This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an... See more...

Aliases for UBL5 Gene

Aliases for UBL5 Gene

  • Ubiquitin Like 5 2 3 5
  • Ubiquitin-Like Protein 5 3 4
  • Testicular Tissue Protein Li 217 3
  • Ubiquitin-Like 5 2
  • Beacon 3
  • HUB1 3

External Ids for UBL5 Gene

Previous GeneCards Identifiers for UBL5 Gene

  • GC19P010060
  • GC19P010161
  • GC19P009783
  • GC19P009799
  • GC19P009766
  • GC19P009938
  • GC19P009520

Summaries for UBL5 Gene

Entrez Gene Summary for UBL5 Gene

  • This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

GeneCards Summary for UBL5 Gene

UBL5 (Ubiquitin Like 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein tag.

Gene Wiki entry for UBL5 Gene

Additional gene information for UBL5 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBL5 Gene

Genomics for UBL5 Gene

GeneHancer (GH) Regulatory Elements for UBL5 Gene

Promoters and enhancers for UBL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009826 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -0.3 -279 3.2 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 USF1 POLR2G SP1 FBXL12 NONHSAG024755.2 UBL5 PIN1 RF00017-2797
GH19J009620 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.7 -206.3 -206259 3.6 ZBTB40 ZNF217 EP300 CTCF MYC TCF12 POLR2G SP1 NCOR1 GTF2E2 ZNF561 ZNF561-AS1 lnc-ZNF562-2 piR-30876-047 EIF3G ZNF266 ZNF558 FBXL12 KRI1 ZNF699
GH19J009795 Enhancer 1 Ensembl ENCODE 12.3 -30.2 -30179 4.6 CTCF ZNF623 REST RFX1 MEF2C MYC RAD21 CTBP1 TRIM22 SMC3 ZNF561 UBL5 ZNF559 ZNF266 ENSG00000266950 piR-55985-092
GH19J009625 Enhancer 0.9 Ensembl ENCODE 10.6 -201.9 -201871 0.8 EP300 CTCF REST TGIF2 RAD21 CTBP1 TRIM22 SMC3 MAFF GATA3 ZNF561 ZNF846 UBL5 ZNF561-AS1 piR-30876-047 piR-59475
GH19J009927 Enhancer 0.8 Ensembl ENCODE 11.1 +99.6 99621 1.8 BCL11A TCF12 SRF MEF2B POLR2A NBN SPI1 SMARCA5 BATF EBF1 OLFM2 COL5A3 RDH8 SHFL UBL5 MRPL4 ICAM1 piR-51671-046
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBL5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBL5

Top Transcription factor binding sites by QIAGEN in the UBL5 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • E47
  • Elk-1
  • LCR-F1
  • Pax-5
  • STAT3

Genomic Locations for UBL5 Gene

Genomic Locations for UBL5 Gene
chr19:9,827,880-9,830,121
(GRCh38/hg38)
Size:
2,242 bases
Orientation:
Plus strand
chr19:9,938,568-9,940,797
(GRCh37/hg19)
Size:
2,230 bases
Orientation:
Plus strand

Genomic View for UBL5 Gene

Genes around UBL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL5 Gene

Proteins for UBL5 Gene

  • Protein details for UBL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZL1-UBL5_HUMAN
    Recommended name:
    Ubiquitin-like protein 5
    Protein Accession:
    Q9BZL1
    Secondary Accessions:
    • Q2NL89

    Protein attributes for UBL5 Gene

    Size:
    73 amino acids
    Molecular mass:
    8547 Da
    Quaternary structure:
    • Interacts with CLK1, CLK3 and CLK4.

    Three dimensional structures from OCA and Proteopedia for UBL5 Gene

neXtProt entry for UBL5 Gene

Post-translational modifications for UBL5 Gene

  • Ubiquitination at Lys41 and Lys46
  • Modification sites at PhosphoSitePlus

Other Protein References for UBL5 Gene