The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enz... See more...

Aliases for UBE2J2 Gene

Aliases for UBE2J2 Gene

  • Ubiquitin Conjugating Enzyme E2 J2 2 3 5
  • NCUBE2 2 3 4
  • Ubiquitin-Conjugating Enzyme E2, J2 (UBC6 Homolog, Yeast) 2 3
  • Non-Canonical Ubiquitin-Conjugating Enzyme 2 3 4
  • Ubiquitin-Conjugating Enzyme E2 J2 3 4
  • E2 Ubiquitin-Conjugating Enzyme J2 3 4
  • NCUBE-2 3 4
  • Ubiquitin-Conjugating Enzyme E2, J2 2
  • Ubiquitin Conjugating Enzyme 6 3
  • Yeast UBC6 Homolog 3
  • EC 6.3.2.19 51
  • EC 2.3.2.23 4
  • PRO2121 3
  • UBE2J2 5
  • Ubc6p 2

External Ids for UBE2J2 Gene

Previous GeneCards Identifiers for UBE2J2 Gene

  • GC01M000941
  • GC01M001066
  • GC01M001095
  • GC01M001229
  • GC01M001182
  • GC01M000461
  • GC01M001189
  • GC01M001254

Summaries for UBE2J2 Gene

Entrez Gene Summary for UBE2J2 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2J2 Gene

UBE2J2 (Ubiquitin Conjugating Enzyme E2 J2) is a Protein Coding gene. Among its related pathways are Parkinsons Disease Pathway and Remodeling of Adherens Junctions. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2J1.

UniProtKB/Swiss-Prot Summary for UBE2J2 Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Additional gene information for UBE2J2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2J2 Gene

Genomics for UBE2J2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UBE2J2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001269 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 618 +1.2 1187 5.8 SP1 CREB1 HNRNPL SIX5 NFKBIZ KDM1A ZNF692 POLR2A BACH1 LARP7 UBE2J2 LINC01786 lnc-C1QTNF12-1 ENSG00000230092 CDK11A ENSG00000269737 ATAD3B ENSG00000237094 CCNL2 INTS11
GH01J001373 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 24.6 -101.3 -101259 3.9 ZNF221 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A PRDM10 REST ZNF629 AURKAIP1 MN308670 lnc-CCNL2-4 lnc-TAS1R3-3 CDK11A ENSG00000230092 ENSG00000269737 ATAD3B ENSG00000237094 LINC01786
GH01J001913 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 19.3 -643.7 -643710 7.7 SP1 HNRNPL GATAD2A PRDM10 TFE3 FOXA1 LARP7 ZNF143 ZIC2 RBFOX2 TMEM52 lnc-CFAP74-4 ENSG00000231050 UBE2J2 CALML6 CFAP74 ENSG00000233542 GABRD
GH01J000997 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 17.4 +273.9 273923 5.3 ZNF221 RNF2 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 ENSG00000272512 ISG15 HES4 INTS11 ATAD3B ENSG00000240731 WASH7P CCNL2 ENSG00000230092 CDK11A
GH01J000826 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 17.3 +446.5 446463 3.6 SP1 CREB1 PRDM10 ZNF629 LEF1 IKZF1 ZNF692 LARP7 DDX20 PRDM1 LINC00115 ENSG00000230021 LINC01409 ENSG00000237094 ENSG00000230092 CDK11A UBE2J2 ATAD3B LINC01128 WASH7P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2J2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2J2

Top Transcription factor binding sites by QIAGEN in the UBE2J2 gene promoter:
  • AhR
  • ATF6
  • CP2
  • ITF-2
  • LCR-F1
  • N-Myc
  • NF-1
  • Roaz
  • Tal-1beta

Genomic Locations for UBE2J2 Gene

Genomic Locations for UBE2J2 Gene
chr1:1,253,909-1,273,864
(GRCh38/hg38)
Size:
19,956 bases
Orientation:
Minus strand
chr1:1,189,289-1,209,265
(GRCh37/hg19)
Size:
19,977 bases
Orientation:
Minus strand

