The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enz... See more...

Aliases for UBE2N Gene

Aliases for UBE2N Gene

  • Ubiquitin Conjugating Enzyme E2 N 2 3 5
  • Ubiquitin-Conjugating Enzyme E2N (Homologous To Yeast UBC13) 2 3
  • Ubiquitin-Conjugating Enzyme E2N (UBC13 Homolog, Yeast) 2 3
  • Ubiquitin-Conjugating Enzyme E2 N 3 4
  • E2 Ubiquitin-Conjugating Enzyme N 3 4
  • Ubiquitin Carrier Protein N 3 4
  • Ubiquitin-Protein Ligase N 3 4
  • UbcH-Ben 2 3
  • UbcH13 3 4
  • UBC13 2 3
  • Bendless-Like Ubiquitin Conjugating Enzyme 3
  • Bendless-Like Ubiquitin-Conjugating Enzyme 4
  • Epididymis Secretory Protein Li 71 3
  • Ubiquitin-Conjugating Enzyme E2N 2
  • Ubiquitin Conjugating Enzyme E2N 3
  • Yeast UBC13 Homolog 3
  • UBCHBEN; UBC13 3
  • EC 6.3.2.19 51
  • EC 2.3.2.23 4
  • HEL-S-71 3
  • MGC8489 2
  • UBE2N 5
  • Ubc13 4
  • BLU 4

External Ids for UBE2N Gene

Previous GeneCards Identifiers for UBE2N Gene

  • GC12M093423
  • GC12M094324
  • GC12M093735
  • GC12M092305
  • GC12M092304
  • GC12M090868

Summaries for UBE2N Gene

Entrez Gene Summary for UBE2N Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2N Gene

UBE2N (Ubiquitin Conjugating Enzyme E2 N) is a Protein Coding gene. Diseases associated with UBE2N include Riddle Syndrome and Machado-Joseph Disease. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2NL.

UniProtKB/Swiss-Prot Summary for UBE2N Gene

  • The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175, PubMed:31006531).

Tocris Summary for UBE2N Gene

  • The ubiquitin (Ub)/Ub-like (Ubl) conjugating enzymes are a conserved family of ligases which mediate the conjugation of Ub and Ubl proteins to target substrates. There have been 35 E2 enzymes identified in the human genome to date.

Gene Wiki entry for UBE2N Gene

Additional gene information for UBE2N Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2N Gene

Genomics for UBE2N Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UBE2N Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J093440 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.7 735 4 CREB1 GATAD2A PRDM10 ZNF629 TFE3 SIX5 SOX13 ZNF692 POLR2A BACH1 LOC112267866 UBE2N lnc-MRPL42-2 MRPL42 ENSG00000257252 piR-30791-024 NUDT4
GH12J093466 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.3 -25.9 -25917 2.7 GATAD2A CTCF PRDM10 ZNF629 TFE3 RFX1 SIX5 LEF1 IKZF1 POLR2A MRPL42 UBE2N lnc-SOCS2-4 SOCS2
GH12J093375 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.9 +62.8 62835 8.2 CTCF TEAD4 PRDM10 ZNF629 ZNF512 IKZF1 ZNF692 POLR2A ZNF174 BACH1 ENSG00000257252 NUDT4 LOC643339 ENSG00000257512 UBE2N LINC02412 MRPL42 MN309585-003
GH12J092987 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.2 +453.5 453484 3.5 SP1 CREB1 GATAD2A CTCF ATF7 RCOR2 POLR2A FOXA1 JUND ZNF143 LINC02413 UBE2N lnc-EEA1-3 EEA1 NUDT4
GH12J093415 Enhancer 0.8 ENCODE dbSUPER 12.4 +26.2 26193 1.5 IKZF2 ARID3A ELK1 RELB RUNX3 CBFB IKZF1 JUNB TOE1 TBX21 UBE2N piR-30791-024 LOC112267866 NUDT4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2N on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2N

Top Transcription factor binding sites by QIAGEN in the UBE2N gene promoter:
  • ATF
  • Egr-1
  • Evi-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Sp1
  • XBP-1

Genomic Locations for UBE2N Gene

Genomic Locations for UBE2N Gene
chr12:93,405,673-93,442,336
(GRCh38/hg38)
Size:
36,664 bases
Orientation:
Minus strand
chr12:93,799,449-93,836,038
(GRCh37/hg19)
Size:
36,590 bases
Orientation:
Minus strand

Genomic View for UBE2N Gene

Genes around UBE2N on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2N Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2N Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2N Gene

Proteins for UBE2N Gene

  • Protein details for UBE2N Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61088-UBE2N_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 N
    Protein Accession:
    P61088
    Secondary Accessions:
    • Q16781
    • Q53Y81

