Aliases for UBE2G2 Gene
Aliases for UBE2G2 Gene
- Ubiquitin Conjugating Enzyme E2 G2 2 3 5
- Ubiquitin-Conjugating Enzyme E2G 2 (Homologous To Yeast UBC7) 2 3
- Ubiquitin-Conjugating Enzyme E2G 2 (UBC7 Homolog, Yeast) 2 3
- E2 Ubiquitin-Conjugating Enzyme G2 3 4
- Ubiquitin Carrier Protein G2 3 4
- Ubiquitin-Protein Ligase G2 3 4
- Ubiquitin-Conjugating Enzyme E2 G2 3
External Ids for UBE2G2 Gene
- HGNC: 12483
- Entrez Gene: 7327
- Ensembl: ENSG00000184787
- OMIM: 603124
- UniProtKB: P60604
Previous GeneCards Identifiers for UBE2G2 Gene
- GC21M042698
- GC21M045045
- GC21M045013
- GC21M046188
- GC21M031563
Summaries for UBE2G2 Gene
-
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for UBE2G2 Gene
UBE2G2 (Ubiquitin Conjugating Enzyme E2 G2) is a Protein Coding gene. Among its related pathways are Parkinsons Disease Pathway and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is UBE2G1.
UniProtKB/Swiss-Prot for UBE2G2 Gene
-
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).
Additional gene information for UBE2G2 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2G2 Gene
Genomics for UBE2G2 Gene
GeneHancer (GH) Regulatory Elements for UBE2G2 Gene
Promoters and enhancers for UBE2G2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around UBE2G2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the UBE2G2 gene promoter:
-
- MEF-2A
- aMEF-2
- AML1a
- ATF6
- p53
- AREB6
- Bach2
Regulatory Element Products
Genomic Locations for UBE2G2 Gene
Genomic Locations for UBE2G2 Gene
- chr21:44,768,580-44,802,019
- (GRCh38/hg38)
- Size:
- 33,440 bases
- Orientation:
- Minus strand
- chr21:46,188,495-46,221,934
- (GRCh37/hg19)
- Size:
- 33,440 bases
- Orientation:
- Minus strand
Genomic View for UBE2G2 Gene
Genes around UBE2G2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by Entrez Gene
- 21q22.3 by HGNC
- 21q22.3 by Ensembl
UBE2G2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UBE2G2 Gene
Proteins for UBE2G2 Gene
-
Protein details for UBE2G2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P60604-UB2G2_HUMAN
- Recommended name:
- Ubiquitin-conjugating enzyme E2 G2
- Protein Accession:
- P60604
- A6NMQ7
- A8K3L4
- D3DSL7
- P56554
Protein attributes for UBE2G2 Gene
- Size:
- 165 amino acids
- Molecular mass:
- 18566 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for UBE2G2 Gene
Protein Expression for UBE2G2 Gene
Post-translational modifications for UBE2G2 Gene
Other Protein References for UBE2G2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for UBE2G2
-
Abcam antibodies for UBE2G2
- Invitrogen Antibodies for UBE2G2
- GeneTex UBE2G2 Antibody for UBE2G2
-
Santa Cruz Biotechnology (SCBT) Antibodies for UBE2G2
Protein Products
- R&D Systems Proteins and Enzymes for UBE2G2
- Search Origene for MassSpec and Protein Over-expression Lysates for UBE2G2
- Origene Custom Protein Services for UBE2G2
- ProSpec Recombinant Proteins for UBE2G2
- GeneTex Proteins for UBE2G2
-
ProSci Proteins for UBE2G2
-
Abcam proteins for UBE2G2
Assay Products
No data available for DME Specific Peptides for UBE2G2 Gene
Domains & Families for UBE2G2 Gene
Gene Families for UBE2G2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for UBE2G2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for UBE2G2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P60604- Family:
-
- Belongs to the ubiquitin-conjugating enzyme family.
