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Aliases for UBFD1 Gene

Aliases for UBFD1 Gene

  • Ubiquitin Family Domain Containing 1 2 3 5
  • Ubiquitin-Binding Protein Homolog 2 3 4
  • UBPH 3 4
  • Ubiquitin Domain-Containing Protein UBFD1 3

External Ids for UBFD1 Gene

Previous GeneCards Identifiers for UBFD1 Gene

  • GC16P023476
  • GC16P023568
  • GC16P021659

Summaries for UBFD1 Gene

GeneCards Summary for UBFD1 Gene

UBFD1 (Ubiquitin Family Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for UBFD1 Gene

  • May play a role as NF-kappa-B regulator.

Additional gene information for UBFD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBFD1 Gene

Genomics for UBFD1 Gene

GeneHancer (GH) Regulatory Elements for UBFD1 Gene

Promoters and enhancers for UBFD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I023556 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.3 +0.3 284 3.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 UBFD1 EARS2 PIR45637 NDUFAB1 GGA2
GH16I023508 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.1 -47.6 -47550 2.6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A GGA2 DCTN5 ENSG00000260751 COG7 NDUFAB1 PALB2 ENSG00000260905 UBFD1 PIR42085 LOC100419017
GH16I023452 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 7.9 -104.5 -104461 1.8 HDGF FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 E2F8 ZNF143 COG7 ENSG00000260136 UBFD1
GH16I023503 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.1 -51.7 -51746 4 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 IRF4 ZNF766 ZNF213 FOS DCTN5 COG7 UBFD1 GGA2 PRKCB LOC100419017 PIR42085
GH16I023496 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 8.5 -60.1 -60059 2 HDAC1 TEAD4 MAX YY1 FOSL1 MTA3 FOXK2 EGR1 ADNP VEZF1 COG7 PALB2 ENSG00000260751 ENSG00000260905 UBFD1 GGA2 LOC100419017 GC16M023463
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBFD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBFD1 gene promoter:

Genomic Locations for UBFD1 Gene

Genomic Locations for UBFD1 Gene
17,033 bases
Plus strand

Genomic View for UBFD1 Gene

Genes around UBFD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBFD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBFD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBFD1 Gene

Proteins for UBFD1 Gene

  • Protein details for UBFD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin domain-containing protein UBFD1
    Protein Accession:
    Secondary Accessions:
    • A8MW58
    • D3DWF2

    Protein attributes for UBFD1 Gene

    309 amino acids
    Molecular mass:
    33382 Da
    Quaternary structure:
    • Binds polyubiquitin.
    • Sequence=AAC05812.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW55818.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW55819.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for UBFD1 Gene

Post-translational modifications for UBFD1 Gene

  • Ubiquitination at isoforms=100, isoforms=111, isoforms=113, posLast=126126, posLast=149149, isoforms=167, posLast=245245, and isoforms=305

Other Protein References for UBFD1 Gene

No data available for DME Specific Peptides for UBFD1 Gene

Domains & Families for UBFD1 Gene

Gene Families for UBFD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBFD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBFD1: view

No data available for UniProtKB/Swiss-Prot for UBFD1 Gene

Function for UBFD1 Gene

Molecular function for UBFD1 Gene

UniProtKB/Swiss-Prot Function:
May play a role as NF-kappa-B regulator.

Gene Ontology (GO) - Molecular Function for UBFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with UBFD1: view
genes like me logo Genes that share phenotypes with UBFD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBFD1 Gene

Localization for UBFD1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBFD1 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBFD1 Gene

Pathways & Interactions for UBFD1 Gene

SuperPathways for UBFD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBFD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for UBFD1 Gene

Drugs & Compounds for UBFD1 Gene

(1) Drugs for UBFD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with UBFD1: view

Transcripts for UBFD1 Gene

Unigene Clusters for UBFD1 Gene

Ubiquitin family domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBFD1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: -
SP3: -
SP4: - -
SP6: - -

Relevant External Links for UBFD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBFD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBFD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBFD1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.2).

Protein differential expression in normal tissues from HIPED for UBFD1 Gene

This gene is overexpressed in Skin (9.5) and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBFD1 Gene

Protein tissue co-expression partners for UBFD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBFD1 Gene:


SOURCE GeneReport for Unigene cluster for UBFD1 Gene:


Evidence on tissue expression from TISSUES for UBFD1 Gene

  • Muscle(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with UBFD1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBFD1 Gene

Orthologs for UBFD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBFD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBFD1 33 34
  • 99.11 (n)
(Bos Taurus)
Mammalia UBFD1 33 34
  • 93.46 (n)
(Canis familiaris)
Mammalia UBFD1 33 34
  • 93.42 (n)
(Rattus norvegicus)
Mammalia Ubfd1 33
  • 91.26 (n)
(Mus musculus)
Mammalia Ubfd1 33 16 34
  • 91.15 (n)
(Ornithorhynchus anatinus)
Mammalia UBFD1 34
  • 82 (a)
(Monodelphis domestica)
Mammalia UBFD1 34
  • 73 (a)
(Gallus gallus)
Aves UBFD1 33 34
  • 78.34 (n)
(Anolis carolinensis)
Reptilia UBFD1 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubfd1 33
  • 74.97 (n)
Str.3410 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11034 33
(Danio rerio)
Actinopterygii ubfd1 33 34
  • 75.48 (n)
Dr.17009 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10126 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4216 33
Species where no ortholog for UBFD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBFD1 Gene

Gene Tree for UBFD1 (if available)
Gene Tree for UBFD1 (if available)

Paralogs for UBFD1 Gene Pseudogenes for UBFD1 Gene

genes like me logo Genes that share paralogs with UBFD1: view

No data available for Paralogs for UBFD1 Gene

Variants for UBFD1 Gene

Sequence variations from dbSNP and Humsavar for UBFD1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs113722817 benign, likely-benign, not specified, not provided 23,557,328(+) T/C upstream_transcript_variant
rs377067442 uncertain-significance, Combined oxidative phosphorylation deficiency 23,557,362(+) C/T upstream_transcript_variant
rs1057523044 likely-benign, not specified 23,557,357(+) G/T upstream_transcript_variant
rs113410455 likely-benign, not specified 23,557,281(+) G/A/C/T upstream_transcript_variant
rs587780932 benign, not provided 23,557,329(+) C/G upstream_transcript_variant

Variation tolerance for UBFD1 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBFD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UBFD1 Gene

Disorders for UBFD1 Gene

Additional Disease Information for UBFD1

No disorders were found for UBFD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBFD1 Gene

Publications for UBFD1 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4 58
  2. Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. (PMID: 19285159) Fenner BJ … Prehn JH (Biochimica et biophysica acta 2009) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for UBFD1 Gene

Sources for UBFD1 Gene

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