Aliases for UBE2E3 Gene
- Ubiquitin Conjugating Enzyme E2 E3 2 3 5
- Ubiquitin-Conjugating Enzyme E2E 3 (Homologous To Yeast UBC4/5) 2 3
- Ubiquitin-Conjugating Enzyme E2E 3 (UBC4/5 Homolog, Yeast) 2 3
- Ubiquitin-Conjugating Enzyme E2-23 KDa 3 4
- Ubiquitin-Conjugating Enzyme E2 E3 3 4
- E2 Ubiquitin-Conjugating Enzyme E3 3 4
- Ubiquitin Carrier Protein E3 3 4
- Ubiquitin-Protein Ligase E3 3 4
External Ids for UBE2E3 Gene
Previous GeneCards Identifiers for UBE2E3 Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]
GeneCards Summary for UBE2E3 Gene
UBE2E3 (Ubiquitin Conjugating Enzyme E2 E3) is a Protein Coding gene. Diseases associated with UBE2E3 include Parkinson Disease, Late-Onset. Among its related pathways are Metabolism of proteins and Remodeling of Adherens Junctions. Gene Ontology (GO) annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2E2.
UniProtKB/Swiss-Prot Summary for UBE2E3 Gene
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.