Function for UBE2G2 Gene
Molecular function for UBE2G2 Gene
- UniProtKB/Swiss-Prot Function:
- Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
- GENATLAS Biochemistry:
- ubiquitin conjugating enzyme,homolog to yeast UBC7,with two transcript,ubiquitously expressed
Enzyme Numbers (IUBMB) for UBE2G2 Gene
Phenotypes From GWAS Catalog for UBE2G2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 20061386 |
| GO:0005515 | protein binding | IPI | 16407162 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0031625 | ubiquitin protein ligase binding | IBA | -- |
Phenotypes for UBE2G2 Gene
- GenomeRNAi human phenotypes for UBE2G2:
-
- Increased G1 DNA content
- Increased cell death HMECs cells
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Model Products
-
Taconic Biosciences Mouse Models for UBE2G2
- Cyagen custom Knockout/knockin (KOKI) mouse models for UBE2G2
-
CRISPR Products
-
OriGene CRISPR knockouts for UBE2G2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2G2
- genomics-online: gRNA clones - Search results for 136 available UBE2G2 gene related products
- Overview of 136 available UBE2G2 gene related products
- Applied Biological Materials CRISPR for UBE2G2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2G2
- GenScript: Design CRISPR guide RNA sequences for UBE2G2
miRNA for UBE2G2 Gene
- miRTarBase miRNAs that target UBE2G2
-
- hsa-mir-615-3p (MIRT040299)
- hsa-mir-125a-5p (MIRT045715)
- hsa-mir-128-3p (MIRT045887)
- hsa-mir-6511b-5p (MIRT156156)
- hsa-mir-6811-5p (MIRT156159)
- hsa-mir-374a-5p (MIRT439361)
- hsa-mir-218-5p (MIRT439363)
- hsa-mir-6807-5p (MIRT520361)
- hsa-mir-519d-5p (MIRT520362)
- hsa-mir-6849-3p (MIRT520363)
- hsa-mir-3065-3p (MIRT520364)
- hsa-mir-500b-3p (MIRT520365)
- hsa-mir-449b-3p (MIRT520366)
- hsa-mir-6871-3p (MIRT520367)
- hsa-mir-129-5p (MIRT673302)
- hsa-mir-8055 (MIRT673303)
- hsa-mir-744-3p (MIRT673304)
- hsa-mir-6864-3p (MIRT673305)
- hsa-mir-3672 (MIRT673306)
- hsa-mir-6794-3p (MIRT673307)
- hsa-mir-4423-5p (MIRT673308)
- hsa-mir-6501-5p (MIRT673309)
- hsa-mir-4524a-3p (MIRT673310)
- hsa-mir-367-5p (MIRT673311)
- hsa-mir-1267 (MIRT673312)
- hsa-mir-1304-3p (MIRT673313)
- hsa-mir-4639-3p (MIRT673314)
- hsa-mir-5007-5p (MIRT673315)
- hsa-mir-3664-5p (MIRT673316)
- hsa-mir-4797-5p (MIRT673317)
- hsa-mir-122-5p (MIRT783161)
- hsa-mir-143-5p (MIRT783832)
- hsa-mir-153-5p (MIRT783915)
- hsa-mir-3135b (MIRT784623)
- hsa-mir-3173-5p (MIRT784739)
- hsa-mir-3193 (MIRT784779)
- hsa-mir-3652 (MIRT785016)
- hsa-mir-4430 (MIRT785844)
- hsa-mir-504-3p (MIRT787028)
- hsa-mir-5693 (MIRT787793)
- hsa-mir-5698 (MIRT787822)
- hsa-mir-6499-3p (MIRT788196)
- hsa-mir-6799-3p (MIRT788802)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for UBE2G2
- Browse OriGene Inhibitory RNA Products For UBE2G2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2G2
- genomics-online: shRNA clones - Search results for 136 available UBE2G2 gene related products
- Overview of 136 available UBE2G2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for UBE2G2
- VectorBuilder custom plasmid, inducible vectors for UBE2G2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UBE2G2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for UBE2G2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2G2
- Applied Biological Materials Clones for UBE2G2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for UBE2G2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2G2 Gene
Localization for UBE2G2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| endoplasmic reticulum | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for UBE2G2 Gene
Pathways & Interactions for UBE2G2 Gene
Pathways by source for UBE2G2 Gene
3 BioSystems pathways for UBE2G2 Gene
8 Reactome pathways for UBE2G2 Gene
3 KEGG pathways for UBE2G2 Gene
1 GeneGo (Thomson Reuters) pathway for UBE2G2 Gene
1 R&D Systems pathway for UBE2G2 Gene
UniProtKB/Swiss-Prot P60604-UB2G2_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for UBE2G2 Gene
Selected Interacting proteins:
P60604-UB2G2_HUMAN
ENSP00000338348
for UBE2G2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for UBE2G2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | IBA | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | TAS | 9693041 |
| GO:0016567 | protein ubiquitination | TAS | -- |
| GO:0018279 | protein N-linked glycosylation via asparagine | IMP | 22607976 |
| GO:0030433 | ubiquitin-dependent ERAD pathway | IMP | 22607976 |
No data available for SIGNOR curated interactions for UBE2G2 Gene
Drugs & Compounds for UBE2G2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Drug Products
Transcripts for UBE2G2 Gene
mRNA/cDNA for UBE2G2 Gene
- (4) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (379) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000345496 3566 bps (uc002zfy.4)
- ENST00000481546 4340 bps (uc062atc.1)
- ENST00000497630 933 bps (uc062atd.1)
- ENST00000477954 1034 bps (uc062ate.1)
- ENST00000491513 744 bps (uc062atf.1)
Unigene Clusters for UBE2G2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for UBE2G2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2G2
- genomics-online: gRNA clones - Search results for 136 available UBE2G2 gene related products
- Overview of 136 available UBE2G2 gene related products
- Applied Biological Materials CRISPR for UBE2G2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2G2
- GenScript: Design CRISPR guide RNA sequences for UBE2G2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for UBE2G2
- Browse OriGene Inhibitory RNA Products For UBE2G2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2G2
- genomics-online: shRNA clones - Search results for 136 available UBE2G2 gene related products
- Overview of 136 available UBE2G2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for UBE2G2
- VectorBuilder custom plasmid, inducible vectors for UBE2G2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UBE2G2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for UBE2G2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2G2
- Applied Biological Materials Clones for UBE2G2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||
| SP8: |
Expression for UBE2G2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
This gene is overexpressed in Bone (15.8) and Breast (10.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2G2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of UBE2G2 Gene:
