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This gene encodes a protein which contains two ubiquitin-like domains and appears to have similar function to ubiquitin. Through covalent attachment, the encoded protein targets other proteins for 26S proteasome degradation. This protein has been implicated to function in many cellular processes, including caspase-dependent apoptosis, formation of aggresomes, mitotic regulation... See more...
Aliases for UBD Gene
Aliases for UBD Gene
External Ids for UBD Gene
- HGNC: 18795
- Entrez Gene: 10537
- Ensembl: ENSG00000213886
- OMIM: 606050
- UniProtKB: O15205
Previous GeneCards Identifiers for UBD Gene
- GC06M029580
- GC06M029294
- GC06M029632
- GC06M029633
- GC06M029634
- GC06Mc29667
- GC06M029525
- GC06M029330
Summaries for UBD Gene
-
This gene encodes a protein which contains two ubiquitin-like domains and appears to have similar function to ubiquitin. Through covalent attachment, the encoded protein targets other proteins for 26S proteasome degradation. This protein has been implicated to function in many cellular processes, including caspase-dependent apoptosis, formation of aggresomes, mitotic regulation, and dendritic cell maturation. Upregulation of this gene may promote inflammation in chronic kidney disease and has been observed in many cancer types. [provided by RefSeq, Aug 2017]
GeneCards Summary for UBD Gene
UBD (Ubiquitin D) is a Protein Coding gene. Diseases associated with UBD include Kidney Disease and Chronic Kidney Disease. Among its related pathways are HIF1Alpha Pathway and TRAF Pathway. Gene Ontology (GO) annotations related to this gene include proteasome binding. An important paralog of this gene is UBC.
UniProtKB/Swiss-Prot Summary for UBD Gene
-
Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).
Additional gene information for UBD Gene
- HGNC(18795)
- Entrez Gene(10537)
- Ensembl(ENSG00000213886)
- OMIM(606050)
- UniProtKB(O15205)
- Open Targets Platform(ENSG00000213886)
- Monarch Initiative
- Search for UBD at DataMed
- Search for UBD at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBD Gene
Genomics for UBD Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UBD Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J029559 | Promoter/Enhancer | 0.9 | EPDnew ENCODE | 600.7 | 0.0 | -20 | 0.1 | RELA RBFOX2 IKZF2 POLR2A SP1 RELB CREM IKZF1 SAP130 TBP | UBD OR2H5P OR2H2 GABBR1 | |
| GH06J029558 | Promoter | 0.7 | Ensembl | 600.7 | +0.6 | 631 | 0.6 | ZNF740 KAT8 POLR2A YY1 ZBTB11 EHMT2 GTF2A2 MLLT1 | UBD HLA-J HLA-W ENSG00000237669 LINC02829 OR2I1P MAS1L GABBR1 | |
| GH06J029477 | Enhancer | 0.5 | FANTOM5 | 10.5 | +81.6 | 81634 | 0.6 | FOXJ2 E2F5 VEZF1 USF2 | lnc-MAS1L-1 MAS1L OR12D3 OR5V1 UBD LINC01015 OR2H2 OR14J1 MAS1LP1 OR2H1 | |
| GH06J029552 | Enhancer | 0.9 | FANTOM5 ENCODE | 4.6 | +7.0 | 6984 | 0.3 | SP1 CREB1 PRDM10 RFX5 ZNF561 SP2 OSR2 ZBTB40 WT1 OVOL3 | TRIM39 HCG18 TRIM26 IFITM4P UBD LINC02829 HLA-F HLA-A OR2I1P MAS1L | |
| GH06J029553 | Enhancer | 0.8 | ENCODE | 0.4 | +6.0 | 6023 | 0.2 | TEAD4 KDM1A ZNF692 ZIC2 RBFOX2 PATZ1 ZNF501 EZH2 SCRT2 CTCF | ZFP57 LINC01015 ENSG00000237669 OR2I1P UBD MAS1L |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UBD on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBD
- Top Transcription factor binding sites by QIAGEN in the UBD gene promoter:
-
- c-Myc
- E47
- Egr-1
- Egr-2
- Hand1
- Max
- Nkx3-1
- SREBP-1a
- SREBP-1b
- SREBP-1c
Genomic Locations for UBD Gene
Genomic Locations for UBD Gene
- chr6:29,555,515-29,559,732
- (GRCh38/hg38)
- Size:
- 4,218 bases
- Orientation:
- Minus strand
- chr6:29,523,292-29,527,702
- (GRCh37/hg19)
- Size:
- 4,411 bases
- Orientation:
- Minus strand
Genomic View for UBD Gene
Genes around UBD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
UBD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UBD Gene
Proteins for UBD Gene
-
Protein details for UBD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15205-UBD_HUMAN
- Recommended name:
- Ubiquitin D
- Protein Accession:
- O15205
- B0UZT6
- Q5STL2
- Q5SUK2
- Q96EC7
Protein attributes for UBD Gene
- Size:
- 165 amino acids
- Molecular mass:
- 18473 Da
- Quaternary structure:
-
- Interacts directly with the 26S proteasome. The interaction with NUB1 via the N-terminal ubiquitin domain facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates its own degradation and that of its conjugates. Interacts (via ubiquitin-like 1 domain) with the spindle checkpoint protein MAD2L1 during mitosis. Present in aggresomes of proteasome inhibited cells. Interacts with HDAC6 under proteasome impairment conditions. Forms a thioester with UBA6 in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg). Interacts with SQSTM1 and TP53/p53 (PubMed:25422469).
