Aliases for UBL7 Gene

Aliases for UBL7 Gene

  • Ubiquitin Like 7 2 3 5
  • Ubiquitin-Like 7 (Bone Marrow Stromal Cell-Derived) 2 3
  • Ubiquitin-Like Protein SB132 3 4
  • Ubiquitin-Like Protein 7 3 4
  • BMSC-UbP 3 4
  • Bone Marrow Stromal Cell Ubiquitin-Like Protein 4
  • Bone Marrow Stromal Cell-Derived Ubiquitin-Like 2
  • Ubiquitin-Like Protein SB132 2
  • Ubiquitin-Like 7 2
  • BMSCUBP 4
  • TCBA1 3

External Ids for UBL7 Gene

Previous GeneCards Identifiers for UBL7 Gene

  • GC15M072526
  • GC15M074738
  • GC15M051534

Summaries for UBL7 Gene

GeneCards Summary for UBL7 Gene

UBL7 (Ubiquitin Like 7) is a Protein Coding gene. Diseases associated with UBL7 include Phlyctenulosis and Chromosome 15Q24 Deletion Syndrome. An important paralog of this gene is UBQLN1.

Additional gene information for UBL7 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBL7 Gene

Genomics for UBL7 Gene

GeneHancer (GH) Regulatory Elements for UBL7 Gene

Promoters and enhancers for UBL7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBL7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBL7

Top Transcription factor binding sites by QIAGEN in the UBL7 gene promoter:
  • AhR
  • aMEF-2
  • Arnt
  • HSF2
  • Pax-3

Genomic Locations for UBL7 Gene

Genomic Locations for UBL7 Gene
chr15:74,445,977-74,461,188
(GRCh38/hg38)
Size:
15,212 bases
Orientation:
Minus strand
chr15:74,738,318-74,753,529
(GRCh37/hg19)
Size:
15,212 bases
Orientation:
Minus strand

Genomic View for UBL7 Gene

Genes around UBL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL7 Gene

Proteins for UBL7 Gene

  • Protein details for UBL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S82-UBL7_HUMAN
    Recommended name:
    Ubiquitin-like protein 7
    Protein Accession:
    Q96S82
    Secondary Accessions:
    • D3DW57
    • Q96I03

    Protein attributes for UBL7 Gene

    Size:
    380 amino acids
    Molecular mass:
    40510 Da
    Quaternary structure:
    • Binds ubiquitin.

    Three dimensional structures from OCA and Proteopedia for UBL7 Gene

neXtProt entry for UBL7 Gene

Post-translational modifications for UBL7 Gene

  • Ubiquitination at Lys11, Lys20, Lys44, Lys71, Lys92, Lys100, and Lys106
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UBL7 Gene

Domains & Families for UBL7 Gene

Gene Families for UBL7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBL7 Gene

Blocks:
  • Ubiquitin domain
  • Ubiquitin-associated domain
  • Protein secE/sec61-gamma protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UBL7 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-like 7 (Bone marrow stromal cell-derived), isoform CRA_a (D3DW56_HUMAN)
  • Ubiquitin-like protein SB132 (UBL7_HUMAN)
genes like me logo Genes that share domains with UBL7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UBL7 Gene

Function for UBL7 Gene

Molecular function for UBL7 Gene

UniProtKB/Swiss-Prot Induction:
Down-regulated by phorbol myristate acetate (PMA) in bone marrow stroma cells.

Phenotypes From GWAS Catalog for UBL7 Gene

Gene Ontology (GO) - Molecular Function for UBL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0031593 polyubiquitin modification-dependent protein binding IBA 21873635
genes like me logo Genes that share ontologies with UBL7: view
genes like me logo Genes that share phenotypes with UBL7: view

Animal Model Products

CRISPR Products

miRNA for UBL7 Gene

miRTarBase miRNAs that target UBL7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBL7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBL7 Gene

Localization for UBL7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBL7 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with UBL7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBL7 Gene

Pathways & Interactions for UBL7 Gene

PathCards logo

SuperPathways for UBL7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IBA 21873635
genes like me logo Genes that share ontologies with UBL7: view

No data available for Pathways by source and SIGNOR curated interactions for UBL7 Gene

Drugs & Compounds for UBL7 Gene

No Compound Related Data Available

Transcripts for UBL7 Gene

mRNA/cDNA for UBL7 Gene

6 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBL7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBL7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d · 13e ^
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - -

ExUns: 14a · 14b ^ 15a · 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:

Relevant External Links for UBL7 Gene

GeneLoc Exon Structure for
UBL7

Expression for UBL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBL7 Gene

This gene is overexpressed in NK cells (10.1) and Heart (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBL7 Gene



Protein tissue co-expression partners for UBL7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBL7

SOURCE GeneReport for Unigene cluster for UBL7 Gene:

Hs.334713

mRNA Expression by UniProt/SwissProt for UBL7 Gene:

Q96S82-UBL7_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in heart, skeletal muscle, testis, thyroid and adrenal gland.

Evidence on tissue expression from TISSUES for UBL7 Gene

  • Nervous system(3.9)
  • Skin(2.7)
  • Lung(2.4)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with UBL7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBL7 Gene

Orthologs for UBL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBL7 31 30
  • 99.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BMSC-UBP 31
  • 98 (a)
OneToOne
UBL7 30
  • 93.25 (n)
dog
(Canis familiaris)
Mammalia UBL7 31 30
  • 92.54 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ubl7 17 31 30
  • 91.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBL7 31
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubl7 30
  • 90.26 (n)
oppossum
(Monodelphis domestica)
Mammalia UBL7 31
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-6703 31
  • 91 (a)
OneToOne
UBL7 30
  • 79.12 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 94 (a)
OneToMany
-- 31
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl7 30
  • 69.09 (n)
Str.16741 30
African clawed frog
(Xenopus laevis)
Amphibia MGC69120 30
zebrafish
(Danio rerio)
Actinopterygii ubl7a 31 30
  • 70.12 (n)
OneToMany
ubl7b 31
  • 61 (a)
OneToMany
Dr.15396 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9241 30
Species where no ortholog for UBL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBL7 Gene

ENSEMBL:
Gene Tree for UBL7 (if available)
TreeFam:
Gene Tree for UBL7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBL7: view image

Paralogs for UBL7 Gene

Paralogs for UBL7 Gene

genes like me logo Genes that share paralogs with UBL7: view

Variants for UBL7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBL7 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
709280 Benign: not provided 74,458,798(-) G/C MISSENSE_VARIANT
712170 Benign: not provided 74,449,991(-) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for UBL7 Gene

Structural Variations from Database of Genomic Variants (DGV) for UBL7 Gene

Variant ID Type Subtype PubMed ID
nsv1121512 CNV deletion 24896259
nsv1122981 CNV deletion 24896259

Variation tolerance for UBL7 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBL7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL7 Gene

Disorders for UBL7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for UBL7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phlyctenulosis
  • phlyctenular keratoconjunctivitis
chromosome 15q24 deletion syndrome
  • 15q24 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search UBL7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UBL7

genes like me logo Genes that share disorders with UBL7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBL7 Gene

Publications for UBL7 Gene

  1. Cloning and identification of a novel ubiquitin-like protein, BMSC-UbP, from human bone marrow stromal cells. (PMID: 12644319) Liu S … Cao X (Immunology letters 2003) 2 3 4 23 54
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  3. Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitin. (PMID: 16731964) Chang YG … Hu HY (Protein science : a publication of the Protein Society 2006) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54

Products for UBL7 Gene

Sources for UBL7 Gene