The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015] See more...

Aliases for UBE2T Gene

Aliases for UBE2T Gene

  • Ubiquitin Conjugating Enzyme E2 T 2 3 5
  • Cell Proliferation-Inducing Gene 50 Protein 3 4
  • Ubiquitin-Conjugating Enzyme E2 T 3 4
  • E2 Ubiquitin-Conjugating Enzyme T 3 4
  • Ubiquitin Carrier Protein T 3 4
  • Ubiquitin-Protein Ligase T 3 4
  • HSPC150 Protein Similar To Ubiquitin-Conjugating Enzyme 3
  • Ubiquitin-Conjugating Enzyme E2T (Putative) 3
  • Ubiquitin Conjugating Enzyme E2T 3
  • Ubiquitin-Conjugating Enzyme E2T 2
  • EC 2.3.2.23 4
  • HSPC150 3
  • FANCT 3
  • PIG50 3

External Ids for UBE2T Gene

Previous GeneCards Identifiers for UBE2T Gene

  • GC01M199033
  • GC01M200567
  • GC01M173466

Summaries for UBE2T Gene

Entrez Gene Summary for UBE2T Gene

  • The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

GeneCards Summary for UBE2T Gene

UBE2T (Ubiquitin Conjugating Enzyme E2 T) is a Protein Coding gene. Diseases associated with UBE2T include Fanconi Anemia, Complementation Group T and Fanconi Anemia, Complementation Group A. Among its related pathways are Protein ubiquitination and Gastric Cancer Network 2. Gene Ontology (GO) annotations related to this gene include chromatin binding and ubiquitin-protein transferase activity. An important paralog of this gene is UBE2N.

UniProtKB/Swiss-Prot Summary for UBE2T Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386).

Additional gene information for UBE2T Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2T Gene

Genomics for UBE2T Gene

GeneHancer (GH) Regulatory Elements for UBE2T Gene

Promoters and enhancers for UBE2T Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J202340 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.4 397 2.8 E2F8 ZBTB40 SP1 SMARCE1 POLR2A ATF1 FOS CREB1 ZNF362 MYC UBE2T lnc-PPP1R12B-7 RNPEP ENSG00000236439 PPP1R12B LMOD1 HNRNPA1P59 ENSG00000224818 IPO9-AS1 ENSG00000235121
GH01J202343 Promoter/Enhancer 1.1 Ensembl ENCODE 750.6 -1.9 -1931 0.2 ZBTB40 CTCF SMARCE1 ZNF362 CC2D1A RAD21 ZC3H8 ZNF384 MLLT1 SMARCA4 UBE2T lnc-PPP1R12B-7 IPO9 IPO9-AS1 KDM5B PPP1R12B
GH01J202344 Promoter 0.5 Ensembl 750.6 -1.2 -1221 0.4 CTCF KDM5A UBE2T lnc-PPP1R12B-7 RNPEP KDM5B ENSG00000235449 ENSG00000236439 PPP1R12B
GH01J203169 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4.7 -832.3 -832322 9.6 CTCF MYC MAX RAD21 MNT SP7 SP5 FOSL2 IKZF1 GLIS2 MYBPH ADORA1 ENSG00000224671 ENSG00000229652 FMOD UBE2T CHI3L1 lnc-CHI3L1-1
GH01J202247 Enhancer 0.9 FANTOM5 Ensembl dbSUPER 1.9 +93.9 93914 1.3 CREB1 SCRT2 EGR1 IKZF1 RCOR1 LGR6 UBE2T NONHSAG003956.2 lnc-PTPN7-2 piR-61128
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2T on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBE2T gene promoter:
  • AP-4
  • Arnt
  • COMP1
  • FAC1
  • HFH-1
  • HNF-3beta
  • MEF-2A
  • MyoD
  • NF-kappaB1
  • Pax-6

Genomic Locations for UBE2T Gene

Genomic Locations for UBE2T Gene
chr1:202,331,657-202,341,980
(GRCh38/hg38)
Size:
10,324 bases
Orientation:
Minus strand
chr1:202,300,785-202,311,108
(GRCh37/hg19)
Size:
10,324 bases
Orientation:
Minus strand

