Aliases for UBE2F Gene
Aliases for UBE2F Gene
External Ids for UBE2F Gene
- HGNC: 12480
- Entrez Gene: 140739
- Ensembl: ENSG00000184182
- OMIM: 617700
- UniProtKB: Q969M7
Previous GeneCards Identifiers for UBE2F Gene
- GC00U990541
- GC02P238658
- GC02P238540
- GC02P238875
- GC02P230667
- GC02P237967
- GC02P237969
- GC02P237979
- GC02P237970
- GC02P237971
- GC02P237972
- GC02P237973
- GC02P237974
- GC02P237975
- GC02P237976
- GC02P237978
Summaries for UBE2F Gene
GeneCards Summary for UBE2F Gene
UBE2F (Ubiquitin Conjugating Enzyme E2 F (Putative)) is a Protein Coding gene. Among its related pathways are Innate Immune System and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2F-SCLY.
UniProtKB/Swiss-Prot for UBE2F Gene
-
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2F Gene
Genomics for UBE2F Gene
GeneHancer (GH) Regulatory Elements for UBE2F Gene
Promoters and enhancers for UBE2F Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J237963 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE | 624.8 | -0.1 | -52 | 6.2 | ZFX SP1 CC2D1A ELF3 ZKSCAN8 MNT CBFA2T2 ZNF148 NKRF POLR2A | UBE2F UBE2F-SCLY ILKAP SCLY ENSG00000227252 RAMP1 TRAF3IP1 ENSG00000225057 ESPNL KLHL30 | |
| GH02J238024 | Promoter/Enhancer | 0.7 | EPDnew ENCODE | 600.2 | +58.4 | 58433 | 0.8 | UBE2F RNU6-1333P UBE2F-SCLY | ||
| GH02J238041 | Promoter | 0.5 | EPDnew | 600.2 | +74.7 | 74668 | 0.1 | PIR44043 UBE2F RNU6-1333P UBE2F-SCLY | ||
| GH02J238043 | Promoter | 0.5 | EPDnew | 600.2 | +74.5 | 74502 | 0.1 | PIR44043 UBE2F RNU6-1333P UBE2F-SCLY | ||
| GH02J238042 | Promoter | 0.5 | EPDnew | 600.2 | +75.4 | 75399 | 0.1 | PIR44043 UBE2F SCLY UBE2F-SCLY |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UBE2F on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the UBE2F gene promoter:
-
- AML1a
- CBF(2)
- FOXD1
- GATA-6
- HNF-3beta
- LUN-1
- NF-Y
- RORalpha2
- TBP
- TFIID
Genomic Locations for UBE2F Gene
Genomic Locations for UBE2F Gene
- chr2:237,966,827-238,042,782
- (GRCh38/hg38)
- Size:
- 75,956 bases
- Orientation:
- Plus strand
- chr2:238,875,469-238,951,423
- (GRCh37/hg19)
- Size:
- 75,955 bases
- Orientation:
- Plus strand
Genomic View for UBE2F Gene
Genes around UBE2F on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.3 by HGNC
- 2q37.3 by Entrez Gene
- 2q37.3 by Ensembl
UBE2F Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UBE2F Gene
Proteins for UBE2F Gene
-
Protein details for UBE2F Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969M7-UBE2F_HUMAN
- Recommended name:
- NEDD8-conjugating enzyme UBE2F
- Protein Accession:
- Q969M7
- A8K1Z8
- B4DDT9
- B4DFI1
- B4DMK3
- B4DZU2
- B8ZZG2
- C9J212
- H9KVB9
Protein attributes for UBE2F Gene
- Size:
- 185 amino acids
- Molecular mass:
- 21077 Da
- Quaternary structure:
-
- Interacts with UBA3 and RBX2.
