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Aliases for UBE2G2 Gene

Aliases for UBE2G2 Gene

  • Ubiquitin Conjugating Enzyme E2 G2 2 3 5
  • Ubiquitin-Conjugating Enzyme E2G 2 (Homologous To Yeast UBC7) 2 3
  • Ubiquitin-Conjugating Enzyme E2G 2 (UBC7 Homolog, Yeast) 2 3
  • E2 Ubiquitin-Conjugating Enzyme G2 3 4
  • Ubiquitin Carrier Protein G2 3 4
  • Ubiquitin-Protein Ligase G2 3 4
  • Ubiquitin-Conjugating Enzyme E2 G2 3
  • Ubiquitin-Conjugating Enzyme E2G 2 2
  • Ubiquitin Conjugating Enzyme G2 3
  • Ubiquitin Conjugating Enzyme 7 3
  • EC 4
  • UBC7 3

External Ids for UBE2G2 Gene

Previous GeneCards Identifiers for UBE2G2 Gene

  • GC21M042698
  • GC21M045045
  • GC21M045013
  • GC21M046188
  • GC21M031563

Summaries for UBE2G2 Gene

Entrez Gene Summary for UBE2G2 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for UBE2G2 Gene

UBE2G2 (Ubiquitin Conjugating Enzyme E2 G2) is a Protein Coding gene. Among its related pathways are Parkinsons Disease Pathway and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is UBE2G1.

UniProtKB/Swiss-Prot for UBE2G2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).

Gene Wiki entry for UBE2G2 Gene

Additional gene information for UBE2G2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2G2 Gene

Genomics for UBE2G2 Gene

GeneHancer (GH) Regulatory Elements for UBE2G2 Gene

Promoters and enhancers for UBE2G2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J044801 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 673.7 +0.1 82 2.6 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 UBE2G2 LINC01424 ENSG00000184441 PWP2 POFUT2 PTTG1IP GC21M045800
GH21J044800 Enhancer 0.6 ENCODE 666.5 +1.7 1738 0.2 CTCF SAP130 L3MBTL2 ARID4B REST MIER2 RAD21 GABPA MLLT1 ZNF558 UBE2G2 LINC01424 GC21M045800
GH21J044803 Enhancer 0.3 ENCODE 650.7 -1.3 -1259 0 THAP11 LINC01424 UBE2G2 GC21P044820
GH21J045589 Enhancer 1.6 FANTOM5 Ensembl ENCODE 116 -789.4 -789425 3.5 HDGF PKNOX1 ARNT YBX1 ZNF2 ZBTB7B POLR2B ZNF207 ZNF143 ZNF548 LINC01694 ENSG00000228137 MCM3AP DIP2A UBE2G2 MCM3AP-AS1 POFUT2 COL6A1 ENSG00000227438 COL6A2
GH21J045073 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 36.3 -273.2 -273184 4 HNRNPUL1 PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B NEUROD1 SIN3A ZNF2 SSR4P1 ADARB1 LOC105372836 POFUT2 ENSG00000184441 UBE2G2 PWP2 COL6A1 LINC00315 LOC105372842
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2G2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBE2G2 gene promoter:
  • MEF-2A
  • aMEF-2
  • AML1a
  • ATF6
  • p53
  • AREB6
  • Bach2

Genomic Locations for UBE2G2 Gene

Genomic Locations for UBE2G2 Gene
33,440 bases
Minus strand
33,440 bases
Minus strand

Genomic View for UBE2G2 Gene

Genes around UBE2G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2G2 Gene

Proteins for UBE2G2 Gene

  • Protein details for UBE2G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 G2
    Protein Accession:
    Secondary Accessions:
    • A6NMQ7
    • A8K3L4
    • D3DSL7
    • P56554

    Protein attributes for UBE2G2 Gene

    165 amino acids
    Molecular mass:
    18566 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBE2G2 Gene

    Alternative splice isoforms for UBE2G2 Gene


neXtProt entry for UBE2G2 Gene

Post-translational modifications for UBE2G2 Gene

  • Ubiquitination at posLast=156156 and posLast=153153
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2G2 Gene

No data available for DME Specific Peptides for UBE2G2 Gene

Domains & Families for UBE2G2 Gene

Gene Families for UBE2G2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for UBE2G2 Gene

Suggested Antigen Peptide Sequences for UBE2G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ubiquitin-conjugating enzyme family.
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2G2: view

Function for UBE2G2 Gene

Molecular function for UBE2G2 Gene

UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
GENATLAS Biochemistry:
ubiquitin conjugating enzyme,homolog to yeast UBC7,with two transcript,ubiquitously expressed

Enzyme Numbers (IUBMB) for UBE2G2 Gene

Phenotypes From GWAS Catalog for UBE2G2 Gene

Gene Ontology (GO) - Molecular Function for UBE2G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 16407162
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with UBE2G2: view
genes like me logo Genes that share phenotypes with UBE2G2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2G2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2G2 Gene

