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Aliases for UBE2O Gene
Aliases for UBE2O Gene
External Ids for UBE2O Gene
- HGNC: 29554
- Entrez Gene: 63893
- Ensembl: ENSG00000175931
- OMIM: 617649
- UniProtKB: Q9C0C9
Previous GeneCards Identifiers for UBE2O Gene
- GC17M071898
- GC17M074385
- GC17M069814
Summaries for UBE2O Gene
GeneCards Summary for UBE2O Gene
UBE2O (Ubiquitin Conjugating Enzyme E2 O) is a Protein Coding gene. Diseases associated with UBE2O include Pontocerebellar Hypoplasia, Type 2A. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2Z.
UniProtKB/Swiss-Prot Summary for UBE2O Gene
-
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).
Additional gene information for UBE2O Gene
- HGNC(29554)
- Entrez Gene(63893)
- Ensembl(ENSG00000175931)
- OMIM(617649)
- UniProtKB(Q9C0C9)
- Open Targets Platform(ENSG00000175931)
- Search for UBE2O at DataMed
- Search for UBE2O at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2O Gene
Genomics for UBE2O Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UBE2O Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UBE2O on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2O
- Top Transcription factor binding sites by QIAGEN in the UBE2O gene promoter:
-
- AREB6
- CREB
- deltaCREB
- MIF-1
- MZF-1
- Nkx6-1
- Pax-4a
- Pax-5
- TBP
Genomic Locations for UBE2O Gene
Genomic Locations for UBE2O Gene
- chr17:76,389,456-76,453,234
- (GRCh38/hg38)
- Size:
- 63,779 bases
- Orientation:
- Minus strand
- chr17:74,385,532-74,449,288
- (GRCh37/hg19)
- Size:
- 63,757 bases
- Orientation:
- Minus strand
Genomic View for UBE2O Gene
Genes around UBE2O on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
UBE2O Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UBE2O Gene
Proteins for UBE2O Gene
-
Protein details for UBE2O Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9C0C9-UBE2O_HUMAN
- Recommended name:
- (E3-independent) E2 ubiquitin-conjugating enzyme
- Protein Accession:
- Q9C0C9
- A6NDU5
- Q69YP4
- Q6PIZ2
- Q86UA4
- Q8N425
- Q8TBN1
- Q9BSW1
- Q9H6E6
- Q9H7E4
- Q9H9B2
Protein attributes for UBE2O Gene
- Size:
- 1292 amino acids
- Molecular mass:
- 141293 Da
- Quaternary structure:
-
- Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain).
- SequenceCaution:
-
- Sequence=AAH22237.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH25977.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH36820.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH51868.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14320.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14948.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15313.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB21825.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for UBE2O Gene
Post-translational modifications for UBE2O Gene
- Phosphorylated. Phosphorylation affects subcellular location.
- Ubiquitinated: autoubiquitinates, possibly affecting its subcellular location.
-
Ubiquitination at Lys132, Lys212, Lys283, Lys373, Lys521, Lys620, Lys815, Lys819, Lys825, Lys866, and Lys990
- NX_Q9C0C9 (NX_Q9C0C9-1)
- Modification sites at PhosphoSitePlus
Other Protein References for UBE2O Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences UBE2O Antibody
-
Custom Antibody ServicesOriGene Antibodies for UBE2O
- Novus Biologicals Antibodies for UBE2O
- Invitrogen Antibodies for UBE2O (AFLGC-UBE2O)
-
Biorbyt antibodies for UBE2O
-
Boster Bio Antibodies for UBE2O
-
Santa Cruz Biotechnology (SCBT) Antibodies for UBE2O
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for UBE2O
- Origene Custom Protein Services for UBE2O
- antibodies-online: Show 7 available UBE2O Proteins ranked by validation data
- Compare Top UBE2O Proteins
-
Quality Products:
-
Abcam proteins for UBE2O
No data available for DME Specific Peptides for UBE2O Gene
Domains & Families for UBE2O Gene
Gene Families for UBE2O Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for UBE2O Gene
- InterPro:
- Blocks:
-
- Ubiquitin-conjugating enzymes
- ProtoNet:
Suggested Antigen Peptide Sequences for UBE2O Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquitin-protein ligase O (UBE2O_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9C0C9- Family:
-
- Belongs to the ubiquitin-conjugating enzyme family.
Function for UBE2O Gene
Molecular function for UBE2O Gene
- UniProtKB/Swiss-Prot Function:
- E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.24; Evidence={ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- inhibited by phenylarsine oxide (PAO).
