The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme fa... See more...

Aliases for UBE2Q1 Gene

Aliases for UBE2Q1 Gene

  • Ubiquitin Conjugating Enzyme E2 Q1 2 3 5
  • Ubiquitin-Conjugating Enzyme E2 Q1 3 4
  • E2 Ubiquitin-Conjugating Enzyme Q1 3 4
  • Ubiquitin Carrier Protein Q1 3 4
  • Ubiquitin-Protein Ligase Q1 3 4
  • Protein NICE-5 3 4
  • UBE2Q 3 4
  • NICE5 3 4
  • Ubiquitin Conjugating Enzyme E2Q Family Member 1 3
  • Ubiquitin-Conjugating Enzyme E2Q Family Member 1 2
  • Ubiquitin-Conjugating Enzyme E2Q (Putative) 1 3
  • Ubiquitin-Conjugating Enzyme E2Q (Putative) 2
  • Galactosyl Transferase-Associated Protein 3
  • EC 6.3.2.19 52
  • EC 2.3.2.23 4
  • PRO3094 3
  • NICE-5 3
  • GTAP 3

External Ids for UBE2Q1 Gene

Previous HGNC Symbols for UBE2Q1 Gene

  • UBE2Q

Previous GeneCards Identifiers for UBE2Q1 Gene

  • GC01M151336
  • GC01M152787
  • GC01M125884

Summaries for UBE2Q1 Gene

Entrez Gene Summary for UBE2Q1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2Q1 Gene

UBE2Q1 (Ubiquitin Conjugating Enzyme E2 Q1) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2Q2.

UniProtKB/Swiss-Prot Summary for UBE2Q1 Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity).

Additional gene information for UBE2Q1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2Q1 Gene

Genomics for UBE2Q1 Gene

GeneHancer (GH) Regulatory Elements for UBE2Q1 Gene

Promoters and enhancers for UBE2Q1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2Q1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2Q1

Top Transcription factor binding sites by QIAGEN in the UBE2Q1 gene promoter:
  • AhR
  • AP-1
  • Arnt
  • CUTL1
  • Egr-3
  • GATA-2
  • HOXA3
  • NRSF form 1
  • NRSF form 2
  • ZID

Genomic Locations for UBE2Q1 Gene

Genomic Locations for UBE2Q1 Gene
chr1:154,548,575-154,559,028
(GRCh38/hg38)
Size:
10,454 bases
Orientation:
Minus strand
chr1:154,521,051-154,531,504
(GRCh37/hg19)
Size:
10,454 bases
Orientation:
Minus strand

Genomic View for UBE2Q1 Gene

Genes around UBE2Q1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2Q1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2Q1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2Q1 Gene

Proteins for UBE2Q1 Gene

  • Protein details for UBE2Q1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7E8-UB2Q1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Q1
    Protein Accession:
    Q7Z7E8
    Secondary Accessions:
    • B4DF92
    • Q29SN7
    • Q3B841
    • Q5I0X2
    • Q6IS04
    • Q6P7P2
    • Q96MV4
    • Q9BVX5
    • Q9UGL6

    Protein attributes for UBE2Q1 Gene

    Size:
    422 amino acids
    Molecular mass:
    46127 Da
    Quaternary structure:
    • Monomer and homodimer. Only the homodimer is linked to ubiquitin through thiolester activation. Interacts (via N-terminus) with B4GALT1 (via N-terminal cytoplasmic domain). The interaction is direct.
    SequenceCaution:
    • Sequence=AAF71141.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH61583.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH87836.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07058.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71173.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB65097.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2Q1 Gene

    Alternative splice isoforms for UBE2Q1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2Q1 Gene

Selected DME Specific Peptides for UBE2Q1 Gene

Q7Z7E8:
  • LNGAVSGSVQA
  • DLQILKEKEG
  • PVLSGGYVLGGGA
  • DRLMKELRDIYRSQS
  • HCNITESYP
  • ATLVKGKARVQFGANK
  • ILLNFSFKDNFPFDPPFVRVV
  • CMELLTKQGWSSAYSIESVIMQI
  • EDLDHYEMKEEEP

Post-translational modifications for UBE2Q1 Gene

  • Autoubiquitinated in vitro in the presence of NEDD4L.
  • Ubiquitination at Lys46
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2Q1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UBE2Q1 Gene

Gene Families for UBE2Q1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for UBE2Q1 Gene

Blocks:
  • Ubiquitin-conjugating enzymes
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UBE2Q1 Gene

GenScript: Design optimal peptide antigens:
  • UBE2Q1 protein (A7MAV4_HUMAN)
  • Galactosyl transferase-associated protein (Q29SN7_HUMAN)
  • Ubiquitin-protein ligase Q1 (UB2Q1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z7E8

UniProtKB/Swiss-Prot:

UB2Q1_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2Q1: view

Function for UBE2Q1 Gene

Molecular function for UBE2Q1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=. ;.

