This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008] See more...

Aliases for UBASH3B Gene

Aliases for UBASH3B Gene

  • Ubiquitin Associated And SH3 Domain Containing B 2 3 5
  • T-Cell Ubiquitin Ligand 2 2 3 4
  • SH3 Domain-Containing 70 KDa Protein, Suppressor Of T-Cell Receptor Signaling 1, Nm23-Phosphorylated Unknown Substrate 2 3
  • Ubiquitin-Associated And SH3 Domain-Containing Protein B 3 4
  • Suppressor Of T-Cell Receptor Signaling 1 3 4
  • Tyrosine-Protein Phosphatase STS1/TULA2 3 4
  • Cbl-Interacting Protein P70 3 4
  • TULA-2 3 4
  • STS-1 3 4
  • STS1 3 4
  • Nm23-Phosphorylated Unknown Substrate 3
  • Cbl-Interacting Protein Sts-1 3
  • EC 3.1.3.48 4
  • KIAA1959 4
  • TULA2 3
  • P70 3

External Ids for UBASH3B Gene

Previous GeneCards Identifiers for UBASH3B Gene

  • GC11P122032
  • GC11P122526
  • GC11P118468

Summaries for UBASH3B Gene

Entrez Gene Summary for UBASH3B Gene

  • This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBASH3B Gene

UBASH3B (Ubiquitin Associated And SH3 Domain Containing B) is a Protein Coding gene. Diseases associated with UBASH3B include Carrion's Disease and B-Cell Adult Acute Lymphocytic Leukemia. Gene Ontology (GO) annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is UBASH3A.

UniProtKB/Swiss-Prot Summary for UBASH3B Gene

  • Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Gene Wiki entry for UBASH3B Gene

Additional gene information for UBASH3B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for UBASH3B Gene

Genomics for UBASH3B Gene

GeneHancer (GH) Regulatory Elements for UBASH3B Gene

Promoters and enhancers for UBASH3B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J122654 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 514.3 +1.0 1005 3.4 CTCF POLR2G PHF8 ZIC2 REST POLR2A ZBTB26 SAP30 TGIF2 CTBP1 UBASH3B ENSG00000286341
GH11J122740 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12.7 +88.7 88713 7.6 SP1 EP300 ZIC2 RELA MEF2C TRIM22 POLR2A BCL11A KDM1A TCF12 UBASH3B CRTAM ENSG00000239079 lnc-BSX-1
GH11J122715 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +61.2 61184 3.3 SP1 MEF2C TCF12 USF2 MEF2B SPI1 POU2F2 EBF1 POLR2A FOXP2 lnc-BSX-2 UBASH3B piR-53338-027
GH11J122681 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 17.9 +26.3 26271 1.4 CTCF FOSL2 POLR2A JUND GLIS1 SMARCA4 SIN3A MYC RAD21 MAFK ENSG00000286341 UBASH3B ENSG00000239079 ENSG00000255342 piR-60246-037
GH11J122632 Enhancer 0.7 Ensembl ENCODE 21.7 -22.9 -22889 2 CTCF ZSCAN5C RAD21 SMC3 NFE2 EBF1 ZNF654 PRDM4 MAX ZBTB12 UBASH3B ENSG00000239079 CRTAM ENSG00000255342 ENSG00000254935 lnc-UBASH3B-3 piR-45035-039
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBASH3B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for UBASH3B

Top Transcription factor binding sites by QIAGEN in the UBASH3B gene promoter:
  • c-Ets-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • GATA-2
  • PPAR-gamma1

Genomic Locations for UBASH3B Gene

Genomic Locations for UBASH3B Gene
chr11:122,655,690-122,814,479
(GRCh38/hg38)
Size:
158,790 bases
Orientation:
Plus strand
chr11:122,526,383-122,685,187
(GRCh37/hg19)
Size:
158,805 bases
Orientation:
Plus strand

Genomic View for UBASH3B Gene

Genes around UBASH3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBASH3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBASH3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBASH3B Gene

Proteins for UBASH3B Gene

  • Protein details for UBASH3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF42-UBS3B_HUMAN
    Recommended name:
    Ubiquitin-associated and SH3 domain-containing protein B
    Protein Accession:
    Q8TF42
    Secondary Accessions:
    • Q53GT5
    • Q53GT8
    • Q8NBV7
    • Q96IG9
    • Q96NZ2

    Protein attributes for UBASH3B Gene

    Size:
    649 amino acids
    Molecular mass:
    72696 Da
    Quaternary structure:
    • Homodimer. Interacts with JAK2 (in vitro) (By similarity). Interacts with CBL (PubMed:15159412). Part of a complex containing CBL and activated EGFR (PubMed:15159412). Interacts with ubiquitin and with mono-ubiquitinated proteins (PubMed:15159412). Interacts with ZAP70 (ubiquitinated form) (PubMed:26903241).
    SequenceCaution:
    • Sequence=AAL16953.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85545.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBASH3B Gene

neXtProt entry for UBASH3B Gene

Post-translational modifications for UBASH3B Gene

  • Ubiquitination at Lys21, Lys112, Lys401, Lys411, Lys567, and Lys596
  • Modification sites at PhosphoSitePlus

Other Protein References for UBASH3B Gene

Antibody Products

  • Abcam antibodies for UBASH3B
  • Boster Bio Antibodies for UBASH3B
  • Santa Cruz Biotechnology (SCBT) Antibodies for UBASH3B

No data available for DME Specific Peptides for UBASH3B Gene

Domains & Families for UBASH3B Gene

Gene Families for UBASH3B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for UBASH3B Gene

Suggested Antigen Peptide Sequences for UBASH3B Gene

GenScript: Design optimal peptide antigens:
  • Tyrosine-protein phosphatase STS1/TULA2 (UBS3B_HUMAN)
genes like me logo Genes that share domains with UBASH3B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for UBASH3B Gene

Function for UBASH3B Gene

Molecular function for UBASH3B Gene

UniProtKB/Swiss-Prot Function:
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence=. ;.

Enzyme Numbers (IUBMB) for UBASH3B Gene

Phenotypes From GWAS Catalog for UBASH3B Gene

Gene Ontology (GO) - Molecular Function for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IBA 21873635
GO:0005515 protein binding IEA,IPI 20585042
GO:0016787 hydrolase activity IEA --
GO:0031625 ubiquitin protein ligase binding IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with UBASH3B: view
genes like me logo Genes that share phenotypes with UBASH3B: view

Animal Models for UBASH3B Gene

MGI Knock Outs for UBASH3B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBASH3B

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBASH3B Gene

Localization for UBASH3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBASH3B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBASH3B gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytosol 3
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBASH3B: view

Pathways & Interactions for UBASH3B Gene

PathCards logo

SuperPathways for UBASH3B Gene

No Data Available

SIGNOR curated interactions for UBASH3B Gene

Inactivates:

Gene Ontology (GO) - Biological Process for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA,IEA 21873635
GO:0009968 negative regulation of signal transduction IBA 21873635
GO:0030168 platelet activation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA,IBA 21873635
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IEA,IBA 21873635
genes like me logo Genes that share ontologies with UBASH3B: view

No data available for Pathways by source for UBASH3B Gene

Drugs & Compounds for UBASH3B Gene

(5) Drugs for UBASH3B Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for UBASH3B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UBASH3B: view

Transcripts for UBASH3B Gene

mRNA/cDNA for UBASH3B Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UBASH3B

Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - -
SP2: -
SP3: - - - - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: - - - - - - - - - -
SP9: - -

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for UBASH3B Gene

GeneLoc Exon Structure for
UBASH3B

Expression for UBASH3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBASH3B Gene

mRNA differential expression in normal tissues according to GTEx for UBASH3B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.2), Brain - Cerebellum (x7.8), and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for UBASH3B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.4), Breast (18.7), and Platelet (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBASH3B Gene



Protein tissue co-expression partners for UBASH3B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for UBASH3B

SOURCE GeneReport for Unigene cluster for UBASH3B Gene:

Hs.444075

Evidence on tissue expression from TISSUES for UBASH3B Gene

  • Nervous system(4.7)
  • Blood(4.5)
  • Kidney(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with UBASH3B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBASH3B Gene

Orthologs for UBASH3B Gene

This gene was present in the common ancestor of animals.

Orthologs for UBASH3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBASH3B 31 30
  • 99.64 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBASH3B 31
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBASH3B 31
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBASH3B 31 30
  • 90.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia UBASH3B 31 30
  • 89.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ubash3b 17 31 30
  • 89.18 (n)
rat
(Rattus norvegicus)
Mammalia Ubash3b 30
  • 87.88 (n)
chicken
(Gallus gallus)
Aves UBASH3B 31 30
  • 80.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBASH3B 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubash3b 30
  • 74.82 (n)
zebrafish
(Danio rerio)
Actinopterygii UBASH3B (1 of 2) 31
  • 74 (a)
OneToMany
UBASH3B (2 of 2) 31
  • 73 (a)
OneToMany
si:ch211-49j11.1 30
  • 70.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002463 30
  • 50 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13604 31 30
  • 49.54 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07F12.1 31 30
  • 48.64 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 39 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
Species where no ortholog for UBASH3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBASH3B Gene

ENSEMBL:
Gene Tree for UBASH3B (if available)
TreeFam:
Gene Tree for UBASH3B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBASH3B: view image

Paralogs for UBASH3B Gene

Paralogs for UBASH3B Gene

(1) SIMAP similar genes for UBASH3B Gene using alignment to 1 proteins:

  • UBS3B_HUMAN
genes like me logo Genes that share paralogs with UBASH3B: view

Variants for UBASH3B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for UBASH3B Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
711917 Benign: not provided 122,796,180(+) G/A MISSENSE_VARIANT
727492 Likely Benign: not provided 122,776,240(+) G/A MISSENSE_VARIANT,SYNONYMOUS_VARIANT
747650 Likely Benign: not provided 122,796,191(+) G/A SYNONYMOUS_VARIANT
774816 Benign: not provided 122,776,228(+) C/G MISSENSE_VARIANT,SYNONYMOUS_VARIANT
776672 Benign: not provided 122,796,957(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for UBASH3B Gene

Structural Variations from Database of Genomic Variants (DGV) for UBASH3B Gene

Variant ID Type Subtype PubMed ID
dgv169n27 CNV loss 19166990
dgv2187n54 CNV loss 21841781
esv3430463 CNV insertion 20981092
esv3627945 CNV loss 21293372
esv9672 OTHER inversion 19470904
nsv1039632 CNV gain 25217958
nsv1050579 CNV gain 25217958
nsv1053418 CNV gain 25217958
nsv527 CNV insertion 18451855
nsv952748 CNV duplication 24416366
nsv952749 CNV duplication 24416366
nsv972955 CNV duplication 23825009
nsv983212 CNV deletion 23825009

Variation tolerance for UBASH3B Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.62; 86.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBASH3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBASH3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBASH3B Gene

Disorders for UBASH3B Gene

MalaCards: The human disease database

(4) MalaCards diseases for UBASH3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
carrion's disease
  • carrion disease
b-cell adult acute lymphocytic leukemia
  • adult b acute lymphoblastic leukemia
bartonellosis
  • bartonella infectious disease
cat-scratch disease
  • oroya fever
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for UBASH3B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UBASH3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBASH3B Gene

Publications for UBASH3B Gene

  1. Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. (PMID: 15159412) Kowanetz K … Dikic I (The Journal of biological chemistry 2004) 3 4 23 54
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 54
  3. Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. (PMID: 23784775) Lee ST … Yu Q (Proceedings of the National Academy of Sciences of the United States of America 2013) 2 3 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. (PMID: 17880946) Raguz J … Hoeller D (FEBS letters 2007) 3 4 54

Products for UBASH3B Gene

Sources for UBASH3B Gene