Genomic View for UBE2J2 Gene

Genes around UBE2J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2J2 Gene

Proteins for UBE2J2 Gene

  • Protein details for UBE2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2K1-UB2J2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 J2
    Protein Accession:
    Q8N2K1
    Secondary Accessions:
    • A8MYC7
    • Q504T9
    • Q96N26
    • Q96T84

    Protein attributes for UBE2J2 Gene

    Size:
    259 amino acids
    Molecular mass:
    28898 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BM544827; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BM544827; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2J2 Gene

    Alternative splice isoforms for UBE2J2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2J2 Gene

Selected DME Specific Peptides for UBE2J2 Gene

Q8N2K1:
  • WNPAWSV
  • NTRLCLS
  • NILEWHYV
  • HPDTWNP

Post-translational modifications for UBE2J2 Gene

Domains & Families for UBE2J2 Gene

Gene Families for UBE2J2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for UBE2J2 Gene

InterPro:
Blocks:
  • Ubiquitin-conjugating enzymes
ProtoNet:

Suggested Antigen Peptide Sequences for UBE2J2 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) (B1AME9_HUMAN)
  • Non-canonical ubiquitin-conjugating enzyme 2 (UB2J2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N2K1

UniProtKB/Swiss-Prot:

UB2J2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2J2: view

Function for UBE2J2 Gene

Molecular function for UBE2J2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255|PROSITE-ProRule:PRU00388};.

Enzyme Numbers (IUBMB) for UBE2J2 Gene

Phenotypes From GWAS Catalog for UBE2J2 Gene

Gene Ontology (GO) - Molecular Function for UBE2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 24019521
GO:0061631 ubiquitin conjugating enzyme activity IDA 20061386
genes like me logo Genes that share ontologies with UBE2J2: view
genes like me logo Genes that share phenotypes with UBE2J2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2J2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2J2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2J2 Gene

Localization for UBE2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2J2 Gene

Endoplasmic reticulum membrane. Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2J2 gene
Compartment Confidence
endoplasmic reticulum 4
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for UBE2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IPI 24807418
GO:0005634 nucleus IBA 21873635
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with UBE2J2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UBE2J2 Gene

Pathways & Interactions for UBE2J2 Gene

genes like me logo Genes that share pathways with UBE2J2: view

Pathways by source for UBE2J2 Gene

1 GeneGo (Thomson Reuters) pathway for UBE2J2 Gene
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
1 R&D Systems pathway for UBE2J2 Gene
2 Qiagen pathways for UBE2J2 Gene
  • Remodeling of Adherens Junctions
  • Ubiquitin-Proteasome Dependent Proteolysis

UniProtKB/Swiss-Prot Q8N2K1-UB2J2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA 21873635
GO:0006986 response to unfolded protein IEA --
GO:0016567 protein ubiquitination TAS --
GO:0030433 ubiquitin-dependent ERAD pathway IBA,IMP 24807418
GO:1903955 positive regulation of protein targeting to mitochondrion HMP 24270810
genes like me logo Genes that share ontologies with UBE2J2: view

No data available for SIGNOR curated interactions for UBE2J2 Gene

Drugs & Compounds for UBE2J2 Gene

(3) Drugs for UBE2J2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for UBE2J2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with UBE2J2: view

Transcripts for UBE2J2 Gene

mRNA/cDNA for UBE2J2 Gene

5 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2J2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - - - - - - - -
SP18: - - - - - -
SP19: - - - - - - - - -
SP20: - -
SP21: - - - - - - - - - -
SP22: - - - - - - - - - - - - - - - - -
SP23: - -
SP24: - - - - - - - - -
SP25:
SP26: -
SP27:

ExUns: 12c · 12d · 12e · 12f · 12g · 12h · 12i · 12j · 12k · 12l
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for UBE2J2 Gene

