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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enz... See more...
Aliases for UBE2G1 Gene
Aliases for UBE2G1 Gene
- Ubiquitin Conjugating Enzyme E2 G1 2 3 5
- UBC7 2 3 4
- Ubiquitin-Conjugating Enzyme E2G 1 (Homologous To C. Elegans UBC7) 2 3
- Ubiquitin-Conjugating Enzyme E2G 1 (UBC7 Homolog, C. Elegans) 2 3
- Ubiquitin-Conjugating Enzyme E2G 1 (UBC7 Homolog, Yeast) 2 3
- Ubiquitin-Conjugating Enzyme E2 G1 3 4
- E2 Ubiquitin-Conjugating Enzyme G1 3 4
- Ubiquitin Carrier Protein G1 3 4
External Ids for UBE2G1 Gene
- HGNC: 12482
- NCBI Entrez Gene: 7326
- Ensembl: ENSG00000132388
- OMIM®: 601569
- UniProtKB/Swiss-Prot: P62253
Previous HGNC Symbols for UBE2G1 Gene
- UBE2G
Previous GeneCards Identifiers for UBE2G1 Gene
- GC17M004492
- GC17M004124
- GC17M004380
- GC17M004120
- GC17M004061
Summaries for UBE2G1 Gene
-
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for UBE2G1 Gene
UBE2G1 (Ubiquitin Conjugating Enzyme E2 G1) is a Protein Coding gene. Diseases associated with UBE2G1 include Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Ubiquitin mediated proteolysis. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is CDC34.
UniProtKB/Swiss-Prot Summary for UBE2G1 Gene
-
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.
Additional gene information for UBE2G1 Gene
- HGNC (12482)
- NCBI Entrez Gene (7326)
- Ensembl (ENSG00000132388)
- OMIM® (601569)
- UniProtKB/Swiss-Prot (P62253)
- Open Targets Platform(ENSG00000132388)
- Search for UBE2G1 at DataMed
- Search for UBE2G1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2G1 Gene
Genomics for UBE2G1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UBE2G1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J004363 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 250.7 | +1.0 | 953 | 3.6 | TBP SP1 FEZF1 SIX5 NR2C1 MNT SMAD5 ETS1 IRF2 MBD2 | UBE2G1 RN7SL774P lnc-ANKFY1-4 ZNF594 CYB5D2 ANKFY1 | |
| GH17J004367 | Promoter/Enhancer | 0.5 | Ensembl dbSUPER | 250.7 | -1.0 | -1025 | 0.2 | UBE2G1 piR-57460-268 SPNS3 | ||
| GH17J004368 | Enhancer | 0.3 | Ensembl | 250.7 | -1.8 | -1826 | 0.2 | ZNF362 | UBE2G1 CYB5D2 piR-57460-268 SPNS3 | |
| GH17J004323 | Enhancer | 0.4 | Ensembl | 14.2 | +42.8 | 42774 | 0.6 | CEBPA HNF4A NFIA | UBE2G1 ANKFY1 HSALNG0114006 lnc-CYB5D2-2 | |
| GH17J003913 | Promoter/Enhancer | 2 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 2.7 | +451.2 | 451177 | 5 | SP1 DEK IKZF1 SMAD5 CTCF BHLHE40 ZIC2 SIN3A REST VEZF1 | P2RX1 ATP2A3 P2RX5 ZZEF1 UBE2G1 HSALNG0113989 CAMKK1 lnc-HASPIN-2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UBE2G1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2G1
- Top Transcription factor binding sites by QIAGEN in the UBE2G1 gene promoter:
-
- AREB6
- Arnt
- LCR-F1
- MRF-2
- MyoD
- Pax-4a
- Pax-5
- POU2F1
- POU2F1a
- Roaz
Genomic Locations for UBE2G1 Gene
Latest Assembly
- chr17:4,269,259-4,366,675
- (GRCh38/hg38)
- Size:
- 97,417 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:4,172,554-4,269,970
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 97,417 bases
- Orientation:
- Minus strand
- chr17:4,172,554-4,269,923
- (GRCh37/hg19 by Ensembl)
- Size:
- 97,370 bases
- Orientation:
- Minus strand
Genomic View for UBE2G1 Gene
Genes around UBE2G1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.2 by HGNC
- 17p13.2 by Entrez Gene
- 17p13.2 by Ensembl
UBE2G1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UBE2G1 Gene
Proteins for UBE2G1 Gene
-
Protein details for UBE2G1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62253-UB2G1_HUMAN
- Recommended name:
- Ubiquitin-conjugating enzyme E2 G1
- Protein Accession:
- P62253
- B2R7P2
- D3DTK0
- Q99462
Protein attributes for UBE2G1 Gene
- Size:
- 170 amino acids
- Molecular mass:
- 19509 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH26288.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for UBE2G1 Gene
Selected DME Specific Peptides for UBE2G1 Gene
- P62253:
-
- GPPDTLYEGG
- FPKDYPL
- DSPANVDAAK
- VCISILH
Post-translational modifications for UBE2G1 Gene
- Autoubiquitinated in vitro.
