UBE2D3 Gene (Protein Coding)

Ubiquitin Conjugating Enzyme E2 D3

GC04M102794
GIFtS:
47
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enz... See more...

Aliases for UBE2D3 Gene

Aliases for UBE2D3 Gene

  • Ubiquitin Conjugating Enzyme E2 D3 2 3 5
  • Ubiquitin-Conjugating Enzyme E2D 3 (Homologous To Yeast UBC4/5) 2 3
  • Ubiquitin-Conjugating Enzyme E2D 3 (UBC4/5 Homolog, Yeast) 2 3
  • (E3-Independent) E2 Ubiquitin-Conjugating Enzyme D3 3 4
  • Ubiquitin-Conjugating Enzyme E2-17 KDa 3 3 4
  • Ubiquitin-Conjugating Enzyme E2(17)KB 3 3 4
  • Ubiquitin-Conjugating Enzyme E2 D3 3 4
  • E2 Ubiquitin-Conjugating Enzyme D3 3 4
  • Ubiquitin Carrier Protein D3 3 4
  • Ubiquitin-Protein Ligase D3 3 4
  • UBCH5C 3 4
  • Ubiquitin-Conjugating Enzyme E2D 3 2
  • Ubiquitin Conjugating Enzyme E2D 3 3
  • EC 6.3.2.19 50
  • EC 2.3.2.23 4
  • EC 2.3.2.24 4
  • E2(17)KB3 3
  • UBC4/5 3
  • UBE2D3 5
  • UbcH5C 2
  • UBC5C 4

External Ids for UBE2D3 Gene

Previous GeneCards Identifiers for UBE2D3 Gene

  • GC04M104116
  • GC04M104026
  • GC04M104175
  • GC04M104074
  • GC04M103936
  • GC04M103717
  • GC04M099453

Summaries for UBE2D3 Gene

Entrez Gene Summary for UBE2D3 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]

GeneCards Summary for UBE2D3 Gene

UBE2D3 (Ubiquitin Conjugating Enzyme E2 D3) is a Protein Coding gene. Diseases associated with UBE2D3 include Gordon Holmes Syndrome. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2D2.

UniProtKB/Swiss-Prot Summary for UBE2D3 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175).

Gene Wiki entry for UBE2D3 Gene

Additional gene information for UBE2D3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2D3 Gene

Genomics for UBE2D3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for UBE2D3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2D3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2D3

Top Transcription factor binding sites by QIAGEN in the UBE2D3 gene promoter:
  • p53

Genomic Locations for UBE2D3 Gene

Latest Assembly
chr4:102,794,383-102,868,896
(GRCh38/hg38)
Size:
74,514 bases
Orientation:
Minus strand

Previous Assembly
chr4:103,715,540-103,790,052
(GRCh37/hg19 by Entrez Gene)
Size:
74,513 bases
Orientation:
Minus strand

chr4:103,715,540-103,790,053
(GRCh37/hg19 by Ensembl)
Size:
74,514 bases
Orientation:
Minus strand

Genomic View for UBE2D3 Gene

Genes around UBE2D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2D3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UBE2D3 Gene

Proteins for UBE2D3 Gene

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  • Protein details for UBE2D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61077-UB2D3_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D3
    Protein Accession:
    P61077
    Secondary Accessions:
    • A6NJ93
    • A6NJB1
    • A6NM99
    • P47986
    • Q6IB88
    • Q6NXS4
    • Q8N924

    Protein attributes for UBE2D3 Gene

    Size:
    147 amino acids
    Molecular mass:
    16687 Da
    Quaternary structure:
    • Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently with ubiquitin. Interacts with E3 ubiquitin-protein ligase CBLC. Interacts with UBTD1 (PubMed:24211586). Interacts with DDX58 and RNF135; involved in DDX58 ubiquitination and activation (PubMed:28469175).

    Three dimensional structures from OCA and Proteopedia for UBE2D3 Gene

    Alternative splice isoforms for UBE2D3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2D3 Gene

Protein Expression for UBE2D3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for UBE2D3 Gene

P61077:
  • CSAGPVG
  • DPNPDDPLVP
  • NSNGSICLDIL
  • YPFKPPK
  • PLVPEIA
  • YQGGVFFLT
  • HPNINSNG
  • IYKTDRDKYNR
  • QWSPALT
  • SLLCDPNP
  • WQATIMGP

Post-translational modifications for UBE2D3 Gene

Other Protein References for UBE2D3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for UBE2D3

Domains & Families for UBE2D3 Gene

Gene Families for UBE2D3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for UBE2D3 Gene

InterPro:
Blocks:
  • Ubiquitin-conjugating enzymes

Suggested Antigen Peptide Sequences for UBE2D3 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-protein ligase D3 (UB2D3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61077

UniProtKB/Swiss-Prot:

UB2D3_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2D3: view

Function for UBE2D3 Gene

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  6. Cell Lines for research

Molecular function for UBE2D3 Gene

UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133, ECO:0000269|PubMed:20061386};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.24; Evidence={ECO:0000269|PubMed:17588522};.

Enzyme Numbers (IUBMB) for UBE2D3 Gene

Phenotypes From GWAS Catalog for UBE2D3 Gene

Gene Ontology (GO) - Molecular Function for UBE2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS,IDA 14765125
GO:0005515 protein binding IPI 14667819
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UBE2D3: view
genes like me logo Genes that share phenotypes with UBE2D3: view

Animal Models for UBE2D3 Gene

MGI Knock Outs for UBE2D3:
  • Ube2d3 Ube2d3<tm1b(EUCOMM)Hmgu>

Animal Models for research

  • Taconic Biosciences Mouse Models for UBE2D3

miRNA for UBE2D3 Gene

miRTarBase miRNAs that target UBE2D3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2D3

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2D3 Gene

Localization for UBE2D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2D3 Gene

Cell membrane. Peripheral membrane protein. Endosome membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2D3 gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 4
endosome 4
cytosol 4
cytoskeleton 2
mitochondrion 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with UBE2D3: view

Pathways & Interactions for UBE2D3 Gene

genes like me logo Genes that share pathways with UBE2D3: view

Pathways by source for UBE2D3 Gene

1 R&D Systems pathway for UBE2D3 Gene
2 Qiagen pathways for UBE2D3 Gene
  • Remodeling of Adherens Junctions
  • Ubiquitin-Proteasome Dependent Proteolysis

UniProtKB/Swiss-Prot P61077-UB2D3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for UBE2D3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for UBE2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS --
GO:0000209 protein polyubiquitination IDA 14765125
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006281 DNA repair IEA --
GO:0006464 cellular protein modification process TAS 8090726
genes like me logo Genes that share ontologies with UBE2D3: view

Drugs & Compounds for UBE2D3 Gene

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(4) Drugs for UBE2D3 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0
NSC697923 Pharma Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective, Selective UBE2N inhibitor 0

(1) Additional Compounds for UBE2D3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
 14000-31-8

(1) ApexBio Compounds for UBE2D3 Gene

Compound Action Cas Number
NSC697923 Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective 343351-67-7
genes like me logo Genes that share compounds with UBE2D3: view

Transcripts for UBE2D3 Gene

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mRNA/cDNA for UBE2D3 Gene

10 REFSEQ mRNAs :
36 NCBI additional mRNA sequence :
33 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2D3

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - - - - - -
SP6: - - - - -
SP7:
SP8: -
SP9: - -

Relevant External Links for UBE2D3 Gene

GeneLoc Exon Structure for
UBE2D3

Expression for UBE2D3 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2D3 Gene

mRNA expression in normal human tissues for UBE2D3 Gene
mRNA expression by GTEx for UBE2D3 GenemRNA expression by BioGPS for UBE2D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2D3 Gene

This gene is overexpressed in Rectum (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2D3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2D3

SOURCE GeneReport for Unigene cluster for UBE2D3 Gene:

Hs.518773

Evidence on tissue expression from TISSUES for UBE2D3 Gene

  • Nervous system(5)
  • Kidney(4.2)
  • Lung(4.1)
  • Intestine(4.1)
  • Skin(3.8)
  • Liver(3.8)
  • Blood(3.7)
  • Eye(3)
  • Heart(2.9)
  • Pancreas(2.9)
  • Spleen(2.9)
  • Muscle(2.8)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with UBE2D3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2D3 Gene

