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Aliases for UBE2I Gene

Aliases for UBE2I Gene

  • Ubiquitin Conjugating Enzyme E2 I 2 3 5
  • Ubiquitin-Conjugating Enzyme E2I (Homologous To Yeast UBC9) 2 3
  • Ubiquitin-Conjugating Enzyme E2I (UBC9 Homolog, Yeast) 2 3
  • RING-Type E3 SUMO Transferase UBC9 3 4
  • Ubiquitin Carrier Protein 9 3 4
  • Ubiquitin Carrier Protein I 3 4
  • Ubiquitin-Protein Ligase I 3 4
  • SUMO-Protein Ligase 3 4
  • UBC9 3 4
  • P18 3 4
  • Ubiquitin-Like Protein SUMO-1 Conjugating Enzyme 3
  • Ubiquitin-Conjugating Enzyme UbcE2A 3
  • Ubiquitin-Conjugating Enzyme E2 I 4
  • Ubiquitin-Conjugating Enzyme E2I 2
  • Ubiquitin Conjugating Enzyme E2I 3
  • Ubiquitin Conjugating Enzyme 9 3
  • SUMO-Conjugating Enzyme UBC9 3
  • Ubiquitin-Protein Ligase E2I 3
  • SUMO-1-Protein Ligase 3
  • EC 2.3.2.- 4
  • C358B7.1 3
  • EC 6.3.2 56
  • UBCE9 4

External Ids for UBE2I Gene

Previous GeneCards Identifiers for UBE2I Gene

  • GC16P001375
  • GC16P001299
  • GC16P001287
  • GC16P001359

Summaries for UBE2I Gene

Entrez Gene Summary for UBE2I Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2I Gene

UBE2I (Ubiquitin Conjugating Enzyme E2 I) is a Protein Coding gene. Diseases associated with UBE2I include Pediatric Fibrosarcoma and Congenital Fibrosarcoma. Among its related pathways are PEDF Induced Signaling and SUMOylation. Gene Ontology (GO) annotations related to this gene include ligase activity.

UniProtKB/Swiss-Prot for UBE2I Gene

  • Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at Lys-386.

Gene Wiki entry for UBE2I Gene

Additional gene information for UBE2I Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2I Gene

Genomics for UBE2I Gene

GeneHancer (GH) Regulatory Elements for UBE2I Gene

Promoters and enhancers for UBE2I Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I001308 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 706.2 +1.9 1874 5.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 UBE2I LOC102723815 WDR90 CRAMP1 TELO2 ENSG00000261505 E4F1 TSC2 ENSG00000260051 IFT140
GH16I000981 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 67.6 -327.5 -327479 1.6 ZNF493 ZNF133 SIN3A GLI4 ZNF2 GLIS2 ZNF213 ZNF416 KLF7 ZNF548 ENSG00000260807 LMF1 SOX8 GC16M000980 GC16M000982 GC16P001002 WDR90 CRAMP1 ENSG00000261505 UBE2I
GH16I001271 Enhancer 1.1 ENCODE 121.7 -37.1 -37054 1.6 PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 ZNF213 ZNF302 ZNF416 KLF13 SP3 CRAMP1 WDR90 IFT140 TELO2 ENSG00000260646 TSC2 ENSG00000261505 E4F1 WDR24 ENSG00000260051
GH16I002266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 42.4 +959.3 959332 3.2 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 RNPS1 LOC106660606 GC16M002266 GC16M002267 ZNF263 ENSG00000260051 ENSG00000261505 E4F1 AMDHD2 TSC2
GH16I002147 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.2 +846.9 846910 17.4 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 TRAF7 SNORD60 SNHG19 ENSG00000281010 GC16M002156 GC16M002158 RAB26 ENSG00000261505 ENSG00000260051 SRRM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBE2I on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBE2I gene promoter:

Genomic Locations for UBE2I Gene

Genomic Locations for UBE2I Gene
chr16:1,308,880-1,327,018
(GRCh38/hg38)
Size:
18,139 bases
Orientation:
Plus strand
chr16:1,355,548-1,377,019
(GRCh37/hg19)

Genomic View for UBE2I Gene

Genes around UBE2I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2I Gene

Proteins for UBE2I Gene

  • Protein details for UBE2I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63279-UBC9_HUMAN
    Recommended name:
    SUMO-conjugating enzyme UBC9
    Protein Accession:
    P63279
    Secondary Accessions:
    • D3DU69
    • P50550
    • Q15698
    • Q59GX1
    • Q86VB3

