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Aliases for UBXN2A Gene

Aliases for UBXN2A Gene

  • UBX Domain Protein 2A 2 3 5
  • UBX Domain-Containing Protein 4 3 4
  • UBX Domain Containing 4 2 3
  • UBXD4 3 4
  • UBX Domain-Containing Protein 2A 3

External Ids for UBXN2A Gene

Previous HGNC Symbols for UBXN2A Gene

  • UBXD4

Previous GeneCards Identifiers for UBXN2A Gene

  • GC02P024003
  • GC02P024150

Summaries for UBXN2A Gene

GeneCards Summary for UBXN2A Gene

UBXN2A (UBX Domain Protein 2A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin binding and acetylcholine receptor binding. An important paralog of this gene is NSFL1C.

Additional gene information for UBXN2A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN2A Gene

Genomics for UBXN2A Gene

GeneHancer (GH) Regulatory Elements for UBXN2A Gene

Promoters and enhancers for UBXN2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I023924 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 563.7 -0.7 -706 3.7 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 UBXN2A ATAD2B FAM228B MFSD2B SF3B6 FKBP1B PFN4 RPS13P4 GC02P023754
GH02I023938 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 569 +13.4 13352 3.4 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A FEZF1 IRF4 ZNF48 YY1 UBXN2A ATAD2B ITSN2 MFSD2B PFN4 GC02P023938 SDHCP3 GC02P023754
GH02I024009 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 +84.2 84184 4.1 HDGF PKNOX1 SMAD1 ARNT ZFP64 YY1 POLR2B ZNF766 ZNF592 MEF2D MFSD2B UBXN2A ATAD2B RNU6-370P GC02P023754
GH02I023900 Enhancer 1 Ensembl ENCODE 22.9 -25.8 -25785 2.8 PKNOX1 NFIB RFX5 ZNF335 SMARCC2 FOS SMARCC1 CEBPB NFIL3 ATF4 RPS13P4 UBXN2A ATAD2B FAM228B SF3B6 PFN4 GC02P023754
GH02I024048 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.7 +122.6 122620 1.8 ELF3 ARID4B KLF17 ZNF2 ZNF48 ZNF335 ZNF121 GLIS2 ZNF366 ZNF391 FKBP1B WDCP FAM228B SF3B6 MFSD2B TP53I3 ATAD2B UBXN2A PFN4 GC02M024079
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBXN2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBXN2A gene promoter:

Genomic Locations for UBXN2A Gene

Genomic Locations for UBXN2A Gene
chr2:23,927,271-24,004,909
(GRCh38/hg38)
Size:
77,639 bases
Orientation:
Plus strand
chr2:24,150,155-24,227,779
(GRCh37/hg19)

Genomic View for UBXN2A Gene

Genes around UBXN2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN2A Gene

Proteins for UBXN2A Gene

  • Protein details for UBXN2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68543-UBX2A_HUMAN
    Recommended name:
    UBX domain-containing protein 2A
    Protein Accession:
    P68543
    Secondary Accessions:
    • A8K577
    • B7ZKP8
    • Q569G8

    Protein attributes for UBXN2A Gene

    Size:
    259 amino acids
    Molecular mass:
    29278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UBXN2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBXN2A Gene

Post-translational modifications for UBXN2A Gene

  • Ubiquitination at posLast=6969 and isoforms=2205
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UBXN2A Gene

Domains & Families for UBXN2A Gene

Gene Families for UBXN2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBXN2A Gene

Suggested Antigen Peptide Sequences for UBXN2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBXN2A: view

No data available for UniProtKB/Swiss-Prot for UBXN2A Gene

Function for UBXN2A Gene

Phenotypes From GWAS Catalog for UBXN2A Gene

Gene Ontology (GO) - Molecular Function for UBXN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21900206
GO:0019888 protein phosphatase regulator activity IBA --
GO:0033130 acetylcholine receptor binding IEA --
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with UBXN2A: view
genes like me logo Genes that share phenotypes with UBXN2A: view

