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UBE2F (Ubiquitin Conjugating Enzyme E2 F (Putative)) is a Protein Coding gene. Diseases associated with UBE2F include Brachydactyly, Type E2. Among its related pathways are Remodeling of Adherens Junctions and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2F-SCLY.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J237963 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas | 624.8 | -0.1 | -52 | 6.2 | CEBPG SP1 CREB1 GATAD2A ZNF629 TFE3 LEF1 IKZF1 NFKBIZ ZNF692 | UBE2F UBE2F-SCLY lnc-ILKAP-5 ILKAP SCLY ENSG00000227252 RAMP1 TRAF3IP1 ENSG00000225057 ESPNL | |
GH02J238024 | Promoter/Enhancer | 0.8 | EPDnew Ensembl ENCODE | 600.2 | +58.4 | 58433 | 0.8 | BHLHE40 | UBE2F RF00026-626 RNU6-1333P SCLY UBE2F-SCLY | |
GH02J238041 | Promoter | 0.3 | EPDnew | 600.2 | +74.7 | 74668 | 0.1 | piR-50044 UBE2F RF00026-626 RNU6-1333P SCLY UBE2F-SCLY | ||
GH02J238043 | Promoter | 0.3 | EPDnew | 600.2 | +74.5 | 74502 | 0.1 | piR-50044 UBE2F RF00026-626 RNU6-1333P SCLY UBE2F-SCLY | ||
GH02J238042 | Promoter | 0.3 | EPDnew | 600.2 | +75.4 | 75399 | 0.1 | piR-50044 UBE2F SCLY piR-47162-072 UBE2F-SCLY |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0005515 | protein binding | IPI | 19250909 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0019788 | NEDD8 transferase activity | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Ubiquitin mediated proteolysis | ||
3 | Protein ubiquitination | ||
4 | Remodeling of Adherens Junctions |
Remodeling of Adherens Junctions
-
|
|
5 | Ubiquitin-Proteasome Dependent Proteolysis |
Ubiquitin-Proteasome Dependent Proteolysis
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000209 | protein polyubiquitination | IBA | 21873635 |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0043687 | post-translational protein modification | TAS | -- |
GO:0045116 | protein neddylation | IBA,IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Phosphoric acid | Approved | Pharma | 0 | |||
Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | UBE2F 30 |
|
||
-- 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
UBE2F 30 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Ube2f 30 17 31 |
|
ManyToMany | |
Gm5434 31 |
|
ManyToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Ube2f 30 |
|
||
Cow (Bos Taurus) |
Mammalia | UBE2F 30 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | UBE2F 30 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ube2f 30 |
|
||
Str.15431 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | ube2f 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012193 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | ubc-12 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBC12 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3148 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4193n100 | CNV | gain | 25217958 |
nsv1000252 | CNV | loss | 25217958 |
nsv1011723 | CNV | gain | 25217958 |
nsv214866 | CNV | deletion | 16902084 |
nsv508205 | CNV | deletion | 20534489 |
nsv979190 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
brachydactyly, type e2 |
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