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This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis,... See more...
Aliases for UBC Gene
External Ids for UBC Gene
- HGNC: 12468
- NCBI Entrez Gene: 7316
- Ensembl: ENSG00000150991
- OMIM®: 191340
- UniProtKB/Swiss-Prot: P0CG48
Previous GeneCards Identifiers for UBC Gene
- GC12M124151
- GC12M125142
- GC12M123749
- GC12M123921
- GC12M125396
- GC12M122360
Summaries for UBC Gene
-
This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]
GeneCards Summary for UBC Gene
UBC (Ubiquitin C) is a Protein Coding gene. Diseases associated with UBC include Middle East Respiratory Syndrome and Cystic Fibrosis. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Downstream signaling events of B Cell Receptor (BCR). Gene Ontology (GO) annotations related to this gene include protease binding. An important paralog of this gene is UBB.
UniProtKB/Swiss-Prot Summary for UBC Gene
-
[Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
Additional gene information for UBC Gene
- HGNC (12468)
- NCBI Entrez Gene (7316)
- Ensembl (ENSG00000150991)
- OMIM® (191340)
- UniProtKB/Swiss-Prot (P0CG48)
- Open Targets Platform(ENSG00000150991)
- Search for UBC at DataMed
- Search for UBC at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBC Gene
Genomics for UBC Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for UBC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around UBC on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBC
- Top Transcription factor binding sites by QIAGEN in the UBC gene promoter:
-
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 3
- AP-2alpha isoform 4
- AP-2alphaA
- c-Myc
- Max1
- MRF-2
- Sp1
Genomic Locations for UBC Gene
Latest Assembly
- chr12:124,911,604-124,917,368
- (GRCh38/hg38)
- Size:
- 5,765 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:125,396,192-125,399,196
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 3,005 bases
- Orientation:
- Minus strand
- chr12:125,396,150-125,401,914
- (GRCh37/hg19 by Ensembl)
- Size:
- 5,765 bases
- Orientation:
- Minus strand
Genomic View for UBC Gene
Genes around UBC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.3 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
UBC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UBC Gene
Proteins for UBC Gene
-
Protein details for UBC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0CG48-UBC_HUMAN
- Recommended name:
- Polyubiquitin-C
- Protein Accession:
- P0CG48
- P02248
- P02249
- P02250
- P62988
- Q29120
- Q6LBL4
- Q6LDU5
- Q8WYN8
- Q91887
- Q91888
- Q9BWD6
- Q9BX98
- Q9UEF2
- Q9UEG1
- Q9UEK8
- Q9UPK7
Protein attributes for UBC Gene
- Size:
- 685 amino acids
- Molecular mass:
- 77039 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.
- For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
Protein Expression for UBC Gene
Post-translational modifications for UBC Gene
- [Ubiquitin]: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).
- [Ubiquitin]: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.
-
Ubiquitination at Lys6, Lys11, Lys27, Lys29, Lys48, and Lys63
- NX_P0CG48 (NX_P0CG48-1)
- Modification sites at PhosphoSitePlus
Other Protein References for UBC Gene
Antibodies for research
- LifeSpan BioSciences UBC / Ubiquitin C Antibody (LS-B3621) and UBC / Ubiquitin C Antibody (LS-B3386)
- HUABIO Ubiquitin Antibody (ER31212)
-
Custom Antibody ServicesOriGene Antibodies for UBC
- Novus Biologicals Antibodies for UBC
- Invitrogen Antibodies for UBC (AFLGC-UBC)
-
Custom Antibody ServicesProSci Antibodies for UBC
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for UBC
- Origene Custom Protein Services for UBC
- Novus Biologicals proteins for UBC
- ProSpec Recombinant Proteins for UBC
- antibodies-online: Show 23 available UBC Proteins ranked by validation data
- Compare Top UBC Proteins
Assay products for research
- antibodies-online: Show 7 available UBC Elisa Kits ranked by validation data
- Compare Top UBC Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for UBC Gene
Domains & Families for UBC Gene
Gene Families for UBC Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for UBC Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for UBC Gene
- GenScript: Design optimal peptide antigens:
-
- Ubiquitin C (A8CGI2_HUMAN)
- Ubiquitin C splice variant (Q5PY61_HUMAN)
- Ubiquitin C splice variant (Q5UGI3_HUMAN)
- UBC protein (Q96H31_HUMAN)
- Polyubiquitin-C (UBC_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P0CG48- Family:
-
- Belongs to the ubiquitin family.