-
Ubiquitination at Lys63, Lys73, Lys101, and Lys163
- NX_P62253 (NX_P62253-1)
- Modification sites at PhosphoSitePlus
Other Protein References for UBE2G1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ UBE2G1 Antibody
- GeneTex Anti-UBE2G1 antibody
-
Custom Antibody ServicesOriGene Antibodies for UBE2G1
- Novus Biologicals Antibodies for UBE2G1
-
Abcam antibodies for UBE2G1
- Invitrogen Antibodies for UBE2G1 (AFLGC-UBE2G1)
-
Custom Antibody ServicesProSci Antibodies for UBE2G1
-
Santa Cruz Biotechnology (SCBT) Antibodies for UBE2G1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for UBE2G1
- Origene Custom Protein Services for UBE2G1
- Sino Biological Recombinant Proteins for UBE2G1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for UBE2G1
- antibodies-online: Show 12 available Ube2g1 Proteins ranked by validation data
- Compare Top Ube2g1 Proteins
-
Quality Products:
-
Abcam proteins for UBE2G1
Assay products for research
Domains & Families for UBE2G1 Gene
Gene Families for UBE2G1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for UBE2G1 Gene
- InterPro:
- Blocks:
-
- Ubiquitin-conjugating enzymes
- ProtoNet:
Suggested Antigen Peptide Sequences for UBE2G1 Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquitin-protein ligase G1 (UB2G1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62253- Family:
-
- Belongs to the ubiquitin-conjugating enzyme family.
Function for UBE2G1 Gene
Molecular function for UBE2G1 Gene
- UniProtKB/Swiss-Prot Function:
- Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133, ECO:0000269|PubMed:20061386};.
- GENATLAS Biochemistry:
- ubiquitin conjugating enzyme E2G,highly homolog to C elegans UBC7,highly expressed in skeletal muscle
Enzyme Numbers (IUBMB) for UBE2G1 Gene
Phenotypes From GWAS Catalog for UBE2G1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | IEA,IDA | 20061386 |
| GO:0005515 | protein binding | IPI | 32814053 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for UBE2G1 Gene
- MGI mutant phenotypes for UBE2G1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for UBE2G1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability after Maraba virus infection
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
Animal Models for UBE2G1 Gene
- MGI Knock Outs for UBE2G1:
-
- Ube2g1 Ube2g1<tm1b(EUCOMM)Hmgu>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for UBE2G1 - Starting at $85 >
- * UBE2G1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for UBE2G1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2G1
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2G1
miRNA for UBE2G1 Gene
- miRTarBase miRNAs that target UBE2G1
-
- rno-miR-199a-5p (MIRT006531)
- hsa-miR-18a-5p (MIRT031342)
- hsa-miR-1226-3p (MIRT036424)
- hsa-miR-320a (MIRT044475)
- hsa-miR-4521 (MIRT146128)
- hsa-miR-6826-5p (MIRT146169)
- hsa-miR-3158-5p (MIRT197208)
- hsa-miR-1827 (MIRT398942)
- hsa-miR-6866-5p (MIRT398943)
- hsa-miR-155-5p (MIRT439362)
- hsa-miR-2467-3p (MIRT464763)
- hsa-miR-6800-5p (MIRT464764)
- hsa-miR-539-5p (MIRT464765)
- hsa-miR-1252-5p (MIRT464766)
- hsa-miR-17-3p (MIRT464767)
- hsa-miR-1205 (MIRT464768)
- hsa-miR-1184 (MIRT464769)
- hsa-miR-3919 (MIRT464770)
- hsa-miR-6511a-5p (MIRT464771)
- hsa-miR-1910-3p (MIRT464772)
- hsa-miR-4759 (MIRT464773)
- hsa-miR-5197-3p (MIRT464774)
- hsa-miR-338-5p (MIRT464775)
- hsa-miR-4517 (MIRT464776)
- hsa-miR-6507-5p (MIRT464777)
- hsa-miR-548c-3p (MIRT464778)
- hsa-miR-493-5p (MIRT464779)
- hsa-miR-5703 (MIRT464780)
- hsa-miR-4516 (MIRT464781)
- hsa-miR-4434 (MIRT464782)
- hsa-miR-4693-3p (MIRT464783)
- hsa-miR-6770-5p (MIRT464784)
- hsa-miR-4712-3p (MIRT464785)
- hsa-miR-6891-5p (MIRT464786)
- hsa-miR-3154 (MIRT464787)
- hsa-miR-3173-3p (MIRT464788)
- hsa-miR-4428 (MIRT464789)
