The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enz... See more...

Aliases for UBE2G2 Gene

Aliases for UBE2G2 Gene

  • Ubiquitin Conjugating Enzyme E2 G2 2 3 5
  • Ubiquitin-Conjugating Enzyme E2G 2 (Homologous To Yeast UBC7) 2 3
  • Ubiquitin-Conjugating Enzyme E2G 2 (UBC7 Homolog, Yeast) 2 3
  • Ubiquitin-Conjugating Enzyme E2 G2 3 4
  • E2 Ubiquitin-Conjugating Enzyme G2 3 4
  • Ubiquitin Carrier Protein G2 3 4
  • Ubiquitin-Protein Ligase G2 3 4
  • Ubiquitin-Conjugating Enzyme E2G 2 2
  • Ubiquitin Conjugating Enzyme G2 3
  • Ubiquitin Conjugating Enzyme 7 3
  • EC 6.3.2.19'); 52
  • EC 6.3.2.19 52
  • EC 2.3.2.23 4
  • UBC7 3

External Ids for UBE2G2 Gene

Previous GeneCards Identifiers for UBE2G2 Gene

  • GC21M042698
  • GC21M045045
  • GC21M045013
  • GC21M046188
  • GC21M031563

Summaries for UBE2G2 Gene

Entrez Gene Summary for UBE2G2 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for UBE2G2 Gene

UBE2G2 (Ubiquitin Conjugating Enzyme E2 G2) is a Protein Coding gene. Diseases associated with UBE2G2 include N Syndrome and Machado-Joseph Disease. Among its related pathways are Metabolism of proteins and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is UBE2G1.

UniProtKB/Swiss-Prot Summary for UBE2G2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).

Gene Wiki entry for UBE2G2 Gene

Additional gene information for UBE2G2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2G2 Gene

Genomics for UBE2G2 Gene

GeneHancer (GH) Regulatory Elements for UBE2G2 Gene

Promoters and enhancers for UBE2G2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J044800 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 553.7 +0.2 209 3.3 HNRNPK ZBTB40 ZNF217 CTCF SIN3A NRF1 POLR2G GTF2E2 PHF8 SIX5 UBE2G2 LINC01424 lnc-SUMO3-1 POFUT2 PTTG1IP lnc-KRTAP10-12-3
GH21J045069 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 65.2 -271.6 -271578 7.6 HNRNPK ZNF217 EP300 ZNF300 POLR2G USF1 GTF2E2 TEAD4 PHB2 ZFX SSR4P1 ADARB1 LOC105372836 lnc-ITGB2-11 UBE2G2 POFUT2 ENSG00000184441 COL6A1 ENSG00000224413 PWP2
GH21J045589 Enhancer 1.3 FANTOM5 ENCODE 73.1 -790.0 -790011 2.7 HNRNPK NRF1 RBAK PHB2 ZNF639 ZBTB5 EP300 ZIC2 ZBTB10 ZNF423 LINC01694 lnc-SLC19A1-5 ENSG00000228137 MCM3AP-AS1 MCM3AP DIP2A UBE2G2 COL6A1 POFUT2 COL6A2
GH21J044803 Enhancer 0.2 ENCODE 500.7 -1.4 -1442 0 LINC01424 UBE2G2 lnc-SUMO3-1 SUMO3
GH21J043863 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 33.5 +935.5 935463 5.5 EP300 FOXK2 HNRNPK SIN3A NRF1 POLR2G USF1 NCOR1 PHF8 ZFX AGPAT3 lnc-RRP1-3 UBE2G2 WDR4 U2AF1 RRP1B RNU6-859P HSF2BP ENSG00000213440 PWP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2G2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2G2

Top Transcription factor binding sites by QIAGEN in the UBE2G2 gene promoter:
  • aMEF-2
  • AML1a
  • AREB6
  • ATF6
  • Bach2
  • MEF-2A
  • p53

Genomic Locations for UBE2G2 Gene

Genomic Locations for UBE2G2 Gene
chr21:44,768,580-44,801,836
(GRCh38/hg38)
Size:
33,257 bases
Orientation:
Minus strand
chr21:46,188,495-46,221,934
(GRCh37/hg19)
Size:
33,440 bases
Orientation:
Minus strand

Genomic View for UBE2G2 Gene

Genes around UBE2G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2G2 Gene

Proteins for UBE2G2 Gene

  • Protein details for UBE2G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60604-UB2G2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 G2
    Protein Accession:
    P60604
    Secondary Accessions:
    • A6NMQ7
    • A8K3L4
    • D3DSL7
    • P56554

    Protein attributes for UBE2G2 Gene

    Size:
    165 amino acids
    Molecular mass:
    18566 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBE2G2 Gene

    Alternative splice isoforms for UBE2G2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2G2 Gene

Selected DME Specific Peptides for UBE2G2 Gene

P60604:
  • DYPLSPPK
  • SMLAEPNDESGAN
  • HPNIYPDG
  • ERWSPVQSVEKILLSV
  • VCISILH

Post-translational modifications for UBE2G2 Gene

  • Ubiquitination at Lys7, Lys153, and Lys156
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2G2 Gene

Domains & Families for UBE2G2 Gene

Gene Families for UBE2G2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for UBE2G2 Gene

Blocks:
  • Ubiquitin-conjugating enzymes
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UBE2G2 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-protein ligase G2 (UB2G2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P60604

UniProtKB/Swiss-Prot:

