The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomav... See more...

Aliases for UBR4 Gene

Aliases for UBR4 Gene

  • Ubiquitin Protein Ligase E3 Component N-Recognin 4 2 3 5
  • RBAF600 2 3 4
  • Retinoblastoma-Associated Factor Of 600 KDa 3 4
  • RING-Type E3 Ubiquitin Transferase UBR4 3 4
  • E3 Ubiquitin-Protein Ligase UBR4 3 4
  • Zinc Finger UBR1-Type Protein 1 3 4
  • N-Recognin-4 3 4
  • KIAA1307 2 4
  • KIAA0462 2 4
  • ZUBR1 3 4
  • P600 3 4
  • Retinoblastoma-Associated Factor 600-Like Protein 3
  • 600 KDa Retinoblastoma Protein-Associated Factor 4
  • Zinc Finger, UBR1 Type 1 2
  • EC 2.3.2.27 4
  • EC 6.3.2 51
  • UBR4 5

External Ids for UBR4 Gene

Previous HGNC Symbols for UBR4 Gene

  • ZUBR1

Previous GeneCards Identifiers for UBR4 Gene

  • GC01M019274
  • GC01M019401
  • GC01M017647

Summaries for UBR4 Gene

Entrez Gene Summary for UBR4 Gene

  • The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

GeneCards Summary for UBR4 Gene

UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) is a Protein Coding gene. Diseases associated with UBR4 include Retinoblastoma and Cerebellar Ataxia Type 48. Among its related pathways are PI3K-Akt signaling pathway and Innate Immune System. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot Summary for UBR4 Gene

  • E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

Gene Wiki entry for UBR4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBR4 Gene

Genomics for UBR4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UBR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J019207 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 614.1 +4.5 4510 4.4 BRCA1 RNF2 CEBPG HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 UBR4 MRTO4 EMC1-AS1 EMC1 OTUD3 piR-42694-003 IFFO2
GH01J018901 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 21.2 +311.5 311480 3.6 BRCA1 RNF2 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 ZNF629 REST ALDH4A1 HSALNG0001341 UBR4 IFFO2 MN308687
GH01J019642 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 18.5 -434.3 -434310 11.7 HNRNPL CTCF TEAD4 PRDM10 IKZF1 JUND LARP7 ZNF143 ZIC2 ZSCAN4 NBL1 UBR4 HTR6 MUL1 piR-48820-002 MICOS10-NBL1
GH01J019310 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 16.7 -99.1 -99083 6.8 ARHGAP35 SP1 HNRNPL TEAD4 TFE3 ZNF512 LEF1 IKZF1 ZNF692 POLR2A AKR7A2 SLC66A1 OTUD3 UBR4 AKR7L EMC1 ENSG00000272084 RF00017-089 lnc-AKR7A2-1 MICOS10
GH01J020184 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.6 -971.8 -971844 4 ZBTB33 RFX1 LEF1 IKZF1 JUND ETV6 FOXA1 DDX20 MTA2 PHF21A UBXN10 ENSG00000225986 PLA2G2C PLA2G2D UBR4 HP1BP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBR4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBR4

Top Transcription factor binding sites by QIAGEN in the UBR4 gene promoter:
  • AML1a
  • AP-1
  • c-Fos
  • c-Jun
  • HEN1
  • POU2F1a
  • SEF-1 (1)
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for UBR4 Gene

Genomic Locations for UBR4 Gene
chr1:19,074,508-19,214,332
(GRCh38/hg38)
Size:
139,825 bases
Orientation:
Minus strand
chr1:19,401,000-19,536,770
(GRCh37/hg19)
Size:
135,771 bases
Orientation:
Minus strand

Genomic View for UBR4 Gene

Genes around UBR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBR4 Gene

Proteins for UBR4 Gene

  • Protein details for UBR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4S7-UBR4_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase UBR4
    Protein Accession:
    Q5T4S7
    Secondary Accessions:
    • A8MPT2
    • A8MQ33
    • A8MQB1
    • O60646
    • O75050
    • Q4QRK5
    • Q5T4S8
    • Q5T4S9
    • Q5TBN8
    • Q5TBP2
    • Q6DKH8
    • Q6P4A4
    • Q7L8P7
    • Q8IXJ4
    • Q8TDN5
    • Q8WV67
    • Q9HA46
    • Q9P2N9
    • Q9UG82

    Protein attributes for UBR4 Gene

    Size:
    5183 amino acids
    Molecular mass:
    573841 Da
    Quaternary structure:
    • Interacts with RB1 and calmodulin.
    • (Microbial infection) Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11.
    SequenceCaution:
    • Sequence=CAD43719.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UBR4 Gene

neXtProt entry for UBR4 Gene

Selected DME Specific Peptides for UBR4 Gene

Q5T4S7:
  • PCLVCNNPEV
  • FFCDCGA

Post-translational modifications for UBR4 Gene

  • Ubiquitination at Lys1150, Lys1741, Lys3405, Lys4035, Lys4122, Lys4215, and Lys4712
  • Modification sites at PhosphoSitePlus

Domains & Families for UBR4 Gene

Gene Families for UBR4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for UBR4 Gene

InterPro:
Blocks:
  • Zn-finger (putative), N-recognin
ProtoNet:

Suggested Antigen Peptide Sequences for UBR4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53474, highly similar to Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA (B4DPF6_HUMAN)
  • cDNA FLJ53484, highly similar to Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA (B4DYV5_HUMAN)
  • UBR4 protein (Q96HY5_HUMAN)
  • Zinc finger UBR1-type protein 1 (UBR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T4S7

UniProtKB/Swiss-Prot:

UBR4_HUMAN :
  • Belongs to the UBR4 family.
Family:
  • Belongs to the UBR4 family.
genes like me logo Genes that share domains with UBR4: view

Function for UBR4 Gene

Molecular function for UBR4 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for UBR4 Gene

Phenotypes From GWAS Catalog for UBR4 Gene

Gene Ontology (GO) - Molecular Function for UBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA 21873635
GO:0005515 protein binding IEA,IPI 16061792
GO:0005516 calmodulin binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UBR4: view
genes like me logo Genes that share phenotypes with UBR4: view

Animal Models for UBR4 Gene

MGI Knock Outs for UBR4:
  • Ubr4 Ubr4<tm1.1Nkt>
  • Ubr4 Ubr4<tm1.1Ytkw>
  • Ubr4 Ubr4<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBR4 Gene

Localization for UBR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBR4 Gene

Membrane. Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBR4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
lysosome 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA,IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IBA,IDA --
GO:0005829 cytosol IBA,IDA --
genes like me logo Genes that share ontologies with UBR4: view

Pathways & Interactions for UBR4 Gene

genes like me logo Genes that share pathways with UBR4: view

UniProtKB/Swiss-Prot Q5T4S7-UBR4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IBA,IDA 23932781
GO:0016032 viral process IEA --
GO:0016567 protein ubiquitination IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with UBR4: view

No data available for SIGNOR curated interactions for UBR4 Gene

Drugs & Compounds for UBR4 Gene

(5) Drugs for UBR4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
PCL-016 Investigational Pharma Target 0
Verpasep caltespen Investigational Pharma Target 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for UBR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with UBR4: view

Transcripts for UBR4 Gene

mRNA/cDNA for UBR4 Gene

1 REFSEQ mRNAs :
29 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBR4

Alternative Splicing Database (ASD) splice patterns (SP) for UBR4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
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