- Miscellaneous:
-
- Common types of chronic kidney disease are associated with tubulointerstitial up-regulation of FAT10. FAT10 may mediate NF-kappa-B activation and may promote tubulointerstitial inflammation in chronic kidney diseases.
Protein Expression for UBD Gene
Post-translational modifications for UBD Gene
- Can be acetylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for UBD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ UBD Antibody
- NSJ Bioreagents FAT10 Antibody
- Novus Biologicals Antibodies for UBD
- Invitrogen Antibodies for UBD (AFLGC-UBD)
-
Custom Antibody ServicesProSci Antibodies for UBD
-
Santa Cruz Biotechnology (SCBT) Antibodies for UBD
- Sino Biological Antibodies for UBD
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for UBD
- Origene Custom Protein Services for UBD
- ProSpec Recombinant Proteins for UBD
- antibodies-online: Show 11 available UBD Proteins ranked by validation data
- Compare Top UBD Proteins
-
Quality Products:
-
Abcam proteins for UBD
Assay Products
- G Biosciences Immunotag™ Human UBD (Ubiquitin D) ELISA and Immunotag™ Ubiquitin D ELISA Kit
- RayBiotech Custom Human Ubiquitin D ELISA
- antibodies-online: Show 23 available UBD Elisa Kits ranked by validation data
- Compare Top UBD Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for UBD
No data available for DME Specific Peptides for UBD Gene
Domains & Families for UBD Gene
Gene Families for UBD Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for UBD Gene
- InterPro:
- Blocks:
-
- Ubiquitin domain
- ProtoNet:
Suggested Antigen Peptide Sequences for UBD Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquitin-like protein FAT10 (UBD_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UBD Gene
Function for UBD Gene
Molecular function for UBD Gene
- UniProtKB/Swiss-Prot Function:
- Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).
- UniProtKB/Swiss-Prot Induction:
- Rapidly degraded by the proteasome. Cell-cycle regulation with highest expression during the S-phase (at protein level). Induced during dendritic cell maturation. Negatively regulated by p53/TP53. High levels in various gastrointestinal and gynecological cancer cells. Induced in RTECs in common renal diseases including diabetic nephropathy (DN), IgA nephropathy (IgAN), and hypertensive nephrosclerosis (HN), as well as in hepatocellular carcinoma (HCC) and during HIVAN. Inducible by the proinflammatory cytokines IFNG/IFN-gamma and TNF in cancers of liver and colon. Repressed by NUB1 (at protein level).