UBE2G2SOURCE GeneReport for Unigene cluster for UBE2G2 Gene:
Hs.529420Evidence on tissue expression from TISSUES for UBE2G2 Gene
- Heart(4)
- Lung(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for UBE2G2
-
OriGene qPCR primer pairs for UBE2G2
- genomics-online: primer clones - Search results for 136 available UBE2G2 gene related products
- Overview of 136 available UBE2G2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2G2 Gene
Orthologs for UBE2G2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | UBE2G2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | UBE2G2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | UBE2G2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | UBE2G2 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | UBE2G2 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ube2g2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ube2g2 33 |
|
||
| chicken (Gallus gallus) |
Aves | UBE2G2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | UBE2G2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ube2g2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ube2g2 34 33 |
|
OneToOne | |
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | crl 34 35 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002169 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ubc-14 34 35 33 |
|
OneToOne | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ABR059W 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E07745g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBC7 36 34 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| Cin.3185 33 |
|
||||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ubc7 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03623 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3185 33 |
|
- Species where no ortholog for UBE2G2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for UBE2G2 Gene
- ENSEMBL:
- Gene Tree for UBE2G2 (if available)
- TreeFam:
- Gene Tree for UBE2G2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UBE2G2: view image
Paralogs for UBE2G2 Gene
(25) SIMAP similar genes for UBE2G2 Gene using alignment to 3 proteins:
- UB2G2_HUMAN
- F8WCB9_HUMAN
- F8WDB1_HUMAN
Variants for UBE2G2 Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057518338 | uncertain-significance, not specified | 44,773,602(-) | C/T | coding_sequence_variant, stop_gained | |
| rs1000054107 | -- | 44,791,987(-) | A/G | intron_variant | |
| rs1000057767 | -- | 44,797,817(-) | C/A | intron_variant | |
| rs1000150315 | -- | 44,783,477(-) | A/G | intron_variant | |
| rs1000292866 | -- | 44,780,645(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3647135 | CNV | loss | 21293372 |
| nsv1116931 | CNV | deletion | 24896259 |
| nsv459298 | CNV | loss | 19166990 |
| nsv476892 | CNV | novel sequence insertion | 20440878 |
| nsv587813 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.07;
1.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UBE2G2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UBE2G2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2G2 Gene
Disorders for UBE2G2 Gene
Additional Disease Information for UBE2G2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for UBE2G2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2G2 Gene
Publications for UBE2G2 Gene
- Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene. (PMID: 9693041) Katsanis N … Fisher EM (Genomics 1998) 2 3 4 22 58
- Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7). (PMID: 16582478) Arai R … Yokoyama S (Acta crystallographica. Section F, Structural biology and crystallization communications 2006) 3 4 22 58
- STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PMID: 22607976) Sato T … Kai H (Molecular cell 2012) 3 4 58
- The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4 58
- Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2. (PMID: 20014027) Ju T … Tolman JR (Proteins 2010) 3 22 58
Products for UBE2G2 Gene
- Browse R&D Systems for Antibodies
- R&D Systems Proteins and Enzymes for UBE2G2
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for UBE2G2
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- Taconic Biosciences Mouse Models for UBE2G2
- Find your next knockout model in the Taconic Knockout Repository
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- Invitrogen Antibodies for UBE2G2
- Cyagen custom Knockout/knockin (KOKI) mouse models for UBE2G2
- VectorBuilder custom plasmid, inducible vectors for UBE2G2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
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- Addgene plasmids for UBE2G2
- antibodies-online: Search results for 91 available UBE2G2 Antibodies ranked by validation data
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- antibodies-online: Search results for available UBE2G2 related products ranked by validation data
- antibodies-online: Search results for 12 available UBE2G2 Proteins ranked by validation data
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- GeneTex UBE2G2 Antibody for UBE2G2
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- Santa Cruz Biotechnology (SCBT) Antibodies for UBE2G2
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- Santa Cruz Biotechnology (SCBT) CRISPR for UBE2G2
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- Horizon Cell Lines for UBE2G2
- genomics-online: cdna clones - Search results for 136 available UBE2G2 gene related products
- Overview of 136 available UBE2G2 gene related products
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- Overview of 136 available UBE2G2 gene related products
- genomics-online: gRNA clones - Search results for 136 available UBE2G2 gene related products
- Overview of 136 available UBE2G2 gene related products
- genomics-online: primer clones - Search results for 136 available UBE2G2 gene related products
- Overview of 136 available UBE2G2 gene related products
- genomics-online: shRNA clones - Search results for 136 available UBE2G2 gene related products
- Overview of 136 available UBE2G2 gene related products
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- GeneCopoeia miRNA 3'UTR Target clone products for UBE2G2
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Sources for UBE2G2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt