This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis,... See more...

Aliases for UBC Gene

Aliases for UBC Gene

  • Ubiquitin C 2 3 5
  • Polyubiquitin-C 2 3 4
  • HMG20 3

External Ids for UBC Gene

Previous GeneCards Identifiers for UBC Gene

  • GC12M124151
  • GC12M125142
  • GC12M123749
  • GC12M123921
  • GC12M125396
  • GC12M122360

Summaries for UBC Gene

Entrez Gene Summary for UBC Gene

  • This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

GeneCards Summary for UBC Gene

UBC (Ubiquitin C) is a Protein Coding gene. Diseases associated with UBC include Cystic Fibrosis and Eccrine Papillary Adenoma. Among its related pathways are Vesicle-mediated transport and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include protease binding. An important paralog of this gene is UBB.

UniProtKB/Swiss-Prot Summary for UBC Gene

  • Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Gene Wiki entry for UBC Gene

Additional gene information for UBC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBC Gene

Genomics for UBC Gene

GeneHancer (GH) Regulatory Elements for UBC Gene

Promoters and enhancers for UBC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBC gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • c-Myc
  • Max1
  • MRF-2
  • Sp1

Genomic Locations for UBC Gene

Genomic Locations for UBC Gene
chr12:124,911,604-124,917,368
(GRCh38/hg38)
Size:
5,765 bases
Orientation:
Minus strand
chr12:125,396,150-125,401,914
(GRCh37/hg19)
Size:
5,765 bases
Orientation:
Minus strand

Genomic View for UBC Gene

Genes around UBC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBC Gene

Proteins for UBC Gene

  • Protein details for UBC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG48-UBC_HUMAN
    Recommended name:
    Polyubiquitin-C
    Protein Accession:
    P0CG48
    Secondary Accessions:
    • P02248
    • P02249
    • P02250
    • P62988
    • Q29120
    • Q6LBL4
    • Q6LDU5
    • Q8WYN8
    • Q91887
    • Q91888
    • Q9BWD6
    • Q9BX98
    • Q9UEF2
    • Q9UEG1
    • Q9UEK8
    • Q9UPK7

    Protein attributes for UBC Gene

    Size:
    685 amino acids
    Molecular mass:
    77039 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.
    • For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.

    Three dimensional structures from OCA and Proteopedia for UBC Gene

neXtProt entry for UBC Gene

Post-translational modifications for UBC Gene

  • Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).
  • Ubiquitin: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.
  • Ubiquitination at Lys6, Lys11, Lys27, Lys29, Lys48, and Lys63
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for UBC Gene

Domains & Families for UBC Gene

Gene Families for UBC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBC Gene

Suggested Antigen Peptide Sequences for UBC Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin C (A8CGI2_HUMAN)
  • Ubiquitin C splice variant (Q5PY61_HUMAN)
  • Ubiquitin C splice variant (Q5UGI3_HUMAN)
  • UBC protein (Q96H31_HUMAN)
  • Polyubiquitin-C (UBC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CG48

UniProtKB/Swiss-Prot:

UBC_HUMAN :
  • Belongs to the ubiquitin family.
Family:
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with UBC: view

Function for UBC Gene

Molecular function for UBC Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
GENATLAS Biochemistry:
poly-ubiquitin,gene C,encoding 9 tandem repeats of the ubiquitin unit

Phenotypes From GWAS Catalog for UBC Gene

Gene Ontology (GO) - Molecular Function for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 21185309
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI,IEA 8702753
GO:0031386 protein tag IBA 21873635
GO:0031625 ubiquitin protein ligase binding IBA 21873635
genes like me logo Genes that share ontologies with UBC: view
genes like me logo Genes that share phenotypes with UBC: view

Animal Models for UBC Gene

MGI Knock Outs for UBC:
  • Ubc Ubc<tm1Rrk>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for UBC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBC Gene

Localization for UBC Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBC Gene

Ubiquitin: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBC gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
mitochondrion 4
endoplasmic reticulum 4
endosome 4
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 16502470
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005741 mitochondrial outer membrane TAS --
genes like me logo Genes that share ontologies with UBC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UBC Gene

Pathways & Interactions for UBC Gene

PathCards logo

SuperPathways for UBC Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.31
2 RET signaling
3 Activated TLR4 signalling
4 HIV Life Cycle
.45
5 Signaling by NOTCH1
genes like me logo Genes that share pathways with UBC: view

SIGNOR curated interactions for UBC Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS --
genes like me logo Genes that share ontologies with UBC: view

Drugs & Compounds for UBC Gene

(3) Drugs for UBC Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Formylmethionine Experimental Pharma Target 0

(1) Additional Compounds for UBC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UBC: view

Transcripts for UBC Gene

mRNA/cDNA for UBC Gene

CRISPR Products