This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008] See more...

Aliases for UBE2S Gene

Aliases for UBE2S Gene

  • Ubiquitin Conjugating Enzyme E2 S 2 3 5
  • Ubiquitin-Conjugating Enzyme E2-24 KDa 3 4
  • Ubiquitin-Conjugating Enzyme E2-24 KD 2 3
  • Ubiquitin-Conjugating Enzyme E2-EPF5 3 4
  • Ubiquitin-Conjugating Enzyme E2 S 3 4
  • E2 Ubiquitin-Conjugating Enzyme S 3 4
  • Ubiquitin Carrier Protein S 3 4
  • Ubiquitin-Protein Ligase S 3 4
  • E2-EPF 3 4
  • E2EPF 3 4
  • Ubiquitin Conjugating Enzyme E2S 3
  • Ubiquitin-Conjugating Enzyme E2S 2
  • Ubiquitin Carrier Protein 2
  • Ubiquitin-Protein Ligase 2
  • EC 6.3.2.19 52
  • EC 2.3.2.23 4
  • E2-EPF5 3
  • EPF5 3

External Ids for UBE2S Gene

Previous GeneCards Identifiers for UBE2S Gene

  • GC19M060604
  • GC19M055912
  • GC19M052233

Summaries for UBE2S Gene

Entrez Gene Summary for UBE2S Gene

  • This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2S Gene

UBE2S (Ubiquitin Conjugating Enzyme E2 S) is a Protein Coding gene. Diseases associated with UBE2S include Charcot-Marie-Tooth Disease, Axonal, Type 2P and Liddle Syndrome 1. Among its related pathways are Metabolism of proteins and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2N.

UniProtKB/Swiss-Prot Summary for UBE2S Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874).

Additional gene information for UBE2S Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2S Gene

Genomics for UBE2S Gene

GeneHancer (GH) Regulatory Elements for UBE2S Gene

Promoters and enhancers for UBE2S Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2S on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2S

Top Transcription factor binding sites by QIAGEN in the UBE2S gene promoter:
  • aMEF-2
  • Egr-3
  • Egr-4
  • MEF-2
  • MEF-2A
  • RREB-1
  • RSRFC4
  • SEF-1 (1)
  • SRF
  • SRF (504 AA)

Genomic Locations for UBE2S Gene

Genomic Locations for UBE2S Gene
chr19:55,399,745-55,408,146
(GRCh38/hg38)
Size:
8,402 bases
Orientation:
Minus strand
chr19:55,912,650-55,919,325
(GRCh37/hg19)
Size:
6,676 bases
Orientation:
Minus strand

Genomic View for UBE2S Gene

Genes around UBE2S on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2S Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2S Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2S Gene

Proteins for UBE2S Gene

  • Protein details for UBE2S Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16763-UBE2S_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 S
    Protein Accession:
    Q16763
    Secondary Accessions:
    • Q9BTC1

    Protein attributes for UBE2S Gene

    Size:
    222 amino acids
    Molecular mass:
    23845 Da
    Quaternary structure:
    • Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2 and ANAPC4 (PubMed:27259151). Interacts with CDC20, FZR1/CDH1 and VHL (PubMed:16819549, PubMed:19822757).

    Three dimensional structures from OCA and Proteopedia for UBE2S Gene

neXtProt entry for UBE2S Gene

Selected DME Specific Peptides for UBE2S Gene

Q16763:
  • LLTIKCLLI
  • PPDGIKV

Post-translational modifications for UBE2S Gene

  • Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.
  • Ubiquitination at Lys18, Lys68, Lys100, Lys117, and Lys197
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2S Gene

Domains & Families for UBE2S Gene

Gene Families for UBE2S Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for UBE2S Gene

Blocks:
  • Ubiquitin-conjugating enzymes
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UBE2S Gene

GenScript: Design optimal peptide antigens:
  • UBE2S protein (Q6NXQ4_HUMAN)
  • Ubiquitin-protein ligase S (UBE2S_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16763

UniProtKB/Swiss-Prot:

UBE2S_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2S: view

Function for UBE2S Gene

Molecular function for UBE2S Gene

UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255 PROSITE-ProRule:PRU00388, ECO:0000255 PROSITE-ProRule:PRU10133, ECO:0000269 PubMed:19820702, ECO:0000269 PubMed:19822757, ECO:0000269 PubMed:20061386};.

