Aliases for UBE2F Gene

Aliases for UBE2F Gene

  • Ubiquitin Conjugating Enzyme E2 F (Putative) 2 3 5
  • NCE2 2 3 4
  • Ubiquitin-Conjugating Enzyme E2F (Putative) 2 3
  • RING-Type E3 NEDD8 Transferase UBE2F 3 4
  • NEDD8-Conjugating Enzyme UBE2F 3 4
  • NEDD8 Carrier Protein UBE2F 3 4
  • NEDD8 Protein Ligase UBE2F 3 4
  • NEDD8-Conjugating Enzyme 2 3 4
  • Ubiquitin-Conjugating Enzyme E2 F 4
  • NEDD8 Conjugating Enzyme 2
  • EC 2.3.2.32 4
  • EC 6.3.2 50
  • UBE2F 5

External Ids for UBE2F Gene

Previous GeneCards Identifiers for UBE2F Gene

  • GC00U990541
  • GC02P238658
  • GC02P238540
  • GC02P238875
  • GC02P230667
  • GC02P237967
  • GC02P237969
  • GC02P237979
  • GC02P237980
  • GC02P237978
  • GC02P237976
  • GC02P237970
  • GC02P237971
  • GC02P237972
  • GC02P237973
  • GC02P237974
  • GC02P237975
  • GC02P237977
  • GC02P237984

Summaries for UBE2F Gene

GeneCards Summary for UBE2F Gene

UBE2F (Ubiquitin Conjugating Enzyme E2 F (Putative)) is a Protein Coding gene. Diseases associated with UBE2F include Brachydactyly, Type E2. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2F-SCLY.

UniProtKB/Swiss-Prot Summary for UBE2F Gene

  • Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2F Gene

Genomics for UBE2F Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UBE2F Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J237963 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 274.8 -0.1 -52 6.2 BCLAF1 SP1 ZNF207 ZNF654 ZNF600 NCOR1 MYC IKZF1 ZNF592 KLF9 UBE2F UBE2F-SCLY lnc-ILKAP-5 ILKAP SCLY ENSG00000227252 RAMP1 TRAF3IP1 ENSG00000225057 ESPNL
GH02J238024 Promoter/Enhancer 0.8 EPDnew Ensembl ENCODE 250.2 +58.4 58433 0.8 BHLHE40 UBE2F HSALNG0023396 SCLY UBE2F-SCLY
GH02J238043 Promoter 0.3 EPDnew 250.2 +74.5 74502 0.1 piR-50044 UBE2F RF00026-601 RNU6-1333P SCLY UBE2F-SCLY
GH02J238041 Promoter 0.3 EPDnew 250.2 +74.7 74668 0.1 piR-50044 UBE2F RF00026-601 RNU6-1333P SCLY UBE2F-SCLY
GH02J238042 Promoter 0.3 EPDnew 250.2 +75.4 75399 0.1 piR-50044 UBE2F SCLY HSALNG0023397 UBE2F-SCLY
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2F on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2F

Top Transcription factor binding sites by QIAGEN in the UBE2F gene promoter:
  • AML1a
  • CBF(2)
  • FOXD1
  • GATA-6
  • HNF-3beta
  • LUN-1
  • NF-Y
  • RORalpha2
  • TBP
  • TFIID

Genomic Locations for UBE2F Gene

Latest Assembly
chr2:237,966,827-238,042,782
(GRCh38/hg38)
Size:
75,956 bases
Orientation:
Plus strand

Previous Assembly
chr2:238,875,656-238,951,423
(GRCh37/hg19 by Entrez Gene)
Size:
75,768 bases
Orientation:
Plus strand

chr2:238,875,469-238,951,236
(GRCh37/hg19 by Ensembl)
Size:
75,768 bases
Orientation:
Plus strand

Genomic View for UBE2F Gene

Genes around UBE2F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2F Gene

Proteins for UBE2F Gene

  • Protein details for UBE2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969M7-UBE2F_HUMAN
    Recommended name:
    NEDD8-conjugating enzyme UBE2F
    Protein Accession:
    Q969M7
    Secondary Accessions:
    • A8K1Z8
    • B4DDT9
    • B4DFI1
    • B4DMK3
    • B4DZU2
    • B8ZZG2
    • C9J212
    • H9KVB9

    Protein attributes for UBE2F Gene

    Size:
    185 amino acids
    Molecular mass:
    21077 Da
    Quaternary structure:
    • Interacts with UBA3 and RBX2 (PubMed:19250909). Interacts (N-terminally acetylated form) with (via DCUN1 domain) DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5 (PubMed:23201271).

    Three dimensional structures from OCA and Proteopedia for UBE2F Gene

    Alternative splice isoforms for UBE2F Gene

neXtProt entry for UBE2F Gene

Selected DME Specific Peptides for UBE2F Gene

Q969M7:
  • GGKFQFE
  • IWHPNITETGEICLSLLREHS
  • DGTGWAPTRTLKDVVWGLNSLFTDLLNF
  • AYNMVPPKVKCLT
  • EVAELEANLP
  • DPLNIEAAEHHL

Post-translational modifications for UBE2F Gene

  • The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UBE2F Gene

Gene Families for UBE2F Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for UBE2F Gene

InterPro:
Blocks:
  • Ubiquitin-conjugating enzymes

Suggested Antigen Peptide Sequences for UBE2F Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-conjugating enzyme E2 F (UBE2F_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969M7

UniProtKB/Swiss-Prot:

UBE2F_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
genes like me logo Genes that share domains with UBE2F: view

Function for UBE2F Gene

Molecular function for UBE2F Gene

UniProtKB/Swiss-Prot Function:
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.; EC=2.3.2.32; Evidence={ECO:0000269|PubMed:23201271};.