Phenotypes From GWAS Catalog for UBD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 10200259 |
| GO:0070628 | proteasome binding | IBA,IDA | 16707496 |
Phenotypes for UBD Gene
- MGI mutant phenotypes for UBD:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for UBD:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UBD - Select products 50% OFF >
- * UBD CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UBD
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBD
miRNA for UBD Gene
- miRTarBase miRNAs that target UBD
-
- hsa-miR-335-5p (MIRT017438)
- hsa-miR-24-3p (MIRT030468)
- hsa-miR-6867-3p (MIRT709742)
- hsa-miR-6826-3p (MIRT709743)
- hsa-miR-6886-3p (MIRT709744)
- hsa-miR-938 (MIRT709745)
- hsa-miR-18a-3p (MIRT709746)
- hsa-miR-4685-3p (MIRT709747)
- hsa-miR-4287 (MIRT709748)
- hsa-miR-7113-3p (MIRT709749)
- hsa-miR-4469 (MIRT709750)
- hsa-miR-6734-3p (MIRT709751)
- hsa-miR-6752-3p (MIRT709752)
- hsa-miR-6892-3p (MIRT709753)
- hsa-miR-331-3p (MIRT709754)
- hsa-miR-6810-3p (MIRT709755)
- hsa-miR-6801-3p (MIRT709756)
- hsa-miR-6795-3p (MIRT709757)
- hsa-miR-6887-3p (MIRT709758)
- hsa-miR-7848-3p (MIRT713475)
- hsa-miR-6749-3p (MIRT713476)
- hsa-miR-6852-3p (MIRT713477)
- hsa-miR-3909 (MIRT713478)
- hsa-miR-6735-3p (MIRT713479)
- hsa-miR-214-5p (MIRT713480)
- hsa-miR-6784-3p (MIRT713481)
- hsa-miR-6862-3p (MIRT713482)
- hsa-miR-6748-3p (MIRT713483)
- hsa-miR-3162-3p (MIRT713484)
- hsa-miR-3620-3p (MIRT713485)
- hsa-miR-6865-3p (MIRT713487)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBD
- Browse OriGene Inhibitory RNA Products For UBD
Clone Products
- Applied Biological Materials (abm): Clones for UBD - Select products 50% OFF >
- * UBD as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UBD
Cell Line Products
-
Horizon Cell Lines for UBD
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBD Gene
Localization for UBD Gene
Subcellular locations from UniProtKB/Swiss-Prot for UBD Gene
- Nucleus. Cytoplasm. Note=Accumulates in aggresomes under proteasome inhibition conditions.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
- Nucleoli fibrillar center (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IBA,IDA | 12730673 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for UBD Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | BRCA1 Pathway |
Fanconi's Anaemia Pathway
.01
|
BRCA1 Pathway
-
|
| 2 | NF-kappaB Signaling | ||
| 3 | Beta-Adrenergic Signaling |
CDK5 Pathway
.37
|
|
| 4 | HIF1Alpha Pathway |
HIF1Alpha Pathway
-
|
|
| 5 | fMLP Pathway |
Huntington's Disease Pathway
.31
|
|
Pathways by source for UBD Gene
17 Qiagen pathways for UBD Gene
- BRCA1 Pathway
- CDK5 Pathway
- Fanconi's Anaemia Pathway
- HIF1Alpha Pathway
- Huntington's Disease Pathway
1 Cell Signaling Technology pathway for UBD Gene
Interacting Proteins for UBD Gene
Selected Interacting proteins:
O15205-UBD_HUMAN
ENSP00000366249
for UBD Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for UBD
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | NAS | 9368598 |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA,IDA | 17889673 |
| GO:0016567 | protein ubiquitination | IBA,IDA | 15831455 |
| GO:0032446 | protein modification by small protein conjugation | NAS | 9368598 |
| GO:0034341 | response to interferon-gamma | IBA,IEP | 17889673 |
No data available for SIGNOR curated interactions for UBD Gene
Transcripts for UBD Gene
mRNA/cDNA for UBD Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000377050 894 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for UBD - Select products 50% OFF >
- * UBD CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for UBD
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBD
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBD
- Browse OriGene Inhibitory RNA Products For UBD
Clone Products
- Applied Biological Materials (abm): Clones for UBD - Select products 50% OFF >
- * UBD as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for UBD
Relevant External Links for UBD Gene
- GeneLoc Exon Structure for
- UBD
Expression for UBD Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
- Inner Cell Mass (Early Embryonic Tissues)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for UBD Gene
This gene is overexpressed in Small Intestine - Terminal Ileum (x6.2), Liver (x5.5), Pancreas (x4.9), and Minor Salivary Gland (x4.8).
