The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enz... See more...

Aliases for UBE2J1 Gene

Aliases for UBE2J1 Gene

  • Ubiquitin Conjugating Enzyme E2 J1 2 3 5
  • NCUBE1 2 3 4
  • Ubiquitin-Conjugating Enzyme E2, J1 (UBC6 Homolog, Yeast) 2 3
  • Yeast Ubiquitin-Conjugating Enzyme UBC6 Homolog E 3 4
  • Non-Canonical Ubiquitin-Conjugating Enzyme 1 3 4
  • Ubiquitin-Conjugating Enzyme E2 J1 3 4
  • E2 Ubiquitin-Conjugating Enzyme J1 3 4
  • HSPC153 2 3
  • NCUBE-1 3 4
  • CGI-76 2 3
  • UBC6 2 3
  • Ubiquitin-Conjugating Enzyme E2, J1, U 3
  • Ubiquitin-Conjugating Enzyme E2, J1 2
  • EC 2.3.2.23 4
  • HSU93243 3
  • HSPC205 3
  • HSUBC6e 3
  • HsUBC6e 4
  • UBE2J1 5
  • UBC6E 3
  • Ubc6p 3

External Ids for UBE2J1 Gene

Previous GeneCards Identifiers for UBE2J1 Gene

  • GC06M090003
  • GC06M090032
  • GC06M090031
  • GC06M090093
  • GC06M087253
  • GC06M090037

Summaries for UBE2J1 Gene

Entrez Gene Summary for UBE2J1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2J1 Gene

UBE2J1 (Ubiquitin Conjugating Enzyme E2 J1) is a Protein Coding gene. Among its related pathways are Pathways of neurodegeneration - multiple diseases and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2J2.

UniProtKB/Swiss-Prot Summary for UBE2J1 Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Gene Wiki entry for UBE2J1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2J1 Gene

Genomics for UBE2J1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UBE2J1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2J1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2J1

Top Transcription factor binding sites by QIAGEN in the UBE2J1 gene promoter:
  • Elk-1
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-5
  • Pax-6
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for UBE2J1 Gene

Latest Assembly
chr6:89,326,625-89,353,155
(GRCh38/hg38)
Size:
26,531 bases
Orientation:
Minus strand

Previous Assembly
chr6:90,036,344-90,062,441
(GRCh37/hg19 by Entrez Gene)
Size:
26,098 bases
Orientation:
Minus strand

chr6:90,036,344-90,062,567
(GRCh37/hg19 by Ensembl)
Size:
26,224 bases
Orientation:
Minus strand

Genomic View for UBE2J1 Gene

Genes around UBE2J1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2J1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2J1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2J1 Gene

Proteins for UBE2J1 Gene

  • Protein details for UBE2J1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y385-UB2J1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 J1
    Protein Accession:
    Q9Y385
    Secondary Accessions:
    • A8K3F9
    • Q53F25
    • Q5W0N4
    • Q9BZ32
    • Q9NQL3
    • Q9NY66
    • Q9P011
    • Q9P0S0
    • Q9UF10

    Protein attributes for UBE2J1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35199 Da
    Quaternary structure:
    • Component of the HRD1 complex, which comprises at least SYNV1/HRD1, DERL1/2, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1.
    SequenceCaution:
    • Sequence=AAD34071.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF36125.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for UBE2J1 Gene

Post-translational modifications for UBE2J1 Gene

  • Ubiquitination at Lys186
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2J1 Gene

No data available for DME Specific Peptides for UBE2J1 Gene

Domains & Families for UBE2J1 Gene

Gene Families for UBE2J1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for UBE2J1 Gene

InterPro:
Blocks:
  • Ubiquitin-conjugating enzymes

Suggested Antigen Peptide Sequences for UBE2J1 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-conjugating enzyme E2, J1 variant (Q53F25_HUMAN)
  • Yeast ubiquitin-conjugating enzyme UBC6 homolog E (UB2J1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y385

UniProtKB/Swiss-Prot:

UB2J1_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2J1: view

Function for UBE2J1 Gene

Molecular function for UBE2J1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255|PROSITE-ProRule:PRU00388};.

