The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enz... See more...

Aliases for UBE2H Gene

Aliases for UBE2H Gene

  • Ubiquitin Conjugating Enzyme E2 H 2 3 5
  • Ubiquitin-Conjugating Enzyme E2H (UBC8 Homolog, Yeast) 2 3
  • (E3-Independent) E2 Ubiquitin-Conjugating Enzyme H 3 4
  • Ubiquitin-Conjugating Enzyme E2-20K 3 4
  • Ubiquitin-Conjugating Enzyme E2 H 3 4
  • E2 Ubiquitin-Conjugating Enzyme H 3 4
  • Ubiquitin Carrier Protein H 3 4
  • Ubiquitin-Protein Ligase H 3 4
  • Ubiquitin-Conjugating Enzyme E2H (Homologous To Yeast UBC8) 3
  • GID Complex Subunit 3, UBC8 Homolog (S. Cerevisiae) 2
  • GID Complex Subunit 3, UBC8 Homolog 3
  • Ubiquitin Conjugating Enzyme E2H 3
  • EC 6.3.2.19 54
  • EC 2.3.2.23 4
  • EC 2.3.2.24 4
  • E2-20K 3
  • UBCH2 3
  • UbcH2 4
  • GID3 3
  • UBC8 3
  • UBCH 3

External Ids for UBE2H Gene

Previous GeneCards Identifiers for UBE2H Gene

  • GC07M127950
  • GC07M129009
  • GC07M129026
  • GC07M129064
  • GC07M129257
  • GC07M129470
  • GC07M123834

Summaries for UBE2H Gene

Entrez Gene Summary for UBE2H Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

GeneCards Summary for UBE2H Gene

UBE2H (Ubiquitin Conjugating Enzyme E2 H) is a Protein Coding gene. Among its related pathways are Protein ubiquitination and Ubiquitin mediated proteolysis. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2N.

UniProtKB/Swiss-Prot Summary for UBE2H Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:8132613, PubMed:17588522, PubMed:20061386). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613).

Gene Wiki entry for UBE2H Gene

Additional gene information for UBE2H Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2H Gene

Genomics for UBE2H Gene

GeneHancer (GH) Regulatory Elements for UBE2H Gene

Promoters and enhancers for UBE2H Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2H on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBE2H gene promoter:
  • c-Myb
  • C/EBPbeta
  • ER-alpha
  • FAC1
  • FOXO1a
  • GATA-3
  • GATA-6
  • PPAR-alpha
  • SRY
  • STAT3

Genomic Locations for UBE2H Gene

Genomic Locations for UBE2H Gene
chr7:129,830,732-129,952,960
(GRCh38/hg38)
Size:
122,229 bases
Orientation:
Minus strand
chr7:129,470,572-129,592,800
(GRCh37/hg19)
Size:
122,229 bases
Orientation:
Minus strand

Genomic View for UBE2H Gene

Genes around UBE2H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2H Gene

Proteins for UBE2H Gene

  • Protein details for UBE2H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62256-UBE2H_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 H
    Protein Accession:
    P62256
    Secondary Accessions:
    • A4D1L6
    • C9JY93
    • P37286
    • Q7Z6F4

    Protein attributes for UBE2H Gene

    Size:
    183 amino acids
    Molecular mass:
    20655 Da
    Quaternary structure:
    • Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.

    Three dimensional structures from OCA and Proteopedia for UBE2H Gene

    Alternative splice isoforms for UBE2H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2H Gene

Selected DME Specific Peptides for UBE2H Gene

P62256:
  • VCLDVINQTW
  • KSPSIGF

Post-translational modifications for UBE2H Gene

  • Autoubiquitinated in vitro in the presence of NEDD4L.
  • Ubiquitination at Lys60, Lys64, and Lys147
  • Modification sites at PhosphoSitePlus

Domains & Families for UBE2H Gene

Gene Families for UBE2H Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for UBE2H Gene

Suggested Antigen Peptide Sequences for UBE2H Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-conjugating enzyme E2H isoform 1 (A4D1L5_HUMAN)
  • Ubiquitin-conjugating enzyme (Q7Z6F4_HUMAN)
  • Ubiquitin-protein ligase H (UBE2H_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62256

UniProtKB/Swiss-Prot:

UBE2H_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2H: view

Function for UBE2H Gene

Molecular function for UBE2H Gene

UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:8132613, PubMed:17588522, PubMed:20061386). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255 PROSITE-ProRule:PRU00388, ECO:0000255 PROSITE-ProRule:PRU10133, ECO:0000269 PubMed:17588522, ECO:0000269 PubMed:20061386, ECO:0000269 PubMed:22496338, ECO:0000269 PubMed:29911972, ECO:0000269 PubMed:8132613};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.24; Evidence={ECO:0000269 PubMed:17588522, ECO:0000269 PubMed:8132613};.
GENATLAS Biochemistry:
ubiquitin conjugating enzyme H2A,homolog to yeast UBC8

Enzyme Numbers (IUBMB) for UBE2H Gene

Phenotypes From GWAS Catalog for UBE2H Gene

Gene Ontology (GO) - Molecular Function for UBE2H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS,IDA 20061386
GO:0005515 protein binding IPI 20028976
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0061631 ubiquitin conjugating enzyme activity IBA 21873635
genes like me logo Genes that share ontologies with UBE2H: view
genes like me logo Genes that share phenotypes with UBE2H: view

Animal Models for UBE2H Gene

MGI Knock Outs for UBE2H:
  • Ube2h Ube2h<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2H

