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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enz... See more...
Aliases for UBE2D3 Gene
Aliases for UBE2D3 Gene
- Ubiquitin Conjugating Enzyme E2 D3 2 3 5
- Ubiquitin-Conjugating Enzyme E2D 3 (Homologous To Yeast UBC4/5) 2 3
- Ubiquitin-Conjugating Enzyme E2D 3 (UBC4/5 Homolog, Yeast) 2 3
- (E3-Independent) E2 Ubiquitin-Conjugating Enzyme D3 3 4
- Ubiquitin-Conjugating Enzyme E2-17 KDa 3 3 4
- Ubiquitin-Conjugating Enzyme E2(17)KB 3 3 4
- Ubiquitin-Conjugating Enzyme E2 D3 3 4
- E2 Ubiquitin-Conjugating Enzyme D3 3 4
- Ubiquitin Carrier Protein D3 3 4
- Ubiquitin-Protein Ligase D3 3 4
External Ids for UBE2D3 Gene
- HGNC: 12476
- Entrez Gene: 7323
- Ensembl: ENSG00000109332
- OMIM: 602963
- UniProtKB: P61077
Previous GeneCards Identifiers for UBE2D3 Gene
- GC04M104116
- GC04M104026
- GC04M104175
- GC04M104074
- GC04M103936
- GC04M103717
- GC04M099453
Summaries for UBE2D3 Gene
-
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]
GeneCards Summary for UBE2D3 Gene
UBE2D3 (Ubiquitin Conjugating Enzyme E2 D3) is a Protein Coding gene. Diseases associated with UBE2D3 include Gordon Holmes Syndrome. Among its related pathways are Signaling by GPCR and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2D2.
UniProtKB/Swiss-Prot Summary for UBE2D3 Gene
-
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175).
Additional gene information for UBE2D3 Gene
- HGNC(12476)
- Entrez Gene(7323)
- Ensembl(ENSG00000109332)
- OMIM(602963)
- UniProtKB(P61077)
- Open Targets Platform(ENSG00000109332)
- Search for UBE2D3 at DataMed
- Search for UBE2D3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2D3 Gene
Genomics for UBE2D3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UBE2D3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UBE2D3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2D3
- Top Transcription factor binding sites by QIAGEN in the UBE2D3 gene promoter:
-
- p53
Genomic Locations for UBE2D3 Gene
Genomic Locations for UBE2D3 Gene
- chr4:102,794,383-102,868,896
- (GRCh38/hg38)
- Size:
- 74,514 bases
- Orientation:
- Minus strand
- chr4:103,715,540-103,790,053
- (GRCh37/hg19)
- Size:
- 74,514 bases
- Orientation:
- Minus strand
Genomic View for UBE2D3 Gene
Genes around UBE2D3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q24 by HGNC
- 4q24 by Entrez Gene
- 4q24 by Ensembl
UBE2D3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UBE2D3 Gene
Proteins for UBE2D3 Gene
-
Protein details for UBE2D3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61077-UB2D3_HUMAN
- Recommended name:
- Ubiquitin-conjugating enzyme E2 D3
- Protein Accession:
- P61077
- A6NJ93
- A6NJB1
- A6NM99
- P47986
- Q6IB88
- Q6NXS4
- Q8N924
Protein attributes for UBE2D3 Gene
- Size:
- 147 amino acids
- Molecular mass:
- 16687 Da
- Quaternary structure:
-
- Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently with ubiquitin. Interacts with E3 ubiquitin-protein ligase CBLC. Interacts with UBTD1 (PubMed:24211586). Interacts with DDX58 and RNF135; involved in DDX58 ubiquitination and activation (PubMed:28469175).
Three dimensional structures from OCA and Proteopedia for UBE2D3 Gene
Protein Expression for UBE2D3 Gene
Selected DME Specific Peptides for UBE2D3 Gene
- P61077:
-
- CSAGPVG
- DPNPDDPLVP
- NSNGSICLDIL
- YPFKPPK
- PLVPEIA
- YQGGVFFLT
- HPNINSNG
- IYKTDRDKYNR
- QWSPALT
- SLLCDPNP
- WQATIMGP
Post-translational modifications for UBE2D3 Gene
- Phosphorylated by AURKB.
-
Ubiquitination at Lys8
- NX_P61077 (NX_P61077-1)
- Modification sites at PhosphoSitePlus
Other Protein References for UBE2D3 Gene
- ENSEMBL proteins:
-
- ENSP00000396901
- ENSP00000378280
- ENSP00000378282
- ENSP00000345285
- ENSP00000318494
- ENSP00000337262
- ENSP00000337208
- ENSP00000344069
- ENSP00000426620
- ENSP00000349722
- ENSP00000426586
- ENSP00000424359
- ENSP00000421904
- ENSP00000427270
- ENSP00000422939
- ENSP00000422134
- ENSP00000424710
- ENSP00000421794
- ENSP00000423487
- ENSP00000423692
- ENSP00000423324
- ENSP00000425762
- ENSP00000423869
- ENSP00000421310
- ENSP00000378283
- ENSP00000481600
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ UBE2D3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for UBE2D3
- Novus Biologicals Antibodies for UBE2D3
-
Abcam antibodies for UBE2D3
- Invitrogen Antibodies for UBE2D3 (AFLGC-UBE2D3)
-
Biorbyt antibodies for UBE2D3
-
Santa Cruz Biotechnology (SCBT) Antibodies for UBE2D3
Protein Products
-
OriGene Purified Proteins for UBE2D3
- NM_003340
- NM_181886
- NM_181889
- NM_181887
- NM_181893
- NM_181886
- NM_181887
- NM_181888
- NM_181889
- NM_181890
- NM_181891
- NM_181893
- NM_003340
- NM_003340
- NM_181886
- NM_181888
- NM_181889
- NM_181890
- NM_181891
- NM_181886
- NM_181887
- NM_181888
- NM_181889
- NM_181890
- NM_181891
- NM_181893
- NM_003340
- NM_003340
- NM_181886
- NM_181888
- NM_181889
- NM_181890
- NM_181891
- NM_001300795
- NM_001300795
- NM_003340
- NM_181886
- NM_181889
- NM_181887
- NM_181893
- NM_025356
- NM_003340
- Search Origene for MassSpec and Protein Over-expression Lysates for UBE2D3
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-
ProSci Proteins for UBE2D3
-
Abcam proteins for UBE2D3
Domains & Families for UBE2D3 Gene
Gene Families for UBE2D3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for UBE2D3 Gene
- InterPro:
- Blocks:
-
- Ubiquitin-conjugating enzymes
- ProtoNet:
Suggested Antigen Peptide Sequences for UBE2D3 Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquitin-protein ligase D3 (UB2D3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P61077- Family:
-
- Belongs to the ubiquitin-conjugating enzyme family.
Function for UBE2D3 Gene
Molecular function for UBE2D3 Gene
- UniProtKB/Swiss-Prot Function:
- Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133, ECO:0000269|PubMed:20061386};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.24; Evidence={ECO:0000269|PubMed:17588522};.
Enzyme Numbers (IUBMB) for UBE2D3 Gene
Phenotypes From GWAS Catalog for UBE2D3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | TAS,IDA | 14765125 |
| GO:0005515 | protein binding | IPI | 14667819 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for UBE2D3 Gene
- MGI mutant phenotypes for UBE2D3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for UBE2D3:
-
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Decreased viability
- Strongly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased NF-kappaB reporter expression
- Decreased shRNA abundance (Z-score < -2)
- Decreased IL-8 secretion
- Decreased interferon-beta reporter expression
Animal Models for UBE2D3 Gene
- MGI Knock Outs for UBE2D3:
-
- Ube2d3 Ube2d3<tm1b(EUCOMM)Hmgu>
Animal Model Products
-
Taconic Biosciences Mouse Models for UBE2D3
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UBE2D3 - Select products 50% OFF >
- * UBE2D3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for UBE2D3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBE2D3
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2D3
miRNA for UBE2D3 Gene
- miRTarBase miRNAs that target UBE2D3
-
- hsa-miR-155-5p (MIRT020637)
- hsa-miR-101-3p (MIRT027292)
- hsa-miR-98-5p (MIRT027590)
- hsa-let-7b-5p (MIRT032304)
- hsa-miR-877-3p (MIRT037185)
- hsa-miR-423-5p (MIRT038113)
- hsa-miR-218-5p (MIRT439364)
- hsa-miR-136-5p (MIRT439365)
- hsa-miR-6126 (MIRT444540)
- hsa-miR-6864-5p (MIRT444541)
- hsa-miR-920 (MIRT444542)
- hsa-miR-6726-5p (MIRT444543)
- hsa-miR-5591-5p (MIRT444544)
- hsa-miR-4300 (MIRT444545)
- hsa-miR-3934-3p (MIRT444546)
- hsa-miR-3670 (MIRT444547)
- hsa-miR-539-5p (MIRT444548)
- hsa-miR-493-3p (MIRT444549)
- hsa-miR-4635 (MIRT444550)
- hsa-miR-3664-3p (MIRT444551)
- hsa-miR-4433a-3p (MIRT444552)
- hsa-miR-4459 (MIRT444553)
- hsa-miR-4768-3p (MIRT444554)
- hsa-miR-4453 (MIRT444555)
- hsa-miR-4538 (MIRT444556)
- hsa-miR-6854-5p (MIRT444557)
- hsa-miR-5003-3p (MIRT444558)
- hsa-miR-6833-5p (MIRT505229)
- hsa-miR-7847-3p (MIRT505230)
- hsa-miR-3190-3p (MIRT505231)
- hsa-miR-6894-5p (MIRT505232)
- hsa-miR-765 (MIRT505233)
- hsa-miR-7154-3p (MIRT505234)
- hsa-miR-766-5p (MIRT505235)
- hsa-miR-1468-3p (MIRT505236)
- hsa-miR-548x-5p (MIRT505237)
- hsa-miR-548g-5p (MIRT505238)
- hsa-miR-548f-5p (MIRT505239)
- hsa-miR-548aj-5p (MIRT505240)
- hsa-miR-4795-5p (MIRT505241)
- hsa-miR-4657 (MIRT505242)
- hsa-miR-4491 (MIRT505243)
- hsa-miR-4519 (MIRT505244)
- hsa-miR-301b-3p (MIRT505245)
- hsa-miR-130b-3p (MIRT505246)
- hsa-miR-301a-3p (MIRT505247)
- hsa-miR-3666 (MIRT505248)
- hsa-miR-4295 (MIRT505249)
- hsa-miR-454-3p (MIRT505250)
- hsa-miR-130a-3p (MIRT505251)
- hsa-miR-19b-3p (MIRT505252)
- hsa-miR-19a-3p (MIRT505253)
- hsa-miR-152-3p (MIRT505254)
- hsa-miR-148b-3p (MIRT505255)
- hsa-miR-148a-3p (MIRT505256)
- hsa-miR-188-3p (MIRT510573)
- hsa-miR-195-3p (MIRT510574)
- hsa-miR-4733-5p (MIRT510575)
- hsa-miR-16-2-3p (MIRT510576)
- hsa-miR-577 (MIRT510577)
- hsa-miR-888-5p (MIRT510578)
- hsa-miR-376c-3p (MIRT510579)
- hsa-miR-421 (MIRT520368)
- hsa-miR-7159-5p (MIRT520369)
- hsa-miR-676-5p (MIRT520370)
- hsa-miR-505-3p (MIRT520371)
- mmu-miR-335-3p (MIRT588591)
- hsa-miR-6864-3p (MIRT697866)
- hsa-miR-3672 (MIRT697867)
- hsa-miR-769-5p (MIRT697868)
- hsa-miR-4786-5p (MIRT697869)
- hsa-miR-664a-5p (MIRT697870)
- hsa-miR-4794 (MIRT697871)
- hsa-miR-7162-3p (MIRT697872)
- hsa-miR-544b (MIRT697873)
- hsa-miR-6849-3p (MIRT697874)
- hsa-miR-6771-3p (MIRT697875)
- hsa-miR-1245b-3p (MIRT736359)
- hsa-miR-1249-5p (MIRT736482)
- hsa-miR-1257 (MIRT736613)
- hsa-miR-1321 (MIRT737380)
- hsa-miR-1343-5p (MIRT737494)
- hsa-miR-30a-5p (MIRT739734)
- hsa-miR-30b-5p (MIRT739806)
- hsa-miR-30c-5p (MIRT739897)
- hsa-miR-30d-5p (MIRT739910)
- hsa-miR-30e-5p (MIRT739923)
