Aliases for UBE2V2 Gene
External Ids for UBE2V2 Gene
Previous GeneCards Identifiers for UBE2V2 Gene
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]
GeneCards Summary for UBE2V2 Gene
UBE2V2 (Ubiquitin Conjugating Enzyme E2 V2) is a Protein Coding gene. Diseases associated with UBE2V2 include Plexopathy and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Shigellosis and DNA Double Strand Break Response. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and acid-amino acid ligase activity. An important paralog of this gene is PEDS1-UBE2V1.
UniProtKB/Swiss-Prot Summary for UBE2V2 Gene
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.