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Aliases for UBL7 Gene

Aliases for UBL7 Gene

  • Ubiquitin Like 7 2 3 5
  • Ubiquitin-Like Protein SB132 2 3 4
  • Ubiquitin-Like 7 (Bone Marrow Stromal Cell-Derived) 2 3
  • BMSC-UbP 3 4
  • Bone Marrow Stromal Cell-Derived Ubiquitin-Like 2
  • Bone Marrow Stromal Cell Ubiquitin-Like Protein 4
  • Ubiquitin-Like Protein 7 3
  • Ubiquitin-Like 7 2
  • BMSCUBP 4
  • TCBA1 3

External Ids for UBL7 Gene

Previous GeneCards Identifiers for UBL7 Gene

  • GC15M072526
  • GC15M074738
  • GC15M051534

Summaries for UBL7 Gene

GeneCards Summary for UBL7 Gene

UBL7 (Ubiquitin Like 7) is a Protein Coding gene.

Additional gene information for UBL7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBL7 Gene

Genomics for UBL7 Gene

GeneHancer (GH) Regulatory Elements for UBL7 Gene

Promoters and enhancers for UBL7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I074460 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 557.1 -0.4 -435 3.1 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 UBL7 PIR40033 UBL7-AS1 SIN3A CLK3 LOC101929333 MAN2C1 PML ENSG00000260274 ARID3B
GH15I074539 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 18.4 -80.8 -80772 4.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B IRF4 YY1 ARID3B SIN3A MAN2C1 EDC3 ENSG00000260274 CLK3 ISLR UBL7-AS1 PML COMMD4
GH15I074373 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +87.0 86985 2 PKNOX1 ARNT ARID4B SIN3A ZNF2 ZNF213 ZNF207 ZNF143 FOS KLF13 ENSG00000274937 CSK SEMA7A UBL7 UBL7-AS1 ARID3B ENSG00000212279 CYP11A1 SCAMP2 PPIAP46
GH15I074613 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 -155.1 -155126 4.9 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 CLK3 ENSG00000260919 LOC102723750 SIN3A EDC3 MAN2C1 ENSG00000260274 PML UBL7-AS1 FAM219B
GH15I074361 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 11.3 +95.3 95294 9 ATF1 ZFP64 SIN3A ZNF48 ZBTB40 RARA SCRT2 RCOR1 ATF7 CREM CYP11A1 ENSG00000261821 CSK SEMA7A UBL7 UBL7-AS1 ENSG00000212279 ARID3B SCAMP5 PPIAP46
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBL7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBL7 gene promoter:

Genomic Locations for UBL7 Gene

Genomic Locations for UBL7 Gene
chr15:74,445,977-74,461,188
(GRCh38/hg38)
Size:
15,212 bases
Orientation:
Minus strand
chr15:74,738,318-74,753,529
(GRCh37/hg19)

Genomic View for UBL7 Gene

Genes around UBL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL7 Gene

Proteins for UBL7 Gene

  • Protein details for UBL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S82-UBL7_HUMAN
    Recommended name:
    Ubiquitin-like protein 7
    Protein Accession:
    Q96S82
    Secondary Accessions:
    • D3DW57
    • Q96I03

    Protein attributes for UBL7 Gene

    Size:
    380 amino acids
    Molecular mass:
    40510 Da
    Quaternary structure:
    • Binds ubiquitin.

    Three dimensional structures from OCA and Proteopedia for UBL7 Gene

neXtProt entry for UBL7 Gene

Post-translational modifications for UBL7 Gene

  • Ubiquitination at posLast=1111, isoforms=20, posLast=4444, posLast=7171, posLast=9292, posLast=100100, and posLast=106106

No data available for DME Specific Peptides for UBL7 Gene

Domains & Families for UBL7 Gene

Gene Families for UBL7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for UBL7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBL7: view

No data available for UniProtKB/Swiss-Prot for UBL7 Gene

Function for UBL7 Gene

Molecular function for UBL7 Gene

UniProtKB/Swiss-Prot Induction:
Down-regulated by phorbol myristate acetate (PMA) in bone marrow stroma cells.

Phenotypes From GWAS Catalog for UBL7 Gene

Gene Ontology (GO) - Molecular Function for UBL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with UBL7: view
genes like me logo Genes that share phenotypes with UBL7: view

miRNA for UBL7 Gene

miRTarBase miRNAs that target UBL7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBL7 Gene

Localization for UBL7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBL7 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBL7 Gene

Pathways & Interactions for UBL7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBL7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBL7 Gene

Drugs & Compounds for UBL7 Gene

No Compound Related Data Available

Transcripts for UBL7 Gene

Unigene Clusters for UBL7 Gene

Ubiquitin-like 7 (bone marrow stromal cell-derived):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBL7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d · 13e ^
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - -

ExUns: 14a · 14b ^ 15a · 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:

Relevant External Links for UBL7 Gene

GeneLoc Exon Structure for
UBL7
ECgene alternative splicing isoforms for
UBL7

Expression for UBL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBL7 Gene

This gene is overexpressed in NK cells (10.1) and Heart (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBL7 Gene



Protein tissue co-expression partners for UBL7 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBL7 Gene:

UBL7

SOURCE GeneReport for Unigene cluster for UBL7 Gene:

Hs.334713

mRNA Expression by UniProt/SwissProt for UBL7 Gene:

Q96S82-UBL7_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in heart, skeletal muscle, testis, thyroid and adrenal gland.

Evidence on tissue expression from TISSUES for UBL7 Gene

  • Nervous system(3.9)
  • Skin(2.7)
  • Lung(2.4)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with UBL7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBL7 Gene

Orthologs for UBL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBL7 33 34
  • 99.13 (n)
cow
(Bos Taurus)
Mammalia BMSC-UBP 34
  • 98 (a)
OneToOne
UBL7 33
  • 93.25 (n)
dog
(Canis familiaris)
Mammalia UBL7 33 34
  • 92.54 (n)
mouse
(Mus musculus)
Mammalia Ubl7 33 16 34
  • 91.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBL7 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubl7 33
  • 90.26 (n)
oppossum
(Monodelphis domestica)
Mammalia UBL7 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-6703 34
  • 91 (a)
OneToOne
UBL7 33
  • 79.12 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 94 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl7 33
  • 69.09 (n)
Str.16741 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69120 33
zebrafish
(Danio rerio)
Actinopterygii ubl7a 33 34
  • 70.12 (n)
ubl7b 34
  • 61 (a)
OneToMany
Dr.15396 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9241 33
Species where no ortholog for UBL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBL7 Gene

ENSEMBL:
Gene Tree for UBL7 (if available)
TreeFam:
Gene Tree for UBL7 (if available)

Paralogs for UBL7 Gene

No data available for Paralogs for UBL7 Gene

Variants for UBL7 Gene

Sequence variations from dbSNP and Humsavar for UBL7 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000045651 -- 74,452,328(-) C/T coding_sequence_variant, missense_variant
rs1000086766 -- 74,445,769(-) GGGGG/GGGGGG downstream_transcript_variant
rs1000168958 -- 74,456,971(-) A/G intron_variant
rs1000401120 -- 74,461,624(-) T/C upstream_transcript_variant
rs1000410621 -- 74,461,460(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UBL7 Gene

Variant ID Type Subtype PubMed ID
nsv1122981 CNV deletion 24896259
nsv1121512 CNV deletion 24896259

Variation tolerance for UBL7 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL7 Gene

Disorders for UBL7 Gene

Additional Disease Information for UBL7

No disorders were found for UBL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBL7 Gene

Publications for UBL7 Gene

  1. Cloning and identification of a novel ubiquitin-like protein, BMSC-UbP, from human bone marrow stromal cells. (PMID: 12644319) Liu S … Cao X (Immunology letters 2003) 2 3 4 22 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitin. (PMID: 16731964) Chang YG … Hu HY (Protein science : a publication of the Protein Society 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 58

Products for UBL7 Gene

Sources for UBL7 Gene

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