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Aliases for UBXN11 Gene

Aliases for UBXN11 Gene

  • UBX Domain Protein 11 2 3 5
  • Socius 2 3 4
  • Colorectal Tumor-Associated Antigen COA-1 3 4
  • UBX Domain-Containing Protein 5 3 4
  • UBXD5 3 4
  • SOC 3 4
  • Colorectal Tumor-Associated Antigen-1 3
  • UBX Domain-Containing Protein 11 3
  • UBX Domain Containing 5 2
  • PP2243 3
  • COA-1 3
  • SOCI 3

External Ids for UBXN11 Gene

Previous HGNC Symbols for UBXN11 Gene

  • UBXD5

Previous GeneCards Identifiers for UBXN11 Gene

  • GC01M026481
  • GC01M026607
  • GC01M024865

Summaries for UBXN11 Gene

Entrez Gene Summary for UBXN11 Gene

  • This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBXN11 Gene

UBXN11 (UBX Domain Protein 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin binding.

UniProtKB/Swiss-Prot for UBXN11 Gene

  • May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).

Gene Wiki entry for UBXN11 Gene

Additional gene information for UBXN11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN11 Gene

Genomics for UBXN11 Gene

GeneHancer (GH) Regulatory Elements for UBXN11 Gene

Promoters and enhancers for UBXN11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I026313 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 568.5 +0.2 193 8.4 HDGF PKNOX1 ATF1 SMAD1 ARNT ARID4B ZNF2 IRF4 BRCA1 ZNF48 CD52 UBXN11 SH3BGRL3 ZNF683 CRYBG2 LIN28A CEP85 ZNF593 ENSG00000236782 FAM110D
GH01I026305 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 560.7 +10.8 10785 4 HDGF HNRNPUL1 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 E2F8 ZNF207 UBXN11 ARID1A HMGN2 LOC101928324 CD52 RPL17P9 NPM1P39 CEP85 FAM110D CNKSR1
GH01I026274 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.9 +34.5 34469 19.1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 NBN SH3BGRL3 HMGN2 ARID1A CD52 LOC101928324 NPM1P39 UBXN11 CEP85 GPN2 LIN28A
GH01I026348 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.1 -36.6 -36570 12.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 CRYBG2 CD52 UBXN11 CEP85 CNKSR1 LIN28A DHDDS SLC30A2 TRIM63 EXTL1
GH01I026233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 17.5 +83.8 83778 2.3 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 CEP85 ARID1A HMGN2 CD52 ZNF593 NPM1P39 UBXN11 ENSG00000261349 LOC101928324 LOC101928728
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBXN11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBXN11 gene promoter:

Genomic Locations for UBXN11 Gene

Genomic Locations for UBXN11 Gene
chr1:26,281,328-26,318,363
(GRCh38/hg38)
Size:
37,036 bases
Orientation:
Minus strand
chr1:26,607,819-26,644,854
(GRCh37/hg19)

Genomic View for UBXN11 Gene

Genes around UBXN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN11 Gene

Proteins for UBXN11 Gene

  • Protein details for UBXN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T124-UBX11_HUMAN
    Recommended name:
    UBX domain-containing protein 11
    Protein Accession:
    Q5T124
    Secondary Accessions:
    • D3DPK6
    • Q5T117
    • Q5T120
    • Q5T125
    • Q5T126
    • Q5T129
    • Q5T131
    • Q5T133
    • Q63HM6
    • Q71RB3
    • Q8IY27
    • Q8N1L6
    • Q8N9M4
    • Q8NA18
    • Q8NFE3
    • Q8NFE4
    • Q8NFE6

    Protein attributes for UBXN11 Gene

    Size:
    520 amino acids
    Molecular mass:
    57373 Da
    Quaternary structure:
    • Interacts with GNA12, GNA13, RND1, RND2 AND RND3.
    SequenceCaution:
    • Sequence=AAM74202.1; Type=Frameshift; Positions=190; Evidence={ECO:0000305}; Sequence=AAQ15261.1; Type=Frameshift; Positions=390; Evidence={ECO:0000305}; Sequence=CAI15828.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UBXN11 Gene

neXtProt entry for UBXN11 Gene

Post-translational modifications for UBXN11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UBXN11 Gene

Domains & Families for UBXN11 Gene

Gene Families for UBXN11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBXN11 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBXN11: view

No data available for UniProtKB/Swiss-Prot for UBXN11 Gene

Function for UBXN11 Gene

Molecular function for UBXN11 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).

Phenotypes From GWAS Catalog for UBXN11 Gene

Gene Ontology (GO) - Molecular Function for UBXN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with UBXN11: view
genes like me logo Genes that share phenotypes with UBXN11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN11 Gene

Localization for UBXN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN11 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBXN11 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 3
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBXN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with UBXN11: view

Pathways & Interactions for UBXN11 Gene

SuperPathways for UBXN11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with UBXN11: view

No data available for Pathways by source and SIGNOR curated interactions for UBXN11 Gene

Drugs & Compounds for UBXN11 Gene

(3) Drugs for UBXN11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for UBXN11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UBXN11: view

Transcripts for UBXN11 Gene

Unigene Clusters for UBXN11 Gene

UBX domain protein 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13a ·
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - - - - - -
SP7: - - -
SP8: -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - - - - - - - -
SP17: - - -
SP18: - - -
SP19: -
SP20: - - - - - - - - - - - -
SP21: - - - - - - - - - - - -

ExUns: 13b ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for UBXN11 Gene

GeneLoc Exon Structure for
UBXN11
ECgene alternative splicing isoforms for
UBXN11

Expression for UBXN11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBXN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBXN11 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for UBXN11 Gene

This gene is overexpressed in Testis (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBXN11 Gene



Protein tissue co-expression partners for UBXN11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBXN11 Gene:

UBXN11

SOURCE GeneReport for Unigene cluster for UBXN11 Gene:

Hs.145061

Evidence on tissue expression from TISSUES for UBXN11 Gene

  • Intestine(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with UBXN11: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBXN11 Gene

Orthologs for UBXN11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBXN11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBXN11 33 34
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia UBXN11 33 34
  • 85.06 (n)
mouse
(Mus musculus)
Mammalia Ubxn11 33 16 34
  • 83.88 (n)
cow
(Bos Taurus)
Mammalia UBXN11 33 34
  • 83.86 (n)
rat
(Rattus norvegicus)
Mammalia Ubxn11 33
  • 83.55 (n)
oppossum
(Monodelphis domestica)
Mammalia UBXN11 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBXN11 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBXN11 33 34
  • 55.85 (n)
lizard
(Anolis carolinensis)
Reptilia UBXN11 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn11 33
  • 49.56 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-11i5.1 33
  • 48.99 (n)
UBXN11 34
  • 35 (a)
OneToOne
Species where no ortholog for UBXN11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBXN11 Gene

ENSEMBL:
Gene Tree for UBXN11 (if available)
TreeFam:
Gene Tree for UBXN11 (if available)

Paralogs for UBXN11 Gene

No data available for Paralogs for UBXN11 Gene

Variants for UBXN11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN11 Gene

UBX11_HUMAN-Q5T124
The number of repeats is polymorphic and varies from 1 to 4.

Sequence variations from dbSNP and Humsavar for UBXN11 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000016449 -- 26,301,969(-) T/C intron_variant
rs1000055212 -- 26,304,491(-) A/G intron_variant
rs1000162128 -- 26,308,410(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000217951 -- 26,285,662(-) C/T intron_variant
rs1000347906 -- 26,301,960(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN11 Gene

Variant ID Type Subtype PubMed ID
esv2745674 CNV deletion 23290073
esv3559826 CNV deletion 23714750
esv3585537 CNV loss 21293372

Variation tolerance for UBXN11 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.23; 81.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBXN11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBXN11

Disorders for UBXN11 Gene

Additional Disease Information for UBXN11

No disorders were found for UBXN11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN11 Gene

Publications for UBXN11 Gene

  1. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. (PMID: 11940653) Katoh H … Negishi M (Molecular and cellular biology 2002) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Identification of a colorectal tumor-associated antigen (COA-1) recognized by CD4(+) T lymphocytes. (PMID: 14583468) Maccalli C … Robbins PF (Cancer research 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for UBXN11 Gene

Sources for UBXN11 Gene

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