Free for academic non-profit institutions. Other users need a Commercial license
UBXN1 (UBX Domain Protein 1) is a Protein Coding gene. Diseases associated with UBXN1 include 3-Methylcrotonyl-Coa Carboxylase Deficiency and St. Louis Encephalitis. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and ATPase binding. An important paralog of this gene is TNRC6C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 18775313 |
GO:0031593 | polyubiquitin modification-dependent protein binding | IDA | 15362974 |
GO:0031625 | ubiquitin protein ligase binding | IDA | 18775313 |
GO:0036435 | K48-linked polyubiquitin modification-dependent protein binding | IDA | 21135095 |
GO:0043130 | ubiquitin binding | IDA | 18775313 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 10942595 |
GO:0005783 | endoplasmic reticulum | IDA | 21135095 |
GO:0005829 | cytosol | IDA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of proteins | ||
2 | Protein processing in endoplasmic reticulum | ||
3 | Transport to the Golgi and subsequent modification | ||
4 | Calnexin/calreticulin cycle |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006457 | protein folding | TAS | -- |
GO:0016032 | viral process | IEA | -- |
GO:0031397 | negative regulation of protein ubiquitination | IDA | 20351172 |
GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | IDA | 20351172 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | NAS | 15362974 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | UBXN1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | UBXN1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | UBXN1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ubxn1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ubxn1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | UBXN1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | UBXN1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | UBXN1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ubxn1 30 |
|
||
Str.4804 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.1496 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ubxn1 30 31 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG8209 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009841 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | ubxn-1 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBX6 33 |
|
|
|
Bread mold (Neurospora crassa) |
Ascomycetes | NCU08955 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1443 31 |
|
OneToOne | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC17C9.11c 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11543359 | - |
p.Leu56Phe |
Disorder | Aliases | PubMed IDs |
---|---|---|
3-methylcrotonyl-coa carboxylase deficiency |
|
|
st. louis encephalitis |
|
|