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Aliases for UBE2Z Gene

Aliases for UBE2Z Gene

  • Ubiquitin Conjugating Enzyme E2 Z 2 3 5
  • Uba6-Specific E2 Conjugating Enzyme 1 3 4
  • E2 Ubiquitin-Conjugating Enzyme Z 3 4
  • Ubiquitin Carrier Protein Z 3 4
  • Ubiquitin-Protein Ligase Z 3 4
  • UBA6-Specific Enzyme E2 2 3
  • USE1 3 4
  • Ubiquitin-Conjugating Enzyme E2 Z 3
  • Ubiquitin-Conjugating Enzyme E2Z 2
  • Ubiquitin Conjugating Enzyme E2Z 3
  • EC 56
  • EC 4
  • HOYS7 3

External Ids for UBE2Z Gene

Previous GeneCards Identifiers for UBE2Z Gene

  • GC17P044341
  • GC17P046985
  • GC17P042357

Summaries for UBE2Z Gene

Entrez Gene Summary for UBE2Z Gene

  • This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]

GeneCards Summary for UBE2Z Gene

UBE2Z (Ubiquitin Conjugating Enzyme E2 Z) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is BIRC6.

UniProtKB/Swiss-Prot for UBE2Z Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.

Additional gene information for UBE2Z Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2Z Gene

Genomics for UBE2Z Gene

GeneHancer (GH) Regulatory Elements for UBE2Z Gene

Promoters and enhancers for UBE2Z Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I048906 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 590.9 +0.4 441 4.4 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 UBE2Z SUMO2P17 ENSG00000262837 ENSG00000266601 ATP5MC1 CALCOCO2 FAM117A ENSG00000264701 ENSG00000230532 SNF8
GH17I047941 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 91.1 -966.5 -966512 2 CLOCK MLX DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 SP3 SP2-AS1 PNPO MRPL45P2 UBE2Z EFCAB13 SP2 ENSG00000264701 ENSG00000266601 CDK5RAP3 RPS2P47
GH17I049190 Enhancer 1.7 FANTOM5 Ensembl ENCODE 119.9 +284.4 284370 4 CLOCK MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 TRQ-TTG1-1 ENSG00000262837 UBE2Z FAM117A FLJ45513 ENSG00000230532 KAT7 TAC4 PICART1 CALCOCO2
GH17I049758 Promoter/Enhancer 2.7 VISTA EPDnew Ensembl ENCODE dbSUPER 71.4 +853.6 853580 6.4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B FAM117A ENSG00000262837 UBE2Z LUC7L3 FLJ45513 SPOP COL1A1 TAC4 SLC35B1 ITGA3
GH17I048538 Promoter/Enhancer 3 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 44.3 -335.2 -335203 68.8 FEZF1 IRF4 YY1 ZNF213 ZNF143 SP3 MEF2D ZNF610 GLIS1 NBN HOXB2 HOXB3 HOXB6 HOXB4 HOXB5 PIR47329 PIR34300 UBE2Z SP2 ENSG00000264701
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBE2Z on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBE2Z gene promoter:

Genomic Locations for UBE2Z Gene

Genomic Locations for UBE2Z Gene
20,692 bases
Plus strand

Genomic View for UBE2Z Gene

Genes around UBE2Z on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2Z Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2Z Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2Z Gene

Proteins for UBE2Z Gene

  • Protein details for UBE2Z Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Z
    Protein Accession:
    Secondary Accessions:
    • A6N8M6
    • A6NC60
    • Q7L354
    • Q8TCM4
    • Q9H893

    Protein attributes for UBE2Z Gene

    354 amino acids
    Molecular mass:
    38210 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH15890.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14724.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2Z Gene

    Alternative splice isoforms for UBE2Z Gene


neXtProt entry for UBE2Z Gene

Selected DME Specific Peptides for UBE2Z Gene


Post-translational modifications for UBE2Z Gene

  • Ubiquitination at posLast=166166
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2Z Gene

Domains & Families for UBE2Z Gene

Gene Families for UBE2Z Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for UBE2Z Gene

Suggested Antigen Peptide Sequences for UBE2Z Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ubiquitin-conjugating enzyme family.
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2Z: view

Function for UBE2Z Gene

Molecular function for UBE2Z Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.

Enzyme Numbers (IUBMB) for UBE2Z Gene

Phenotypes From GWAS Catalog for UBE2Z Gene

Gene Ontology (GO) - Molecular Function for UBE2Z Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with UBE2Z: view
genes like me logo Genes that share phenotypes with UBE2Z: view

Animal Model Products

miRNA for UBE2Z Gene

miRTarBase miRNAs that target UBE2Z

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2Z Gene

Localization for UBE2Z Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2Z Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2Z gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2Z Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 17464193
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2Z: view

Pathways & Interactions for UBE2Z Gene

genes like me logo Genes that share pathways with UBE2Z: view

Pathways by source for UBE2Z Gene

UniProtKB/Swiss-Prot Q9H832-UBE2Z_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2Z Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0016567 protein ubiquitination TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IEA --
GO:0043065 positive regulation of apoptotic process IDA 17464193
genes like me logo Genes that share ontologies with UBE2Z: view

No data available for SIGNOR curated interactions for UBE2Z Gene

Drugs & Compounds for UBE2Z Gene

(3) Drugs for UBE2Z Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for UBE2Z Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with UBE2Z: view

Transcripts for UBE2Z Gene

Unigene Clusters for UBE2Z Gene

Ubiquitin-conjugating enzyme E2Z:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Z Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b
SP1: - - - -
SP2: - - -
SP3: -
SP5: - -

Relevant External Links for UBE2Z Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2Z Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2Z Gene

Protein differential expression in normal tissues from HIPED for UBE2Z Gene

This gene is overexpressed in Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2Z Gene

Protein tissue co-expression partners for UBE2Z Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2Z Gene:


SOURCE GeneReport for Unigene cluster for UBE2Z Gene:


mRNA Expression by UniProt/SwissProt for UBE2Z Gene:

Tissue specificity: Widely expressed. Highly in placenta, pancreas, spleen and testis.

Evidence on tissue expression from TISSUES for UBE2Z Gene

  • Nervous system(4.8)
  • Skin(4.4)
  • Thyroid gland(4.3)
  • Pancreas(4.2)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with UBE2Z: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2Z Gene

Orthologs for UBE2Z Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBE2Z Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBE2Z 33 34
  • 99.19 (n)
(Canis familiaris)
Mammalia UBE2Z 34
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia UBE2Z 34
  • 97 (a)
(Bos Taurus)
Mammalia UBE2Z 33 34
  • 95.57 (n)
(Rattus norvegicus)
Mammalia Ube2z 33
  • 93.31 (n)
(Mus musculus)
Mammalia Ube2z 33 16 34
  • 93.22 (n)
(Monodelphis domestica)
Mammalia UBE2Z 34
  • 92 (a)
(Gallus gallus)
Aves UBE2Z 33 34
  • 82.28 (n)
(Anolis carolinensis)
Reptilia UBE2Z 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2z 33
  • 76.75 (n)
Str.10246 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69155 33
(Danio rerio)
Actinopterygii ube2z 33 34
  • 72.94 (n)
Dr.28857 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8725 33
Species where no ortholog for UBE2Z was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2Z Gene

Gene Tree for UBE2Z (if available)
Gene Tree for UBE2Z (if available)

Paralogs for UBE2Z Gene

Paralogs for UBE2Z Gene

genes like me logo Genes that share paralogs with UBE2Z: view

Variants for UBE2Z Gene

Sequence variations from dbSNP and Humsavar for UBE2Z Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000135803 -- 48,906,459(+) T/C upstream_transcript_variant
rs1000246447 -- 48,912,619(+) A/G intron_variant
rs1000331721 -- 48,924,231(+) C/G/T intron_variant
rs1000521090 -- 48,908,228(+) G/A upstream_transcript_variant
rs1000555858 -- 48,920,939(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2Z Gene

Variant ID Type Subtype PubMed ID
esv3640729 CNV loss 21293372
nsv1112711 CNV deletion 24896259
nsv2073 CNV insertion 18451855
nsv482969 CNV loss 15286789
nsv833472 CNV gain 17160897

Variation tolerance for UBE2Z Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2Z Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2Z Gene

Disorders for UBE2Z Gene

Additional Disease Information for UBE2Z

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UBE2Z Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2Z Gene

Publications for UBE2Z Gene

  1. Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. (PMID: 17597759) Jin J … Harper JW (Nature 2007) 2 3 4 58
  2. Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z). (PMID: 17160626) Gu X … Mao Y (Molecular biology reports 2007) 3 4 22 58
  3. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H … Samani NJ (Nature genetics 2011) 3 44 58
  4. Identification of novel regulators of apoptosis using a high-throughput cell-based screen. (PMID: 17464193) Park KM … Kim SJ (Molecules and cells 2007) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for UBE2Z Gene

Sources for UBE2Z Gene