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Aliases for UBE2F Gene
Aliases for UBE2F Gene
External Ids for UBE2F Gene
- HGNC: 12480
- NCBI Entrez Gene: 140739
- Ensembl: ENSG00000184182
- OMIM®: 617700
- UniProtKB/Swiss-Prot: Q969M7
Previous GeneCards Identifiers for UBE2F Gene
- GC00U990541
- GC02P238658
- GC02P238540
- GC02P238875
- GC02P230667
- GC02P237967
- GC02P237969
- GC02P237979
- GC02P237980
- GC02P237978
- GC02P237976
- GC02P237970
- GC02P237971
- GC02P237972
- GC02P237973
- GC02P237974
- GC02P237975
- GC02P237977
- GC02P237984
Summaries for UBE2F Gene
GeneCards Summary for UBE2F Gene
UBE2F (Ubiquitin Conjugating Enzyme E2 F (Putative)) is a Protein Coding gene. Diseases associated with UBE2F include Brachydactyly, Type E2. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2F-SCLY.
UniProtKB/Swiss-Prot Summary for UBE2F Gene
-
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
Additional gene information for UBE2F Gene
- HGNC (12480)
- NCBI Entrez Gene (140739)
- Ensembl (ENSG00000184182)
- OMIM® (617700)
- UniProtKB/Swiss-Prot (Q969M7)
- Open Targets Platform(ENSG00000184182)
- Alliance of Genome Resources
- Search for UBE2F at DataMed
- Search for UBE2F at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2F Gene
Genomics for UBE2F Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UBE2F Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J237963 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas | 274.8 | -0.1 | -52 | 6.2 | BCLAF1 SP1 ZNF207 ZNF654 ZNF600 NCOR1 MYC IKZF1 ZNF592 KLF9 | UBE2F UBE2F-SCLY lnc-ILKAP-5 ILKAP SCLY ENSG00000227252 RAMP1 TRAF3IP1 ENSG00000225057 ESPNL | |
| GH02J238024 | Promoter/Enhancer | 0.8 | EPDnew Ensembl ENCODE | 250.2 | +58.4 | 58433 | 0.8 | BHLHE40 | UBE2F HSALNG0023396 SCLY UBE2F-SCLY | |
| GH02J238043 | Promoter | 0.3 | EPDnew | 250.2 | +74.5 | 74502 | 0.1 | piR-50044 UBE2F RF00026-601 RNU6-1333P SCLY UBE2F-SCLY | ||
| GH02J238041 | Promoter | 0.3 | EPDnew | 250.2 | +74.7 | 74668 | 0.1 | piR-50044 UBE2F RF00026-601 RNU6-1333P SCLY UBE2F-SCLY | ||
| GH02J238042 | Promoter | 0.3 | EPDnew | 250.2 | +75.4 | 75399 | 0.1 | piR-50044 UBE2F SCLY HSALNG0023397 UBE2F-SCLY |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UBE2F on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2F
- Top Transcription factor binding sites by QIAGEN in the UBE2F gene promoter:
-
- AML1a
- CBF(2)
- FOXD1
- GATA-6
- HNF-3beta
- LUN-1
- NF-Y
- RORalpha2
- TBP
- TFIID
Genomic Locations for UBE2F Gene
Latest Assembly
- chr2:237,966,827-238,042,782
- (GRCh38/hg38)
- Size:
- 75,956 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:238,875,656-238,951,423
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 75,768 bases
- Orientation:
- Plus strand
Genomic View for UBE2F Gene
Genes around UBE2F on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.3 by HGNC
- 2q37.3 by Entrez Gene
- 2q37.3 by Ensembl
UBE2F Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UBE2F Gene
Proteins for UBE2F Gene
-
Protein details for UBE2F Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969M7-UBE2F_HUMAN
- Recommended name:
- NEDD8-conjugating enzyme UBE2F
- Protein Accession:
- Q969M7
- A8K1Z8
- B4DDT9
- B4DFI1
- B4DMK3
- B4DZU2
- B8ZZG2
- C9J212
- H9KVB9
Protein attributes for UBE2F Gene
- Size:
- 185 amino acids
- Molecular mass:
- 21077 Da
- Quaternary structure:
-
- Interacts with UBA3 and RBX2 (PubMed:19250909). Interacts (N-terminally acetylated form) with (via DCUN1 domain) DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5 (PubMed:23201271).
