Aliases for UBTD2 Gene

Aliases for UBTD2 Gene

  • Ubiquitin Domain Containing 2 2 3 5
  • Ubiquitin Domain-Containing Protein 2 3 4
  • Ubiquitin-Like Protein SB72 3 4
  • DCUBP 3 4
  • Dendritic Cell-Derived Ubiquitin-Like Protein 4
  • Dendritic Cell Derived Ubiquitin Like Protein 2
  • DC-UbP 4

External Ids for UBTD2 Gene

Previous GeneCards Identifiers for UBTD2 Gene

  • GC05M171573
  • GC05M166732

Summaries for UBTD2 Gene

GeneCards Summary for UBTD2 Gene

UBTD2 (Ubiquitin Domain Containing 2) is a Protein Coding gene. Diseases associated with UBTD2 include Vesicoureteral Reflux 1. An important paralog of this gene is UBTD1.

Additional gene information for UBTD2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBTD2 Gene

Genomics for UBTD2 Gene

GeneHancer (GH) Regulatory Elements for UBTD2 Gene

Promoters and enhancers for UBTD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBTD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBTD2 gene promoter:
  • Max1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2C
  • Sox5

Genomic Locations for UBTD2 Gene

Genomic Locations for UBTD2 Gene
chr5:172,209,645-172,283,791
(GRCh38/hg38)
Size:
74,147 bases
Orientation:
Minus strand
chr5:171,636,644-171,711,075
(GRCh37/hg19)
Size:
74,432 bases
Orientation:
Minus strand

Genomic View for UBTD2 Gene

Genes around UBTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBTD2 Gene

Proteins for UBTD2 Gene

  • Protein details for UBTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUN7-UBTD2_HUMAN
    Recommended name:
    Ubiquitin domain-containing protein 2
    Protein Accession:
    Q8WUN7
    Secondary Accessions:
    • Q8TDQ3

    Protein attributes for UBTD2 Gene

    Size:
    234 amino acids
    Molecular mass:
    26190 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH19910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL99389.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBTD2 Gene

neXtProt entry for UBTD2 Gene

Post-translational modifications for UBTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBTD2 Gene

Domains & Families for UBTD2 Gene

Gene Families for UBTD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBTD2 Gene

Suggested Antigen Peptide Sequences for UBTD2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93786, Homo sapiens dendritic cell-derived ubiquitin-like protein(DC-UbP), mRNA (B2R886_HUMAN)
  • Ubiquitin-like protein SB72 (UBTD2_HUMAN)
genes like me logo Genes that share domains with UBTD2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UBTD2 Gene

Function for UBTD2 Gene

Phenotypes From GWAS Catalog for UBTD2 Gene

genes like me logo Genes that share phenotypes with UBTD2: view

Animal Model Products

CRISPR Products

miRNA for UBTD2 Gene

miRTarBase miRNAs that target UBTD2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBTD2 Gene

Localization for UBTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBTD2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBTD2 gene
Compartment Confidence
mitochondrion 2
cytosol 2
nucleus 1
extracellular 0

Gene Ontology (GO) - Cellular Components for UBTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBTD2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UBTD2 Gene

Pathways & Interactions for UBTD2 Gene

PathCards logo

SuperPathways for UBTD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBTD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBTD2 Gene

Drugs & Compounds for UBTD2 Gene

No Compound Related Data Available

Transcripts for UBTD2 Gene

mRNA/cDNA for UBTD2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(161) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBTD2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for UBTD2 Gene

GeneLoc Exon Structure for
UBTD2
ECgene alternative splicing isoforms for
UBTD2

Expression for UBTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBTD2 Gene

Protein differential expression in normal tissues from HIPED for UBTD2 Gene

This gene is overexpressed in Fetal Brain (46.2) and Urine (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBTD2 Gene



Protein tissue co-expression partners for UBTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBTD2 Gene:

UBTD2

SOURCE GeneReport for Unigene cluster for UBTD2 Gene:

Hs.131570

mRNA Expression by UniProt/SwissProt for UBTD2 Gene:

Q8WUN7-UBTD2_HUMAN
Tissue specificity: Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues.

Evidence on tissue expression from TISSUES for UBTD2 Gene

  • Spleen(4.4)
  • Lymph node(4.3)
  • Blood(4)
genes like me logo Genes that share expression patterns with UBTD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBTD2 Gene

Orthologs for UBTD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBTD2 33 32
  • 99.82 (n)
OneToOne
dog
(Canis familiaris)
Mammalia UBTD2 33 32
  • 94.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UBTD2 33 32
  • 93.87 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ubtd2 17 33 32
  • 90.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBTD2 33
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubtd2 32
  • 87.2 (n)
oppossum
(Monodelphis domestica)
Mammalia UBTD2 33
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBTD2 33 32
  • 83.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBTD2 33
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubtd2 32
  • 81.62 (n)
Str.20052 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.14979 32
zebrafish
(Danio rerio)
Actinopterygii ubtd2 33 32
  • 73.79 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1172 33 32
  • 54.56 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001747 32
  • 52.87 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G53400 32
  • 54.05 (n)
rice
(Oryza sativa)
Liliopsida Os09g0345000 32
  • 57.99 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5948 33
  • 51 (a)
OneToMany
Species where no ortholog for UBTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBTD2 Gene

ENSEMBL:
Gene Tree for UBTD2 (if available)
TreeFam:
Gene Tree for UBTD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBTD2: view image

Paralogs for UBTD2 Gene

Paralogs for UBTD2 Gene

(3) SIMAP similar genes for UBTD2 Gene using alignment to 1 proteins:

  • UBTD2_HUMAN

Pseudogenes.org Pseudogenes for UBTD2 Gene

genes like me logo Genes that share paralogs with UBTD2: view

Variants for UBTD2 Gene

Sequence variations from dbSNP and Humsavar for UBTD2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000014923 -- 172,285,171(-) G/A upstream_transcript_variant
rs1000044577 -- 172,217,452(-) G/A intron_variant
rs1000044931 -- 172,247,002(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000090845 -- 172,257,631(-) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000123292 -- 172,210,020(-) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for UBTD2 Gene

Variant ID Type Subtype PubMed ID
dgv3214n106 CNV deletion 24896259
esv2731093 CNV deletion 23290073
esv2759392 CNV gain+loss 17122850
nsv1015251 CNV gain 25217958
nsv1033257 CNV gain 25217958
nsv1074348 CNV deletion 25765185
nsv830554 CNV loss 17160897

Variation tolerance for UBTD2 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBTD2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBTD2 Gene

Disorders for UBTD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBTD2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vesicoureteral reflux 1
  • vur1
- elite association - COSMIC cancer census association via MalaCards
Search UBTD2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UBTD2

genes like me logo Genes that share disorders with UBTD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBTD2 Gene

Publications for UBTD2 Gene

  1. Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells. (PMID: 12507522) Liu S … Cao X (Biochemical and biophysical research communications 2003) 2 3 4 23 56
  2. Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells. (PMID: 15987890) Gao YG … Hu HY (Protein science : a publication of the Protein Society 2005) 3 4 23 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for UBTD2 Gene

Sources for UBTD2 Gene