Enzyme Numbers (IUBMB) for UBE2O Gene
Phenotypes From GWAS Catalog for UBE2O Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22681889 |
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 23455153 |
| GO:0004869 | cysteine-type endopeptidase inhibitor activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 23455153 |
Phenotypes for UBE2O Gene
- MGI mutant phenotypes for UBE2O:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for UBE2O:
Animal Models for UBE2O Gene
- MGI Knock Outs for UBE2O:
-
- Ube2o Ube2o<tm1.1(KOMP)Mbp>
Animal Model Products
-
Taconic Biosciences Mouse Models for UBE2O
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UBE2O - Select products 50% OFF >
- * UBE2O CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UBE2O
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2O
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2O
miRNA for UBE2O Gene
- miRTarBase miRNAs that target UBE2O
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBE2O
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Clone Products
- Applied Biological Materials (abm): Clones for UBE2O - Select products 50% OFF >
- * UBE2O as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UBE2O
- Addgene plasmids for UBE2O
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2O
Cell Line Products
-
Horizon Cell Lines for UBE2O
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2O Gene
Localization for UBE2O Gene
Subcellular locations from UniProtKB/Swiss-Prot for UBE2O Gene
- Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | 24703950 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA | 24703950 |
| GO:0005829 | cytosol | IEA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for UBE2O Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Ubiquitin mediated proteolysis | ||
| 3 | Innate Immune System |
.61
|
|
Pathways by source for UBE2O Gene
4 Reactome pathways for UBE2O Gene
1 KEGG pathway for UBE2O Gene
UniProtKB/Swiss-Prot Q9C0C9-UBE2O_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for UBE2O Gene
Selected Interacting proteins:
Q9C0C9-UBE2O_HUMAN
ENSP00000323687
for UBE2O Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for UBE2O
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process | IBA | -- |
| GO:0006513 | protein monoubiquitination | IDA | 23455153 |
| GO:0010951 | negative regulation of endopeptidase activity | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0030513 | positive regulation of BMP signaling pathway | IDA | 23455153 |
Drugs & Compounds for UBE2O Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Phosphoric acid | Approved | Pharma | 0 | |||
| Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for UBE2O Gene
mRNA/cDNA for UBE2O Gene
- 1 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000319380 5377 nts (view in UCSC)
- ENST00000586409 3579 nts (view in UCSC)
- ENST00000586505 522 nts (view in UCSC)
- ENST00000587127 3569 nts (view in UCSC)
- ENST00000587581 545 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UBE2O - Select products 50% OFF >
- * UBE2O CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UBE2O
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2O
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2O
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBE2O
- Browse OriGene Inhibitory RNA Products For UBE2O
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2O
Clone Products
- Applied Biological Materials (abm): Clones for UBE2O - Select products 50% OFF >
- * UBE2O as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UBE2O
- Addgene plasmids for UBE2O
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2O
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for UBE2O Gene
- GeneLoc Exon Structure for
- UBE2O
Expression for UBE2O Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Erythroblasts Hematopoietic Bone Marrow
- Eye (Sensory Organs)
This gene is overexpressed in Peripheral blood mononuclear cells (15.8) and Heart (12.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2O Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2O
SOURCE GeneReport for Unigene cluster for UBE2O Gene:
Hs.16130mRNA Expression by UniProt/SwissProt for UBE2O Gene:
Q9C0C9-UBE2O_HUMAN
Tissue specificity:
Predominantly expressed in skeletal muscle and heart.
Evidence on tissue expression from TISSUES for UBE2O Gene
- Nervous system(4.8)
- Skin(4.4)
- Liver(4.3)
- Blood(2.9)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for UBE2O
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2O Gene
Orthologs for UBE2O Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | UBE2O 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | UBE2O 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | UBE2O 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ube2o 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ube2o 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | UBE2O 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | UBE2O 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | UBE2O 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | UBE2O 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ube2o 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | UBE2O 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG10254 31 |
|
OneToOne | |
| Barley (Hordeum vulgare) |
Liliopsida | Hv.2300 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.2040 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for UBE2O was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for UBE2O Gene
- ENSEMBL:
- Gene Tree for UBE2O (if available)
- TreeFam:
- Gene Tree for UBE2O (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UBE2O: view image
Paralogs for UBE2O Gene
Paralogs for UBE2O Gene
(5) SIMAP similar genes for UBE2O Gene using alignment to 3 proteins:
- UBE2O_HUMAN
- K7EQ12_HUMAN
- K7ES11_HUMAN
Variants for UBE2O Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3397284 | CNV | duplication | 20981092 |
| esv3399280 | CNV | duplication | 20981092 |
| esv3582913 | CNV | loss | 25503493 |
| esv3641287 | CNV | loss | 21293372 |
| esv3641288 | CNV | loss | 21293372 |
| esv3641289 | CNV | insertion | 21293372 |
| nsv1143862 | CNV | deletion | 24896259 |
| nsv2145 | CNV | deletion | 18451855 |
| nsv833547 | CNV | loss | 17160897 |
| nsv833549 | CNV | gain | 17160897 |
| nsv978463 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
5.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.80;
93.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UBE2O Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UBE2O
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2O Gene
Disorders for UBE2O Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pontocerebellar hypoplasia, type 2a |
|
|
Search UBE2O in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UBE2O
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2O Gene
Publications for UBE2O Gene
- Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k. (PMID: 11311559) Yokota T … Emi M (Gene 2001) 2 3 4
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
- Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O. (PMID: 24703950) Mashtalir N … Affar el B (Molecular cell 2014) 3 4
- Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. (PMID: 23455153) Zhang X … Ten Dijke P (The EMBO journal 2013) 3 4
- Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. (PMID: 23452853) Hao YH … Potts PR (Cell 2013) 3 4
ExternalLinks
Products for UBE2O Gene
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- Taconic Biosciences Mouse Models for UBE2O
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for UBE2O (AFLGC-UBE2O)
- VectorBuilder Custom and pre-made DNA vectors for UBE2O (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for UBE2O (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for UBE2O (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for UBE2O CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for UBE2O
- Addgene plasmids for UBE2O
- antibodies-online: Show 9 available UBE2O Antibodies ranked by validation data
- Compare Top UBE2O Antibodies
- antibodies-online: Search results for available UBE2O related products ranked by validation data
- antibodies-online: Show 7 available UBE2O Proteins ranked by validation data
- Compare Top UBE2O Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for UBE2O
- Search Santa Cruz Biotechnology (SCBT) for UBE2O siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for UBE2O
- Horizon Cell Lines for UBE2O
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2O
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2O
- Search GeneCopoeia for miRNA 3'UTR Target clone products for UBE2O
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2O
- Boster Bio Antibodies for UBE2O
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for UBE2O
Sources for UBE2O Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB