B Gene

Genomic Locations for UBXN2B Gene
chr8:58,411,264-58,451,501
(GRCh38/hg38)
Size:
40,238 bases
Orientation:
Plus strand
chr8:59,323,823-59,364,060
(GRCh37/hg19)

Genomic View for UBXN2B Gene

Genes around UBXN2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN2B Gene

Proteins for UBXN2B Gene

  • Protein details for UBXN2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CS0-UBX2B_HUMAN
    Recommended name:
    UBX domain-containing protein 2B
    Protein Accession:
    Q14CS0
    Secondary Accessions:
    • B3KWZ3

    Protein attributes for UBXN2B Gene

    Size:
    331 amino acids
    Molecular mass:
    37077 Da
    Quaternary structure:
    • Interacts with VCP. Does not bind ubiquitin (By similarity).

neXtProt entry for UBXN2B Gene

Post-translational modifications for UBXN2B Gene

No data available for DME Specific Peptides for UBXN2B Gene

Domains & Families for UBXN2B Gene

Gene Families for UBXN2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBXN2B Gene

Suggested Antigen Peptide Sequences for UBXN2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14CS0

UniProtKB/Swiss-Prot:

UBX2B_HUMAN :
  • Belongs to the NSFL1C family.
Family:
  • Belongs to the NSFL1C family.
genes like me logo Genes that share domains with UBXN2B: view

Function for UBXN2B Gene

Molecular function for UBXN2B Gene

UniProtKB/Swiss-Prot Function:
Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.

Phenotypes From GWAS Catalog for UBXN2B Gene

Gene Ontology (GO) - Molecular Function for UBXN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019888 protein phosphatase regulator activity IBA --
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with UBXN2B: view

Animal Model Products

CRISPR Products

miRNA for UBXN2B Gene

miRTarBase miRNAs that target UBXN2B

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN2B Gene

Localization for UBXN2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN2B Gene

Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBXN2B gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 3
golgi apparatus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBXN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with UBXN2B: view

Pathways & Interactions for UBXN2B Gene

SuperPathways for UBXN2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0007030 Golgi organization IBA --
GO:0031468 nuclear envelope reassembly IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with UBXN2B: view

No data available for Pathways by source and SIGNOR curated interactions for UBXN2B Gene

Drugs & Compounds for UBXN2B Gene

No Compound Related Data Available

Transcripts for UBXN2B Gene

Unigene Clusters for UBXN2B Gene

UBX domain protein 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN2B Gene

No ASD Table

Relevant External Links for UBXN2B Gene

GeneLoc Exon Structure for
UBXN2B
ECgene alternative splicing isoforms for
UBXN2B

Expression for UBXN2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBXN2B Gene

mRNA differential expression in normal tissues according to GTEx for UBXN2B Gene

This gene is overexpressed in Whole Blood (x8.7).

Protein differential expression in normal tissues from HIPED for UBXN2B Gene

This gene is overexpressed in Fetal Brain (32.1), Pancreatic juice (12.8), Peripheral blood mononuclear cells (10.9), and Frontal cortex (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBXN2B Gene



NURSA nuclear receptor signaling pathways regulating expression of UBXN2B Gene:

UBXN2B

SOURCE GeneReport for Unigene cluster for UBXN2B Gene:

Hs.155572

Evidence on tissue expression from TISSUES for UBXN2B Gene

  • Liver(4.2)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with UBXN2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBXN2B Gene

Orthologs for UBXN2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBXN2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBXN2B 33 34
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia UBXN2B 33 34
  • 93.43 (n)
cow
(Bos Taurus)
Mammalia UBXN2B 33 34
  • 89.7 (n)
rat
(Rattus norvegicus)
Mammalia Ubxn2b 33
  • 86.91 (n)
mouse
(Mus musculus)
Mammalia Ubxn2b 33 16 34
  • 85.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBXN2B 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBXN2B 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBXN2B 33 34
  • 77.2 (n)
lizard
(Anolis carolinensis)
Reptilia UBXN2B 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn2b 33
  • 67.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32474 33
fruit fly
(Drosophila melanogaster)
Insecta p47 34
  • 25 (a)
ManyToMany
CG42383 34
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ubxn-2 34
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SHP1 34
  • 19 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os06g0634600 33
  • 47.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2402 34
  • 34 (a)
OneToMany
Species where no ortholog for UBXN2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBXN2B Gene

ENSEMBL:
Gene Tree for UBXN2B (if available)
TreeFam:
Gene Tree for UBXN2B (if available)

Paralogs for UBXN2B Gene

Paralogs for UBXN2B Gene

(2) SIMAP similar genes for UBXN2B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for UBXN2B Gene

genes like me logo Genes that share paralogs with UBXN2B: view

Variants for UBXN2B Gene

Sequence variations from dbSNP and Humsavar for UBXN2B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000078717 -- 58,432,736(+) C/A intron_variant
rs1000108107 -- 58,438,808(+) G/A/C genic_downstream_transcript_variant, intron_variant
rs1000176613 -- 58,416,248(+) T/C intron_variant
rs1000276657 -- 58,419,844(+) C/T intron_variant
rs1000754239 -- 58,423,727(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN2B Gene

Variant ID Type Subtype PubMed ID
nsv971657 CNV duplication 23825009
nsv971656 CNV duplication 23825009
esv2759619 CNV gain 17122850

Variation tolerance for UBXN2B Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBXN2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBXN2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN2B Gene

Disorders for UBXN2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBXN2B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UBXN2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UBXN2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBXN2B Gene

Publications for UBXN2B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis. (PMID: 17141156) Uchiyama K … Kondo H (Developmental cell 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58

Products for UBXN2B Gene

Sources for UBXN2B Gene

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