    Protein attributes for UBE2N Gene

    Size:
    152 amino acids
    Molecular mass:
    17138 Da
    Quaternary structure:
    • Heterodimer with UBE2V2 (PubMed:10089880, PubMed:11473255, PubMed:14562038, PubMed:16307917, PubMed:16307917). Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity (PubMed:16307917). Interacts with RNF8 and RNF168 (PubMed:16215985, PubMed:19203578). Interacts with RNF11 (PubMed:18615712). Interacts with the E3 ligases, HLTF and SHPRH; the interactions promote the 'Lys-63'-linked polyubiquitination of PCNA upon genotoxic stress and lead to DNA repair (PubMed:17108083, PubMed:17130289, PubMed:18316726, PubMed:18719106). Interacts with ARIH2 (via RING-type 2) (PubMed:19340006). Interacts with OTUB1; leading to inhibit E2-conjugating activity (PubMed:20725033, PubMed:22325355, PubMed:22367539). Interacts with GPS2; leading to inhibit E2-conjugating activity (By similarity). Interacts with DDX58 and RNF135; involved in DDX58 ubiquitination and activation (PubMed:28469175).

    Three dimensional structures from OCA and Proteopedia for UBE2N Gene

neXtProt entry for UBE2N Gene

Selected DME Specific Peptides for UBE2N Gene

P61088:
  • FKLELFLPE
  • LPRRIIKETQRL
  • DPLANDVAE
  • ICLDILK
  • SIQALLSAP
  • TKIYHPN

Post-translational modifications for UBE2N Gene

  • Conjugation to ISG15 impairs formation of the thioester bond with ubiquitin but not interaction with UBE2V2.
  • Ubiquitination at Lys68, Lys82, and Lys92
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2N Gene

Domains & Families for UBE2N Gene

Gene Families for UBE2N Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for UBE2N Gene

InterPro:
Blocks:
  • Ubiquitin-conjugating enzymes
ProtoNet:

Suggested Antigen Peptide Sequences for UBE2N Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-protein ligase N (UBE2N_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61088

UniProtKB/Swiss-Prot:

UBE2N_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2N: view

Function for UBE2N Gene

Molecular function for UBE2N Gene

UniProtKB/Swiss-Prot Function:
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175, PubMed:31006531).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133, ECO:0000269|PubMed:20061386};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is inhibited by binding to OTUB1, which prevents 'Lys-63'-linked polyubiquitination (PubMed:20725033, PubMed:22325355, PubMed:22367539). Activity is inhibited by GPS2, leading to prevent 'Lys-63'-linked polyubiquitination (By similarity).

Enzyme Numbers (IUBMB) for UBE2N Gene

Phenotypes From GWAS Catalog for UBE2N Gene

Gene Ontology (GO) - Molecular Function for UBE2N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22681889
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 11473255
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with UBE2N: view
genes like me logo Genes that share phenotypes with UBE2N: view

Animal Models for UBE2N Gene

MGI Knock Outs for UBE2N:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2N

CRISPR Products

miRNA for UBE2N Gene

miRTarBase miRNAs that target UBE2N

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2N

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2N Gene

Localization for UBE2N Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2N Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2N gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
mitochondrion 3
plasma membrane 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 16307917
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IBA,IDA 16129784
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm TAS 16129784
genes like me logo Genes that share ontologies with UBE2N: view

Pathways & Interactions for UBE2N Gene

PathCards logo

SuperPathways for UBE2N Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 DNA Double-Strand Break Repair
3 Diseases associated with the TLR signaling cascade
4 Protein ubiquitination
5 Class I MHC mediated antigen processing and presentation
genes like me logo Genes that share pathways with UBE2N: view

Pathways by source for UBE2N Gene

2 KEGG pathways for UBE2N Gene
3 GeneGo (Thomson Reuters) pathways for UBE2N Gene
  • Immune response IL-1 signaling pathway
  • Immune response T cell receptor signaling pathway
  • Proteolysis_Putative ubiquitin pathway
1 R&D Systems pathway for UBE2N Gene
3 Qiagen pathways for UBE2N Gene
  • Remodeling of Adherens Junctions
  • Toll-Like Receptors Pathway
  • Ubiquitin-Proteasome Dependent Proteolysis
2 Cell Signaling Technology pathways for UBE2N Gene

UniProtKB/Swiss-Prot P61088-UBE2N_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for UBE2N Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for UBE2N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0000209 protein polyubiquitination IBA 21873635
GO:0000724 double-strand break repair via homologous recombination IMP 17349954
GO:0000729 DNA double-strand break processing IMP 17349954
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with UBE2N: view

Drugs & Compounds for UBE2N Gene

(4) Drugs for UBE2N Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
NSC697923 Pharma Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective, Selective UBE2N inhibitor 0