Orthologs for UBE2D3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2D3 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
 Mammalia UBE2D3 29 30 30
  • 99.32 (n)
 OneToMany
-- 30
  • 93 (a)
 OneToMany
-- 30
  • 93 (a)
 OneToMany
-- 30
  • 93 (a)
 OneToMany
-- 30
  • 93 (a)
 OneToMany
-- 30
  • 93 (a)
 OneToMany
-- 30
  • 93 (a)
 OneToMany
-- 30
  • 93 (a)
 OneToMany
-- 30
  • 93 (a)
 OneToMany
-- 30
  • 93 (a)
 OneToMany
-- 30
  • 93 (a)
 OneToMany
-- 30
  • 92 (a)
 OneToMany
-- 30
  • 82 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Ube2d3 29 16 30
  • 98.41 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ube2d3 29
  • 98.41 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia UBE2D3 30
  • 97 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia UBE2D3 29 30
  • 96.6 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia UBE2D3 30
  • 96 (a)
 OneToOne
Chimpanzee
(Pan troglodytes)
 Mammalia UBE2D3 30
  • 95 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves UBE2D3 29 30
  • 93.42 (n)
 OneToOne
African clawed frog
(Xenopus laevis)
 Amphibia Xl.20094 29
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia Str.15169 29
Zebrafish
(Danio rerio)
 Actinopterygii ube2d2l 30
  • 93 (a)
 OneToMany
ube2d3 29
  • 80.73 (n)
wufj13d01 29
Fruit Fly
(Drosophila melanogaster)
 Insecta eff 30 31
  • 90 (a)
 OneToMany
CG10862 31
  • 50 (a)
CG2574 31
  • 50 (a)
Worm
(Caenorhabditis elegans)
 Secernentea let-70 30 31
  • 90 (a)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes UBC5 32
Soybean
(Glycine max)
 eudicotyledons Gma.13248 29
Rice
(Oryza sativa)
 Liliopsida Os02g0120600 29
  • 65.31 (n)
Os.11479 29
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.10809 30
  • 81 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.1816 29
Species where no ortholog for UBE2D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UBE2D3 Gene

ENSEMBL:
Gene Tree for UBE2D3 (if available)
TreeFam:
Gene Tree for UBE2D3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2D3: view image
Alliance of Genome Resources:
Additional Orthologs for UBE2D3

Paralogs for UBE2D3 Gene

Paralogs for UBE2D3 Gene

(31) SIMAP similar genes for UBE2D3 Gene using alignment to 11 proteins:

  • UB2D3_HUMAN
  • D6R933_HUMAN
  • D6R980_HUMAN
  • D6R9F6_HUMAN
  • D6RA11_HUMAN
  • D6RAH7_HUMAN
  • D6RAW0_HUMAN
  • D6RGD0_HUMAN
  • D6RIZ3_HUMAN
  • D6RJB3_HUMAN
  • H9KV45_HUMAN

Pseudogenes.org Pseudogenes for UBE2D3 Gene

genes like me logo Genes that share paralogs with UBE2D3: view

Variants for UBE2D3 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UBE2D3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UBE2D3 Gene

Variant ID Type Subtype PubMed ID
dgv9182n54 CNV loss 21841781
dgv9183n54 CNV loss 21841781
dgv9184n54 CNV loss 21841781
dgv9185n54 CNV loss 21841781
dgv9186n54 CNV loss 21841781
dgv965e199 CNV deletion 23128226
esv23610 CNV loss 19812545
esv2672686 CNV deletion 23128226
esv2675680 CNV deletion 23128226
esv2728080 CNV deletion 23290073
esv2759270 CNV gain 17122850
esv3564363 CNV deletion 23714750
esv3564364 CNV deletion 23714750
esv3564365 CNV deletion 23714750
esv3569635 CNV loss 25503493
esv3601621 CNV loss 21293372
esv3601622 CNV loss 21293372
nsv10541 CNV loss 18304495
nsv473003 CNV novel sequence insertion 20440878
nsv526256 CNV loss 19592680
nsv594957 CNV loss 21841781
nsv980236 CNV duplication 23825009

Variation tolerance for UBE2D3 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2D3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2D3
Leiden Open Variation Database (LOVD)
UBE2D3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2D3 Gene

Disorders for UBE2D3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBE2D3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
gordon holmes syndrome
  • gdhs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UBE2D3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UBE2D3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2D3 Gene

Publications for UBE2D3 Gene

  1. Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. (PMID: 15247280) Rajendra R … Rubin EH (The Journal of biological chemistry 2004) 3 4 22
  2. Identification of a family of closely related human ubiquitin conjugating enzymes. (PMID: 8530467) Jensen JP … Weissman AM (The Journal of biological chemistry 1995) 2 3 4
  3. Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity. (PMID: 28469175) Shi Y … Hou F (Nature communications 2017) 3 4
  4. The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. (PMID: 24211586) Uhler JP … Gustafsson CM (Biochemical and biophysical research communications 2014) 3 4
  5. UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. (PMID: 21532592) Wenzel DM … Klevit RE (Nature 2011) 3 4

ExternalLinks

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