This gene is overexpressed in Monocytes (32.0), Ovary (16.7), Liver (12.8), and Islet of Langerhans (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UBD Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBD
SOURCE GeneReport for Unigene cluster for UBD Gene:
Hs.44532mRNA Expression by UniProt/SwissProt for UBD Gene:
O15205-UBD_HUMAN
Tissue specificity:
Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland.
Evidence on tissue expression from TISSUES for UBD Gene
- Spleen(4.6)
- Kidney(2.6)
- Heart(2.4)
- Liver(2.3)
- Intestine(2.2)
- Lung(2.1)
- Muscle(2)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for UBD
-
OriGene qPCR primer pairs and template standards for UBD
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UBD Gene
Orthologs for UBD Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | UBD 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LOC100687262 30 |
|
||
| UBD 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | UBD 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Ubd 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ubd 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | UBD 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | UBD 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | UBD 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ubi-p63E 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBI4 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for UBD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for UBD Gene
- ENSEMBL:
- Gene Tree for UBD (if available)
- TreeFam:
- Gene Tree for UBD (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for UBD: view image
Paralogs for UBD Gene
Paralogs for UBD Gene
(5) SIMAP similar genes for UBD Gene using alignment to 1 proteins:
- UBD_HUMAN
Pseudogenes.org Pseudogenes for UBD Gene
Variants for UBD Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBD Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 749159 | Likely Benign: not provided | 29,555,933(-) | C/T | MISSENSE_VARIANT | |
| rs17184290 | - | p.Glu120Lys | |||
| rs2076484 | - | p.Leu51Ser | |||
| rs2076485 | - | p.Ile68Thr | |||
| rs2076486 | - | p.Ser95Pro |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759411 | CNV | gain+loss | 17122850 |
| nsv1074389 | CNV | deletion | 25765185 |
| nsv1122126 | CNV | deletion | 24896259 |
| nsv1145096 | CNV | deletion | 24896259 |
| nsv5239 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.26;
90.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UBD Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBD Gene
Disorders for UBD Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kidney disease |
|
|
| chronic kidney disease |
|
|
| diabetes mellitus, insulin-dependent, 20 |
|
|
| diabetes mellitus, insulin-dependent, 24 |
|
|
| hepatocellular carcinoma |
|
|
Search UBD in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UBD
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for UBD Gene
Publications for UBD Gene
- A regulatory single nucleotide polymorphism in the ubiquitin D gene associated with celiac disease. (PMID: 19808075) Castellanos-Rubio A … Bilbao JR (Human immunology 2010) 3 23 41
- The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition. (PMID: 19033385) Kalveram B … Groettrup M (Journal of cell science 2008) 3 4 23
- SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PMID: 17971048) Burfoot RK … Rubio JP (Tissue antigens 2008) 3 23 41
- FAT10 plays a role in the regulation of chromosomal stability. (PMID: 16495226) Ren J … Lee CG (The Journal of biological chemistry 2006) 3 4 23
- Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease. (PMID: 16495380) Ross MJ … Klotman PE (Journal of the American Society of Nephrology : JASN 2006) 3 4 23
ExternalLinks
Products for UBD Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for UBD
- Origene Custom Protein Services for UBD
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBD
- Browse OriGene Inhibitory RNA Products For UBD
- OriGene qPCR primer pairs for UBD
- OriGene qPCR primer pairs and template standards for UBD
- OriGene CRISPR knockouts for UBD
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For UBD
- Sino Biological Human cDNA Clone for UBD
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for UBD
- Browse Sino Biological Assays
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for UBD
- Novus Biologicals proteins and lysates for UBD
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for UBD
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for UBD (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for UBD (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for UBD (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for UBD CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for UBD
- antibodies-online: Show 23 available UBD Antibodies ranked by validation data
- Compare Top UBD Antibodies
- antibodies-online: Show 23 available UBD Elisa Kits ranked by validation data
- Compare Top UBD Elisa Kits
- Quality Products:
- antibodies-online: Show 11 available UBD Proteins ranked by validation data
- Compare Top UBD Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for UBD
- Search Santa Cruz Biotechnology (SCBT) for UBD siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for UBD
- Custom Antibody ServicesProSci Antibodies for UBD
- Search for UBD Proteins at ProSci
- Horizon Cell Lines for UBD
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for UBD
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for UBD
- Search GeneCopoeia for miRNA 3'UTR Target clone products for UBD
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for UBD
Sources for UBD Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB