UBL4B Gene (Protein Coding)

Ubiquitin Like 4B

GC01P110137
GIFtS:
31
See more...

Aliases for UBL4B Gene

Aliases for UBL4B Gene

  • Ubiquitin Like 4B 2 3 5
  • Ubiquitin-Like Protein 4B 3 4
  • Ubiquitin-Like 4B 2
  • FLJ25690 2
  • UBL4B 5

External Ids for UBL4B Gene

Previous GeneCards Identifiers for UBL4B Gene

  • GC01P110368
  • GC01P110456
  • GC01P110655
  • GC01P108524
  • GC01P110113
  • GC01P110115
  • GC01P110124

Summaries for UBL4B Gene

GeneCards Summary for UBL4B Gene

UBL4B (Ubiquitin Like 4B) is a Protein Coding gene. Diseases associated with UBL4B include Hereditary Breast Ovarian Cancer Syndrome. An important paralog of this gene is UBL4A.

Additional gene information for UBL4B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBL4B Gene

Genomics for UBL4B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for UBL4B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBL4B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBL4B

Top Transcription factor binding sites by QIAGEN in the UBL4B gene promoter:
  • AP-2rep
  • AREB6
  • c-Ets-1
  • Cart-1
  • HNF-3beta
  • LUN-1
  • MyoD
  • POU2F1
  • POU2F1a
  • Sp1

Genomic Locations for UBL4B Gene

Genomic Locations for UBL4B Gene
chr1:110,112,443-110,113,947
(GRCh38/hg38)
Size:
1,505 bases
Orientation:
Plus strand
chr1:110,655,062-110,656,569
(GRCh37/hg19)
Size:
1,508 bases
Orientation:
Plus strand

Genomic View for UBL4B Gene

Genes around UBL4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL4B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UBL4B Gene

Proteins for UBL4B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for UBL4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7F7-UBL4B_HUMAN
    Recommended name:
    Ubiquitin-like protein 4B
    Protein Accession:
    Q8N7F7

    Protein attributes for UBL4B Gene

    Size:
    174 amino acids
    Molecular mass:
    19909 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May have arisen from retrotransposition of the X-linked UBL4A gene during mammalian evolution.

neXtProt entry for UBL4B Gene

Post-translational modifications for UBL4B Gene

No Post-translational modifications

Other Protein References for UBL4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBL4B Gene

Domains & Families for UBL4B Gene

Gene Families for UBL4B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBL4B Gene

InterPro:
Blocks:
  • Ubiquitin domain
ProtoNet:

Suggested Antigen Peptide Sequences for UBL4B Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-like protein 4B (UBL4B_HUMAN)
genes like me logo Genes that share domains with UBL4B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UBL4B Gene

Function for UBL4B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for UBL4B Gene

Gene Ontology (GO) - Molecular Function for UBL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with UBL4B: view
genes like me logo Genes that share phenotypes with UBL4B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBL4B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBL4B Gene

Localization for UBL4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL4B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBL4B gene
Compartment Confidence
mitochondrion 2
cytosol 2
extracellular 0

Gene Ontology (GO) - Cellular Components for UBL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBL4B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UBL4B Gene

Pathways & Interactions for UBL4B Gene

PathCards logo

SuperPathways for UBL4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903955 positive regulation of protein targeting to mitochondrion HMP 24270810
genes like me logo Genes that share ontologies with UBL4B: view

No data available for Pathways by source and SIGNOR curated interactions for UBL4B Gene

Drugs & Compounds for UBL4B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for UBL4B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for UBL4B Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBL4B

Alternative Splicing Database (ASD) splice patterns (SP) for UBL4B Gene

No ASD Table

Relevant External Links for UBL4B Gene

GeneLoc Exon Structure for
UBL4B

Expression for UBL4B Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBL4B Gene

mRNA expression in normal human tissues for UBL4B Gene
mRNA expression by GTEx for UBL4B GenemRNA expression by BioGPS for UBL4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for UBL4B Gene

This gene is overexpressed in Testis (x47.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBL4B

SOURCE GeneReport for Unigene cluster for UBL4B Gene:

Hs.374027

Evidence on tissue expression from TISSUES for UBL4B Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with UBL4B: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBL4B Gene

Orthologs for UBL4B Gene

This gene was present in the common ancestor of animals.

Orthologs for UBL4B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia UBL4B 30 31
  • 99.03 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia UBL4B 30 31
  • 81.59 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia UBL4B 30 31
  • 80.08 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ubl4b 30 17 31
  • 75.11 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia UBL4B 31
  • 42 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 42 (a)
 OneToMany
Zebrafish
(Danio rerio)
 Actinopterygii UBL4A 31
  • 38 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta CG7215 31
  • 22 (a)
 OneToMany
Species where no ortholog for UBL4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for UBL4B Gene

ENSEMBL:
Gene Tree for UBL4B (if available)
TreeFam:
Gene Tree for UBL4B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBL4B: view image

Paralogs for UBL4B Gene

Paralogs for UBL4B Gene

(1) SIMAP similar genes for UBL4B Gene using alignment to 1 proteins:

  • UBL4B_HUMAN
genes like me logo Genes that share paralogs with UBL4B: view

Variants for UBL4B Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for UBL4B Gene

Structural Variations from Database of Genomic Variants (DGV) for UBL4B Gene

Variant ID Type Subtype PubMed ID
nsv2343 CNV insertion 18451855
nsv509424 CNV insertion 20534489

Variation tolerance for UBL4B Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBL4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBL4B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBL4B Gene

Disorders for UBL4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBL4B Gene - From: DISEASES

Disorder Aliases PubMed IDs
hereditary breast ovarian cancer syndrome
  • brca1- and brca2-associated hereditary breast and ovarian cancer
- elite association - COSMIC cancer census association via MalaCards
Search UBL4B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UBL4B

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with UBL4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBL4B Gene

Publications for UBL4B Gene

  1. Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals. (PMID: 16872915) Yang F … Wang PJ (Gene expression patterns : GEP 2007) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

ExternalLinks

View latest publications for UBL4B gene in Mastermind

Products for UBL4B Gene

  • Signalway Proteins for UBL4B

Sources for UBL4B Gene