Genomic View for UBE2T Gene

Genes around UBE2T on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2T Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2T Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2T Gene

Proteins for UBE2T Gene

  • Protein details for UBE2T Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPD8-UBE2T_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 T
    Protein Accession:
    Q9NPD8
    Secondary Accessions:
    • Q2TU36

    Protein attributes for UBE2T Gene

    Size:
    197 amino acids
    Molecular mass:
    22521 Da
    Quaternary structure:
    • Directly interacts with FANCL (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:21775430, PubMed:24389026). Interacts with BRCA1 (PubMed:19887602).

    Three dimensional structures from OCA and Proteopedia for UBE2T Gene

neXtProt entry for UBE2T Gene

Post-translational modifications for UBE2T Gene

  • Auto-ubiquitinated. Effects of auto-monoubiquitination at Lys-91 and Lys-182 are unclear: according to a report, monoubiquitination inactivates E2 enzyme activity (PubMed:16916645). In contrast, according to another report, autoubiquitination does not affect E2 enzyme activity (PubMed:19111657).
  • Ubiquitination at Lys48, Lys91, and Lys182
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2T Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBE2T Gene

Domains & Families for UBE2T Gene

Gene Families for UBE2T Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for UBE2T Gene

Suggested Antigen Peptide Sequences for UBE2T Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-protein ligase T (UBE2T_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPD8

UniProtKB/Swiss-Prot:

UBE2T_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2T: view

Function for UBE2T Gene

Molecular function for UBE2T Gene

UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255 PROSITE-ProRule:PRU00388, ECO:0000255 PROSITE-ProRule:PRU10133, ECO:0000269 PubMed:20061386};.
UniProtKB/Swiss-Prot Induction:
Down-regulated following hypoxia. Up-regulated in breast cancers.

Enzyme Numbers (IUBMB) for UBE2T Gene

Phenotypes From GWAS Catalog for UBE2T Gene

Gene Ontology (GO) - Molecular Function for UBE2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 17938197
GO:0004842 ubiquitin-protein transferase activity IDA 16916645
GO:0005515 protein binding IPI 24389026
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UBE2T: view
genes like me logo Genes that share phenotypes with UBE2T: view

Human Phenotype Ontology for UBE2T Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2T

CRISPR Products

Clone Products

  • Addgene plasmids for UBE2T

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBE2T Gene

Localization for UBE2T Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2T Gene

Nucleus. Note=Accumulates to chromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2T gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IBA 17938197
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with UBE2T: view

Pathways & Interactions for UBE2T Gene

genes like me logo Genes that share pathways with UBE2T: view

Pathways by source for UBE2T Gene

1 R&D Systems pathway for UBE2T Gene
2 Qiagen pathways for UBE2T Gene
  • Remodeling of Adherens Junctions
  • Ubiquitin-Proteasome Dependent Proteolysis
1 Cell Signaling Technology pathway for UBE2T Gene

UniProtKB/Swiss-Prot Q9NPD8-UBE2T_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for UBE2T Gene

Gene Ontology (GO) - Biological Process for UBE2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IMP 16916645
GO:0006513 protein monoubiquitination IDA 16916645
GO:0006974 cellular response to DNA damage stimulus IBA,IMP 16916645
GO:0016567 protein ubiquitination TAS --
GO:0035519 protein K29-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2T: view

No data available for SIGNOR curated interactions for UBE2T Gene

Drugs & Compounds for UBE2T Gene

(2) Drugs for UBE2T Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for UBE2T Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with UBE2T: view

Transcripts for UBE2T Gene

mRNA/cDNA for UBE2T Gene

CRISPR Products

Clone Products

  • Addgene plasmids for UBE2T

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2T Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for UBE2T Gene

GeneLoc Exon Structure for
UBE2T
ECgene alternative splicing isoforms for
UBE2T

Expression for UBE2T Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2T Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2T Gene

This gene is overexpressed in Liver, secretome (46.3) and Fetal ovary (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2T Gene



Protein tissue co-expression partners for UBE2T Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2T Gene:

UBE2T

SOURCE GeneReport for Unigene cluster for UBE2T Gene:

Hs.5199

Evidence on tissue expression from TISSUES for UBE2T Gene

  • Blood(4.3)
  • Lung(4.2)
  • Adrenal gland(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2T Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • neck
  • nose
  • outer ear
  • pituitary gland
  • skull
Thorax:
  • breast
  • esophagus
  • heart
  • lung
  • rib
  • rib cage
Abdomen:
  • intestine
  • kidney
  • large intestine
  • liver
  • stomach
Pelvis:
  • anus
  • ovary
  • pelvis
  • penis
  • prostate
  • rectum
  • testicle
  • ureter
  • uterus
  • vagina
  • vulva
Limb:
  • arm
  • digit
  • finger
  • forearm
  • hand
  • radius
  • upper limb
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with UBE2T: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2T Gene

Orthologs for UBE2T Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2T Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2T 33 32
  • 99.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2T 33 32
  • 90.52 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2t 17 33 32
  • 84.18 (n)
rat
(Rattus norvegicus)
Mammalia Ube2t 32
  • 83.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2T 33
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2T 33 32
  • 80.51 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2T 33
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2T 33 32
  • 68.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2T 33
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2t 32
  • 69.44 (n)
Str.3516 32
African clawed frog
(Xenopus laevis)
Amphibia hspc150-prov 32
zebrafish
(Danio rerio)
Actinopterygii ube2t 33 32
  • 71.76 (n)
OneToOne
wufj86h11 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10911 32
fruit fly
(Drosophila melanogaster)
Insecta ben 33
  • 48 (a)
OneToMany
CG3473 33
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC13 33
  • 44 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os01g0605300 32
  • 60.27 (n)
Os.23694 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3070 33
  • 49 (a)
OneToOne
Species where no ortholog for UBE2T was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2T Gene

ENSEMBL:
Gene Tree for UBE2T (if available)
TreeFam:
Gene Tree for UBE2T (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2T: view image

Paralogs for UBE2T Gene

(21) SIMAP similar genes for UBE2T Gene using alignment to 1 proteins:

  • UBE2T_HUMAN
genes like me logo Genes that share paralogs with UBE2T: view

Variants for UBE2T Gene

Sequence variations from dbSNP and Humsavar for UBE2T Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs774357609 pathogenic, Fanconi anemia, complementation group T, Fanconi anemia complementation group T (FANCT) [MIM:616435] 202,335,751(-) G/C 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs796052212 pathogenic, Fanconi anemia, complementation group T 202,334,984(-) C/T intron_variant
rs1000418710 -- 202,334,189(-) C/A intron_variant
rs1000474381 -- 202,334,489(-) T/G intron_variant
rs1000571613 -- 202,339,797(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2T Gene

Variant ID Type Subtype PubMed ID
esv2721572 CNV deletion 23290073
esv3578378 CNV loss 25503493
esv3588581 CNV loss 21293372

Variation tolerance for UBE2T Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2T Gene

Human Gene Mutation Database (HGMD)
UBE2T
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2T

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2T Gene

Disorders for UBE2T Gene

MalaCards: The human disease database

(8) MalaCards diseases for UBE2T Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

UniProtKB/Swiss-Prot

UBE2T_HUMAN
  • Fanconi anemia complementation group T (FANCT) [MIM:616435]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. {ECO:0000269 PubMed:26046368}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for UBE2T

genes like me logo Genes that share disorders with UBE2T: view

No data available for Genatlas for UBE2T Gene

Publications for UBE2T Gene

  1. Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia. (PMID: 26046368) Hira A … Yabe M (American journal of human genetics 2015) 2 3 4 56
  2. Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells. (PMID: 19887602) Ueki T … Katagiri T (Cancer research 2009) 3 4 23 56
  3. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. (PMID: 16916645) Machida YJ … Dutta A (Molecular cell 2006) 2 3 4 56
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 56
  5. Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening. (PMID: 28437106) Morreale FE … Ciulli A (Journal of medicinal chemistry 2017) 3 4 56

Products for UBE2T Gene

Sources for UBE2T Gene