Protein Expression for UBE2F Gene
Selected DME Specific Peptides for UBE2F Gene
- Q969M7:
-
- GGKFQFE
- IWHPNITETGEICLSLLREHS
- DGTGWAPTRTLKDVVWGLNSLFTDLLNF
- AYNMVPPKVKCLT
- EVAELEANLP
- DPLNIEAAEHHL
Post-translational modifications for UBE2F Gene
- The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for UBE2F Gene
- ENSEMBL proteins:
-
- ENSP00000396003
- ENSP00000390813
- ENSP00000410345
- ENSP00000393515
- ENSP00000272930
- ENSP00000409749
- ENSP00000414619
- ENSP00000399183
- ENSP00000389685
- ENSP00000386680
- ENSP00000387060
- ENSP00000406113
- ENSP00000396296
- ENSP00000410867
- ENSP00000408823
- ENSP00000478474
- ENSP00000408676
- ENSP00000412965
- ENSP00000396630
- ENSP00000387299
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-UBE2F Antibody
-
Custom Antibody ServicesOriGene Antibodies for UBE2F
- Novus Biologicals Antibodies for UBE2F
-
Abcam antibodies for UBE2F
- Invitrogen Antibodies for UBE2F (AFLGC-UBE2F)
-
Biorbyt antibodies for UBE2F
-
Santa Cruz Biotechnology (SCBT) Antibodies for UBE2F
- Sino Biological Antibodies for UBE2F
Protein Products
- Atlas Antibodies PrEST Antigen UBE2F
-
OriGene Purified Proteins for UBE2F
- Search Origene for MassSpec and Protein Over-expression Lysates for UBE2F
- Origene Custom Protein Services for UBE2F
- Sino Biological Recombinant Proteins for UBE2F
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for UBE2F
-
ProSci Proteins for UBE2F
-
Abcam proteins for UBE2F
Domains & Families for UBE2F Gene
Gene Families for UBE2F Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for UBE2F Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for UBE2F Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquitin-conjugating enzyme E2 F (UBE2F_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q969M7UniProtKB/Swiss-Prot:
UBE2F_HUMAN :- Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
- Family:
-
- Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
Function for UBE2F Gene
Molecular function for UBE2F Gene
- UniProtKB/Swiss-Prot Function:
- Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.; EC=2.3.2.32; Evidence=. ;.
Enzyme Numbers (IUBMB) for UBE2F Gene
Phenotypes From GWAS Catalog for UBE2F Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19250909 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0019788 | NEDD8 transferase activity | TAS | -- |
| GO:0061654 | NEDD8 conjugating enzyme activity | IDA | 19250909 |
Phenotypes for UBE2F Gene
- MGI mutant phenotypes for UBE2F:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for UBE2F:
Animal Model Products
-
Taconic Biosciences Mouse Models for UBE2F
- Cyagen custom Knockout/knockin (KOKI) mouse models for UBE2F
-
CRISPR Products
-
OriGene CRISPR knockouts for UBE2F
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2F
- genomics-online: gRNA clones - Search results for 126 available UBE2F gene related products
- Overview of 126 available UBE2F gene related products
- Applied Biological Materials (abm): CRISPR Clones for UBE2F - Now 50% OFF >
- * UBE2F CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * UBE2F CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2F
miRNA for UBE2F Gene
- miRTarBase miRNAs that target UBE2F
-
- hsa-mir-335-5p (MIRT004083)
- hsa-mir-129-5p (MIRT006660)
- hsa-mir-129-2-3p (MIRT006661)
- hsa-mir-615-3p (MIRT040036)
- hsa-mir-6516-5p (MIRT464790)
- hsa-mir-455-3p (MIRT464791)
- hsa-mir-1273g-5p (MIRT464792)
- hsa-mir-656-5p (MIRT464793)
- hsa-mir-6851-5p (MIRT464794)
- hsa-mir-876-3p (MIRT464795)
- hsa-mir-3689d (MIRT464796)
- hsa-mir-6134 (MIRT464797)
- hsa-mir-1233-3p (MIRT464798)
- hsa-mir-1225-3p (MIRT464799)
- hsa-mir-6840-3p (MIRT464800)
- hsa-mir-4459 (MIRT464801)
- hsa-mir-665 (MIRT464802)
- hsa-mir-320e (MIRT464803)
- hsa-mir-6513-5p (MIRT633877)
- hsa-mir-887-5p (MIRT633878)
- hsa-mir-3913-5p (MIRT633879)
- hsa-mir-3122 (MIRT633880)
- hsa-mir-450a-1-3p (MIRT633881)
- hsa-mir-5089-5p (MIRT633882)
- hsa-mir-6728-5p (MIRT633883)
- hsa-mir-769-3p (MIRT633884)
- hsa-mir-450b-3p (MIRT633885)
- hsa-mir-7977 (MIRT633886)
- hsa-mir-5187-5p (MIRT633887)
- hsa-mir-383-3p (MIRT633888)
- hsa-mir-3922-5p (MIRT633889)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for UBE2F
- Browse OriGene Inhibitory RNA Products For UBE2F
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2F
- genomics-online: shRNA clones - Search results for 126 available UBE2F gene related products
- Overview of 126 available UBE2F gene related products
Clone Products
-
- MG201724
- MR201724
- MR201724L1
- MR201724L1V
- MR201724L2
- MR201724L2V
- MR201724L3
- MR201724L3V
- MR201724L4
- MR201724L4V
- RC203942
- RC203942L1
- RC203942L1V
- RC203942L2
- RC203942L2V
- RC203942L3
- RC203942L3V
- RC203942L4
- RC203942L4V
- RC236100
- RC236184
- RC236197
- RC236372
- RC503942
- RG203942
- RR208623
- RR208623L1
- RR208623L1V
- RR208623L2
- RR208623L2V
- RR208623L3
- RR208623L3V
- RR208623L4
- RR208623L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for UBE2F
- Addgene plasmids for UBE2F
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2F
- Applied Biological Materials (abm): Clones for UBE2F - Now 50% OFF >
- * UBE2F as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * UBE2F tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for UBE2F
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2F Gene
Localization for UBE2F Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2F Gene
Pathways & Interactions for UBE2F Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Ubiquitin mediated proteolysis | ||
| 3 | Protein ubiquitination | ||
| 4 | Remodeling of Adherens Junctions | ||
| 5 | Ubiquitin-Proteasome Dependent Proteolysis | ||
Pathways by source for UBE2F Gene
2 BioSystems pathways for UBE2F Gene
4 Reactome pathways for UBE2F Gene
1 KEGG pathway for UBE2F Gene
1 R&D Systems pathway for UBE2F Gene
2 Qiagen pathways for UBE2F Gene
UniProtKB/Swiss-Prot Q969M7-UBE2F_HUMAN
- Pathway: Protein modification; protein neddylation.
Interacting Proteins for UBE2F Gene
GPS-Prot Interaction Network for UBE2F
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0043687 | post-translational protein modification | TAS | -- |
| GO:0045116 | protein neddylation | IBA,IEA | -- |
No data available for SIGNOR curated interactions for UBE2F Gene
Drugs & Compounds for UBE2F Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Drug Products
- Atlas Antibodies PrEST Antigen UBE2F
Transcripts for UBE2F Gene
mRNA/cDNA for UBE2F Gene
- (5) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (318) Selected AceView cDNA sequences:
- (23) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000440223 830 bps (ENST00000440223.5)
- ENST00000441728 1242 bps (ENST00000441728.6)
- ENST00000272930 2009 bps (ENST00000272930.8)
- ENST00000433568 574 bps (ENST00000433568.5)
- ENST00000448502 561 bps (ENST00000448502.5)
Unigene Clusters for UBE2F Gene
CRISPR Products
-
OriGene CRISPR knockouts for UBE2F
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2F
- genomics-online: gRNA clones - Search results for 126 available UBE2F gene related products
- Overview of 126 available UBE2F gene related products
- Applied Biological Materials (abm): CRISPR Clones for UBE2F - Now 50% OFF >
- * UBE2F CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * UBE2F CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2F
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for UBE2F
- Browse OriGene Inhibitory RNA Products For UBE2F
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2F
- genomics-online: shRNA clones - Search results for 126 available UBE2F gene related products
- Overview of 126 available UBE2F gene related products
Clone Products
-
- MG201724
- MR201724
- MR201724L1
- MR201724L1V
- MR201724L2
- MR201724L2V
- MR201724L3
- MR201724L3V
- MR201724L4
- MR201724L4V
- RC203942
- RC203942L1
- RC203942L1V
- RC203942L2
- RC203942L2V
- RC203942L3
- RC203942L3V
- RC203942L4
- RC203942L4V
- RC236100
- RC236184
- RC236197
- RC236372
- RC503942
- RG203942
- RR208623
- RR208623L1
- RR208623L1V
- RR208623L2
- RR208623L2V
- RR208623L3
- RR208623L3V
- RR208623L4
- RR208623L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for UBE2F
- Addgene plasmids for UBE2F
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2F
- Applied Biological Materials (abm): Clones for UBE2F - Now 50% OFF >
- * UBE2F as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * UBE2F tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: |
Expression for UBE2F Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
This gene is overexpressed in Peripheral blood mononuclear cells (16.9) and Platelet (9.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2F Gene
NURSA nuclear receptor signaling pathways regulating expression of UBE2F Gene:
UBE2FSOURCE GeneReport for Unigene cluster for UBE2F Gene:
Hs.471785mRNA Expression by UniProt/SwissProt for UBE2F Gene:
Q969M7-UBE2F_HUMAN
Tissue specificity:
Widely expressed (at protein level).
