Aliases for UBL3 Gene

Aliases for UBL3 Gene

  • Ubiquitin Like 3 2 3 5
  • Membrane-Anchored Ubiquitin-Fold Protein 3 4
  • Ubiquitin-Like Protein 3 3 4
  • Protein HCG-1 3 4
  • HsMUB 3 4
  • PNSC1 3 4
  • MUB 3 4
  • Ubiquitin-Like 3 2
  • HCG-1 3

External Ids for UBL3 Gene

Previous HGNC Symbols for UBL3 Gene

  • PNSC1

Previous GeneCards Identifiers for UBL3 Gene

  • GC13M028318
  • GC13M024318
  • GC13M029268
  • GC13M028136
  • GC13M029236
  • GC13M030338
  • GC13M011152

Summaries for UBL3 Gene

GeneCards Summary for UBL3 Gene

UBL3 (Ubiquitin Like 3) is a Protein Coding gene.

Gene Wiki entry for UBL3 Gene

Additional gene information for UBL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBL3 Gene

Genomics for UBL3 Gene

GeneHancer (GH) Regulatory Elements for UBL3 Gene

Promoters and enhancers for UBL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J029846 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 506.3 +2.3 2283 6.4 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A POLR2G PHF8 SIX5 ZFX UBL3 SLC7A1 RF00017-1382
GH13J029851 Enhancer 0.2 Ensembl 500.7 -1.2 -1218 0.2 UBL3 ENSG00000278172
GH13J030462 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.5 -614.1 -614139 5.3 FOXK2 ZNF217 EP300 ZSCAN5C SIN3A NRF1 POLR2G SP1 GTF2E2 PHF8 HMGB1 ENSG00000285840 lnc-KATNAL1-6 USPL1 KATNAL1 UBL3 lnc-KATNAL1-5
GH13J030113 Promoter/Enhancer 1.6 ENCODE CraniofacialAtlas dbSUPER 11.1 -263.7 -263716 2.7 EP300 CTCF SIN3A NRF1 POLR2G TEAD4 ZFX POLR2A ZBTB26 REST UBL3 LINC00365 RF00017-1384
GH13J030145 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 -302.0 -301982 14.5 RXRA CTCF USF1 FOS ZIC2 REST JUND RELA MEF2C RAD21 LINC00385 KATNAL1 UBL3 USPL1 LINC00384
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBL3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBL3

Top Transcription factor binding sites by QIAGEN in the UBL3 gene promoter:
  • AML1a
  • AP-2gamma
  • AP-4
  • CUTL1
  • Egr-4
  • HOXA3
  • IRF-1
  • LCR-F1
  • MyoD

Genomic Locations for UBL3 Gene

Genomic Locations for UBL3 Gene
chr13:29,764,371-29,850,683
(GRCh38/hg38)
Size:
86,313 bases
Orientation:
Minus strand
chr13:30,338,508-30,424,821
(GRCh37/hg19)
Size:
86,314 bases
Orientation:
Minus strand

Genomic View for UBL3 Gene

Genes around UBL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL3 Gene

Proteins for UBL3 Gene

  • Protein details for UBL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95164-UBL3_HUMAN
    Recommended name:
    Ubiquitin-like protein 3
    Protein Accession:
    O95164
    Secondary Accessions:
    • B2R4J1
    • Q5RL72
    • Q5VZS0
    • Q6FIG8
    • Q96SG7

    Protein attributes for UBL3 Gene

    Size:
    117 amino acids
    Molecular mass:
    13157 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBL3 Gene

neXtProt entry for UBL3 Gene

Post-translational modifications for UBL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for UBL3

No data available for DME Specific Peptides for UBL3 Gene

Domains & Families for UBL3 Gene

Gene Families for UBL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBL3 Gene

Suggested Antigen Peptide Sequences for UBL3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92110, Homo sapiens ubiquitin-like 3 (UBL3), mRNA (B2R4J1_HUMAN)
  • Protein HCG-1 (UBL3_HUMAN)
genes like me logo Genes that share domains with UBL3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UBL3 Gene

Function for UBL3 Gene

Molecular function for UBL3 Gene

GENATLAS Biochemistry:
ubiquitin-like protein 3, Drosophila homolog,highly conserved in man and C elegans

Phenotypes From GWAS Catalog for UBL3 Gene

genes like me logo Genes that share phenotypes with UBL3: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for UBL3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBL3 Gene

Localization for UBL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL3 Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBL3 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with UBL3: view

Pathways & Interactions for UBL3 Gene

PathCards logo

SuperPathways for UBL3 Gene

No Data Available

Interacting Proteins for UBL3 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000370055 O95164-UBL3_HUMAN for UBL3 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for UBL3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBL3 Gene

Drugs & Compounds for UBL3 Gene

No Compound Related Data Available

Transcripts for UBL3 Gene

mRNA/cDNA for UBL3 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for UBL3

Alternative Splicing Database (ASD) splice patterns (SP) for UBL3 Gene

No ASD Table

Relevant External Links for UBL3 Gene

GeneLoc Exon Structure for
UBL3

Expression for UBL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBL3 Gene

This gene is overexpressed in Cervix (43.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBL3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBL3

SOURCE GeneReport for Unigene cluster for UBL3 Gene:

Hs.145575

mRNA Expression by UniProt/SwissProt for UBL3 Gene:

O95164-UBL3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for UBL3 Gene

  • Nervous system(4.9)
  • Skin(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with UBL3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBL3 Gene

Orthologs for UBL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBL3 31 30
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBL3 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBL3 31 30
  • 97.72 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBL3 31
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBL3 31 30
  • 93.16 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ubl3 17 31 30
  • 88.32 (n)
rat
(Rattus norvegicus)
Mammalia Ubl3 30
  • 87.46 (n)
chicken
(Gallus gallus)
Aves UBL3 31 30
  • 86.89 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBL3 31
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl3 30
  • 84.62 (n)
Str.5748 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.21417 30
zebrafish
(Danio rerio)
Actinopterygii ubl3a 31 30
  • 79.2 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013294 30
  • 64.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta UBL3 31 32 30
  • 63.74 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C46F11.6 31 30
  • 55.15 (n)
OneToOne
Species where no ortholog for UBL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBL3 Gene

ENSEMBL:
Gene Tree for UBL3 (if available)
TreeFam:
Gene Tree for UBL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBL3: view image

Paralogs for UBL3 Gene

No data available for Paralogs for UBL3 Gene

Variants for UBL3 Gene

Additional dbSNP identifiers (rs#s) for UBL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for UBL3 Gene

Variant ID Type Subtype PubMed ID
esv1537429 CNV deletion 17803354

Variation tolerance for UBL3 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBL3 Gene

Disorders for UBL3 Gene

Additional Disease Information for UBL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UBL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBL3 Gene

Publications for UBL3 Gene

  1. Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene. (PMID: 10375635) Chadwick BP … Frischauf AM (Gene 1999) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. (PMID: 20460270) Garcia-Barceló MM … Tam PK (Human molecular genetics 2010) 3 41 54
  4. MUBs, a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation. (PMID: 16831869) Downes BP … Vierstra RD (The Journal of biological chemistry 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for UBL3 Gene

Sources for UBL3 Gene