Protein Expression for UBE2F Gene
Selected DME Specific Peptides for UBE2F Gene
- Q969M7:
-
- GGKFQFE
- IWHPNITETGEICLSLLREHS
- DGTGWAPTRTLKDVVWGLNSLFTDLLNF
- AYNMVPPKVKCLT
- EVAELEANLP
- DPLNIEAAEHHL
Post-translational modifications for UBE2F Gene
- The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for UBE2F Gene
- ENSEMBL proteins:
-
- ENSP00000409749
- ENSP00000412965
- ENSP00000272930
- ENSP00000399183
- ENSP00000410867
- ENSP00000396003
- ENSP00000390813
- ENSP00000387299
- ENSP00000389685
- ENSP00000408823
- ENSP00000396296
- ENSP00000410345
- ENSP00000396630
- ENSP00000408676
- ENSP00000393515
- ENSP00000386680
- ENSP00000387060
- ENSP00000406113
- ENSP00000478474
- ENSP00000414619
- Q969M7.158
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences UBE2F Antibody
-
Custom Antibody ServicesOriGene Antibodies for UBE2F
- Novus Biologicals Antibodies for UBE2F
-
Abcam antibodies for UBE2F
- Invitrogen Antibodies for UBE2F (AFLGC-UBE2F)
-
Biorbyt antibodies for UBE2F
-
Boster Bio Antibodies for UBE2F
-
Custom Antibody ServicesProSci Antibodies for UBE2F
-
Santa Cruz Biotechnology (SCBT) Antibodies for UBE2F
- Sino Biological Antibodies for UBE2F
Protein products for research
-
OriGene Purified Proteins for UBE2F
- Search Origene for MassSpec and Protein Over-expression Lysates for UBE2F
- Origene Custom Protein Services for UBE2F
- Sino Biological Recombinant Proteins for UBE2F
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for UBE2F
-
Abcam proteins for UBE2F
Assay products for research
- RayBiotech Custom Human UBE2F ELISA
Domains & Families for UBE2F Gene
Gene Families for UBE2F Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for UBE2F Gene
- InterPro:
- Blocks:
-
- Ubiquitin-conjugating enzymes
Suggested Antigen Peptide Sequences for UBE2F Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquitin-conjugating enzyme E2 F (UBE2F_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q969M7UniProtKB/Swiss-Prot:
UBE2F_HUMAN :- Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
- Family:
-
- Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
Function for UBE2F Gene
Molecular function for UBE2F Gene
- UniProtKB/Swiss-Prot Function:
- Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.; EC=2.3.2.32; Evidence={ECO:0000269|PubMed:23201271};.
Enzyme Numbers (IUBMB) for UBE2F Gene
Phenotypes From GWAS Catalog for UBE2F Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 19250909 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0019788 | NEDD8 transferase activity | TAS | -- |
Phenotypes for UBE2F Gene
- MGI mutant phenotypes for UBE2F:
-
inferred from 1 alleles
- nervous system phenotype
- growth/size/body region phenotype
- cardiovascular system phenotype
- immune system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for UBE2F:
-
- Increased vaccinia virus (VACV) infection
- Increased G1 DNA content
- Decreased viability
- no effect
- Inconclusive
- Decreased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased Cyt C expression
Animal Models for research
-
Taconic Biosciences Mouse Models for UBE2F
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for UBE2F - Starting at $85 >
- * UBE2F CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for UBE2F
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2F
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2F
miRNA for UBE2F Gene
- miRTarBase miRNAs that target UBE2F
-
- hsa-miR-335-5p (MIRT004083)
- hsa-miR-129-5p (MIRT006660)
- hsa-miR-129-2-3p (MIRT006661)
- hsa-miR-615-3p (MIRT040036)
- hsa-miR-6516-5p (MIRT464790)
- hsa-miR-455-3p (MIRT464791)
- hsa-miR-1273g-5p (MIRT464792)
- hsa-miR-656-5p (MIRT464793)
- hsa-miR-6851-5p (MIRT464794)
- hsa-miR-876-3p (MIRT464795)
- hsa-miR-3689d (MIRT464796)
- hsa-miR-6134 (MIRT464797)
- hsa-miR-1233-3p (MIRT464798)
- hsa-miR-1225-3p (MIRT464799)
- hsa-miR-6840-3p (MIRT464800)
- hsa-miR-4459 (MIRT464801)
- hsa-miR-665 (MIRT464802)
- hsa-miR-320e (MIRT464803)
- hsa-miR-6513-5p (MIRT633877)
- hsa-miR-887-5p (MIRT633878)
- hsa-miR-3913-5p (MIRT633879)
- hsa-miR-3122 (MIRT633880)
- hsa-miR-450a-1-3p (MIRT633881)
- hsa-miR-5089-5p (MIRT633882)
- hsa-miR-6728-5p (MIRT633883)
- hsa-miR-769-3p (MIRT633884)
- hsa-miR-450b-3p (MIRT633885)
- hsa-miR-7977 (MIRT633886)
- hsa-miR-5187-5p (MIRT633887)
- hsa-miR-383-3p (MIRT633888)
- hsa-miR-3922-5p (MIRT633889)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBE2F
- Browse OriGene Inhibitory RNA Products For UBE2F
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2F
Clone products for research
- Applied Biological Materials (abm): Clones for UBE2F - Starting at $45 >
- * UBE2F as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for UBE2F
- Addgene plasmids for UBE2F
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2F
Cell Lines for research
-
Horizon Cell Lines for UBE2F
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2F Gene
Localization for UBE2F Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| extracellular | 2 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2F Gene
Pathways & Interactions for UBE2F Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Ubiquitin mediated proteolysis | ||
| 3 | Protein ubiquitination | ||
| 4 | Remodeling of Adherens Junctions |
Remodeling of Adherens Junctions
-
|
|
| 5 | Ubiquitin-Proteasome Dependent Proteolysis |
Ubiquitin-Proteasome Dependent Proteolysis
-
|
|
Pathways by source for UBE2F Gene
2 BioSystems pathways for UBE2F Gene
4 Reactome pathways for UBE2F Gene
1 KEGG pathway for UBE2F Gene
1 R&D Systems pathway for UBE2F Gene
2 Qiagen pathways for UBE2F Gene
- Remodeling of Adherens Junctions
- Ubiquitin-Proteasome Dependent Proteolysis
UniProtKB/Swiss-Prot Q969M7-UBE2F_HUMAN
- Pathway: Protein modification; protein neddylation.