Localization for UBE2G2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2G2 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for UBE2G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2G2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for UBE2G2 Gene

Pathways & Interactions for UBE2G2 Gene

genes like me logo Genes that share pathways with UBE2G2: view

UniProtKB/Swiss-Prot P60604-UB2G2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0006511 ubiquitin-dependent protein catabolic process TAS 9693041
GO:0016567 protein ubiquitination TAS --
GO:0018279 protein N-linked glycosylation via asparagine IMP 22607976
GO:0030433 ubiquitin-dependent ERAD pathway IMP 22607976
genes like me logo Genes that share ontologies with UBE2G2: view

No data available for SIGNOR curated interactions for UBE2G2 Gene

Drugs & Compounds for UBE2G2 Gene

(2) Drugs for UBE2G2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for UBE2G2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
genes like me logo Genes that share compounds with UBE2G2: view

Transcripts for UBE2G2 Gene

mRNA/cDNA for UBE2G2 Gene

Unigene Clusters for UBE2G2 Gene

Ubiquitin-conjugating enzyme E2G 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2G2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - - - - - - - - -
SP6: - - - -

Relevant External Links for UBE2G2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2G2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2G2 Gene

This gene is overexpressed in Bone (15.8) and Breast (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2G2 Gene

Protein tissue co-expression partners for UBE2G2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2G2 Gene:


SOURCE GeneReport for Unigene cluster for UBE2G2 Gene:


Evidence on tissue expression from TISSUES for UBE2G2 Gene

  • Heart(4)
  • Lung(4)
genes like me logo Genes that share expression patterns with UBE2G2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2G2 Gene

Orthologs for UBE2G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2G2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBE2G2 34 33
  • 99.39 (n)
(Monodelphis domestica)
Mammalia UBE2G2 34
  • 99 (a)
(Bos Taurus)
Mammalia UBE2G2 34 33
  • 91.52 (n)
(Canis familiaris)
Mammalia UBE2G2 34 33
  • 90.71 (n)
(Ornithorhynchus anatinus)
Mammalia UBE2G2 34
  • 90 (a)
(Mus musculus)
Mammalia Ube2g2 16 34 33
  • 89.49 (n)
(Rattus norvegicus)
Mammalia Ube2g2 33
  • 89.49 (n)
(Gallus gallus)
Aves UBE2G2 34 33
  • 82.42 (n)
(Anolis carolinensis)
Reptilia UBE2G2 34
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2g2 33
  • 82.22 (n)
(Danio rerio)
Actinopterygii ube2g2 34 33
  • 78.18 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta crl 34 35 33
  • 71.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002169 33
  • 70.91 (n)
(Caenorhabditis elegans)
Secernentea ubc-14 34 35 33
  • 65.05 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR059W 33
  • 60.61 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07745g 33
  • 57.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC7 36 34 33
  • 56.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 79 (a)
Cin.3185 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc7 33
  • 60.25 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03623 33
  • 59.71 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3185 33
Species where no ortholog for UBE2G2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2G2 Gene

Gene Tree for UBE2G2 (if available)
Gene Tree for UBE2G2 (if available)
Evolutionary constrained regions (ECRs) for UBE2G2: view image

Paralogs for UBE2G2 Gene

Paralogs for UBE2G2 Gene

(25) SIMAP similar genes for UBE2G2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UBE2G2: view

Variants for UBE2G2 Gene

Sequence variations from dbSNP and Humsavar for UBE2G2 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1057518338 uncertain-significance, not specified 44,773,602(-) C/T coding_sequence_variant, stop_gained
rs1000054107 -- 44,791,987(-) A/G intron_variant
rs1000057767 -- 44,797,817(-) C/A intron_variant
rs1000150315 -- 44,783,477(-) A/G intron_variant
rs1000292866 -- 44,780,645(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2G2 Gene

Variant ID Type Subtype PubMed ID
esv3647135 CNV loss 21293372
nsv1116931 CNV deletion 24896259
nsv459298 CNV loss 19166990
nsv476892 CNV novel sequence insertion 20440878
nsv587813 CNV loss 21841781

Variation tolerance for UBE2G2 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2G2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2G2 Gene

Disorders for UBE2G2 Gene

Additional Disease Information for UBE2G2

No disorders were found for UBE2G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2G2 Gene

Publications for UBE2G2 Gene

  1. Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene. (PMID: 9693041) Katsanis N … Fisher EM (Genomics 1998) 2 3 4 22 58
  2. Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7). (PMID: 16582478) Arai R … Yokoyama S (Acta crystallographica. Section F, Structural biology and crystallization communications 2006) 3 4 22 58
  3. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PMID: 22607976) Sato T … Kai H (Molecular cell 2012) 3 4 58
  4. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4 58
  5. Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2. (PMID: 20014027) Ju T … Tolman JR (Proteins 2010) 3 22 58

Products for UBE2G2 Gene

Sources for UBE2G2 Gene

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