Animal Model Products

CRISPR Products

miRNA for UBXN2A Gene

miRTarBase miRNAs that target UBXN2A

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN2A Gene

Localization for UBXN2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBXN2A gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBXN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005801 cis-Golgi network IEA --
GO:0005829 cytosol IBA,IEA --
genes like me logo Genes that share ontologies with UBXN2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBXN2A Gene

Pathways & Interactions for UBXN2A Gene

SuperPathways for UBXN2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0007030 Golgi organization IBA --
GO:0010468 regulation of gene expression IEA --
GO:0031396 regulation of protein ubiquitination IEA --
GO:0031468 nuclear envelope reassembly IBA --
genes like me logo Genes that share ontologies with UBXN2A: view

No data available for Pathways by source and SIGNOR curated interactions for UBXN2A Gene

Drugs & Compounds for UBXN2A Gene

No Compound Related Data Available

Transcripts for UBXN2A Gene

Unigene Clusters for UBXN2A Gene

UBX domain protein 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN2A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for UBXN2A Gene

GeneLoc Exon Structure for
UBXN2A
ECgene alternative splicing isoforms for
UBXN2A

Expression for UBXN2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBXN2A Gene

Protein differential expression in normal tissues from HIPED for UBXN2A Gene

This gene is overexpressed in Heart (38.8), Platelet (16.2), and Placenta (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBXN2A Gene



Protein tissue co-expression partners for UBXN2A Gene

NURSA nuclear receptor signaling pathways regulating expression of UBXN2A Gene:

UBXN2A

SOURCE GeneReport for Unigene cluster for UBXN2A Gene:

Hs.591576

Evidence on tissue expression from TISSUES for UBXN2A Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with UBXN2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBXN2A Gene

Orthologs for UBXN2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBXN2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBXN2A 33 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia UBXN2A 33
  • 90.4 (n)
cow
(Bos Taurus)
Mammalia UBXN2A 33 34
  • 89.75 (n)
mouse
(Mus musculus)
Mammalia Ubxn2a 33 16 34
  • 87.76 (n)
rat
(Rattus norvegicus)
Mammalia Ubxn2a 33
  • 87.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBXN2A 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBXN2A 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBXN2A 33 34
  • 68.12 (n)
lizard
(Anolis carolinensis)
Reptilia UBXN2A 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn2a 33
  • 58.23 (n)
zebrafish
(Danio rerio)
Actinopterygii ubxn2a 33 34
  • 53 (n)
fruit fly
(Drosophila melanogaster)
Insecta p47 34
  • 18 (a)
ManyToMany
CG42383 34
  • 17 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ubxn-2 34
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SHP1 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2402 34
  • 22 (a)
OneToMany
Species where no ortholog for UBXN2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBXN2A Gene

ENSEMBL:
Gene Tree for UBXN2A (if available)
TreeFam:
Gene Tree for UBXN2A (if available)

Paralogs for UBXN2A Gene

Paralogs for UBXN2A Gene

(2) SIMAP similar genes for UBXN2A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for UBXN2A Gene

genes like me logo Genes that share paralogs with UBXN2A: view

Variants for UBXN2A Gene

Sequence variations from dbSNP and Humsavar for UBXN2A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000015619 -- 23,931,162(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000069667 -- 23,985,253(+) T/G intron_variant
rs1000123154 -- 23,985,544(+) G/A intron_variant
rs1000128894 -- 23,975,224(+) C/T intron_variant
rs1000180223 -- 23,936,070(+) AATAAATAAATA/AATAAATA genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN2A Gene

Variant ID Type Subtype PubMed ID
nsv1114059 CNV deletion 24896259
nsv961019 CNV duplication 23825009
nsv997445 CNV gain 25217958

Variation tolerance for UBXN2A Gene

Residual Variation Intolerance Score: 52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBXN2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBXN2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN2A Gene

Disorders for UBXN2A Gene

Additional Disease Information for UBXN2A

No disorders were found for UBXN2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN2A Gene

Publications for UBXN2A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. (PMID: 26634371) Sane S … Rezvani K (Cell stress & chaperones 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for UBXN2A Gene

Sources for UBXN2A Gene

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