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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]
UBE2G1 (Ubiquitin Conjugating Enzyme E2 G1) is a Protein Coding gene. Diseases associated with UBE2G1 include Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Ubiquitin mediated proteolysis. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is CDC34.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J004363 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 250.7 | +1.0 | 953 | 3.6 | TBP SP1 FEZF1 SIX5 NR2C1 MNT SMAD5 ETS1 IRF2 MBD2 | UBE2G1 RN7SL774P lnc-ANKFY1-4 ZNF594 CYB5D2 ANKFY1 | |
GH17J004367 | Promoter/Enhancer | 0.5 | Ensembl dbSUPER | 250.7 | -1.0 | -1025 | 0.2 | UBE2G1 piR-57460-268 SPNS3 | ||
GH17J004368 | Enhancer | 0.3 | Ensembl | 250.7 | -1.8 | -1826 | 0.2 | ZNF362 | UBE2G1 CYB5D2 piR-57460-268 SPNS3 | |
GH17J004323 | Enhancer | 0.4 | Ensembl | 14.2 | +42.8 | 42774 | 0.6 | CEBPA HNF4A NFIA | UBE2G1 ANKFY1 HSALNG0114006 lnc-CYB5D2-2 | |
GH17J003913 | Promoter/Enhancer | 2 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 2.7 | +451.2 | 451177 | 5 | SP1 DEK IKZF1 SMAD5 CTCF BHLHE40 ZIC2 SIN3A REST VEZF1 | P2RX1 ATP2A3 P2RX5 ZZEF1 UBE2G1 HSALNG0113989 CAMKK1 lnc-HASPIN-2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004842 | ubiquitin-protein transferase activity | IEA,IDA | 20061386 |
GO:0005515 | protein binding | IPI | 32814053 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Protein ubiquitination | ||
2 | Class I MHC mediated antigen processing and presentation | ||
3 | Metabolism of proteins | ||
4 | Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway |
Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
.97
|
|
5 | Prion disease |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000209 | protein polyubiquitination | IBA | 21873635 |
GO:0006511 | ubiquitin-dependent protein catabolic process | TAS,IBA | 21873635 |
GO:0016567 | protein ubiquitination | TAS | -- |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IBA | 21873635 |
GO:0044257 | cellular protein catabolic process | IMP | 21628527 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Platypus (Ornithorhynchus anatinus) |
Mammalia | UBE2G1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | UBE2G1 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | UBE2G1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ube2g1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ube2g1 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | UBE2G1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | UBE2G1 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | UBE2G1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | UBE2G1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ube2g1 30 |
|
||
MGC75869 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | ube2g1-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ube2g1a 30 31 |
|
OneToOne | |
wufi33c04 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9602 31 32 |
|
OneToMany | |
CG40045 30 31 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002251 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | ubc-7 31 32 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBC7 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | UBC13 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.3757 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os05g0460200 30 |
|
||
Os.12603 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.12670 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ubc15 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv509n67 | CNV | loss | 20364138 |
esv2660255 | CNV | deletion | 23128226 |
esv2715552 | CNV | deletion | 23290073 |
esv2762544 | CNV | gain | 21179565 |
esv3368111 | CNV | duplication | 20981092 |
esv3639772 | CNV | gain | 21293372 |
esv3639773 | CNV | gain | 21293372 |
esv3639774 | CNV | loss | 21293372 |
esv3892955 | CNV | gain | 25118596 |
nsv1058176 | CNV | gain | 25217958 |
nsv1065237 | CNV | gain | 25217958 |
nsv1066651 | CNV | gain | 25217958 |
nsv515940 | CNV | gain+loss | 19592680 |
nsv821134 | CNV | duplication | 20802225 |
nsv833345 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
leukoencephalopathy with vanishing white matter |
|
|