This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an... See more...

Aliases for UBL5 Gene

Aliases for UBL5 Gene

  • Ubiquitin Like 5 2 3 5
  • Ubiquitin-Like Protein 5 3 4
  • Testicular Tissue Protein Li 217 3
  • Ubiquitin-Like 5 2
  • Beacon 3
  • HUB1 3
  • UBL5 5

External Ids for UBL5 Gene

Previous GeneCards Identifiers for UBL5 Gene

  • GC19P010060
  • GC19P010161
  • GC19P009783
  • GC19P009799
  • GC19P009766
  • GC19P009938
  • GC19P009520

Summaries for UBL5 Gene

Entrez Gene Summary for UBL5 Gene

  • This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

GeneCards Summary for UBL5 Gene

UBL5 (Ubiquitin Like 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein tag.

Gene Wiki entry for UBL5 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBL5 Gene

Genomics for UBL5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UBL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009826 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.3 -291 3.2 SP1 HNRNPL GATAD2A TFE3 RFX1 ZNF692 POLR2A JUND FOXA1 GABPA FBXL12 NONHSAG024755.2 UBL5 PIN1 ILF3 ZNF266 RAVER1 DNMT1 KRI1 ZNF317
GH19J009620 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.7 -206.3 -206271 3.6 SP1 CREB1 ATF7 PRDM10 ZNF629 TFE3 SIX5 LEF1 ZNF692 POLR2A ZNF561 ZNF561-AS1 piR-30876-047 lnc-ZNF562-2 ZNF266 KRI1 FBXL12 ZNF558 RAVER1 PPAN
GH19J009795 Enhancer 1 Ensembl ENCODE 12.3 -30.2 -30191 4.6 CTCF RFX1 JUND PRDM1 PKNOX1 REST NR2C1 RAD21 TRIM22 HDAC1 ZNF561 UBL5 ZNF559 ZNF266 ENSG00000266950 LOC100505555 ZNF846 piR-55985-092 FBXL12
GH19J009625 Enhancer 0.9 Ensembl ENCODE 10.6 -201.9 -201883 0.8 CTCF JUND PKNOX1 RXRB REST RAD21 IRF2 TRIM22 SCRT2 CTBP1 ZNF561 ZNF846 UBL5 ZNF561-AS1 piR-30876-047 piR-59475 ZNF562
GH19J009927 Enhancer 0.8 Ensembl ENCODE 11.1 +99.6 99609 1.8 IKZF2 PKNOX1 EED DPF2 RELB RUNX3 BCLAF1 TCF12 BCL11A NBN OLFM2 COL5A3 RDH8 SHFL UBL5 MRPL4 ICAM1 piR-51671-046 PIN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBL5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBL5

Top Transcription factor binding sites by QIAGEN in the UBL5 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • E47
  • Elk-1
  • LCR-F1
  • Pax-5
  • STAT3

Genomic Locations for UBL5 Gene

Genomic Locations for UBL5 Gene
chr19:9,827,892-9,830,115
(GRCh38/hg38)
Size:
2,224 bases
Orientation:
Plus strand
chr19:9,938,568-9,940,797
(GRCh37/hg19)
Size:
2,230 bases
Orientation:
Plus strand

Genomic View for UBL5 Gene

Genes around UBL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL5 Gene

Proteins for UBL5 Gene

  • Protein details for UBL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZL1-UBL5_HUMAN
    Recommended name:
    Ubiquitin-like protein 5
    Protein Accession:
    Q9BZL1
    Secondary Accessions:
    • Q2NL89

    Protein attributes for UBL5 Gene

    Size:
    73 amino acids
    Molecular mass:
    8547 Da
    Quaternary structure:
    • Interacts with CLK1, CLK3 and CLK4.

    Three dimensional structures from OCA and Proteopedia for UBL5 Gene

neXtProt entry for UBL5 Gene

Post-translational modifications for UBL5 Gene

  • Ubiquitination at Lys41 and Lys46
  • Modification sites at PhosphoSitePlus

Other Protein References for UBL5 Gene

No data available for DME Specific Peptides for UBL5 Gene

Domains & Families for UBL5 Gene

Gene Families for UBL5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBL5 Gene

InterPro:
Blocks:
  • Ubiquitin domain
ProtoNet:

Suggested Antigen Peptide Sequences for UBL5 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-like protein 5 (UBL5_HUMAN)
genes like me logo Genes that share domains with UBL5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UBL5 Gene

Function for UBL5 Gene

Phenotypes From GWAS Catalog for UBL5 Gene

Gene Ontology (GO) - Molecular Function for UBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15620657
GO:0031386 protein tag IBA 21873635
genes like me logo Genes that share ontologies with UBL5: view
genes like me logo Genes that share phenotypes with UBL5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBL5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBL5 Gene