- hsa-miR-620 (MIRT553166)
- hsa-miR-1270 (MIRT553167)
- hsa-miR-4531 (MIRT553168)
- hsa-miR-514b-5p (MIRT553169)
- hsa-miR-513c-5p (MIRT553170)
- hsa-miR-139-3p (MIRT553171)
- hsa-miR-4725-5p (MIRT553172)
- hsa-miR-4670-3p (MIRT553173)
- hsa-miR-345-3p (MIRT553174)
- mmu-miR-1953 (MIRT580132)
- hsa-miR-27b-3p (MIRT726197)
- hsa-miR-27a-3p (MIRT726198)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBE2G1
- Browse OriGene Inhibitory RNA Products For UBE2G1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2G1
Clone products for research
- Applied Biological Materials (abm): Clones for UBE2G1 - Starting at $45 >
- * UBE2G1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for UBE2G1
- Addgene plasmids for UBE2G1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2G1
Cell Lines for research
-
Horizon Cell Lines for UBE2G1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2G1 Gene
Localization for UBE2G1 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2G1 Gene
Pathways & Interactions for UBE2G1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Protein ubiquitination | ||
| 2 | Class I MHC mediated antigen processing and presentation | ||
| 3 | Metabolism of proteins | ||
| 4 | Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway |
Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
.97
|
|
| 5 | Prion disease | ||
Pathways by source for UBE2G1 Gene
2 BioSystems pathways for UBE2G1 Gene
8 Reactome pathways for UBE2G1 Gene
4 KEGG pathways for UBE2G1 Gene
1 GeneGo (Thomson Reuters) pathway for UBE2G1 Gene
- Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
1 R&D Systems pathway for UBE2G1 Gene
2 Qiagen pathways for UBE2G1 Gene
- Remodeling of Adherens Junctions
- Ubiquitin-Proteasome Dependent Proteolysis
UniProtKB/Swiss-Prot P62253-UB2G1_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for UBE2G1 Gene
Selected Interacting proteins:
P62253-UB2G1_HUMAN
ENSP00000380178
for UBE2G1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for UBE2G1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | IBA | 21873635 |
| GO:0006511 | ubiquitin-dependent protein catabolic process | TAS,IBA | 21873635 |
| GO:0016567 | protein ubiquitination | TAS | -- |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IBA | 21873635 |
| GO:0044257 | cellular protein catabolic process | IMP | 21628527 |
No data available for SIGNOR curated interactions for UBE2G1 Gene
Drugs & Compounds for UBE2G1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for UBE2G1 Gene
mRNA/cDNA for UBE2G1 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000396981 3974 nts (view in UCSC)
- ENST00000571953 553 nts (view in UCSC)
- ENST00000571980 984 nts (view in UCSC)
- ENST00000572484 1514 nts (view in UCSC)
- ENST00000574059 569 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for UBE2G1 - Starting at $85 >
- * UBE2G1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for UBE2G1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2G1
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2G1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBE2G1
- Browse OriGene Inhibitory RNA Products For UBE2G1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2G1
Clone products for research
- Applied Biological Materials (abm): Clones for UBE2G1 - Starting at $45 >
- * UBE2G1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for UBE2G1
- Addgene plasmids for UBE2G1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2G1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||
| SP6: |
Relevant External Links for UBE2G1 Gene
- GeneLoc Exon Structure for
- UBE2G1
Expression for UBE2G1 Gene
mRNA differential expression in normal tissues according to GTEx for UBE2G1 Gene
This gene is overexpressed in Muscle - Skeletal (x5.5).