Function for UBC Gene
Molecular function for UBC Gene
- UniProtKB/Swiss-Prot Function:
- [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
- GENATLAS Biochemistry:
- poly-ubiquitin,gene C,encoding 9 tandem repeats of the ubiquitin unit
Phenotypes From GWAS Catalog for UBC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IPI | 21185309 |
| GO:0003723 | RNA binding | HDA | 22681889 |
| GO:0005515 | protein binding | IEA,IPI | 8702753 |
| GO:0031386 | protein tag | IBA | 21873635 |
| GO:0031625 | ubiquitin protein ligase binding | IBA | 21873635 |
Phenotypes for UBC Gene
- MGI mutant phenotypes for UBC:
-
inferred from 2 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for UBC:
-
- Increased gamma-H2AX phosphorylation
- Decreased viability
- no effect
- Synthetic lethal with Ras
- shRNA abundance <= 50%
- FOXO1 nuclear localization
- Increased number of mitotic cells
- Increased hepcidin::fluc mRNA expression
- Inconclusive
- Increased cell death HMECs cells
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased cell death in HCT116 cells
- Increased cell death in DLD-1 cells
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased cell number
- Decreased homologous recombination repair frequency
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability of wild-type and TP53 knockout cells
- Multipolar spindles
- Increased shRNA abundance (Z-score > 2)
- Decreased nuclei size in G2M
- Cell division defect
- Decreased viability with paclitaxel
- Decreased Sindbis virus (SINV) infection
- Inhibition of centrosomal clustering
- HIV Rev nuclear localization
- Decreased cell number, increased S DNA content
Animal Models for UBC Gene
- MGI Knock Outs for UBC:
-
- Ubc Ubc<tm1Rrk>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for UBC - Starting at $85 >
- * UBC CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for UBC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBC
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBC
miRNA for UBC Gene
- miRTarBase miRNAs that target UBC
-
- hsa-miR-24-3p (MIRT030628)
- hsa-miR-877-5p (MIRT037302)
- hsa-miR-296-3p (MIRT038409)
- hsa-miR-769-3p (MIRT039075)
- hsa-miR-615-3p (MIRT039711)
- hsa-miR-324-3p (MIRT042909)
- hsa-miR-221-3p (MIRT046896)
- hsa-miR-18a-5p (MIRT050710)
- hsa-miR-20a-5p (MIRT439366)
- hsa-miR-106b-5p (MIRT439367)
- hsa-miR-519d-3p (MIRT726199)
- hsa-miR-20b-5p (MIRT726200)
- hsa-miR-93-5p (MIRT726201)
- hsa-miR-17-5p (MIRT726202)
- hsa-miR-106a-3p (MIRT735821)
- hsa-miR-106a-5p (MIRT735830)
- hsa-miR-130a-3p (MIRT737295)
- hsa-miR-130b-3p (MIRT737304)
- hsa-miR-301a-3p (MIRT739615)
- hsa-miR-301b-3p (MIRT739625)
- hsa-miR-3666 (MIRT742077)
- hsa-miR-4295 (MIRT743790)
- hsa-miR-450a-1-3p (MIRT745575)
- hsa-miR-454-3p (MIRT746144)
- hsa-miR-488-3p (MIRT749157)
- hsa-miR-510-3p (MIRT749725)
- hsa-miR-519a-3p (MIRT750118)
- hsa-miR-519b-3p (MIRT750136)
- hsa-miR-519c-3p (MIRT750154)
- hsa-miR-526b-3p (MIRT750324)
- hsa-miR-5681a (MIRT751159)
- hsa-miR-651-3p (MIRT753266)
- hsa-miR-653-5p (MIRT753422)
- hsa-miR-6716-5p (MIRT753727)
- hsa-miR-6730-5p (MIRT753981)
- hsa-miR-1273a (MIRT783285)
- hsa-miR-1273g-3p (MIRT783340)
- hsa-miR-4486 (MIRT785996)
- hsa-miR-4649-5p (MIRT786298)
- hsa-miR-4793-3p (MIRT786802)
- hsa-miR-508-5p (MIRT787061)
- hsa-miR-6512-3p (MIRT788304)
- hsa-miR-661 (MIRT788417)
- hsa-miR-6720-5p (MIRT788466)
- hsa-miR-6729-5p (MIRT788480)
- hsa-miR-6849-3p (MIRT789072)
- hsa-miR-766-3p (MIRT789527)
- hsa-miR-7703 (MIRT789549)
- hsa-miR-939-3p (MIRT789990)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBC
- Browse OriGene Inhibitory RNA Products For UBC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBC
Clone products for research
- Applied Biological Materials (abm): Clones for UBC - Starting at $45 >
- * UBC as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Addgene plasmids for UBC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for UBC
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBC Gene
Localization for UBC Gene
Subcellular locations from UniProtKB/Swiss-Prot for UBC Gene
- [Ubiquitin]: Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 4 |
| mitochondrion | 4 |
| endosome | 4 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 16502470 |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005741 | mitochondrial outer membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for UBC Gene
Pathways & Interactions for UBC Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Activated TLR4 signalling | ||
| 4 | HIV Life Cycle |
.91
.64
|
.45
|
| 5 | Signaling by NOTCH1 | ||
Pathways by source for UBC Gene
3 BioSystems pathways for UBC Gene
328 Reactome pathways for UBC Gene
23 GeneGo (Thomson Reuters) pathways for UBC Gene
- Cell cycle ESR1 regulation of G1/S transition
- Cell cycle Regulation of G1/S transition (part 1)
- Cell cycle Role of SCF complex in cell cycle regulation
- Cell cycle Transition and termination of DNA replication
- Cell cycle_Spindle assembly and chromosome separation
17 Qiagen pathways for UBC Gene
- BRCA1 Pathway
- CDK5 Pathway
- Fanconi's Anaemia Pathway
- HIF1Alpha Pathway
- Huntington's Disease Pathway
1 Cell Signaling Technology pathway for UBC Gene
Interacting Proteins for UBC Gene
Selected Interacting proteins:
P0CG48-UBC_HUMAN
ENSP00000441543
for UBC Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for UBC
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | -- |
| GO:0000187 | activation of MAPK activity | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0000715 | nucleotide-excision repair, DNA damage recognition | TAS | -- |
| GO:0000717 | nucleotide-excision repair, DNA duplex unwinding | TAS | -- |
Transcripts for UBC Gene
mRNA/cDNA for UBC Gene
- 1 REFSEQ mRNAs :
- 27 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000339647 2193 nts (view in UCSC)
- ENST00000535131 563 nts (view in UCSC)
- ENST00000535859 582 nts (view in UCSC)
- ENST00000536661 624 nts (view in UCSC)
- ENST00000536769 3745 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for UBC - Starting at $85 >
- * UBC CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for UBC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for UBC
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBC
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for UBC
- Browse OriGene Inhibitory RNA Products For UBC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBC
Clone products for research
- Applied Biological Materials (abm): Clones for UBC - Starting at $45 >
- * UBC as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.