Aliases for UBE2F Gene
External Ids for UBE2F Gene
Previous GeneCards Identifiers for UBE2F Gene
GeneCards Summary for UBE2F Gene
UBE2F (Ubiquitin Conjugating Enzyme E2 F (Putative)) is a Protein Coding gene. Diseases associated with UBE2F include Brachydactyly, Type E2. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2F-SCLY.
UniProtKB/Swiss-Prot Summary for UBE2F Gene
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.