GeneLoc Exon Structure for
UBE2J2

Expression for UBE2J2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2J2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for UBE2J2 Gene

This gene is overexpressed in Testis (30.5), Retina (21.5), and Placenta (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2J2 Gene



Protein tissue co-expression partners for UBE2J2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2J2

SOURCE GeneReport for Unigene cluster for UBE2J2 Gene:

Hs.191987

Evidence on tissue expression from TISSUES for UBE2J2 Gene

  • Nervous system(4.8)
  • Lung(2.4)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with UBE2J2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2J2 Gene

Orthologs for UBE2J2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2J2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UBE2J2 30
  • 94.49 (n)
Oppossum
(Monodelphis domestica)
Mammalia UBE2J2 31
  • 92 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia UBE2J2 31
  • 91 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia UBE2J2 30 31
  • 89.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia UBE2J2 30 31
  • 89.58 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ube2j2 30 17 31
  • 86.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ube2j2 30
  • 86.49 (n)
Chicken
(Gallus gallus)
Aves UBE2J2 30 31
  • 79.92 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia UBE2J2 31
  • 90 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ube2j2 30
  • 76.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5968 30
Zebrafish
(Danio rerio)
Actinopterygii ube2j2 30 31
  • 74.77 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG5823 30 31
  • 55.94 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005954 30
  • 55.51 (n)
Worm
(Caenorhabditis elegans)
Secernentea ubc-26 30 31
  • 61.74 (n)
OneToMany
ubc-15 31
  • 41 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC6 30 31 33
  • 57.59 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20395g 30
  • 55.41 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR372W 30
  • 51.72 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons UBC34 30
  • 55.22 (n)
Rice
(Oryza sativa)
Liliopsida Os06g0193000 30
  • 52.75 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 63 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc6 30
  • 55.41 (n)
Species where no ortholog for UBE2J2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UBE2J2 Gene

ENSEMBL:
Gene Tree for UBE2J2 (if available)
TreeFam:
Gene Tree for UBE2J2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2J2: view image

Paralogs for UBE2J2 Gene

(9) SIMAP similar genes for UBE2J2 Gene using alignment to 10 proteins:

  • UB2J2_HUMAN
  • A6NGS0_HUMAN
  • B1AMF0_HUMAN
  • B1AMF1_HUMAN
  • D6R9H0_HUMAN
  • D6RA15_HUMAN
  • D6RB84_HUMAN
  • D6RC43_HUMAN
  • D6RD90_HUMAN
  • D6REN4_HUMAN
genes like me logo Genes that share paralogs with UBE2J2: view

Variants for UBE2J2 Gene

Additional dbSNP identifiers (rs#s) for UBE2J2 Gene

Structural Variations from Database of Genomic Variants (DGV) for UBE2J2 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
esv2758912 CNV loss 17122850
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1074020 CNV deletion 25765185
nsv1118089 CNV deletion 24896259
nsv1160772 CNV duplication 26073780
nsv455661 CNV loss 19166990
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544964 CNV loss 21841781
nsv544965 CNV loss 21841781
nsv817616 CNV loss 17921354
nsv950452 CNV deletion 24416366

Variation tolerance for UBE2J2 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2J2 Gene

Human Gene Mutation Database (HGMD)
UBE2J2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2J2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2J2 Gene

Disorders for UBE2J2 Gene

Additional Disease Information for UBE2J2

No disorders were found for UBE2J2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2J2 Gene

Publications for UBE2J2 Gene

  1. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). (PMID: 11278356) Tiwari S … Weissman AM (The Journal of biological chemistry 2001) 2 3 4
  2. A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. (PMID: 22496338) Sheng Y … Dhe-Paganon S (Molecular & cellular proteomics : MCP 2012) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis. (PMID: 30658189) Tan JME … Loregger A (Atherosclerosis 2019) 3

Products for UBE2J2 Gene

Sources for UBE2J2 Gene