Enzyme Numbers (IUBMB) for UBE2F Gene

Phenotypes From GWAS Catalog for UBE2F Gene

Gene Ontology (GO) - Molecular Function for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 19250909
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0019788 NEDD8 transferase activity TAS --
genes like me logo Genes that share ontologies with UBE2F: view
genes like me logo Genes that share phenotypes with UBE2F: view

Animal Models for research

  • Taconic Biosciences Mouse Models for UBE2F

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2F

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2F Gene

Localization for UBE2F Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2F gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2F: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2F Gene

Pathways & Interactions for UBE2F Gene

genes like me logo Genes that share pathways with UBE2F: view

Pathways by source for UBE2F Gene

1 R&D Systems pathway for UBE2F Gene
2 Qiagen pathways for UBE2F Gene
  • Remodeling of Adherens Junctions
  • Ubiquitin-Proteasome Dependent Proteolysis

UniProtKB/Swiss-Prot Q969M7-UBE2F_HUMAN

  • Pathway: Protein modification; protein neddylation.

Gene Ontology (GO) - Biological Process for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0018215 protein phosphopantetheinylation IEA --
GO:0043687 post-translational protein modification TAS --
GO:0045116 protein neddylation IBA,IEA --
genes like me logo Genes that share ontologies with UBE2F: view

No data available for SIGNOR curated interactions for UBE2F Gene

Drugs & Compounds for UBE2F Gene

(3) Drugs for UBE2F Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for UBE2F Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8
genes like me logo Genes that share compounds with UBE2F: view

Transcripts for UBE2F Gene

mRNA/cDNA for UBE2F Gene

5 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2F

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2F Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3:

Relevant External Links for UBE2F Gene

GeneLoc Exon Structure for
UBE2F

Expression for UBE2F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2F Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.9) and Platelet (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2F Gene



Protein tissue co-expression partners for UBE2F Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2F

SOURCE GeneReport for Unigene cluster for UBE2F Gene:

Hs.471785

mRNA Expression by UniProt/SwissProt for UBE2F Gene:

Q969M7-UBE2F_HUMAN
Tissue specificity: Widely expressed (at protein level).

Evidence on tissue expression from TISSUES for UBE2F Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with UBE2F: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2F Gene

Orthologs for UBE2F Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2F Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia UBE2F 29
  • 99.82 (n)
-- 30
  • 42 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 97 (a)
OneToMany
UBE2F 29
  • 92.25 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 93 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ube2f 29 16 30
  • 92.25 (n)
ManyToMany
Gm5434 30
  • 89 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Ube2f 29
  • 91.62 (n)
Cow
(Bos Taurus)
Mammalia UBE2F 29 30
  • 90.63 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 67 (a)
OneToMany
Chicken
(Gallus gallus)
Aves UBE2F 29 30
  • 85.95 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 91 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ube2f 29
  • 78.56 (n)
Str.15431 29
Zebrafish
(Danio rerio)
Actinopterygii ube2f 29 30
  • 74.05 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012193 29
  • 57.66 (n)
Worm
(Caenorhabditis elegans)
Secernentea ubc-12 29 30
  • 52.69 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC12 30
  • 28 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3148 30
  • 48 (a)
OneToMany
Species where no ortholog for UBE2F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UBE2F Gene

ENSEMBL:
Gene Tree for UBE2F (if available)
TreeFam:
Gene Tree for UBE2F (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2F: view image
Alliance of Genome Resources:
Additional Orthologs for UBE2F

Paralogs for UBE2F Gene

(17) SIMAP similar genes for UBE2F Gene using alignment to 15 proteins:

  • UBE2F_HUMAN
  • C9IZ93_HUMAN
  • C9J212_HUMAN
  • C9J9P8_HUMAN
  • C9JF62_HUMAN
  • C9JFD2_HUMAN
  • C9JSK8_HUMAN
  • F2Z363_HUMAN
  • F8WB39_HUMAN
  • F8WCT3_HUMAN
  • F8WD80_HUMAN
  • F8WDQ9_HUMAN
  • F8WFB7_HUMAN
  • G5E9R6_HUMAN
  • H9KVB9_HUMAN

Pseudogenes.org Pseudogenes for UBE2F Gene

genes like me logo Genes that share paralogs with UBE2F: view

Variants for UBE2F Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UBE2F Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UBE2F Gene

Variant ID Type Subtype PubMed ID
dgv4193n100 CNV gain 25217958
nsv1000252 CNV loss 25217958
nsv1011723 CNV gain 25217958
nsv214866 CNV deletion 16902084
nsv508205 CNV deletion 20534489
nsv979190 CNV duplication 23825009

Variation tolerance for UBE2F Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2F Gene

Human Gene Mutation Database (HGMD)
UBE2F
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2F
Leiden Open Variation Database (LOVD)
UBE2F

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2F Gene

Disorders for UBE2F Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBE2F Gene - From: COP

Disorder Aliases PubMed IDs
brachydactyly, type e2
  • bde2
- elite association - COSMIC cancer census association via MalaCards
Search UBE2F in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UBE2F

genes like me logo Genes that share disorders with UBE2F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2F Gene

Publications for UBE2F Gene

  1. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PMID: 19250909) Huang DT … Schulman BA (Molecular cell 2009) 2 3 4 22
  2. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PMID: 23201271) Monda JK … Schulman BA (Structure (London, England : 1993) 2013) 2 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for UBE2F Gene

Sources for UBE2F Gene