Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is... See more...

Aliases for UBE2D2 Gene

Aliases for UBE2D2 Gene

  • Ubiquitin Conjugating Enzyme E2 D2 2 3 5
  • UBC4 2 3 4
  • Ubiquitin-Conjugating Enzyme E2D 2 (Homologous To Yeast UBC4/5) 2 3
  • (E3-Independent) E2 Ubiquitin-Conjugating Enzyme D2 3 4
  • P53-Regulated Ubiquitin-Conjugating Enzyme 1 3 4
  • Ubiquitin-Conjugating Enzyme E2-17 KDa 2 3 4
  • Ubiquitin-Conjugating Enzyme E2 D2 3 4
  • E2 Ubiquitin-Conjugating Enzyme D2 3 4
  • Ubiquitin Carrier Protein D2 3 4
  • Ubiquitin-Protein Ligase D2 3 4
  • UBCH5B 3 4
  • PUBC1 3 4
  • UBCH4 3 4
  • Ubiquitin-Conjugating Enzyme E2D 2 (UBC4/5 Homolog, Yeast) 2
  • Ubiquitin-Conjugating Enzyme E2(17)KB 2 4
  • Ubiquitin-Conjugating Enzyme E2D 2 2
  • Ubiquitin Conjugating Enzyme E2D 2 3
  • EC 6.3.2.19 50
  • EC 2.3.2.23 4
  • EC 2.3.2.24 4
  • E2(17)KB2 3
  • UBC4/5 3
  • UBE2D2 5
  • UbcH5B 2
  • UBC5B 4

External Ids for UBE2D2 Gene

Previous GeneCards Identifiers for UBE2D2 Gene

  • GC05P138764
  • GC05P139524
  • GC05P138923
  • GC05P138969
  • GC05P138920
  • GC05P134083

Summaries for UBE2D2 Gene

Entrez Gene Summary for UBE2D2 Gene

  • Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for UBE2D2 Gene

UBE2D2 (Ubiquitin Conjugating Enzyme E2 D2) is a Protein Coding gene. Diseases associated with UBE2D2 include Gordon Holmes Syndrome and Machado-Joseph Disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and IKK complex recruitment mediated by RIP1. Gene Ontology (GO) annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2D4.

UniProtKB/Swiss-Prot Summary for UBE2D2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

Gene Wiki entry for UBE2D2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBE2D2 Gene

Genomics for UBE2D2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for UBE2D2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J139560 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.3 +35.9 35856 4.2 SP1 MYC ZNF600 ZNF592 POLR2A ZNF10 BRCA1 CHD4 YY1 NONO NONHSAG041703.2 UBE2D2 CXXC5 ANKHD1 DNAJC18 PURA STING1 hsa-miR-1273e-060 RF00017-4466
GH05J139523 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 250.7 -1.1 -1065 4.1 ZIC2 TRIM22 KMT2B SMAD4 SAP130 IRF4 RARA YY1 TEAD3 EBF1 UBE2D2 ENSG00000253965 HSALNG0045250 STING1 RF00017-4466
GH05J138843 Enhancer 0.7 Ensembl ENCODE 4.9 -682.0 -681970 3.7 CEBPB PRDM6 JUND ATF4 BHLHE40 ZNF660 OSR2 ATF7 ZNF335 SCRT2 CTNNA1-AS1 CTNNA1 UBE2D2 lnc-EGR1-6 HSALNG0045204 LRRTM2 RF00017-4462
GH05J139517 Promoter/Enhancer 1.7 FANTOM5 ENCODE CraniofacialAtlas 0.4 -8.3 -8256 1.9 BCLAF1 SP1 ZNF654 ZNF207 NCOR1 MYC IKZF1 ZNF600 SSRP1 JUND PURA ANKHD1 MALINC1 IGIP DNAJC18 SLC23A1 CTNNA1 PSD2 MATR3 HSALNG0045250
GH05J139284 Enhancer 0.5 FANTOM5 1.4 -241.7 -241670 0.2 SUPT5H POLR2A RBFOX2 SLC23A1 PAIP2 MATR3 HSPA9 UBE2D2 piR-62007 SIL1 lnc-SIL1-3 ENSG00000280987 SNHG4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2D2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBE2D2

Top Transcription factor binding sites by QIAGEN in the UBE2D2 gene promoter:
  • GATA-1
  • p53

