Aliases for UBN1 Gene
External Ids for UBN1 Gene
Previous GeneCards Identifiers for UBN1 Gene
Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
GeneCards Summary for UBN1 Gene
UBN1 (Ubinuclein 1) is a Protein Coding gene. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is UBN2.
UniProtKB/Swiss-Prot for UBN1 Gene
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.