(3) Additional Compounds for UBE2N Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
Bay 11-7821
19542-67-7
CC 0651
1319207-44-7

(3) Tocris Compounds for UBE2N Gene

Compound Action Cas Number
Bay 11-7821 E2 ubiquitin (Ub) conjugating enzymes inhibitor 19542-67-7
CC 0651 Allosteric inhibitor of hCdc34 1319207-44-7
NSC 697923 Selective UBE2N inhibitor 343351-67-7

(1) ApexBio Compounds for UBE2N Gene

Compound Action Cas Number
NSC697923 Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective 343351-67-7
genes like me logo Genes that share compounds with UBE2N: view

Drug Products

Transcripts for UBE2N Gene

mRNA/cDNA for UBE2N Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2N

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2N Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -

Relevant External Links for UBE2N Gene

GeneLoc Exon Structure for
UBE2N

Expression for UBE2N Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2N Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2N Gene



Protein tissue co-expression partners for UBE2N Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2N

SOURCE GeneReport for Unigene cluster for UBE2N Gene:

Hs.524630

Evidence on tissue expression from TISSUES for UBE2N Gene

  • Nervous system(5)
  • Lung(4.6)
  • Kidney(2.9)
  • Intestine(2.8)
  • Lymph node(2.8)
  • Skin(2.8)
  • Spleen(2.6)
  • Muscle(2.5)
  • Liver(2.5)
  • Heart(2.5)
  • Blood(2.5)
  • Bone marrow(2.5)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with UBE2N: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2N Gene

Orthologs for UBE2N Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2N Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UBE2N 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia UBE2N 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia UBE2N 30 31
  • 98.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia UBE2N 30 31
  • 98.25 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ube2n 30 17 31
  • 97.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ube2n 30
  • 97.15 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia UBE2N 31
  • 95 (a)
OneToOne
Chicken
(Gallus gallus)
Aves UBE2N 30 31
  • 92.54 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia UBE2N 31
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ube2n 30
  • 89.04 (n)
MGC75672 30
African clawed frog
(Xenopus laevis)
Amphibia ube2n-prov 30
Zebrafish
(Danio rerio)
Actinopterygii ube2nb 31
  • 94 (a)
ManyToMany
ube2na 30 31
  • 85.53 (n)
ManyToMany
Dr.5512 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8375 30
Fruit Fly
(Drosophila melanogaster)
Insecta BG:DS01486.1 32
  • 83 (a)
ben 32
  • 80 (a)
CG3473 30
  • 70.64 (n)
Worm
(Caenorhabditis elegans)
Secernentea ubc-13 30 31
  • 70.95 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC13 31 33
  • 66 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons UBC36 30
  • 66.44 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.508 30
Rice
(Oryza sativa)
Liliopsida Os.14354 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 71 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3622 30
Species where no ortholog for UBE2N was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UBE2N Gene

ENSEMBL:
Gene Tree for UBE2N (if available)
TreeFam:
Gene Tree for UBE2N (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2N: view image

Paralogs for UBE2N Gene

(32) SIMAP similar genes for UBE2N Gene using alignment to 5 proteins:

  • UBE2N_HUMAN
  • F8VQQ8_HUMAN
  • F8VSD4_HUMAN
  • F8VV71_HUMAN
  • F8VZ29_HUMAN
genes like me logo Genes that share paralogs with UBE2N: view

Variants for UBE2N Gene

Additional dbSNP identifiers (rs#s) for UBE2N Gene

Structural Variations from Database of Genomic Variants (DGV) for UBE2N Gene

Variant ID Type Subtype PubMed ID
esv3414128 CNV insertion 20981092
nsv1044304 CNV gain 25217958
nsv528151 CNV loss 19592680
nsv7234 OTHER inversion 18451855
nsv823 CNV deletion 18451855
nsv983353 CNV duplication 23825009

Variation tolerance for UBE2N Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2N Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2N

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2N Gene

Disorders for UBE2N Gene

MalaCards: The human disease database

(6) MalaCards diseases for UBE2N Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search UBE2N in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UBE2N

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with UBE2N: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2N Gene

Publications for UBE2N Gene

  1. Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes. (PMID: 18615712) Scheper J … Thomson TM (Proteins 2009) 3 4 23
  2. The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains. (PMID: 19340006) Marteijn JA … van der Reijden BA (Leukemia 2009) 3 4 23
  3. The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation. (PMID: 16215985) Plans V … Thomson TM (Journal of cellular biochemistry 2006) 3 4 23
  4. ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity. (PMID: 16112642) Takeuchi T … Yokosawa H (Biochemical and biophysical research communications 2005) 3 4 23
  5. Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. (PMID: 8902611) Yamaguchi T … Kato S (Journal of biochemistry 1996) 2 3 4

Products for UBE2N Gene

Sources for UBE2N Gene