Aliases for UBL4A Gene

Aliases for UBL4A Gene

  • Ubiquitin Like 4A 2 3 5
  • Ubiquitin-Like Protein GDX 3 4
  • Ubiquitin-Like Protein 4A 3 4
  • Ubiquitin-Like 4 2 3
  • DXS254E 3 4
  • UBL4 3 4
  • GDX 3 4
  • Ubiquitin-Like 4A 2
  • DX254E 3
  • TMA24 3
  • G6PD 3
  • GET5 3
  • MDY2 3

External Ids for UBL4A Gene

Previous HGNC Symbols for UBL4A Gene

  • UBL4

Previous GeneCards Identifiers for UBL4A Gene

  • GC0XM153276
  • GC0XM153365
  • GC0XM153712
  • GC0XM142288

Summaries for UBL4A Gene

GeneCards Summary for UBL4A Gene

UBL4A (Ubiquitin Like 4A) is a Protein Coding gene. Diseases associated with UBL4A include Acute Apical Periodontitis and Optic Disk Drusen. Gene Ontology (GO) annotations related to this gene include ubiquitin-like protein transferase activity. An important paralog of this gene is UBL4B.

UniProtKB/Swiss-Prot Summary for UBL4A Gene

  • As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).

Gene Wiki entry for UBL4A Gene

Additional gene information for UBL4A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBL4A Gene

Genomics for UBL4A Gene

GeneHancer (GH) Regulatory Elements for UBL4A Gene

Promoters and enhancers for UBL4A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ154483 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.8 836 3.8 ZFX ZIC2 ZBTB10 ZBTB11 ZNF423 ZBTB26 TARDBP MYC CHD1 CTBP1 UBL4A lnc-SLC10A3-1 LAGE3 FAM3A FAM50A GDI1 ATP6AP1 CH17-340M24.3 SLC10A3 RF00017-8815
GH0XJ154489 Promoter 0.6 Ensembl 500.7 -1.6 -1631 0.6 GLIS1 GLIS2 RBFOX2 UBL4A lnc-SLC10A3-1 piR-51082 SLC10A3 RF00017-8815
GH0XJ154487 Promoter 0.3 EPDnew 500.7 -1.2 -1173 0.1 UBL4A lnc-SLC10A3-1 piR-51082 SLC10A3 RF00017-8815
GH0XJ154443 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 13.7 +42.2 42237 2.7 NRF1 ZIC2 ZBTB26 MYC CTBP1 SIN3A POLR2A KDM5B CREB1 SMC3 FAM50A NONHSAG055593.2 LAGE3 UBL4A RPL10 GDI1 MIR6858
GH0XJ154481 Enhancer 0.8 Ensembl ENCODE 0.7 +3.9 3869 2 ZNF341 RAD51 KDM5B POLR2A MYNN CTCF POLR2G ZNF592 SUPT5H ZBTB7A FAM3A F8A1 LAGE3 UBL4A lnc-SLC10A3-1 RF00017-8815
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBL4A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBL4A

Top Transcription factor binding sites by QIAGEN in the UBL4A gene promoter:
  • Arnt
  • ATF-2
  • c-Jun
  • CREB
  • E47
  • GATA-2
  • HOXA3
  • MIF-1
  • p53
  • RSRFC4

Genomic Locations for UBL4A Gene

Genomic Locations for UBL4A Gene
chrX:154,483,717-154,486,670
(GRCh38/hg38)
Size:
2,954 bases
Orientation:
Minus strand
chrX:153,712,056-153,715,009
(GRCh37/hg19)
Size:
2,954 bases
Orientation:
Minus strand

Genomic View for UBL4A Gene

Genes around UBL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL4A Gene

Proteins for UBL4A Gene

  • Protein details for UBL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11441-UBL4A_HUMAN
    Recommended name:
    Ubiquitin-like protein 4A
    Protein Accession:
    P11441
    Secondary Accessions:
    • Q5HY80

    Protein attributes for UBL4A Gene

    Size:
    157 amino acids
    Molecular mass:
    17777 Da
    Quaternary structure:
    • Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35 (PubMed:20676083, PubMed:25535373). Interacts with BAG6; the interaction is direct and required for UBL4A protein stability (PubMed:25713138, PubMed:25535373). Interacts with USP13; may be indirect via BAG6 (PubMed:24424410).

    Three dimensional structures from OCA and Proteopedia for UBL4A Gene

neXtProt entry for UBL4A Gene

Post-translational modifications for UBL4A Gene

  • Polyubiquitinated. Ubiquitination by AMFR and deubiquitination by USP13 may regulate the interaction between the BAG6/BAT3 complex and SGTA and therefore may regulate client proteins fate.
  • Ubiquitination at Lys48, Lys101, and Lys153
  • Modification sites at PhosphoSitePlus

Other Protein References for UBL4A Gene

No data available for DME Specific Peptides for UBL4A Gene

Domains & Families for UBL4A Gene

Gene Families for UBL4A Gene

Protein Domains for UBL4A Gene

Suggested Antigen Peptide Sequences for UBL4A Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-like protein GDX (UBL4A_HUMAN)
genes like me logo Genes that share domains with UBL4A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UBL4A Gene

Function for UBL4A Gene

Molecular function for UBL4A Gene

UniProtKB/Swiss-Prot Function:
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).

Gene Ontology (GO) - Molecular Function for UBL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19615732
GO:0019787 ubiquitin-like protein transferase activity TAS 2829204
GO:0051087 chaperone binding IPI 25535373
genes like me logo Genes that share ontologies with UBL4A: view
genes like me logo Genes that share phenotypes with UBL4A: view

Animal Models for UBL4A Gene

MGI Knock Outs for UBL4A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBL4A

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBL4A Gene

Localization for UBL4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL4A Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBL4A gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21636303
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 21636303
GO:0005829 cytosol IDA 20676083
GO:0016020 membrane IDA 23246001
genes like me logo Genes that share ontologies with UBL4A: view

Pathways & Interactions for UBL4A Gene

PathCards logo

SuperPathways for UBL4A Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 2829204
GO:0071816 tail-anchored membrane protein insertion into ER membrane IMP 20676083
genes like me logo Genes that share ontologies with UBL4A: view

No data available for Pathways by source and SIGNOR curated interactions for UBL4A Gene

Drugs & Compounds for UBL4A Gene

No Compound Related Data Available

Transcripts for UBL4A Gene

mRNA/cDNA for UBL4A Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBL4A

Alternative Splicing Database (ASD) splice patterns (SP) for UBL4A Gene

No ASD Table

Relevant External Links for UBL4A Gene

GeneLoc Exon Structure for
UBL4A

Expression for UBL4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBL4A Gene

Protein differential expression in normal tissues from HIPED for UBL4A Gene

This gene is overexpressed in Bone (21.4) and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBL4A Gene



Protein tissue co-expression partners for UBL4A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBL4A

SOURCE GeneReport for Unigene cluster for UBL4A Gene:

Hs.76480

Evidence on tissue expression from TISSUES for UBL4A Gene

  • Nervous system(4.9)
  • Lung(4.4)
  • Eye(3.4)
  • Muscle(2.4)
  • Adrenal gland(2.3)
genes like me logo Genes that share expression patterns with UBL4A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBL4A Gene

Orthologs for UBL4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBL4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBL4A 31 30
  • 100 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ubl4 31
  • 90 (a)
OneToOne
Slc10a3-ubl4 30
  • 85.56 (n)
Ubl4a 17
dog
(Canis familiaris)
Mammalia UBL4A 31 30
  • 88.96 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UBL4A 31 30
  • 84.93 (n)
OneToMany
-- 31
  • 69 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ubl4a 30
  • 84.93 (n)
oppossum
(Monodelphis domestica)
Mammalia UBL4A 31
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBL4A 31
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl4a 30
  • 57.31 (n)
zebrafish
(Danio rerio)
Actinopterygii UBL4A 31
  • 62 (a)
OneToMany
zgc:56596 30
  • 57.79 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8734 30
fruit fly
(Drosophila melanogaster)
Insecta CG7215 31
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDY2 33
Species where no ortholog for UBL4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBL4A Gene

ENSEMBL:
Gene Tree for UBL4A (if available)
TreeFam:
Gene Tree for UBL4A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBL4A: view image

Paralogs for UBL4A Gene

(8) SIMAP similar genes for UBL4A Gene using alignment to 4 proteins:

  • UBL4A_HUMAN
  • F8WB70_HUMAN
  • F8WCT8_HUMAN
  • Q5HY81_HUMAN
genes like me logo Genes that share paralogs with UBL4A: view

Variants for UBL4A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBL4A Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
771063 Benign: not provided 154,485,912(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for UBL4A Gene

Structural Variations from Database of Genomic Variants (DGV) for UBL4A Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv519042 CNV gain 19592680

Variation tolerance for UBL4A Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.50; 77.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBL4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBL4A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL4A Gene

Disorders for UBL4A Gene

MalaCards: The human disease database

(3) MalaCards diseases for UBL4A Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute apical periodontitis
  • acute apical periodontitis of pulpal origin
optic disk drusen
  • drusen of optic disc
primary hypomagnesemia
  • hypomagnesemia 1, intestinal
- elite association - COSMIC cancer census association via MalaCards
Search UBL4A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UBL4A

genes like me logo Genes that share disorders with UBL4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBL4A Gene

Publications for UBL4A Gene

  1. A "housekeeping" gene on the X chromosome encodes a protein similar to ubiquitin. (PMID: 2829204) Toniolo D … Alcalay M (Proceedings of the National Academy of Sciences of the United States of America 1988) 2 3 4 54
  2. Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis. (PMID: 25713138) Kuwabara N … Kato R (The Journal of biological chemistry 2015) 3 4 54
  3. Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain. (PMID: 25535373) Mock JY … Clemons WM (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 4 54
  4. USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation. (PMID: 24424410) Liu Y … Ye Y (eLife 2014) 3 4 54
  5. A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. (PMID: 21636303) Wang Q … Ye Y (Molecular cell 2011) 3 4 54

Products for UBL4A Gene

Sources for UBL4A Gene