Enzyme Numbers (IUBMB) for UBE2Q1 Gene

Phenotypes From GWAS Catalog for UBE2Q1 Gene

Gene Ontology (GO) - Molecular Function for UBE2Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16275660
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0061631 ubiquitin conjugating enzyme activity IBA,IEA 21873635
genes like me logo Genes that share ontologies with UBE2Q1: view
genes like me logo Genes that share phenotypes with UBE2Q1: view

Animal Models for UBE2Q1 Gene

MGI Knock Outs for UBE2Q1:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2Q1

CRISPR Products

miRNA for UBE2Q1 Gene

miRTarBase miRNAs that target UBE2Q1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2Q1 Gene

Localization for UBE2Q1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2Q1 Gene

Nucleus. Cell projection, filopodium. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2Q1 gene
Compartment Confidence
nucleus 4
cytosol 4
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0030175 filopodium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with UBE2Q1: view

Pathways & Interactions for UBE2Q1 Gene

genes like me logo Genes that share pathways with UBE2Q1: view

Pathways by source for UBE2Q1 Gene

1 R&D Systems pathway for UBE2Q1 Gene
2 Qiagen pathways for UBE2Q1 Gene
  • Remodeling of Adherens Junctions
  • Ubiquitin-Proteasome Dependent Proteolysis

UniProtKB/Swiss-Prot Q7Z7E8-UB2Q1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001967 suckling behavior IEA --
GO:0007566 embryo implantation IEA --
GO:0007617 mating behavior IEA --
GO:0009566 fertilization IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with UBE2Q1: view

No data available for SIGNOR curated interactions for UBE2Q1 Gene

Drugs & Compounds for UBE2Q1 Gene

(3) Drugs for UBE2Q1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for UBE2Q1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with UBE2Q1: view

Transcripts for UBE2Q1 Gene

mRNA/cDNA for UBE2Q1 Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1:
SP2:
SP3: - -

Relevant External Links for UBE2Q1 Gene

GeneLoc Exon Structure for
UBE2Q1

Expression for UBE2Q1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2Q1 Gene

Protein differential expression in normal tissues from HIPED for UBE2Q1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.6) and Frontal cortex (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2Q1 Gene



Protein tissue co-expression partners for UBE2Q1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2Q1

SOURCE GeneReport for Unigene cluster for UBE2Q1 Gene:

Hs.607928

mRNA Expression by UniProt/SwissProt for UBE2Q1 Gene:

Q7Z7E8-UB2Q1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for UBE2Q1 Gene

  • Nervous system(4.6)
  • Skin(4.3)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with UBE2Q1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2Q1 Gene

Orthologs for UBE2Q1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBE2Q1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia UBE2Q1 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2Q1 31 30
  • 99.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2Q1 31 30
  • 97.55 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2q1 17 31 30
  • 94.94 (n)
rat
(Rattus norvegicus)
Mammalia Ube2q1 30
  • 94.55 (n)
dog
(Canis familiaris)
Mammalia UBE2Q1 31 30
  • 93.06 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 68 (a)
ManyToMany
chicken
(Gallus gallus)
Aves UBE2Q1 31
  • 95 (a)
OneToOne
LOC100858564 30
  • 82.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2924 31
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-25 31
  • 46 (a)
OneToMany
Species where no ortholog for UBE2Q1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBE2Q1 Gene

ENSEMBL:
Gene Tree for UBE2Q1 (if available)
TreeFam:
Gene Tree for UBE2Q1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2Q1: view image

Paralogs for UBE2Q1 Gene

(3) SIMAP similar genes for UBE2Q1 Gene using alignment to 2 proteins:

  • UB2Q1_HUMAN
  • A7MAV4_HUMAN
genes like me logo Genes that share paralogs with UBE2Q1: view

Variants for UBE2Q1 Gene

Additional dbSNP identifiers (rs#s) for UBE2Q1 Gene

Structural Variations from Database of Genomic Variants (DGV) for UBE2Q1 Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV gain 19592680

Variation tolerance for UBE2Q1 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2Q1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2Q1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2Q1 Gene

Disorders for UBE2Q1 Gene

Additional Disease Information for UBE2Q1

No disorders were found for UBE2Q1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2Q1 Gene

Publications for UBE2Q1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PMID: 11230159) Marenholz I … Mischke D (Genome research 2001) 3 4 54
  5. Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through β-catenin-EGFR-PI3K-Akt-mTOR signaling pathway. (PMID: 29027712) Zhang B … Zou X (Molecular carcinogenesis 2018) 3 54

Products for UBE2Q1 Gene