Interacting Proteins for UBE2F Gene
Selected Interacting proteins:
Q969M7-UBE2F_HUMAN
ENSP00000478474
for UBE2F Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for UBE2F
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | IBA | -- |
| GO:0018215 | protein phosphopantetheinylation | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
| GO:0045116 | protein neddylation | IBA,IEA | -- |
No data available for SIGNOR curated interactions for UBE2F Gene
Drugs & Compounds for UBE2F Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for UBE2F Gene
mRNA/cDNA for UBE2F Gene
- 5 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000272930 2137 nts (view in UCSC)
- ENST00000409332 1138 nts (view in UCSC)
- ENST00000409633 837 nts (view in UCSC)
- ENST00000409953 924 nts (view in UCSC)
- ENST00000414443 2100 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for UBE2F - Starting at $85 >
- * UBE2F CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for UBE2F
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2F
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2F
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBE2F
- Browse OriGene Inhibitory RNA Products For UBE2F
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2F
Clone products for research
- Applied Biological Materials (abm): Clones for UBE2F - Starting at $45 >
- * UBE2F as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for UBE2F
- Addgene plasmids for UBE2F
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2F
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: |
Relevant External Links for UBE2F Gene
- GeneLoc Exon Structure for
- UBE2F
Expression for UBE2F Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
This gene is overexpressed in Peripheral blood mononuclear cells (16.9) and Platelet (9.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2F Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2F
SOURCE GeneReport for Unigene cluster for UBE2F Gene:
Hs.471785mRNA Expression by UniProt/SwissProt for UBE2F Gene:
Q969M7-UBE2F_HUMAN
Tissue specificity:
Widely expressed (at protein level).
Evidence on tissue expression from TISSUES for UBE2F Gene
- Nervous system(4.7)
Primer products for research
-
OriGene qPCR primer pairs for UBE2F
-
OriGene qPCR primer pairs and template standards for UBE2F
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2F Gene
Orthologs for UBE2F Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | UBE2F 29 |
|
||
| -- 30 |
|
ManyToMany | |||
| Dog (Canis familiaris) |
Mammalia | -- 30 |
|
OneToMany | |
| UBE2F 29 |
|
||||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Ube2f 29 16 30 |
|
ManyToMany | |
| Gm5434 30 |
|
ManyToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Ube2f 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | UBE2F 29 30 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 30 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | UBE2F 29 30 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ube2f 29 |
|
||
| Str.15431 29 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | ube2f 29 30 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012193 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | ubc-12 29 30 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBC12 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3148 30 |
|
OneToMany |
- Species where no ortholog for UBE2F was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for UBE2F Gene
- ENSEMBL:
- Gene Tree for UBE2F (if available)
- TreeFam:
- Gene Tree for UBE2F (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UBE2F: view image
- Alliance of Genome Resources:
- Additional Orthologs for UBE2F
Paralogs for UBE2F Gene
Paralogs for UBE2F Gene
(17) SIMAP similar genes for UBE2F Gene using alignment to 15 proteins:
- UBE2F_HUMAN
- C9IZ93_HUMAN
- C9J212_HUMAN
- C9J9P8_HUMAN
- C9JF62_HUMAN
- C9JFD2_HUMAN
- C9JSK8_HUMAN
- F2Z363_HUMAN
- F8WB39_HUMAN
- F8WCT3_HUMAN
- F8WD80_HUMAN
- F8WDQ9_HUMAN
- F8WFB7_HUMAN
- G5E9R6_HUMAN
- H9KVB9_HUMAN
Pseudogenes.org Pseudogenes for UBE2F Gene
Variants for UBE2F Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4193n100 | CNV | gain | 25217958 |
| nsv1000252 | CNV | loss | 25217958 |
| nsv1011723 | CNV | gain | 25217958 |
| nsv214866 | CNV | deletion | 16902084 |
| nsv508205 | CNV | deletion | 20534489 |
| nsv979190 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UBE2F Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2F Gene
Disorders for UBE2F Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| brachydactyly, type e2 |
|
|
Search UBE2F in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UBE2F
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2F Gene
Publications for UBE2F Gene
- E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PMID: 19250909) Huang DT … Schulman BA (Molecular cell 2009) 2 3 4 22
- Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PMID: 23201271) Monda JK … Schulman BA (Structure (London, England : 1993) 2013) 2 3 4
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
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Sources for UBE2F Gene
- (1) GeneCards
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