UBR2 Gene (Protein Coding)

Ubiquitin Protein Ligase E3 Component N-Recognin 2

GC06P047519
GIFtS:
39
This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] See more...

Aliases for UBR2 Gene

Aliases for UBR2 Gene

  • Ubiquitin Protein Ligase E3 Component N-Recognin 2 2 3 5
  • RING-Type E3 Ubiquitin Transferase UBR2 3 4
  • Ubiquitin-Protein Ligase E3-Alpha-II 3 4
  • Ubiquitin-Protein Ligase E3-Alpha-2 3 4
  • E3 Ubiquitin-Protein Ligase UBR2 3 4
  • DJ392M17.3 2 3
  • C6orf133 3 4
  • BA49A4.1 2 3
  • KIAA0349 2 4
  • Chromosome 6 Open Reading Frame 133 2
  • N-Recognin-2 4
  • EC 2.3.2.27 4
  • DJ242G1.1 3
  • UBR2 5

External Ids for UBR2 Gene

Previous HGNC Symbols for UBR2 Gene

  • C6orf133

Previous GeneCards Identifiers for UBR2 Gene

  • GC06P042641
  • GC06P042531
  • GC06P042250
  • GC06P042944
  • GC06P043272
  • GC06P043423
  • GC06P046109
  • GC06P042779
  • GC06P042781

Summaries for UBR2 Gene

Entrez Gene Summary for UBR2 Gene

  • This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for UBR2 Gene

UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2) is a Protein Coding gene. Diseases associated with UBR2 include Johanson-Blizzard Syndrome and Autoimmune Pancreatitis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and leucine binding. An important paralog of this gene is UBR1.

UniProtKB/Swiss-Prot Summary for UBR2 Gene

  • E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity).

Gene Wiki entry for UBR2 Gene

Additional gene information for UBR2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBR2 Gene

Genomics for UBR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for UBR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBR2

Top Transcription factor binding sites by QIAGEN in the UBR2 gene promoter:
  • E2F
  • E2F-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • YY1

Genomic Locations for UBR2 Gene

Genomic Locations for UBR2 Gene
chr6:42,563,954-42,693,505
(GRCh38/hg38)
Size:
129,552 bases
Orientation:
Plus strand
chr6:42,531,760-42,661,243
(GRCh37/hg19)
Size:
129,484 bases
Orientation:
Plus strand

Genomic View for UBR2 Gene

Genes around UBR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBR2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UBR2 Gene

Proteins for UBR2 Gene

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  2. Protein
  3. Assay

  • Protein details for UBR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWV8-UBR2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase UBR2
    Protein Accession:
    Q8IWV8
    Secondary Accessions:
    • O15057
    • Q4VXK2
    • Q5TFH6
    • Q6P2I2
    • Q6ZUD0

    Protein attributes for UBR2 Gene

    Size:
    1755 amino acids
    Molecular mass:
    200538 Da
    Quaternary structure:
    • Interacts with UBE2B; promotes the UBE2B-H2A interaction and the ubiquitination of histone H2A by UBE2B and UBR2 (By similarity). Interacts with RECQL4 (PubMed:15317757, PubMed:20835242). Interacts with TEX19; does not lead to TEX19 degradation and stabilizes it (By similarity). Interacts with CASP8 (PubMed:28602583). Interacts with ATXN3 (PubMed:30455355).
    Miscellaneous:
    • [Isoform 4]: Derived from mouse cDNA data.

    Three dimensional structures from OCA and Proteopedia for UBR2 Gene

    Alternative splice isoforms for UBR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBR2 Gene

Protein Expression for UBR2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for UBR2 Gene

  • Ubiquitination at Lys255, Lys994, Lys1187, and Lys1255
  • Modification sites at PhosphoSitePlus

Other Protein References for UBR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBR2 Gene

Domains & Families for UBR2 Gene

Gene Families for UBR2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for UBR2 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • Zn-finger (putative), N-recognin
  • Regulator of chromosome condensation, RCC1
  • Protein of unknown function DUF174
ProtoNet:

Suggested Antigen Peptide Sequences for UBR2 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-protein ligase E3-alpha-II (UBR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IWV8

UniProtKB/Swiss-Prot:

UBR2_HUMAN :
  • The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
  • Belongs to the UBR1 family.
Domain:
  • The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
  • The UBR-type zinc finger forms a pocket that mediates recognition of type 1 N-degrons. It exhibits preference for Arginine in first position, has poor affinity for histidine, and doesn't bind acetylated peptides.
Family:
  • Belongs to the UBR1 family.
genes like me logo Genes that share domains with UBR2: view

Function for UBR2 Gene

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  2. CRISPR
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Molecular function for UBR2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for UBR2 Gene

Phenotypes From GWAS Catalog for UBR2 Gene

Gene Ontology (GO) - Molecular Function for UBR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with UBR2: view
genes like me logo Genes that share phenotypes with UBR2: view

Animal Models for UBR2 Gene

MGI Knock Outs for UBR2:
  • Ubr2 Ubr2<tm1Ytkw>
  • Ubr2 Ubr2<tm1e.1(KOMP)Mbp>

Animal Model Products

CRISPR Products

miRNA for UBR2 Gene

miRTarBase miRNAs that target UBR2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBR2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBR2 Gene

Localization for UBR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBR2 Gene

Nucleus. Note=Associated with chromatin during meiosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBR2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA 21873635
GO:0000785 chromatin IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBR2: view

Pathways & Interactions for UBR2 Gene

genes like me logo Genes that share pathways with UBR2: view

Pathways by source for UBR2 Gene

3 Qiagen pathways for UBR2 Gene
  • RAR-Gamma-RXR-Alpha Degradation
  • SMAD Signaling Network
  • Ubiquitin-Proteasome Dependent Proteolysis

UniProtKB/Swiss-Prot Q8IWV8-UBR2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for UBR2 Gene

Activates:

Gene Ontology (GO) - Biological Process for UBR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006342 chromatin silencing ISS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007131 reciprocal meiotic recombination ISS --
GO:0007140 male meiotic nuclear division ISS --
genes like me logo Genes that share ontologies with UBR2: view

Drugs & Compounds for UBR2 Gene

Products:

  1. Drug

(3) Drugs for UBR2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for UBR2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
 14000-31-8
genes like me logo Genes that share compounds with UBR2: view

Transcripts for UBR2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for UBR2 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBR2

Alternative Splicing Database (ASD) splice patterns (SP) for UBR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^
SP1: - - - - -
SP2: - -
SP3: - - -
SP4:
SP5: - -
SP6:
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39a · 39b ^ 40 ^ 41a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 41b ^ 42 ^ 43 ^ 44a · 44b ^ 45a · 45b ^ 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50 ^ 51a · 51b · 51c
SP1: - - -
SP2: - - - -
SP3:
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for UBR2 Gene

GeneLoc Exon Structure for
UBR2

Expression for UBR2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBR2 Gene

mRNA expression in normal human tissues for UBR2 Gene
mRNA expression by GTEx for UBR2 GenemRNA expression by BioGPS for UBR2 Gene

Protein differential expression in normal tissues from HIPED for UBR2 Gene

This gene is overexpressed in Plasma (23.0) and Lymph node (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBR2 Gene



Protein tissue co-expression partners for UBR2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBR2

SOURCE GeneReport for Unigene cluster for UBR2 Gene:

Hs.529925

mRNA Expression by UniProt/SwissProt for UBR2 Gene:

Q8IWV8-UBR2_HUMAN
Tissue specificity: Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).

Evidence on tissue expression from TISSUES for UBR2 Gene

  • Nervous system(4.7)
  • Muscle(2.6)
  • Kidney(2.4)
  • Heart(2.3)
  • Pancreas(2.3)
  • Skin(2.2)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with UBR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBR2 Gene

Orthologs for UBR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia UBR2 30 31
  • 99.56 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia UBR2 30 31
  • 93.54 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia UBR2 30 31
  • 92.38 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia UBR2 31
  • 91 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia UBR2 31
  • 90 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ubr2 30 17 31
  • 84.37 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ubr2 30
  • 84.24 (n)
Chicken
(Gallus gallus)
 Aves UBR2 30 31
  • 82.78 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia UBR2 31
  • 85 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ubr2 30
  • 74.52 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.24432 30
Zebrafish
(Danio rerio)
 Actinopterygii ubr2 30 31
  • 67.74 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG9086 30 31
  • 45.94 (n)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP000171 30
  • 44.73 (n)
Worm
(Caenorhabditis elegans)
 Secernentea ubr-1 30 31
  • 47.64 (n)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes UBR1 31 33
  • 16 (a)
 ManyToMany
UBR2 31
  • 16 (a)
 ManyToMany
Species where no ortholog for UBR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UBR2 Gene

ENSEMBL:
Gene Tree for UBR2 (if available)
TreeFam:
Gene Tree for UBR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBR2: view image

Paralogs for UBR2 Gene

Paralogs for UBR2 Gene

(1) SIMAP similar genes for UBR2 Gene using alignment to 1 proteins:

  • UBR2_HUMAN
genes like me logo Genes that share paralogs with UBR2: view

Variants for UBR2 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBR2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
768093 Benign: not provided 42,659,728(+) C/T SYNONYMOUS_VARIANT
rs6917033 -. -. - p.Ala1095Thrp.Ala1095Prop.Ala1095Ser
rs6905054 - p.Glu172Asp

Additional dbSNP identifiers (rs#s) for UBR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for UBR2 Gene

Variant ID Type Subtype PubMed ID
esv2233433 CNV deletion 18987734
esv2671214 CNV deletion 23128226
esv2731988 CNV deletion 23290073
esv2731989 CNV deletion 23290073
esv2731990 CNV deletion 23290073
esv3308392 CNV mobile element insertion 20981092
esv3356212 CNV insertion 20981092
esv3567710 CNV deletion 23714750
esv3608800 CNV loss 21293372
esv3890843 CNV gain 25118596
nsv1017398 CNV gain 25217958
nsv1137076 CNV deletion 24896259
nsv350088 CNV insertion 16902084
nsv518847 CNV loss 19592680
nsv520653 CNV gain 19592680
nsv524011 CNV loss 19592680
nsv526599 CNV gain 19592680
nsv5280 CNV insertion 18451855
nsv830650 CNV loss 17160897
nsv958365 CNV deletion 24416366

Variation tolerance for UBR2 Gene

Residual Variation Intolerance Score: 2.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.07; 92.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBR2 Gene

Human Gene Mutation Database (HGMD)
UBR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBR2 Gene

Disorders for UBR2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for UBR2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
johanson-blizzard syndrome
  • jbs
autoimmune pancreatitis
  • aip
oligospermia
retinitis pigmentosa 61
  • rp61
rapadilino syndrome
  • absent thumbs, dislocated joints, long face with narrow palpebral fissures, long slender nose, arched palate
- elite association - COSMIC cancer census association via MalaCards
Search UBR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UBR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with UBR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBR2 Gene

Publications for UBR2 Gene

  1. Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. (PMID: 20298436) Kume K … Handa H (Genes to cells : devoted to molecular & cellular mechanisms 2010) 3 4 23
  2. RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. (PMID: 15317757) Yin J … Wang W (Human molecular genetics 2004) 3 4 23
  3. Physiological and pathophysiological characteristics of ataxin-3 isoforms. (PMID: 30455355) Weishäupl D … Schmidt T (The Journal of biological chemistry 2019) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Identification of a novel antibody associated with autoimmune pancreatitis. (PMID: 19940298) Frulloni L … Puccetti A (The New England journal of medicine 2009) 3 23

ExternalLinks

View latest publications for UBR2 gene in Mastermind

Products for UBR2 Gene

  • Signalway Proteins for UBR2

Sources for UBR2 Gene