Aliases for UBE2N Gene
- Ubiquitin Conjugating Enzyme E2 N 2 3 5
- Ubiquitin-Conjugating Enzyme E2N (Homologous To Yeast UBC13) 2 3
- Ubiquitin-Conjugating Enzyme E2N (UBC13 Homolog, Yeast) 2 3
- Ubiquitin-Conjugating Enzyme E2 N 3 4
- E2 Ubiquitin-Conjugating Enzyme N 3 4
- Ubiquitin Carrier Protein N 3 4
- Ubiquitin-Protein Ligase N 3 4
- UbcH-Ben 2 3
- UbcH13 3 4
- UBC13 2 3
- Bendless-Like Ubiquitin Conjugating Enzyme 3
- Bendless-Like Ubiquitin-Conjugating Enzyme 4
External Ids for UBE2N Gene
Previous GeneCards Identifiers for UBE2N Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]
GeneCards Summary for UBE2N Gene
UBE2N (Ubiquitin Conjugating Enzyme E2 N) is a Protein Coding gene. Diseases associated with UBE2N include Riddle Syndrome and Machado-Joseph Disease. Among its related pathways are DNA Double-Strand Break Repair and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2NL.
UniProtKB/Swiss-Prot Summary for UBE2N Gene
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175, PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.
The ubiquitin (Ub)/Ub-like (Ubl) conjugating enzymes are a conserved family of ligases which mediate the conjugation of Ub and Ubl proteins to target substrates. There have been 35 E2 enzymes identified in the human genome to date.