Aliases for UBR7 Gene
External Ids for UBR7 Gene
Previous HGNC Symbols for UBR7 Gene
Previous GeneCards Identifiers for UBR7 Gene
This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome. [provided by RefSeq, Jul 2016]
GeneCards Summary for UBR7 Gene
UBR7 (Ubiquitin Protein Ligase E3 Component N-Recognin 7 (Putative)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000259066.
UniProtKB/Swiss-Prot for UBR7 Gene
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.