CRISPR Products

miRNA for UBE2H Gene

miRTarBase miRNAs that target UBE2H

Clone Products

  • Addgene plasmids for UBE2H

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2H Gene

Localization for UBE2H Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2H gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBE2H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2H: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2H Gene

Pathways & Interactions for UBE2H Gene

genes like me logo Genes that share pathways with UBE2H: view

Pathways by source for UBE2H Gene

1 R&D Systems pathway for UBE2H Gene
2 Qiagen pathways for UBE2H Gene
  • Remodeling of Adherens Junctions
  • Ubiquitin-Proteasome Dependent Proteolysis

UniProtKB/Swiss-Prot P62256-UBE2H_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IBA,TAS 21873635
GO:0016567 protein ubiquitination TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA --
GO:0070936 protein K48-linked ubiquitination IDA 20061386
GO:0070979 protein K11-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2H: view

No data available for SIGNOR curated interactions for UBE2H Gene

Drugs & Compounds for UBE2H Gene

(3) Drugs for UBE2H Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for UBE2H Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with UBE2H: view

Transcripts for UBE2H Gene

CRISPR Products

Clone Products

  • Addgene plasmids for UBE2H

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2H Gene

No ASD Table

Relevant External Links for UBE2H Gene

GeneLoc Exon Structure for
UBE2H
ECgene alternative splicing isoforms for
UBE2H

Expression for UBE2H Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2H Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2H Gene



Protein tissue co-expression partners for UBE2H Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2H Gene:

UBE2H

SOURCE GeneReport for Unigene cluster for UBE2H Gene:

Hs.643548

Evidence on tissue expression from TISSUES for UBE2H Gene

  • Nervous system(4.2)
  • Lung(3.9)
  • Skin(3.4)
  • Intestine(2.7)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with UBE2H: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2H Gene

Orthologs for UBE2H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2H Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia UBE2H 33
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2H 33 32
  • 99.82 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gm2058 33
  • 99 (a)
OneToMany
Ube2h 17 33 32
  • 93.81 (n)
dog
(Canis familiaris)
Mammalia UBE2H 33 32
  • 96.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2H 33 32
  • 95.08 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2h 32
  • 93.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2H 33
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2H 33 32
  • 89.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2H 33
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2h 32
  • 87.07 (n)
Str.5927 32
African clawed frog
(Xenopus laevis)
Amphibia ube2h-prov 32
zebrafish
(Danio rerio)
Actinopterygii ube2h 33 32
  • 82.33 (n)
OneToOne
wufc07a05 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1397 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001068 32
  • 70.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ubc-E2H 33 34 32
  • 65.76 (n)
OneToOne
CG14739 34
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea ubc-8 33 34 32
  • 62.58 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC8 35 33 32
  • 58.99 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11198g 32
  • 58.28 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL045W 32
  • 55.7 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC4 32
  • 63.5 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7729 32
soybean
(Glycine max)
eudicotyledons Gma.18138 32
rice
(Oryza sativa)
Liliopsida Os10g0447100 32
  • 61.15 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10046 32
  • 64.79 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc8 32
  • 60.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.3173 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3173 32
Species where no ortholog for UBE2H was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2H Gene

ENSEMBL:
Gene Tree for UBE2H (if available)
TreeFam:
Gene Tree for UBE2H (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2H: view image

Paralogs for UBE2H Gene

(19) SIMAP similar genes for UBE2H Gene using alignment to 7 proteins:

  • UBE2H_HUMAN
  • A4D1L5_HUMAN
  • C9J8Q9_HUMAN
  • C9JZG9_HUMAN
  • C9JZY6_HUMAN
  • H7C4M9_HUMAN
  • Q75MF5_HUMAN

Pseudogenes.org Pseudogenes for UBE2H Gene

genes like me logo Genes that share paralogs with UBE2H: view

Variants for UBE2H Gene

Sequence variations from dbSNP and Humsavar for UBE2H Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1554434216 uncertain-significance, not provided 129,879,637(-) A/G 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000002044 -- 129,928,517(-) T/C intron_variant
rs1000059125 -- 129,872,399(-) C/A intron_variant
rs1000095198 -- 129,928,281(-) AAAAAAA/AAAAAA/AAAAAAAA intron_variant
rs1000116794 -- 129,845,002(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2H Gene

Variant ID Type Subtype PubMed ID
esv2735150 CNV deletion 23290073
esv3572138 CNV loss 25503493
esv3615007 CNV loss 21293372
nsv366414 CNV deletion 16902084
nsv510968 OTHER complex 20534489
nsv831129 CNV loss 17160897
nsv949947 CNV duplication 24416366

Variation tolerance for UBE2H Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2H Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2H

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2H Gene

Disorders for UBE2H Gene

Additional Disease Information for UBE2H

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UBE2H Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2H Gene

Publications for UBE2H Gene

  1. A human ubiquitin-conjugating enzyme homologous to yeast UBC8. (PMID: 8132613) Kaiser P … Schneider R (The Journal of biological chemistry 1994) 2 3 4 23 56
  2. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. (PMID: 29911972) Lampert F … Peter M (eLife 2018) 3 4 56
  3. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4 56
  4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 43 56
  5. Association study of the ubiquitin conjugating enzyme gene UBE2H in sporadic ALS. (PMID: 19922136) Martin I … French ALS Study Group (Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2009) 3 43 56

Products for UBE2H Gene

Sources for UBE2H Gene