Aliases for UBE2G1 Gene
- Ubiquitin Conjugating Enzyme E2 G1 2 3 5
- Ubiquitin-Conjugating Enzyme E2G 1 (Homologous To C. Elegans UBC7) 2 3
- Ubiquitin-Conjugating Enzyme E2G 1 (UBC7 Homolog, C. Elegans) 2 3
- Ubiquitin-Conjugating Enzyme E2G 1 (UBC7 Homolog, Yeast) 2 3
- Ubiquitin-Conjugating Enzyme E2 G1 3 4
- E2 Ubiquitin-Conjugating Enzyme G1 3 4
- Ubiquitin Carrier Protein G1 3 4
External Ids for UBE2G1 Gene
Previous HGNC Symbols for UBE2G1 Gene
Previous GeneCards Identifiers for UBE2G1 Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for UBE2G1 Gene
UBE2G1 (Ubiquitin Conjugating Enzyme E2 G1) is a Protein Coding gene. Diseases associated with UBE2G1 include Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Metabolism of proteins and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2R2.
UniProtKB/Swiss-Prot Summary for UBE2G1 Gene
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.