This gene is overexpressed in Plasma (10.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2G1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2G1
SOURCE GeneReport for Unigene cluster for UBE2G1 Gene:
Hs.741319mRNA Expression by UniProt/SwissProt for UBE2G1 Gene:
P62253-UB2G1_HUMAN
Tissue specificity:
Widely expressed, mainly in skeletal muscle.
Evidence on tissue expression from TISSUES for UBE2G1 Gene
- Nervous system(4.7)
- Blood(4.4)
- Muscle(2.7)
- Heart(2)
Primer products for research
-
OriGene qPCR primer pairs for UBE2G1
-
OriGene qPCR primer pairs and template standards for UBE2G1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2G1 Gene
Orthologs for UBE2G1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | UBE2G1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | UBE2G1 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | UBE2G1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ube2g1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ube2g1 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | UBE2G1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | UBE2G1 30 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | UBE2G1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | UBE2G1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ube2g1 30 |
|
||
| MGC75869 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | ube2g1-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ube2g1a 30 31 |
|
OneToOne | |
| wufi33c04 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG9602 31 32 |
|
OneToMany | |
| CG40045 30 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002251 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | ubc-7 31 32 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBC7 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | UBC13 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.3757 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os05g0460200 30 |
|
||
| Os.12603 30 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.12670 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ubc15 30 |
|
- Species where no ortholog for UBE2G1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for UBE2G1 Gene
- ENSEMBL:
- Gene Tree for UBE2G1 (if available)
- TreeFam:
- Gene Tree for UBE2G1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UBE2G1: view image
Paralogs for UBE2G1 Gene
Paralogs for UBE2G1 Gene
(25) SIMAP similar genes for UBE2G1 Gene using alignment to 5 proteins:
- UB2G1_HUMAN
- I3L0Q0_HUMAN
- I3L2H7_HUMAN
- I3L2Q4_HUMAN
- K7EPR7_HUMAN
Pseudogenes.org Pseudogenes for UBE2G1 Gene
Variants for UBE2G1 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv509n67 | CNV | loss | 20364138 |
| esv2660255 | CNV | deletion | 23128226 |
| esv2715552 | CNV | deletion | 23290073 |
| esv2762544 | CNV | gain | 21179565 |
| esv3368111 | CNV | duplication | 20981092 |
| esv3639772 | CNV | gain | 21293372 |
| esv3639773 | CNV | gain | 21293372 |
| esv3639774 | CNV | loss | 21293372 |
| esv3892955 | CNV | gain | 25118596 |
| nsv1058176 | CNV | gain | 25217958 |
| nsv1065237 | CNV | gain | 25217958 |
| nsv1066651 | CNV | gain | 25217958 |
| nsv515940 | CNV | gain+loss | 19592680 |
| nsv821134 | CNV | duplication | 20802225 |
| nsv833345 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.11;
2.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UBE2G1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UBE2G1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2G1 Gene
Disorders for UBE2G1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukoencephalopathy with vanishing white matter |
|
|
Search UBE2G1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UBE2G1
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2G1 Gene
Publications for UBE2G1 Gene
- Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans. (PMID: 8893823) Watanabe TK … Takahashi E (Cytogenetics and cell genetics 1996) 2 3 4
- The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4
- Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. (PMID: 12933904) Kim BW … Bianco AC (Molecular endocrinology (Baltimore, Md.) 2003) 3 23
ExternalLinks
Products for UBE2G1 Gene
- Custom Antibody ServicesOriGene Antibodies for UBE2G1
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- antibodies-online: Show 23 available Ube2g1 Antibodies ranked by validation data
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Sources for UBE2G1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (128) SNPedia
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB