Aliases for UBFD1 Gene

Aliases for UBFD1 Gene

  • Ubiquitin Family Domain Containing 1 2 3 5
  • Ubiquitin-Binding Protein Homolog 2 3 4
  • UBPH 2 3 4
  • Ubiquitin Domain-Containing Protein UBFD1 3 4
  • FLJ42145 2
  • FLJ38870 2
  • UBFD1 5

External Ids for UBFD1 Gene

Previous GeneCards Identifiers for UBFD1 Gene

  • GC16P023476
  • GC16P023568
  • GC16P021659

Summaries for UBFD1 Gene

GeneCards Summary for UBFD1 Gene

UBFD1 (Ubiquitin Family Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for UBFD1 Gene

Additional gene information for UBFD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBFD1 Gene

Genomics for UBFD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UBFD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBFD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBFD1

Top Transcription factor binding sites by QIAGEN in the UBFD1 gene promoter:
  • Elk-1
  • NF-1
  • NF-1/L
  • Nkx2-5
  • p53
  • Pax-2
  • Pax-2a
  • Pax-2b
  • Pax-4a
  • POU3F1

Genomic Locations for UBFD1 Gene

Genomic Locations for UBFD1 Gene
16,837 bases
Plus strand
17,319 bases
Plus strand

Genomic View for UBFD1 Gene

Genes around UBFD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBFD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBFD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBFD1 Gene

Proteins for UBFD1 Gene

  • Protein details for UBFD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin domain-containing protein UBFD1
    Protein Accession:
    Secondary Accessions:
    • A8MW58
    • D3DWF2

    Protein attributes for UBFD1 Gene

    309 amino acids
    Molecular mass:
    33382 Da
    Quaternary structure:
    • Binds polyubiquitin.
    • Sequence=AAC05812.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=EAW55818.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=EAW55819.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for UBFD1 Gene

Post-translational modifications for UBFD1 Gene

  • Ubiquitination at Lys100, Lys111, Lys113, Lys126, Lys149, Lys167, Lys245, and Lys305
  • Modification sites at PhosphoSitePlus

Other Protein References for UBFD1 Gene

No data available for DME Specific Peptides for UBFD1 Gene

Domains & Families for UBFD1 Gene

Gene Families for UBFD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBFD1 Gene

  • Ubiquitin domain

Suggested Antigen Peptide Sequences for UBFD1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ42145 fis, clone TESTI4000228, highly similar to Mus musculus ubiquitin family domain containing 1 (Ubfd1), mRNA (B3KW52_HUMAN)
  • Ubiquitin-binding protein homolog (UBFD1_HUMAN)
genes like me logo Genes that share domains with UBFD1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UBFD1 Gene

Function for UBFD1 Gene

Molecular function for UBFD1 Gene

UniProtKB/Swiss-Prot Function:
May play a role as NF-kappa-B regulator.

Phenotypes From GWAS Catalog for UBFD1 Gene

Gene Ontology (GO) - Molecular Function for UBFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IEA --
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with UBFD1: view
genes like me logo Genes that share phenotypes with UBFD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBFD1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBFD1 Gene

Localization for UBFD1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBFD1 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 1
mitochondrion 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBFD1 Gene

Pathways & Interactions for UBFD1 Gene

PathCards logo

SuperPathways for UBFD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBFD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for UBFD1 Gene

Drugs & Compounds for UBFD1 Gene

(1) Drugs for UBFD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with UBFD1: view

Transcripts for UBFD1 Gene

mRNA/cDNA for UBFD1 Gene

8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBFD1

Alternative Splicing Database (ASD) splice patterns (SP) for UBFD1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: -
SP3: -
SP4: - -
SP6: - -

Relevant External Links for UBFD1 Gene

GeneLoc Exon Structure for

Expression for UBFD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBFD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBFD1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.2).

Protein differential expression in normal tissues from HIPED for UBFD1 Gene

This gene is overexpressed in Skin (9.5) and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBFD1 Gene

Protein tissue co-expression partners for UBFD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBFD1

SOURCE GeneReport for Unigene cluster for UBFD1 Gene:


Evidence on tissue expression from TISSUES for UBFD1 Gene

  • Muscle(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with UBFD1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBFD1 Gene

Orthologs for UBFD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBFD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBFD1 30 31
  • 99.11 (n)
(Bos Taurus)
Mammalia UBFD1 30 31
  • 93.46 (n)
(Canis familiaris)
Mammalia UBFD1 30 31
  • 93.42 (n)
(Rattus norvegicus)
Mammalia Ubfd1 30
  • 91.26 (n)
(Mus musculus)
Mammalia Ubfd1 30 17 31
  • 91.15 (n)
(Ornithorhynchus anatinus)
Mammalia UBFD1 31
  • 82 (a)
(Monodelphis domestica)
Mammalia UBFD1 31
  • 73 (a)
(Gallus gallus)
Aves UBFD1 30 31
  • 78.34 (n)
(Anolis carolinensis)
Reptilia UBFD1 31
  • 90 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ubfd1 30
  • 74.97 (n)
Str.3410 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.11034 30
(Danio rerio)
Actinopterygii ubfd1 30 31
  • 75.48 (n)
Dr.17009 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10126 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4216 30
Species where no ortholog for UBFD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for UBFD1 Gene

Gene Tree for UBFD1 (if available)
Gene Tree for UBFD1 (if available)
Evolutionary constrained regions (ECRs) for UBFD1: view image

Paralogs for UBFD1 Gene Pseudogenes for UBFD1 Gene

genes like me logo Genes that share paralogs with UBFD1: view

No data available for Paralogs for UBFD1 Gene

Variants for UBFD1 Gene

Additional dbSNP identifiers (rs#s) for UBFD1 Gene

Variation tolerance for UBFD1 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBFD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for UBFD1 Gene

Disorders for UBFD1 Gene

No disorders were found for UBFD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBFD1 Gene

Publications for UBFD1 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4
  2. Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. (PMID: 19285159) Fenner BJ … Prehn JH (Biochimica et biophysica acta 2009) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. (PMID: 31452512) Pech MF … Settleman J (eLife 2019) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for UBFD1 Gene

Sources for UBFD1 Gene