Genomic Locations for UBE2D2 Gene

Latest Assembly
chr5:139,526,431-139,628,434
(GRCh38/hg38)
Size:
102,004 bases
Orientation:
Plus strand

Previous Assembly
chr5:138,940,924-139,008,019
(GRCh37/hg19 by Entrez Gene)
Size:
67,096 bases
Orientation:
Plus strand

chr5:138,906,016-139,008,018
(GRCh37/hg19 by Ensembl)
Size:
102,003 bases
Orientation:
Plus strand

Genomic View for UBE2D2 Gene

Genes around UBE2D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2D2 Gene

Proteins for UBE2D2 Gene

  • Protein details for UBE2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62837-UB2D2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D2
    Protein Accession:
    P62837
    Secondary Accessions:
    • D3DQC9
    • P51669
    • Q3MN78
    • Q96RP6

    Protein attributes for UBE2D2 Gene

    Size:
    147 amino acids
    Molecular mass:
    16735 Da
    Quaternary structure:
    • Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3. Interacts with PPP1R11 (By similarity).

    Three dimensional structures from OCA and Proteopedia for UBE2D2 Gene

    Alternative splice isoforms for UBE2D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2D2 Gene

Selected DME Specific Peptides for UBE2D2 Gene

P62837:
  • CSAGPVG
  • DPNPDDPLVP
  • NSNGSICLDIL
  • YPFKPPK
  • PLVPEIA
  • YQGGVFFLT
  • HPNINSNG
  • QWSPALT
  • DREKYNR
  • SLLCDPNP
  • WQATIMGP

Post-translational modifications for UBE2D2 Gene

  • Ubiquitination at Lys8
  • Modification sites at PhosphoSitePlus

Domains & Families for UBE2D2 Gene

Gene Families for UBE2D2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for UBE2D2 Gene

InterPro:
Blocks:
  • Ubiquitin-conjugating enzymes

Suggested Antigen Peptide Sequences for UBE2D2 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin-protein ligase D2 (UB2D2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62837

UniProtKB/Swiss-Prot:

UB2D2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2D2: view

Function for UBE2D2 Gene

Molecular function for UBE2D2 Gene

UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133, ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18703417, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.24; Evidence={ECO:0000269|PubMed:17588522};.

Enzyme Numbers (IUBMB) for UBE2D2 Gene

Phenotypes From GWAS Catalog for UBE2D2 Gene

Gene Ontology (GO) - Molecular Function for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS,IDA 18359941
GO:0005515 protein binding IPI 14667819
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UBE2D2: view
genes like me logo Genes that share phenotypes with UBE2D2: view

Animal Models for UBE2D2 Gene

MGI Knock Outs for UBE2D2:

miRNA for UBE2D2 Gene

miRTarBase miRNAs that target UBE2D2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2D2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2D2 Gene

Localization for UBE2D2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2D2 gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 4
plasma membrane 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 15247280
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0032991 protein-containing complex IDA 22797923
genes like me logo Genes that share ontologies with UBE2D2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2D2 Gene

Pathways & Interactions for UBE2D2 Gene

genes like me logo Genes that share pathways with UBE2D2: view

Pathways by source for UBE2D2 Gene

1 R&D Systems pathway for UBE2D2 Gene
3 Qiagen pathways for UBE2D2 Gene
  • Remodeling of Adherens Junctions
  • Ubiquitin-Proteasome Dependent Proteolysis
  • WNT Signaling

UniProtKB/Swiss-Prot P62837-UB2D2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for UBE2D2 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 15247280
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006464 cellular protein modification process TAS 8090726
GO:0006511 ubiquitin-dependent protein catabolic process TAS 7724550
GO:0006625 protein targeting to peroxisome TAS --
genes like me logo Genes that share ontologies with UBE2D2: view

Drugs & Compounds for UBE2D2 Gene

(4) Drugs for UBE2D2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
(R,R)-2,3-Butanediol Experimental Pharma Target 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for UBE2D2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8
genes like me logo Genes that share compounds with UBE2D2: view

Transcripts for UBE2D2 Gene

mRNA/cDNA for UBE2D2 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBE2D2

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D2 Gene

No ASD Table

Relevant External Links for UBE2D2 Gene

GeneLoc Exon Structure for
UBE2D2

Expression for UBE2D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2D2 Gene

