Aliases for UBN1 Gene
External Ids for UBN1 Gene
Previous GeneCards Identifiers for UBN1 Gene
Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
GeneCards Summary for UBN1 Gene
UBN1 (Ubinuclein 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and DNA Damage/Telomere Stress Induced Senescence. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is UBN2.
UniProtKB/Swiss-Prot Summary for UBN1 Gene
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.