Aliases for UBE2G2 Gene
- Ubiquitin Conjugating Enzyme E2 G2 2 3 5
- Ubiquitin-Conjugating Enzyme E2G 2 (Homologous To Yeast UBC7) 2 3
- Ubiquitin-Conjugating Enzyme E2G 2 (UBC7 Homolog, Yeast) 2 3
- Ubiquitin-Conjugating Enzyme E2 G2 3 4
- E2 Ubiquitin-Conjugating Enzyme G2 3 4
- Ubiquitin Carrier Protein G2 3 4
- Ubiquitin-Protein Ligase G2 3 4
External Ids for UBE2G2 Gene
Previous GeneCards Identifiers for UBE2G2 Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for UBE2G2 Gene
UBE2G2 (Ubiquitin Conjugating Enzyme E2 G2) is a Protein Coding gene. Diseases associated with UBE2G2 include Machado-Joseph Disease and N Syndrome. Among its related pathways are Metabolism of proteins and Parkinsons Disease Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is UBE2G1.
UniProtKB/Swiss-Prot Summary for UBE2G2 Gene
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).