This gene is overexpressed in Rectum (15.6), Uterus (12.8), and Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UBE2D2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBE2D2

SOURCE GeneReport for Unigene cluster for UBE2D2 Gene:

Hs.108332

Evidence on tissue expression from TISSUES for UBE2D2 Gene

  • Nervous system(4.8)
  • Blood(4.4)
  • Kidney(2.6)
  • Lung(2.6)
  • Skin(2.5)
  • Muscle(2.5)
  • Lymph node(2.5)
  • Intestine(2.5)
  • Heart(2.4)
  • Spleen(2.3)
  • Liver(2.2)
  • Pancreas(2.2)
  • Eye(2.1)
  • Bone marrow(2.1)
  • Thyroid gland(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with UBE2D2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2D2 Gene

Orthologs for UBE2D2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2D2 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia UBE2D2 30
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia UBE2D2 29 30
  • 99.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia UBE2D2 29 30
  • 98.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia UBE2D2 29 30
  • 97.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ube2d2a 29 16 30
  • 97.28 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ube2d2 29
  • 97.28 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia UBE2D2 30
  • 95 (a)
OneToOne
Chicken
(Gallus gallus)
Aves UBE2D2 29
  • 95.98 (n)
Lizard
(Anolis carolinensis)
Reptilia UBE2D2 30
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ube2d3 29
  • 87.3 (n)
Zebrafish
(Danio rerio)
Actinopterygii ube2d2l 30
  • 97 (a)
OneToMany
zgc:77149 29
  • 83.45 (n)
-- 29
Fruit Fly
(Drosophila melanogaster)
Insecta eff 29 30 31
  • 77.1 (n)
OneToMany
CG2574 31
  • 51 (a)
CG10862 31
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000145 29
  • 75.74 (n)
Worm
(Caenorhabditis elegans)
Secernentea let-70 29 30 31
  • 76.42 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12563g 29
  • 70.32 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC4 29
  • 68.98 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER173C 29
  • 66.89 (n)
Soybean
(Glycine max)
eudicotyledons Gma.6374 29
Rice
(Oryza sativa)
Liliopsida Os09g0293400 29
  • 65.76 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10809 30
  • 85 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc4 29
  • 72.79 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU02289 29
  • 66.44 (n)
Species where no ortholog for UBE2D2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for UBE2D2 Gene

ENSEMBL:
Gene Tree for UBE2D2 (if available)
TreeFam:
Gene Tree for UBE2D2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2D2: view image
Alliance of Genome Resources:
Additional Orthologs for UBE2D2

Paralogs for UBE2D2 Gene

(30) SIMAP similar genes for UBE2D2 Gene using alignment to 2 proteins:

  • UB2D2_HUMAN
  • D6RFM0_HUMAN

Pseudogenes.org Pseudogenes for UBE2D2 Gene

genes like me logo Genes that share paralogs with UBE2D2: view

Variants for UBE2D2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for UBE2D2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for UBE2D2 Gene

Variant ID Type Subtype PubMed ID
nsv462460 CNV loss 19166990
nsv5028 CNV insertion 18451855
nsv519808 CNV loss 19592680
nsv599820 CNV loss 21841781
nsv830504 CNV gain 17160897
nsv830505 CNV loss 17160897
nsv980732 CNV duplication 23825009

Variation tolerance for UBE2D2 Gene

Residual Variation Intolerance Score: 55.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2D2
Leiden Open Variation Database (LOVD)
UBE2D2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBE2D2 Gene

Disorders for UBE2D2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for UBE2D2 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UBE2D2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with UBE2D2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2D2 Gene

Publications for UBE2D2 Gene

  1. Identification of a family of closely related human ubiquitin conjugating enzymes. (PMID: 8530467) Jensen JP … Weissman AM (The Journal of biological chemistry 1995) 2 3 4
  2. Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity. (PMID: 26656854) Wright JD … Day CL (Nature structural & molecular biology 2016) 3 4
  3. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4
  4. The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme. (PMID: 20525694) Ryan PE … Lipkowitz S (The Journal of biological chemistry 2010) 3 4
  5. Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates. (PMID: 20152160) Sakata E … Kato K (Structure (London, England : 1993) 2010) 3 4

Products for UBE2D2 Gene

Sources for UBE2D2 Gene