- hsa-miR-3607-5p (MIRT741529)
- hsa-miR-3613-3p (MIRT741638)
- hsa-miR-4330 (MIRT744128)
- hsa-miR-4419a (MIRT744222)
- hsa-miR-4510 (MIRT745662)
- hsa-miR-4739 (MIRT748097)
- hsa-miR-4756-5p (MIRT748469)
- hsa-miR-4790-3p (MIRT748905)
- hsa-miR-4802-5p (MIRT749021)
- hsa-miR-551b-5p (MIRT750875)
- hsa-miR-6081 (MIRT751785)
- hsa-miR-6127 (MIRT752136)
- hsa-miR-6129 (MIRT752209)
- hsa-miR-6130 (MIRT752297)
- hsa-miR-6133 (MIRT752401)
- hsa-miR-6515-5p (MIRT753309)
- hsa-miR-6783-5p (MIRT755767)
- hsa-miR-6797-5p (MIRT756242)
- hsa-miR-6799-5p (MIRT756349)
- hsa-miR-6824-5p (MIRT756950)
- hsa-miR-939-5p (MIRT760785)
- hsa-miR-942-5p (MIRT760864)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBE2D3
- Browse OriGene Inhibitory RNA Products For UBE2D3
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Clone Products
- Applied Biological Materials (abm): Clones for UBE2D3 - Select products 50% OFF >
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-
- MG200987
- MG200991
- MR200987
- MR200987L3
- MR200987L4
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- RC207371
- RC207371L1
- RC207371L2
- RC207371L3
- RC207371L4
- RC213585
- RC213585L3
- RC213585L4
- RC213686
- RC213686L3
- RC213686L4
- RC215841
- RC215841L3
- RC215841L4
- RC216319
- RC216319L3
- RC216319L4
- RC218977
- RC218977L3
- RC218977L4
- RC219091
- RC219091L3
- RC219091L4
- RC222586
- RC222586L3
- RC222586L4
- RC222643
- RC222643L3
- RC222643L4
- RC235753
- RG207371
- RG213585
- RG213686
- RG215841
- RG216319
- RG218977
- RG219091
- RG222586
- RG222643
- RR215445
- RR215445L3
- RR215445L4
- MR200987L3V
- MR200987L4V
- RC207371L1V
- RC207371L2V
- RC207371L3V
- RC207371L4V
- RC213585L3V
- RC213585L4V
- RC213686L3V
- RC213686L4V
- RC215841L3V
- RC215841L4V
- RC216319L3V
- RC216319L4V
- RC218977L3V
- RC218977L4V
- RC219091L3V
- RC219091L4V
- RC222586L3V
- RC222586L4V
- RC222643L3V
- RC222643L4V
- RR215445L3V
- RR215445L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for UBE2D3
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Cell Line Products
-
Horizon Cell Lines for UBE2D3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2D3 Gene
Localization for UBE2D3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for UBE2D3 Gene
- Cell membrane. Peripheral membrane protein. Endosome membrane. Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 4 |
| nucleus | 4 |
| endosome | 4 |
| cytosol | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IBA | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for UBE2D3 Gene
Pathways by source for UBE2D3 Gene
5 BioSystems pathways for UBE2D3 Gene
29 Reactome pathways for UBE2D3 Gene
3 KEGG pathways for UBE2D3 Gene
1 R&D Systems pathway for UBE2D3 Gene
2 Qiagen pathways for UBE2D3 Gene
- Remodeling of Adherens Junctions
- Ubiquitin-Proteasome Dependent Proteolysis
UniProtKB/Swiss-Prot P61077-UB2D3_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for UBE2D3 Gene
Selected Interacting proteins:
P61077-UB2D3_HUMAN
ENSP00000349722
for UBE2D3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for UBE2D3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | -- |
| GO:0000209 | protein polyubiquitination | IDA | 14765125 |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | -- |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006464 | cellular protein modification process | TAS | 8090726 |
Drugs & Compounds for UBE2D3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Phosphoric acid | Approved | Pharma | 0 | |||
| Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
| NSC697923 | Pharma | Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective, Selective UBE2N inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
(1) ApexBio Compounds for UBE2D3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| NSC697923 | Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective | 343351-67-7 |
Drug Products
- ApexBio compounds for UBE2D3
Transcripts for UBE2D3 Gene
mRNA/cDNA for UBE2D3 Gene
- 10 REFSEQ mRNAs :
- 36 NCBI additional mRNA sequence :
- 33 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000321805 1087 nts (view in UCSC)
- ENST00000338145 896 nts (view in UCSC)
- ENST00000343106 2389 nts (view in UCSC)
- ENST00000349311 838 nts (view in UCSC)
- ENST00000350435 711 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UBE2D3 - Select products 50% OFF >
- * UBE2D3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for UBE2D3
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-
Santa Cruz Biotechnology (SCBT) CRISPR for UBE2D3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBE2D3
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Clone Products
- Applied Biological Materials (abm): Clones for UBE2D3 - Select products 50% OFF >
- * UBE2D3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG200987
- MG200991
- MR200987
- MR200987L3
- MR200987L4
- MR200991
- RC207371
- RC207371L1
- RC207371L2
- RC207371L3
- RC207371L4
- RC213585
- RC213585L3
- RC213585L4
- RC213686
- RC213686L3
- RC213686L4
- RC215841
- RC215841L3
- RC215841L4
- RC216319
- RC216319L3
- RC216319L4
- RC218977
- RC218977L3
- RC218977L4
- RC219091
- RC219091L3
- RC219091L4
- RC222586
- RC222586L3
- RC222586L4
- RC222643
- RC222643L3
- RC222643L4
- RC235753
- RG207371
- RG213585
- RG213686
- RG215841
- RG216319
- RG218977
- RG219091
- RG222586
- RG222643
- RR215445
- RR215445L3
- RR215445L4
- MR200987L3V
- MR200987L4V
- RC207371L1V
- RC207371L2V
- RC207371L3V
- RC207371L4V
- RC213585L3V
- RC213585L4V
- RC213686L3V
- RC213686L4V
- RC215841L3V
- RC215841L4V
- RC216319L3V
- RC216319L4V
- RC218977L3V
- RC218977L4V
- RC219091L3V
- RC219091L4V
- RC222586L3V
- RC222586L4V
- RC222643L3V
- RC222643L4V
- RR215445L3V
- RR215445L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for UBE2D3
- Addgene plasmids for UBE2D3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBE2D3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||
| SP9: | - | - |
Relevant External Links for UBE2D3 Gene
- GeneLoc Exon Structure for
- UBE2D3
Expression for UBE2D3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Rectum (14.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2D3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2D3
SOURCE GeneReport for Unigene cluster for UBE2D3 Gene:
Hs.518773Evidence on tissue expression from TISSUES for UBE2D3 Gene
- Nervous system(5)
- Kidney(4.3)
- Lung(4.1)
- Intestine(4.1)
- Skin(3.9)
- Liver(3.8)
- Blood(3.7)
- Eye(3)
- Heart(3)
- Spleen(2.9)
- Pancreas(2.9)
- Muscle(2.9)
- Stomach(2.3)
Primer Products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2D3 Gene
Orthologs for UBE2D3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Cow (Bos Taurus) |
Mammalia | UBE2D3 30 31 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Ube2d3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ube2d3 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | UBE2D3 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | UBE2D3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | UBE2D3 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | UBE2D3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | UBE2D3 30 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.20094 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.15169 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ube2d2l 31 |
|
OneToMany | |
| ube2d3 30 |
|
||||
| wufj13d01 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | eff 31 32 |
|
OneToMany | |
| CG10862 32 |
|
|
|||