UB2G2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2G2: view

Function for UBE2G2 Gene

Molecular function for UBE2G2 Gene

UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence=. ;.
GENATLAS Biochemistry:
ubiquitin conjugating enzyme,homolog to yeast UBC7,with two transcript,ubiquitously expressed

Enzyme Numbers (IUBMB) for UBE2G2 Gene

Phenotypes From GWAS Catalog for UBE2G2 Gene

Gene Ontology (GO) - Molecular Function for UBE2G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 16407162
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with UBE2G2: view
genes like me logo Genes that share phenotypes with UBE2G2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2G2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2G2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2G2 Gene

Localization for UBE2G2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2G2 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for UBE2G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2G2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for UBE2G2 Gene

Pathways & Interactions for UBE2G2 Gene

genes like me logo Genes that share pathways with UBE2G2: view

Pathways by source for UBE2G2 Gene

1 GeneGo (Thomson Reuters) pathway for UBE2G2 Gene
  • Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
1 R&D Systems pathway for UBE2G2 Gene

UniProtKB/Swiss-Prot P60604-UB2G2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA 21873635
GO:0006511 ubiquitin-dependent protein catabolic process IBA,TAS 21873635
GO:0016567 protein ubiquitination TAS --
GO:0018279 protein N-linked glycosylation via asparagine IMP 22607976
GO:0030433 ubiquitin-dependent ERAD pathway IMP,IBA 22607976
genes like me logo Genes that share ontologies with UBE2G2: view

No data available for SIGNOR curated interactions for UBE2G2 Gene

Drugs & Compounds for UBE2G2 Gene

(2) Drugs for UBE2G2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for UBE2G2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with UBE2G2: view

Transcripts for UBE2G2 Gene

mRNA/cDNA for UBE2G2 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2G2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2G2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - - - - - - - - -
SP5:
SP6: - - - -
SP7:
SP8:

Relevant External Links for UBE2G2 Gene

GeneLoc Exon Structure for
UBE2G2

Expression for UBE2G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2G2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2G2 Gene

This gene is overexpressed in Bone (15.8) and Breast (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2G2 Gene



Protein tissue co-expression partners for UBE2G2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2G2

SOURCE GeneReport for Unigene cluster for UBE2G2 Gene:

Hs.529420

Evidence on tissue expression from TISSUES for UBE2G2 Gene

  • Heart(4)
  • Lung(4)
genes like me logo Genes that share expression patterns with UBE2G2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2G2 Gene

Orthologs for UBE2G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2G2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2G2 31 30
  • 99.39 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2G2 31
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2G2 31 30
  • 91.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2G2 31 30
  • 90.71 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2G2 31
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2g2 17 31 30
  • 89.49 (n)
rat
(Rattus norvegicus)
Mammalia Ube2g2 30
  • 89.49 (n)
chicken
(Gallus gallus)
Aves UBE2G2 31 30
  • 82.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2G2 31
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2g2 30
  • 82.22 (n)
zebrafish
(Danio rerio)
Actinopterygii ube2g2 31 30
  • 78.18 (n)
OneToOne
-- 30
fruit fly
(Drosophila melanogaster)
Insecta crl 31 32 30
  • 71.72 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002169 30
  • 70.91 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-14 31 32 30
  • 65.05 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR059W 30
  • 60.61 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07745g 30
  • 57.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC7 33 31 30
  • 56.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 79 (a)
OneToOne
Cin.3185 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc7 30
  • 60.25 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03623 30
  • 59.71 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3185 30
Species where no ortholog for UBE2G2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2G2 Gene

ENSEMBL:
Gene Tree for UBE2G2 (if available)
TreeFam:
Gene Tree for UBE2G2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2G2: view image

Paralogs for UBE2G2 Gene

(25) SIMAP similar genes for UBE2G2 Gene using alignment to 3 proteins:

  • UB2G2_HUMAN
  • F8WCB9_HUMAN
  • F8WDB1_HUMAN
genes like me logo Genes that share paralogs with UBE2G2: view

Variants for UBE2G2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2G2 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
rs1057518338 Uncertain Significance: not specified 44,773,602(-) C/T NONSENSE

Additional dbSNP identifiers (rs#s) for UBE2G2 Gene

Structural Variations from Database of Genomic Variants (DGV) for UBE2G2 Gene

Variant ID Type Subtype PubMed ID
esv3647135 CNV loss 21293372
nsv1116931 CNV deletion 24896259
nsv459298 CNV loss 19166990
nsv476892 CNV novel sequence insertion 20440878
nsv587813 CNV loss 21841781

Variation tolerance for UBE2G2 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2G2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2G2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2G2 Gene

Disorders for UBE2G2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for UBE2G2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
n syndrome
  • nsx
machado-joseph disease
  • mjd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UBE2G2

genes like me logo Genes that share disorders with UBE2G2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2G2 Gene

Publications for UBE2G2 Gene

  1. Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene. (PMID: 9693041) Katsanis N … Fisher EM (Genomics 1998) 2 3 4 23 54
  2. Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7). (PMID: 16582478) Arai R … Yokoyama S (Acta crystallographica. Section F, Structural biology and crystallization communications 2006) 3 4 23 54
  3. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PMID: 22607976) Sato T … Kai H (Molecular cell 2012) 3 4 54
  4. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4 54
  5. Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2. (PMID: 20014027) Ju T … Tolman JR (Proteins 2010) 3 23 54

Products for UBE2G2 Gene

Sources for UBE2G2 Gene