Evidence on tissue expression from TISSUES for UBE2F Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs for UBE2F
-
OriGene qPCR primer pairs and template standards for UBE2F
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2F Gene
Orthologs for UBE2F Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | UBE2F 34 |
|
||
| -- 35 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| UBE2F 34 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Ube2f 17 34 35 |
|
||
| Gm5434 35 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Ube2f 34 |
|
||
| cow (Bos Taurus) |
Mammalia | UBE2F 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | UBE2F 35 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ube2f 34 |
|
||
| Str.15431 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | ube2f 35 34 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012193 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ubc-12 35 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBC12 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3148 35 |
|
OneToMany |
- Species where no ortholog for UBE2F was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for UBE2F Gene
- ENSEMBL:
- Gene Tree for UBE2F (if available)
- TreeFam:
- Gene Tree for UBE2F (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UBE2F: view image
Paralogs for UBE2F Gene
Paralogs for UBE2F Gene
(17) SIMAP similar genes for UBE2F Gene using alignment to 15 proteins:
- UBE2F_HUMAN
- C9IZ93_HUMAN
- C9J212_HUMAN
- C9J9P8_HUMAN
- C9JF62_HUMAN
- C9JFD2_HUMAN
- C9JSK8_HUMAN
- F2Z363_HUMAN
- F8WB39_HUMAN
- F8WCT3_HUMAN
- F8WD80_HUMAN
- F8WDQ9_HUMAN
- F8WFB7_HUMAN
- G5E9R6_HUMAN
- H9KVB9_HUMAN
Pseudogenes.org Pseudogenes for UBE2F Gene
Variants for UBE2F Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000011574 | -- | 237,984,385(+) | T/C | intron_variant | |
| rs1000012568 | -- | 238,026,050(+) | T/G | intron_variant | |
| rs1000024575 | -- | 238,023,706(+) | C/A | intron_variant | |
| rs1000061179 | -- | 237,991,405(+) | A/G | intron_variant | |
| rs1000071563 | -- | 237,986,080(+) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4193n100 | CNV | gain | 25217958 |
| nsv1000252 | CNV | loss | 25217958 |
| nsv1011723 | CNV | gain | 25217958 |
| nsv214866 | CNV | deletion | 16902084 |
| nsv508205 | CNV | deletion | 20534489 |
| nsv979190 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UBE2F Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2F Gene
Disorders for UBE2F Gene
Additional Disease Information for UBE2F
No disorders were found for UBE2F Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2F Gene
Publications for UBE2F Gene
- E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PMID: 19250909) Huang DT … Schulman BA (Molecular cell 2009) 2 3 4 23 58
- Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PMID: 23201271) Monda JK … Schulman BA (Structure (London, England : 1993) 2013) 2 3 4 58
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F. (PMID: 29932898) Zhou W … Sun Y (Molecular cell 2018) 3 58
ExternalLinks
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Sources for UBE2F Gene
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