Enzyme Numbers (IUBMB) for UBE2S Gene

Phenotypes From GWAS Catalog for UBE2S Gene

Gene Ontology (GO) - Molecular Function for UBE2S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 19820702
GO:0005515 protein binding IPI 23708001
GO:0005524 ATP binding IEA --
GO:0010997 anaphase-promoting complex binding IPI 23708001
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UBE2S: view
genes like me logo Genes that share phenotypes with UBE2S: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for UBE2S

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2S Gene

Localization for UBE2S Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2S gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 19822757
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2S: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2S Gene

Pathways & Interactions for UBE2S Gene

genes like me logo Genes that share pathways with UBE2S: view

Pathways by source for UBE2S Gene

1 R&D Systems pathway for UBE2S Gene
2 Qiagen pathways for UBE2S Gene
  • Remodeling of Adherens Junctions
  • Ubiquitin-Proteasome Dependent Proteolysis
1 Cell Signaling Technology pathway for UBE2S Gene

UniProtKB/Swiss-Prot Q16763-UBE2S_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 1379239
GO:0006511 ubiquitin-dependent protein catabolic process IBA 21873635
GO:0007049 cell cycle IEA --
GO:0010458 exit from mitosis IMP 19822757
GO:0010994 free ubiquitin chain polymerization IDA 19822757
genes like me logo Genes that share ontologies with UBE2S: view

No data available for SIGNOR curated interactions for UBE2S Gene

Drugs & Compounds for UBE2S Gene

(3) Drugs for UBE2S Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for UBE2S Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with UBE2S: view

Transcripts for UBE2S Gene

mRNA/cDNA for UBE2S Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for UBE2S

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2S Gene

No ASD Table

Relevant External Links for UBE2S Gene

GeneLoc Exon Structure for
UBE2S

Expression for UBE2S Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2S Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2S Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for UBE2S Gene

This gene is overexpressed in Breast (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2S Gene



Protein tissue co-expression partners for UBE2S Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2S

SOURCE GeneReport for Unigene cluster for UBE2S Gene:

Hs.396393

Evidence on tissue expression from TISSUES for UBE2S Gene

  • Skin(4.5)
  • Intestine(4.3)
  • Nervous system(3.4)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with UBE2S: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2S Gene

Orthologs for UBE2S Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2S Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2S 31 30
  • 99.1 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2S 31 30
  • 88.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2S 31 30
  • 88.14 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2s 30
  • 87.24 (n)
mouse
(Mus musculus)
Mammalia Ube2s 17 31 30
  • 86.19 (n)
oppossum
(Monodelphis domestica)
Mammalia UBE2S 31
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2S 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2s 30
  • 67.93 (n)
Str.6451 30
African clawed frog
(Xenopus laevis)
Amphibia MGC52831 30
zebrafish
(Danio rerio)
Actinopterygii UBE2S 31
  • 69 (a)
OneToOne
zgc:114060 30
  • 66.99 (n)
Dr.17970 30
fruit fly
(Drosophila melanogaster)
Insecta CG8188 31 30
  • 65.5 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD6 31
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC22 30
  • 60 (n)
soybean
(Glycine max)
eudicotyledons Gma.5718 30
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.761 30
rice
(Oryza sativa)
Liliopsida Os06g0660700 30
  • 57.03 (n)
corn
(Zea mays)
Liliopsida Zm.6927 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.991 31
  • 60 (a)
OneToOne
Cin.648 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.648 30
Species where no ortholog for UBE2S was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2S Gene

ENSEMBL:
Gene Tree for UBE2S (if available)
TreeFam:
Gene Tree for UBE2S (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2S: view image

Paralogs for UBE2S Gene

(23) SIMAP similar genes for UBE2S Gene using alignment to 4 proteins:

  • UBE2S_HUMAN
  • K7EM75_HUMAN
  • K7EPJ1_HUMAN
  • Q6NXQ4_HUMAN

Pseudogenes.org Pseudogenes for UBE2S Gene

genes like me logo Genes that share paralogs with UBE2S: view

Variants for UBE2S Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2S Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
716611 Benign: not provided 55,401,610(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
734684 Benign: not provided 55,404,483(-) A/T INTRON_VARIANT
759928 Likely Benign: not provided 55,406,971(-) G/A INTRON_VARIANT
770812 Benign: not provided 55,401,578(-) T/G MISSENSE_VARIANT,INTRON_VARIANT
781884 Likely Benign: not provided 55,401,601(-) A/C SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for UBE2S Gene

Structural Variations from Database of Genomic Variants (DGV) for UBE2S Gene

Variant ID Type Subtype PubMed ID
nsv953624 CNV deletion 24416366

Variation tolerance for UBE2S Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2S Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2S

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2S Gene

Disorders for UBE2S Gene

MalaCards: The human disease database

(5) MalaCards diseases for UBE2S Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search UBE2S in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UBE2S

genes like me logo Genes that share disorders with UBE2S: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2S Gene

Publications for UBE2S Gene

  1. cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. (PMID: 1379239) Liu Z … Giudice GJ (The Journal of biological chemistry 1992) 2 3 4 54
  2. Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. (PMID: 27259151) Brown NG … Schulman BA (Cell 2016) 3 4 54
  3. Crystal Structure of a Ube2S-Ubiquitin Conjugate. (PMID: 26828794) Lorenz S … Kuriyan J (PloS one 2016) 3 4 54
  4. Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. (PMID: 20622874) Bremm A … Komander D (Nature structural & molecular biology 2010) 3 4 54
  5. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4 54

Products for UBE2S Gene

Sources for UBE2S Gene