UBTFL1 is a preimplantation-specific gene and is involved in early development, implantation, and embryonic stem (ES) cell derivation (summary by Yamada et al., 2010 [PubMed 19915186]).[supplied by OMIM, Jan 2011] See more...

Aliases for UBTFL1 Gene

Aliases for UBTFL1 Gene

  • Upstream Binding Transcription Factor Like 1 2 3 5
  • Upstream Binding Transcription Factor, RNA Polymerase I-Like 1 2 3
  • Upstream-Binding Factor 1-Like Protein 1 3 4
  • C11orf27 3 4
  • Putative Upstream-Binding Factor 1-Like Protein 1 3
  • Chromosome 11 Open Reading Frame 27 2
  • HMGPI 3

External Ids for UBTFL1 Gene

Previous HGNC Symbols for UBTFL1 Gene

  • C11orf27

Previous GeneCards Identifiers for UBTFL1 Gene

  • GC11P089460
  • GC11P089819

Summaries for UBTFL1 Gene

Entrez Gene Summary for UBTFL1 Gene

  • UBTFL1 is a preimplantation-specific gene and is involved in early development, implantation, and embryonic stem (ES) cell derivation (summary by Yamada et al., 2010 [PubMed 19915186]).[supplied by OMIM, Jan 2011]

GeneCards Summary for UBTFL1 Gene

UBTFL1 (Upstream Binding Transcription Factor Like 1) is a Protein Coding gene. Diseases associated with UBTFL1 include Obsessive-Compulsive Personality Disorder. An important paralog of this gene is UBTF.

UniProtKB/Swiss-Prot Summary for UBTFL1 Gene

  • Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development.

Additional gene information for UBTFL1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBTFL1 Gene

Genomics for UBTFL1 Gene

GeneHancer (GH) Regulatory Elements for UBTFL1 Gene


Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBTFL1

Top Transcription factor binding sites by QIAGEN in the UBTFL1 gene promoter:
  • aMEF-2
  • Evi-1
  • FOXF2
  • FOXO4
  • GATA-1
  • MEF-2A
  • p53
  • POU2F1
  • POU2F1a

Genomic Locations for UBTFL1 Gene

Genomic Locations for UBTFL1 Gene
chr11:90,085,950-90,087,131
(GRCh38/hg38)
Size:
1,182 bases
Orientation:
Plus strand
chr11:89,819,081-89,820,299
(GRCh37/hg19)
Size:
1,219 bases
Orientation:
Plus strand

Genomic View for UBTFL1 Gene

Genes around UBTFL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBTFL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBTFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBTFL1 Gene

Proteins for UBTFL1 Gene

  • Protein details for UBTFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CB47-UBFL1_HUMAN
    Recommended name:
    Upstream-binding factor 1-like protein 1
    Protein Accession:
    P0CB47
    Secondary Accessions:
    • C9JMX8

    Protein attributes for UBTFL1 Gene

    Size:
    393 amino acids
    Molecular mass:
    46134 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UBTFL1 Gene

Post-translational modifications for UBTFL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBTFL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBTFL1 Gene

Domains & Families for UBTFL1 Gene

Gene Families for UBTFL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for UBTFL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UBTFL1 Gene

GenScript: Design optimal peptide antigens:
  • Putative upstream-binding factor 1-like protein 1 (UBFL1_HUMAN)
genes like me logo Genes that share domains with UBTFL1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UBTFL1 Gene

Function for UBTFL1 Gene

Molecular function for UBTFL1 Gene

UniProtKB/Swiss-Prot Function:
Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development.

Gene Ontology (GO) - Molecular Function for UBTFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with UBTFL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBTFL1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBTFL1 Gene

Localization for UBTFL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBTFL1 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic from the 4-cell stage to the morula stage. Becomes nuclear at the blastocyst stage. {ECO:0000250 UniProtKB:Q3USZ2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBTFL1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for UBTFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBTFL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UBTFL1 Gene

Pathways & Interactions for UBTFL1 Gene

PathCards logo

SuperPathways for UBTFL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBTFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001832 blastocyst growth IEA --
GO:0007275 multicellular organism development IEA --
GO:0007566 embryo implantation IEA --
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with UBTFL1: view

No data available for Pathways by source and SIGNOR curated interactions for UBTFL1 Gene

Drugs & Compounds for UBTFL1 Gene

No Compound Related Data Available

Transcripts for UBTFL1 Gene

mRNA/cDNA for UBTFL1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBTFL1

Alternative Splicing Database (ASD) splice patterns (SP) for UBTFL1 Gene

No ASD Table

Relevant External Links for UBTFL1 Gene

GeneLoc Exon Structure for
UBTFL1

Expression for UBTFL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBTFL1 Gene

Protein differential expression in normal tissues from HIPED for UBTFL1 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UBTFL1 Gene



Protein tissue co-expression partners for UBTFL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBTFL1

SOURCE GeneReport for Unigene cluster for UBTFL1 Gene:

Hs.719885
genes like me logo Genes that share expression patterns with UBTFL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBTFL1 Gene

Orthologs for UBTFL1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for UBTFL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBTFL1 30
  • 97.63 (n)
Species where no ortholog for UBTFL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UBTFL1 Gene

ENSEMBL:
Gene Tree for UBTFL1 (if available)
TreeFam:
Gene Tree for UBTFL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBTFL1: view image

Paralogs for UBTFL1 Gene

(2) SIMAP similar genes for UBTFL1 Gene using alignment to 1 proteins:

  • UBFL1_HUMAN
genes like me logo Genes that share paralogs with UBTFL1: view

Variants for UBTFL1 Gene

Additional dbSNP identifiers (rs#s) for UBTFL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for UBTFL1 Gene

Variant ID Type Subtype PubMed ID
esv2759849 CNV gain+loss 17122850
esv3579841 CNV loss 25503493
esv3579993 CNV gain 25503493
esv3892056 CNV gain+loss 25118596
nsv1036092 CNV loss 25217958
nsv1136138 CNV deletion 24896259
nsv8859 CNV loss 18304495
nsv951056 CNV deletion 24416366
nsv975216 CNV duplication 23825009

Additional Variant Information for UBTFL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBTFL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for UBTFL1 Gene

Disorders for UBTFL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBTFL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
obsessive-compulsive personality disorder
  • anankastic personality disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UBTFL1

genes like me logo Genes that share disorders with UBTFL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBTFL1 Gene

Publications for UBTFL1 Gene

  1. Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development. (PMID: 19915186) Yamada M … Umezawa A (Human molecular genetics 2010) 2 3 54
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 54

Products for UBTFL1 Gene

Sources for UBTFL1 Gene