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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]
UBE2D3 (Ubiquitin Conjugating Enzyme E2 D3) is a Protein Coding gene. Diseases associated with UBE2D3 include Gordon Holmes Syndrome. Among its related pathways are Signaling by GPCR and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2D2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004842 | ubiquitin-protein transferase activity | TAS,IDA | 14765125 |
GO:0005515 | protein binding | IPI | 14667819 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000151 | ubiquitin ligase complex | IBA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005768 | endosome | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | -- |
GO:0000209 | protein polyubiquitination | IDA | 14765125 |
GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | -- |
GO:0006281 | DNA repair | IEA | -- |
GO:0006464 | cellular protein modification process | TAS | 8090726 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Phosphoric acid | Approved | Pharma | 0 | |||
Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
NSC697923 | Pharma | Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective, Selective UBE2N inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
Compound | Action | Cas Number |
---|---|---|
NSC697923 | Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective | 343351-67-7 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||||
SP9: | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | UBE2D3 30 31 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Ube2d3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ube2d3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | UBE2D3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | UBE2D3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | UBE2D3 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | UBE2D3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | UBE2D3 30 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | Xl.20094 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.15169 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ube2d2l 31 |
|
OneToMany | |
ube2d3 30 |
|
||||
wufj13d01 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | eff 31 32 |
|
OneToMany | |
CG10862 32 |
|
|
|||
CG2574 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | let-70 31 32 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBC5 33 |
|
|
|
Soybean (Glycine max) |
eudicotyledons | Gma.13248 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0120600 30 |
|
||
Os.11479 30 |
|
||||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10809 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1816 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv9182n54 | CNV | loss | 21841781 |
dgv9183n54 | CNV | loss | 21841781 |
dgv9184n54 | CNV | loss | 21841781 |
dgv9185n54 | CNV | loss | 21841781 |
dgv9186n54 | CNV | loss | 21841781 |
dgv965e199 | CNV | deletion | 23128226 |
esv23610 | CNV | loss | 19812545 |
esv2672686 | CNV | deletion | 23128226 |
esv2675680 | CNV | deletion | 23128226 |
esv2728080 | CNV | deletion | 23290073 |
esv2759270 | CNV | gain | 17122850 |
esv3564363 | CNV | deletion | 23714750 |
esv3564364 | CNV | deletion | 23714750 |
esv3564365 | CNV | deletion | 23714750 |
esv3569635 | CNV | loss | 25503493 |
esv3601621 | CNV | loss | 21293372 |
esv3601622 | CNV | loss | 21293372 |
nsv10541 | CNV | loss | 18304495 |
nsv473003 | CNV | novel sequence insertion | 20440878 |
nsv526256 | CNV | loss | 19592680 |
nsv594957 | CNV | loss | 21841781 |
nsv980236 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
gordon holmes syndrome |
|
|