Localization for UBL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBL5 gene
Compartment Confidence
nucleus 4
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for UBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA,IDA 11161819
genes like me logo Genes that share ontologies with UBL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UBL5 Gene

Pathways & Interactions for UBL5 Gene

PathCards logo

SuperPathways for UBL5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA 21873635
GO:0006464 cellular protein modification process IEA,IBA 21873635
GO:1903955 positive regulation of protein targeting to mitochondrion HMP 24270810
genes like me logo Genes that share ontologies with UBL5: view

No data available for Pathways by source and SIGNOR curated interactions for UBL5 Gene

Drugs & Compounds for UBL5 Gene

No Compound Related Data Available

Transcripts for UBL5 Gene

mRNA/cDNA for UBL5 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBL5

Alternative Splicing Database (ASD) splice patterns (SP) for UBL5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: -

Relevant External Links for UBL5 Gene

GeneLoc Exon Structure for
UBL5

Expression for UBL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBL5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBL5 Gene



Protein tissue co-expression partners for UBL5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBL5

SOURCE GeneReport for Unigene cluster for UBL5 Gene:

Hs.534477

mRNA Expression by UniProt/SwissProt for UBL5 Gene:

Q9BZL1-UBL5_HUMAN
Tissue specificity: Ubiquitous. Highest level of expression in heart, skeletal muscle, kidney, liver, iris and lymphoblasts.

Evidence on tissue expression from TISSUES for UBL5 Gene

  • Liver(4.5)
  • Kidney(4.4)
  • Eye(4.3)
  • Nervous system(3.7)
  • Muscle(3)
  • Heart(2.7)
  • Skin(2.5)
  • Intestine(2.4)
  • Adrenal gland(2.2)
  • Lymph node(2.2)
  • Thyroid gland(2.1)
  • Pancreas(2.1)
  • Gall bladder(2.1)
  • Lung(2.1)
  • Bone marrow(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with UBL5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBL5 Gene

Orthologs for UBL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBL5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UBL5 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia UBL5 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia UBL5 30 31
  • 95.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia UBL5 30 31
  • 94.52 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 93 (a)
OneToMany
-- 31
  • 88 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ubl5 30 17 31
  • 88.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ubl5 30
  • 87.67 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ubl5 30
  • 80.82 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:66388 30
  • 83.8 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG3450 32
  • 86 (a)
ubl 30 31
  • 74.43 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011251 30
  • 75.8 (n)
Worm
(Caenorhabditis elegans)
Secernentea ubl-5 30 31
  • 67.12 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUB1 30 31 33
  • 62.96 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08470g 30
  • 59.72 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G45180 30
  • 69.91 (n)
Rice
(Oryza sativa)
Liliopsida Os12g0143150 30
  • 73.61 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 89 (a)
OneToMany
-- 31
  • 54 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hub1 30
  • 69.41 (n)
Species where no ortholog for UBL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UBL5 Gene

ENSEMBL:
Gene Tree for UBL5 (if available)
TreeFam:
Gene Tree for UBL5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBL5: view image

Paralogs for UBL5 Gene

Pseudogenes.org Pseudogenes for UBL5 Gene

genes like me logo Genes that share paralogs with UBL5: view

No data available for Paralogs for UBL5 Gene

Variants for UBL5 Gene

Additional dbSNP identifiers (rs#s) for UBL5 Gene

Structural Variations from Database of Genomic Variants (DGV) for UBL5 Gene

Variant ID Type Subtype PubMed ID
nsv520683 CNV loss 19592680

Variation tolerance for UBL5 Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBL5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBL5 Gene

Disorders for UBL5 Gene

Additional Disease Information for UBL5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for UBL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBL5 Gene

Publications for UBL5 Gene

  1. Identification of sequence variants in the UBL5 (ubiquitin-like 5 or BEACON) gene in obese children by PCR-SSCP: no evidence for association with obesity. (PMID: 19189687) Sentinelli F … Baroni MG (Journal of pediatric endocrinology & metabolism : JPEM 2008) 3 23 41
  2. Structural analysis of UBL5, a novel ubiquitin-like modifier. (PMID: 12824502) McNally T … Reilly RM (Protein science : a publication of the Protein Society 2003) 3 4 23
  3. Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes. (PMID: 11161819) Friedman JS … Walter MA (Genomics 2001) 3 4 23
  4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 41
  5. Beacon-like/ubiquitin-5-like immunoreactivity is highly expressed in human hypothalamus and increased in haloperidol-treated schizophrenics and a rat model of schizophrenia. (PMID: 18191906) Bernstein HG … Bogerts B (Psychoneuroendocrinology 2008) 3 23

Products for UBL5 Gene

Sources for UBL5 Gene