    Protein attributes for UBE2I Gene

    Size:
    158 amino acids
    Molecular mass:
    18007 Da
    Quaternary structure:
    • Interacts with SETX (PubMed:24105744). Interacts with HIPK1, HIPK2, PPM1J, RASD2 and TCF3 Interacts with NR2C1; the interaction promotes its sumoylation (By similarity). Forms a tight complex with RANGAP1 and RANBP2. Interacts with SIAH1 and PARP. Interacts with various transcription factors such as TFAP2A, TFAP2B, TFAP2C, AR, ETS1 and SOX4. Interacts with RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B. Interacts with DNMT1. Interacts with FOXL2. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Interacts with human herpesvirus 6 IE2. Interacts with human adenovirus early E1A protein; this interaction interferes with polysumoylation (Probable). Interacts with DNM1l (via its GTPase and B domains); the interaction promotes sumoylation of DNM1L, mainly in its B domain. Interacts with PML-RARA oncoprotein (via the coiled-colied domain); the interaction is required for sumoylation of the PML-RARA oncoprotein. Interacts with IPO13. Interacts with NFATC2IP; this inhibits formation of poly-SUMO chains. Interacts with FHIT. Interacts with PRKRA and p53/TP53 (By similarity). Interacts with UHRF2. Interacts with NR3C1 and this interaction is enhanced in the presence of RWDD3. Interacts with MTA1. Interacts with ZNF451. Identified in a complex with SUMO2 and UBC9, where one ZNF451 interacts with one UBC9 and two SUMO2 chains, one bound to the UBC9 active site and the other to another region of the same UBC9 molecule. Interacts with Epstein-barr virus protein LMP1. Interacts with CPEB3 (By similarity).
    SequenceCaution:
    • Sequence=AAH51289.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92225.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2I Gene

neXtProt entry for UBE2I Gene

Selected DME Specific Peptides for UBE2I Gene

P63279:
  • HPNVYPSGT
  • VAVPTKNPDGTMNLMN
  • PAITIKQILLGIQ
  • PAQAEAYTIYCQNRVEYEKR
  • GIQELLNEPNIQ
  • DWRPAIT

Post-translational modifications for UBE2I Gene

  • Phosphorylation at Ser-71 significantly enhances SUMOylation activity.
  • Ubiquitination at isoforms=18, posLast=5959, and isoforms=65
  • Modification sites at PhosphoSitePlus

Domains & Families for UBE2I Gene

Gene Families for UBE2I Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for UBE2I Gene

Graphical View of Domain Structure for InterPro Entry

P63279

UniProtKB/Swiss-Prot:

UBC9_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2I: view

Function for UBE2I Gene

Molecular function for UBE2I Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme E2I,homolog to yeast UBC9,associating with RAD51,RAD52 proteins in the double strand RAD51/RAD52 repair pathway,also associating with UBL1 and PT53,involved in DNA recombination and essential for cell-cycle progression
UniProtKB/Swiss-Prot CatalyticActivity:
SUMOyl-[E2 SUMO-conjugating enzyme]-L-cysteine + [acceptor-protein]-L-lysine = [E2 SUMO-conjugating enzyme]-L-cysteine + N(6)-SUMOyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at Lys-386.

Enzyme Numbers (IUBMB) for UBE2I Gene

Phenotypes From GWAS Catalog for UBE2I Gene

Gene Ontology (GO) - Molecular Function for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 9885291
GO:0005524 ATP binding IEA --
GO:0008134 transcription factor binding IPI 19744555
genes like me logo Genes that share ontologies with UBE2I: view
genes like me logo Genes that share phenotypes with UBE2I: view

Animal Models for UBE2I Gene

MGI Knock Outs for UBE2I:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2I

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2I

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2I Gene

Localization for UBE2I Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2I Gene

Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2I gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex TAS 8610150
GO:0005634 nucleus IDA,IEA 9223278
GO:0005635 nuclear envelope TAS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 9223278
genes like me logo Genes that share ontologies with UBE2I: view

Pathways & Interactions for UBE2I Gene

genes like me logo Genes that share pathways with UBE2I: view

UniProtKB/Swiss-Prot P63279-UBC9_HUMAN

  • Pathway: Protein modification; protein sumoylation.

SIGNOR curated interactions for UBE2I Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS --
GO:0006464 cellular protein modification process TAS 8798754
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8565643
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IEA --
genes like me logo Genes that share ontologies with UBE2I: view

Drugs & Compounds for UBE2I Gene

(10) Drugs for UBE2I Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 2906
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1181
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0

(2) Additional Compounds for UBE2I Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2I: view

Transcripts for UBE2I Gene

Unigene Clusters for UBE2I Gene

Ubiquitin-conjugating enzyme E2I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2I

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2I Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: - -
SP12: - -
SP13:
SP14:

Relevant External Links for UBE2I Gene

GeneLoc Exon Structure for
UBE2I
ECgene alternative splicing isoforms for
UBE2I

Expression for UBE2I Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2I Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2I Gene



Protein tissue co-expression partners for UBE2I Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2I Gene:

UBE2I

SOURCE GeneReport for Unigene cluster for UBE2I Gene:

Hs.302903

mRNA Expression by UniProt/SwissProt for UBE2I Gene:

P63279-UBC9_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.

Evidence on tissue expression from TISSUES for UBE2I Gene

  • Nervous system(4.8)
  • Lung(4.6)
  • Liver(4.4)
  • Stomach(3.3)
  • Intestine(2.9)
  • Pancreas(2.7)
  • Kidney(2.4)
  • Muscle(2.3)
  • Adrenal gland(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with UBE2I: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2I Gene

Orthologs for UBE2I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2I Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia UBE2I 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2I 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2I 33 34
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia UBE2I 33 34
  • 91.98 (n)
cow
(Bos Taurus)
Mammalia UBE2I 33 34
  • 90.72 (n)
mouse
(Mus musculus)
Mammalia Ube2i 33 16 34
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia Ube2i 33
  • 89.24 (n)
chicken
(Gallus gallus)
Aves UBE2I 33 34
  • 87.13 (n)
lizard
(Anolis carolinensis)
Reptilia UBE2I 34
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2i 33
  • 85.65 (n)
Str.8764 33
African clawed frog
(Xenopus laevis)
Amphibia ube2i-prov 33
zebrafish
(Danio rerio)
Actinopterygii ube2i2 33 34 34
  • 81.32 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta lwr 33 34 35
  • 70.89 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011076 33
  • 68.99 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-9 35 34
  • 76 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05039g 33
  • 57.91 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER056C 33
  • 56.62 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC9 33 34 36
  • 54.91 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SCE1 33
  • 62.77 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2303 33
rice
(Oryza sativa)
Liliopsida Os03g0123100 33
  • 62.82 (n)
Os.9019 33
barley
(Hordeum vulgare)
Liliopsida Hv.919 33
corn
(Zea mays)
Liliopsida Zm.4940 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 79 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hus5 33
  • 60.3 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04302 33
  • 58.44 (n)
Species where no ortholog for UBE2I was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2I Gene

ENSEMBL:
Gene Tree for UBE2I (if available)
TreeFam:
Gene Tree for UBE2I (if available)

Paralogs for UBE2I Gene

Pseudogenes.org Pseudogenes for UBE2I Gene

genes like me logo Genes that share paralogs with UBE2I: view

No data available for Paralogs for UBE2I Gene

Variants for UBE2I Gene

Sequence variations from dbSNP and Humsavar for UBE2I Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000089291 -- 1,321,158(+) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000094979 -- 1,315,978(+) A/G intron_variant
rs1000282388 -- 1,319,222(+) G/A intron_variant
rs1000290145 -- 1,310,381(+) G/A intron_variant
rs1000393207 -- 1,323,219(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2I Gene

Variant ID Type Subtype PubMed ID
dgv2692n100 CNV gain 25217958
dgv4842n54 CNV loss 21841781
dgv4843n54 CNV gain 21841781
dgv4844n54 CNV gain 21841781
dgv4845n54 CNV gain 21841781
dgv4846n54 CNV gain 21841781
dgv4847n54 CNV gain+loss 21841781
dgv4848n54 CNV gain 21841781
dgv4849n54 CNV gain 21841781
esv22390 CNV loss 19812545
esv2422427 CNV duplication 17116639
esv2762143 CNV gain 21179565
nsv103725 CNV deletion 16902084
nsv1046314 CNV loss 25217958
nsv1069895 CNV deletion 25765185
nsv1143799 CNV deletion 24896259
nsv428316 CNV gain+loss 18775914
nsv471066 CNV loss 18288195
nsv571116 CNV gain 21841781
nsv571117 CNV loss 21841781
nsv571118 CNV loss 21841781
nsv571124 CNV loss 21841781
nsv571134 CNV loss 21841781
nsv571140 CNV loss 21841781
nsv571142 CNV loss 21841781
nsv571143 CNV loss 21841781
nsv833117 CNV loss 17160897
nsv952899 CNV deletion 24416366

Variation tolerance for UBE2I Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2I Gene

Human Gene Mutation Database (HGMD)
UBE2I
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2I

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2I Gene

Disorders for UBE2I Gene

MalaCards: The human disease database

(3) MalaCards diseases for UBE2I Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pediatric fibrosarcoma
  • childhood fibrosarcoma
congenital fibrosarcoma
  • infantile fibrosarcoma
split hand-foot malformation
  • lobster-claw deformity
- elite association - COSMIC cancer census association via MalaCards
Search UBE2I in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UBE2I

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UBE2I: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2I Gene

Publications for UBE2I Gene

  1. Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle. (PMID: 8565643) Watanabe TK … Shin S (Cytogenetics and cell genetics 1996) 2 3 4 22 58
  2. Association of SUMO1 and UBC9 genotypes with tumor response in non-small-cell lung cancer treated with irinotecan-based chemotherapy. (PMID: 19859084) Han JY … Lee JS (The pharmacogenomics journal 2010) 3 22 44 58
  3. Common variants in the UBC9 gene encoding the SUMO-conjugating enzyme are associated with breast tumor grade. (PMID: 19358266) Dünnebier T … Hamann U (International journal of cancer 2009) 3 22 44 58
  4. Ubc9 gene polymorphisms and late-onset Alzheimer's disease in the Korean population: a genetic association study. (PMID: 19765634) Ahn K … Koh YH (Neuroscience letters 2009) 3 22 44 58
  5. Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction. (PMID: 17466333) Capili AD … Lima CD (Journal of molecular biology 2007) 3 4 22 58

Products for UBE2I Gene