Aliases for UBE2V2 Gene
External Ids for UBE2V2 Gene
Previous GeneCards Identifiers for UBE2V2 Gene
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]
GeneCards Summary for UBE2V2 Gene
UBE2V2 (Ubiquitin Conjugating Enzyme E2 V2) is a Protein Coding gene. Diseases associated with UBE2V2 include Plexopathy and Xeroderma Pigmentosum, Variant Type. Among its related pathways are DNA Double-Strand Break Repair and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and acid-amino acid ligase activity. An important paralog of this gene is UBE2V1.
UniProtKB/Swiss-Prot Summary for UBE2V2 Gene
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.