| CG2574 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | let-70 31 32 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBC5 33 |
|
|
|
| Soybean (Glycine max) |
eudicotyledons | Gma.13248 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0120600 30 |
|
||
| Os.11479 30 |
|
||||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10809 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1816 30 |
|
- Species where no ortholog for UBE2D3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for UBE2D3 Gene
- ENSEMBL:
- Gene Tree for UBE2D3 (if available)
- TreeFam:
- Gene Tree for UBE2D3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UBE2D3: view image
Paralogs for UBE2D3 Gene
Paralogs for UBE2D3 Gene
(31) SIMAP similar genes for UBE2D3 Gene using alignment to 11 proteins:
- UB2D3_HUMAN
- D6R933_HUMAN
- D6R980_HUMAN
- D6R9F6_HUMAN
- D6RA11_HUMAN
- D6RAH7_HUMAN
- D6RAW0_HUMAN
- D6RGD0_HUMAN
- D6RIZ3_HUMAN
- D6RJB3_HUMAN
- H9KV45_HUMAN
Pseudogenes.org Pseudogenes for UBE2D3 Gene
Variants for UBE2D3 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv9182n54 | CNV | loss | 21841781 |
| dgv9183n54 | CNV | loss | 21841781 |
| dgv9184n54 | CNV | loss | 21841781 |
| dgv9185n54 | CNV | loss | 21841781 |
| dgv9186n54 | CNV | loss | 21841781 |
| dgv965e199 | CNV | deletion | 23128226 |
| esv23610 | CNV | loss | 19812545 |
| esv2672686 | CNV | deletion | 23128226 |
| esv2675680 | CNV | deletion | 23128226 |
| esv2728080 | CNV | deletion | 23290073 |
| esv2759270 | CNV | gain | 17122850 |
| esv3564363 | CNV | deletion | 23714750 |
| esv3564364 | CNV | deletion | 23714750 |
| esv3564365 | CNV | deletion | 23714750 |
| esv3569635 | CNV | loss | 25503493 |
| esv3601621 | CNV | loss | 21293372 |
| esv3601622 | CNV | loss | 21293372 |
| nsv10541 | CNV | loss | 18304495 |
| nsv473003 | CNV | novel sequence insertion | 20440878 |
| nsv526256 | CNV | loss | 19592680 |
| nsv594957 | CNV | loss | 21841781 |
| nsv980236 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UBE2D3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UBE2D3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2D3 Gene
Disorders for UBE2D3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gordon holmes syndrome |
|
|
Search UBE2D3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UBE2D3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2D3 Gene
Publications for UBE2D3 Gene
- Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. (PMID: 15247280) Rajendra R … Rubin EH (The Journal of biological chemistry 2004) 3 4 23
- Identification of a family of closely related human ubiquitin conjugating enzymes. (PMID: 8530467) Jensen JP … Weissman AM (The Journal of biological chemistry 1995) 2 3 4
- Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity. (PMID: 28469175) Shi Y … Hou F (Nature communications 2017) 3 4
- The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. (PMID: 24211586) Uhler JP … Gustafsson CM (Biochemical and biophysical research communications 2014) 3 4
- UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. (PMID: 21532592) Wenzel DM … Klevit RE (Nature 2011) 3 4
ExternalLinks
Products for UBE2D3 Gene
- Custom Antibody ServicesOriGene Antibodies for UBE2D3
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- OriGene Purified Proteins for UBE2D3
- NM_003340
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- NM_181887
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- NM_181888
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- NM_181890
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- NM_001300795
- NM_001300795
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- NM_181886
- NM_181889
- NM_181887
- NM_181893
- NM_025356
- NM_003340
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