Enzyme Numbers (IUBMB) for UBE2J1 Gene

Phenotypes From GWAS Catalog for UBE2J1 Gene

Gene Ontology (GO) - Molecular Function for UBE2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 19690564
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 11439185
genes like me logo Genes that share ontologies with UBE2J1: view
genes like me logo Genes that share phenotypes with UBE2J1: view

Animal Models for UBE2J1 Gene

MGI Knock Outs for UBE2J1:

Animal Models for research

  • Taconic Biosciences Mouse Models for UBE2J1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2J1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2J1 Gene

Localization for UBE2J1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2J1 Gene

Endoplasmic reticulum membrane. Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2J1 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 2
endoplasmic reticulum 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for UBE2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UBE2J1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UBE2J1 Gene

Pathways & Interactions for UBE2J1 Gene

genes like me logo Genes that share pathways with UBE2J1: view

Pathways by source for UBE2J1 Gene

3 GeneGo (Thomson Reuters) pathways for UBE2J1 Gene
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
  • Regulation of degradation of deltaF508 CFTR in CF
  • Regulation of degradation of wt-CFTR
1 R&D Systems pathway for UBE2J1 Gene
2 Qiagen pathways for UBE2J1 Gene
  • Remodeling of Adherens Junctions
  • Ubiquitin-Proteasome Dependent Proteolysis

UniProtKB/Swiss-Prot Q9Y385-UB2J1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for UBE2J1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for UBE2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA 21873635
GO:0007286 spermatid development IEA --
GO:0016567 protein ubiquitination IEA --
GO:0018279 protein N-linked glycosylation via asparagine IMP 22607976
GO:0030433 ubiquitin-dependent ERAD pathway IEA,IMP 21245296
genes like me logo Genes that share ontologies with UBE2J1: view

Drugs & Compounds for UBE2J1 Gene

(3) Drugs for UBE2J1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for UBE2J1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8
genes like me logo Genes that share compounds with UBE2J1: view

Transcripts for UBE2J1 Gene

mRNA/cDNA for UBE2J1 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2J1

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - - -
SP2: -
SP3:
SP4: - -
SP5: -

Relevant External Links for UBE2J1 Gene

GeneLoc Exon Structure for
UBE2J1

Expression for UBE2J1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2J1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2J1 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for UBE2J1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.1) and Stomach (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2J1 Gene



Protein tissue co-expression partners for UBE2J1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2J1

SOURCE GeneReport for Unigene cluster for UBE2J1 Gene:

Hs.163776

Evidence on tissue expression from TISSUES for UBE2J1 Gene

  • Liver(4.4)
  • Spleen(4.4)
  • Blood(4.4)
  • Muscle(4.3)
  • Nervous system(3.2)
  • Lung(2.7)
  • Skin(2.6)
  • Kidney(2.2)
  • Lymph node(2.1)
  • Thyroid gland(2.1)
  • Bone marrow(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with UBE2J1: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2J1 Gene

Orthologs for UBE2J1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2J1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UBE2J1 29 30
  • 99.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia UBE2J1 29 30
  • 93.19 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia UBE2J1 29 30
  • 92.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ube2j1 29
  • 91.55 (n)
Mouse
(Mus musculus)
Mammalia Ube2j1 29 16 30
  • 88.16 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 83 (a)
OneToMany
-- 30
  • 76 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia UBE2J1 30
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves UBE2J1 29 30
  • 73.8 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia UBE2J1 30
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ube2j1 29
  • 70.47 (n)
Zebrafish
(Danio rerio)
Actinopterygii ube2j1 29 30
  • 61.08 (n)
OneToOne
Dr.28798 29
Worm
(Caenorhabditis elegans)
Secernentea ubc-6 29 30
  • 60.43 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC6 30
  • 28 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1220 30
  • 55 (a)
OneToOne
Species where no ortholog for UBE2J1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UBE2J1 Gene

ENSEMBL:
Gene Tree for UBE2J1 (if available)
TreeFam:
Gene Tree for UBE2J1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2J1: view image
Alliance of Genome Resources:
Additional Orthologs for UBE2J1

Paralogs for UBE2J1 Gene

(1) SIMAP similar genes for UBE2J1 Gene using alignment to 1 proteins:

  • UB2J1_HUMAN
genes like me logo Genes that share paralogs with UBE2J1: view

Variants for UBE2J1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2J1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs10502 -- p.Leu229Val
rs8099 -- p.Gly55Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UBE2J1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UBE2J1 Gene

Variant ID Type Subtype PubMed ID
esv27467 CNV loss 19812545
esv3890901 CNV gain 25118596
nsv1027007 CNV gain 25217958

Variation tolerance for UBE2J1 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.62; 65.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2J1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2J1
Leiden Open Variation Database (LOVD)
UBE2J1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2J1 Gene

Disorders for UBE2J1 Gene

Additional Disease Information for UBE2J1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for UBE2J1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2J1 Gene

Publications for UBE2J1 Gene

  1. Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6. (PMID: 10708578) Lester D … Houston B (Biochemical and biophysical research communications 2000) 2 3 4 22
  2. Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). (PMID: 28827405) Schulz J … Christianson JC (Journal of cell science 2017) 3 4
  3. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PMID: 22607976) Sato T … Kai H (Molecular cell 2012) 3 4
  4. A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level. (PMID: 20222955) Pattaro C … EUROSPAN consortium (BMC medical genetics 2010) 3 22
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for UBE2J1 Gene

Sources for UBE2J1 Gene