Aliases for UBR4 Gene
External Ids for UBR4 Gene
Previous HGNC Symbols for UBR4 Gene
Previous GeneCards Identifiers for UBR4 Gene
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]
GeneCards Summary for UBR4 Gene
UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) is a Protein Coding gene. Diseases associated with UBR4 include Retinoblastoma and Cerebellar Ataxia Type 48. Among its related pathways are PI3K-Akt signaling pathway and Innate Immune System. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot Summary for UBR4 Gene
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.